{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "17e05a00-a859-4098-b28a-a3a28da094ef", "code": "P53396", "type": "PRIMARY", "url": "https://www.uniprot.org/uniprot/P53396", "code_system": "UNIPROT" }, { "uuid": "832a3597-3e0c-4d17-b287-bf2346a103f6", "code": "YY45HG905G", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "86aedb3c-24a0-5b47-9c07-839a39460e3a", "citation": "https://www.uniprot.org/uniprot/P53396", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE", "NOMEN" ] }, { "uuid": "cad89075-6fb1-44c4-8d5f-fa16e1dff89a", "url": 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\"Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.\" Journal of Medicinal Chemistry 66.14 (2023): 9229-9250.", "url": "https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00179", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "d81c1208-a2d7-40d2-81ab-bec588ccbac4", "citation": "Zhang, Li’ao, et al. \"Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.\" Journal of Medicinal Chemistry 66.14 (2023): 9229-9250.", "url": "https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00179", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "ce7e6646-9c79-42c8-9bad-955d866d196b", "version": "12", "unii": "YY45HG905G", "relationships": [ { "uuid": "63ae884a-8b64-4196-b5d8-205a2fa975bc", "amount": { "uuid": "1592fd62-4d7b-4a2f-bdc5-5b844227597d", "average": 8000, "units": "NANOMOLAR" }, 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acid", "substance_class": "reference" } } ], "names": [ { "uuid": "8df695ad-0152-992c-2e92-dd23ec159dd5", "name": "ACL", "stdName": "ACL", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "86aedb3c-24a0-5b47-9c07-839a39460e3a" ], "display_name": false }, { "uuid": "61acdc1d-7b5a-4515-b954-fb07df177df3", "name": "ACLY", "stdName": "ACLY", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e655d10d-b009-49f9-ab72-b95f4e9bea53" ], "display_name": false }, { "uuid": "108eaf30-8356-4b6e-8f47-3adcba5ca90e", "name": "ATP citrate lyase", "stdName": "ATP CITRATE LYASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e655d10d-b009-49f9-ab72-b95f4e9bea53" ], "display_name": false }, { "uuid": "39041042-dd1c-bef5-995a-f08bb18decda", "name": "ATP-CITRATE (PRO-S-)-LYASE", "stdName": "ATP-CITRATE (PRO-S-)-LYASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "86aedb3c-24a0-5b47-9c07-839a39460e3a" ], "display_name": false }, { "uuid": "80b05b35-7633-b7c5-3e5b-908b07dfe565", "name": "ATP-CITRATE SYNTHASE", "stdName": "ATP-CITRATE SYNTHASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "86aedb3c-24a0-5b47-9c07-839a39460e3a" ], "display_name": true } ], "protein": { "uuid": "9d2c97aa-568a-451e-b17d-27274ee066ea", "glycosylation": { "uuid": "72eea136-798d-4712-b7ca-48c22179efbf" }, "subunits": [ { "uuid": "fef296e4-b5ae-4932-a535-cd03b7ee037a", "sequence": "MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM", 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"MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM", "subunit_index": 2 }, { "uuid": "aa53082e-c527-4ab3-b6f7-9612a64f13b6", "sequence": "MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM", "subunit_index": 3 }, { "uuid": "3c60c0e1-fbc6-4efb-9db1-7540d8cebe96", "sequence": "MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM", "subunit_index": 4 } ], "references": [ "86aedb3c-24a0-5b47-9c07-839a39460e3a" ], "protein_sub_type": "", "protein_type": "ENZYME", "sequence_origin": "HUMAN", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "d322bb52-0c10-4051-8f67-72cf5ec9a406", "name": "MOL_WEIGHT:NUMBER(CALCULATED)", "type": "amount", "value": { "uuid": "71ffbd8f-198a-45ba-b3f8-0d1863fd3d08", "type": "ESTIMATED", "average": 121000, "units": "Da" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "5011ae16-d368-48c2-b5bf-64bf943d407b", "name": "Molecular Formula", "value": { "uuid": "1466593b-e647-4517-864f-e8e023c39112", "type": "ESTIMATED", "non_numeric_value": "C21688H34036N5784O6312S200" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "7983dcee-6a27-46fe-987d-f3b9fd274dc1" } } ] }