{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "7670fc3f-aea9-412d-86e0-5645d80baa21", "code": "ABCC1", "comments": "UCSF-FDA TRANSPORTAL|DRUG TRANSPORTER", "type": "PRIMARY", "url": "http://transportal.compbio.ucsf.edu/transporters/ABCC1/", "code_system": "UCSF-FDA TRANSPORTAL", "references": [ "29033019-e725-4581-966d-25aef426a6f9" ] }, { "uuid": "beb6523e-ad3f-471f-989f-0464edfc4be1", "code": "P33527", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/P33527", "code_system": "UNIPROT", "references": [ "29033019-e725-4581-966d-25aef426a6f9" ] }, { "uuid": "9342a545-45ae-4e42-be63-b8193cc00441", "code": "1646536-20-0", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=1646536-20-0", "code_system": "CAS", "references": [ "9e9dd018-b103-b582-d12f-1b460ecd5ca9" ] }, { "uuid": "1c17c90f-e813-4711-8c20-ee6b0f63491a", "code": "Y49M64GZ4Q", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "07481531-4243-49fa-b49d-a52c0d77d54c", "citation": "FDA_SRS", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "abc3c369-925a-4d6c-befe-e084e25f4f9a", "citation": "http://www.uniprot.org/uniprot/P33527", "url": "http://www.uniprot.org/uniprot/P33527", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "413db227-2365-4919-b12e-52870b4b3731", "citation": "http://bts.ucsf.edu/fdatransportal/transporters/ABCC1/", "url": "http://bts.ucsf.edu/fdatransportal/transporters/ABCC1/", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "29033019-e725-4581-966d-25aef426a6f9", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493392561000, "tags": [ "NOMEN" ] }, { "uuid": "03655a7b-b247-4ffa-a5d4-0c43731014d6", "citation": "http://bts.ucsf.edu/fdatransportal/transporters/ABCC1/", "url": "http://bts.ucsf.edu/fdatransportal/transporters/ABCC1/", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "487d46a5-6d42-439a-83aa-59bd3d3923df", "citation": "DRUG METABOLISM HANDBOOK, ED. A.F. NASSER, 2009, PG:91", "doc_type": "BOOK", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "4912d767-999a-4d79-a024-91ea6280bc7b", "citation": "DRUG METABOLISM HANDBOOK, ED. A.F. NASSER, 2009, pg:91", "url": "DRUG METABOLISM HANDBOOK, ED. A.F. NASSER, 2009, pg:91", "doc_type": "BOOK", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "77f3f940-7195-4f17-9446-1db0b5ee6edb", "citation": "SRS import [Y49M64GZ4Q]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=Y49M64GZ4Q", "doc_type": "SRS", "public_domain": true, "document_date": 1493392561000, "tags": [ "NOMEN" ] }, { "uuid": "8c665769-7387-4430-a747-6d38b7a51ad3", "citation": "https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71621", "url": "https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71621", "doc_type": "NCI THESAURUS", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "96f4157e-cdf4-4abe-99d2-6ceff175e7c5", "citation": "https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71621", "url": "https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71621", "doc_type": "NCI THESAURUS", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9e9dd018-b103-b582-d12f-1b460ecd5ca9", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "21f062a6-2b83-4e54-b799-5edee9abee31", "citation": "Engle, Kritika, and Gautam Kumar. \"Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.\" European Journal of Medicinal Chemistry (2022): 114542.", "url": "https://reader.elsevier.com/reader/sd/pii/S0223523422004445?token=B3EF98BA0FAAF433D381FC1940C0A0821598B2CD02A38085CDCBCDC6820386D96F5F5C32DDBD9012577502F3F6A9B6C9&originRegion=us-east-1&originCreation=20220716171256", "doc_type": "JA", "public_domain": true }, { "uuid": "5d547bed-252b-481c-93e7-2504b78d1349", "citation": "Čvorović, Jovana, and Sabina Passamonti. \"Membrane transporters for bilirubin and its conjugates: a systematic review.\" Frontiers in pharmacology 8 (2017): 887.", "url": "https://www.frontiersin.org/articles/10.3389/fphar.2017.00887/full", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "a92ba84a-46dc-4e3f-80d1-e490da271998", "version": "13", "unii": "Y49M64GZ4Q", "relationships": [ { "uuid": "7b8c9456-daff-4871-9b08-d76331948083", "amount": { "uuid": "adf97180-c9bf-42b0-becd-ff8b15a3aa4e" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "0098a13f-80e2-4f5f-91df-064e360bbce0", "refuuid": "cf42852a-3942-4aea-a4d9-0842d85d210d", "name": "CURCUMIN", "unii": "IT942ZTH98", "linking_id": "IT942ZTH98", "ref_pname": "CURCUMIN", "substance_class": "reference" } }, { "uuid": "333e2b91-5918-404f-ae0f-11a5694a9ae5", "amount": { "uuid": "134e7dc4-def1-4350-b67e-3e8fe116abe7" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "fcafcdb5-4f1d-4712-a7f7-77117fbffba9", "refuuid": "2017927d-5141-48f8-848d-6c1b26165593", "name": "Cyclosporine", "unii": "83HN0GTJ6D", "linking_id": "83HN0GTJ6D", "ref_pname": "Cyclosporine", "substance_class": "reference" } }, { "uuid": "15ccdc40-80fe-439f-8162-674218eb00ee", "amount": { "uuid": "facdd005-28fe-41d5-ad2a-444b3c80fbb5" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "9d79a16a-3316-4d3b-82aa-04debf6734fb", "refuuid": "7b458395-4aa1-46ba-94bd-95eef84b12e3", "name": "GENISTEIN", "unii": "DH2M523P0H", "linking_id": "DH2M523P0H", "ref_pname": "GENISTEIN", "substance_class": "reference" } }, { "uuid": "839e4327-817f-49e5-b3f9-3e16a3c6ae17", "amount": { "uuid": "b7de83a9-b82a-49fd-9ae4-f3943d9140cc" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "0a749aae-a68e-4c21-a1cb-4b66b5aa3fb6", "refuuid": "36bb067c-6dfc-4a3a-b81f-19f15a5ebb5a", "name": "INDOMETHACIN", "unii": "XXE1CET956", "linking_id": "XXE1CET956", "ref_pname": "INDOMETHACIN", "substance_class": "reference" } }, { "uuid": "4e67859c-9b09-40b4-9ba0-25894fe32d0f", "amount": { "uuid": "7ca44efa-27a1-4c1f-b9f9-06e91a764bee" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "f575ae2a-6839-496c-b10b-dbe75e41a255", "refuuid": "eee03996-1928-4043-890f-e554b0a15767", "name": "KAEMPFEROL", "unii": "731P2LE49E", "linking_id": "731P2LE49E", "ref_pname": "KAEMPFEROL", "substance_class": "reference" } }, { "uuid": "9a7b17da-eaae-4c7e-8d34-f48ce20e311e", "amount": { "uuid": "598a0bdc-0094-48c9-ac0c-5731080061f8" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "3a0a3191-1412-4521-a6ab-eec7343007ae", "refuuid": "fe46acbb-e38d-4416-aab8-6d50a48d2fb2", "name": "MK-571", "unii": "76LB1G2X6V", "linking_id": "76LB1G2X6V", "ref_pname": "MK-571", "substance_class": "reference" } }, { "uuid": "89f53a02-9a6d-4630-bc76-fd5207eeebc9", "amount": { "uuid": "7290dac3-2564-4463-a1a7-6b9d6ba601fa" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "5d144fee-6b02-4ada-a66f-07b55a7bab30", "refuuid": "5cbea2ee-e7d4-44e3-aa54-20e3c2fe5019", "name": "MYRICETIN", "unii": "76XC01FTOJ", "linking_id": "76XC01FTOJ", "ref_pname": "MYRICETIN", "substance_class": "reference" } }, { "uuid": "c755e06b-3424-4dc0-8f7e-c74a174d8457", "amount": { "uuid": "e707e818-3b23-469a-9784-97d236d73f0b" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "05b84b0d-892a-491f-b751-9ff06cba378b", "refuuid": "04621855-3c6a-428c-a1cd-544e8f79d1fd", "name": "QUERCETIN", "unii": "9IKM0I5T1E", "linking_id": "9IKM0I5T1E", "ref_pname": "QUERCETIN", "substance_class": "reference" } }, { "uuid": "a8a7d925-b5ae-4015-9fb7-c4fa6e4fd350", "amount": { "uuid": "5022f39c-2169-4ba2-ae05-ee7674bbc3e9" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "fe83575c-a6d5-4a5f-bca1-749cd17eced8", "refuuid": "7cbdfd14-a66b-4cc3-93ec-d2894bfc27ab", "name": "VERAPAMIL", "unii": "CJ0O37KU29", "linking_id": "CJ0O37KU29", "ref_pname": "VERAPAMIL", "substance_class": "reference" } }, { "uuid": "05266160-10a3-4793-9939-1b72d5011eff", "amount": { "uuid": "b2048feb-bd03-4451-bfff-7e41a09694a5" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "03655a7b-b247-4ffa-a5d4-0c43731014d6" ], "related_substance": { "uuid": "803cbb26-acc1-419f-b2d9-76fa595e0afb", "refuuid": "9734c046-2111-4f08-9d6b-b9188d9b9029", "name": "ESTRONE SULFATE", "unii": "QTL48N278K", "linking_id": "QTL48N278K", "ref_pname": "ESTRONE SULFATE", "substance_class": "reference" } }, { "uuid": "7a69052e-fe96-49f6-ab54-d25f333f30b1", "amount": { "uuid": "a7070b3e-01ab-4670-85de-be3ced0250c6" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "6b5b284d-e0f4-442b-be92-4d8c0c631c65", "refuuid": "2de072bd-9bf1-47cd-839e-e006ef7ff722", "name": "KETOCONAZOLE", "unii": "R9400W927I", "linking_id": "R9400W927I", "ref_pname": "KETOCONAZOLE", "substance_class": "reference" } }, { "uuid": "21f50d82-2a94-46f1-8ed1-4481e3aca5dc", "amount": { "uuid": "01b67690-4758-49fc-a5d1-c7931cfbf131" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "2ddfabc8-ad81-4f38-bad8-8542f319c205", "refuuid": "69a901de-d577-481e-bd9f-3d9d11dde852", "name": "Glutathione", "unii": "GAN16C9B8O", "linking_id": "GAN16C9B8O", "ref_pname": "Glutathione", "substance_class": "reference" } }, { "uuid": "2c097e6c-47ee-434a-9642-3780bab7f593", "amount": { "uuid": "753f7812-c692-4e93-b4a1-3d0298cbcf1a" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "49c6895d-e83e-445b-ba1c-00ac3aebc8ed", "refuuid": "64b792dc-2854-40a7-b087-9fead3a64d6a", "name": "INDINAVIR", "unii": "5W6YA9PKKH", "linking_id": "5W6YA9PKKH", "ref_pname": "INDINAVIR", "substance_class": "reference" } }, { "uuid": "eb151dd8-5e91-4370-a7c8-fbbcf6d24417", "amount": { "uuid": "69db3978-73fa-4742-9240-3e13a79073ef" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "ba9b409e-4827-4365-8adb-631948888c77", "refuuid": "a49705c2-661a-4ad6-8568-92b86c89854a", "name": "CISPLATIN", "unii": "Q20Q21Q62J", "linking_id": "Q20Q21Q62J", "ref_pname": "CISPLATIN", "substance_class": "reference" } }, { "uuid": "4a466abc-7839-47a4-b982-9b9bda2ab339", "amount": { "uuid": "dc85f6ab-b980-4045-b0e6-a6dd78bf8029" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "0789cd17-6df6-4adf-a21f-4693759fd0b2", "refuuid": "1f379bda-9108-429e-a90b-e4f3bc6f7864", "name": "ETOPOSIDE", "unii": "6PLQ3CP4P3", "linking_id": "6PLQ3CP4P3", "ref_pname": "ETOPOSIDE", "substance_class": "reference" } }, { "uuid": "86d849a5-a511-4f5a-9973-1093e99999ce", "amount": { "uuid": "fdd03abe-d0d5-4bf7-b1b0-28350b331c21" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "d059adeb-9b40-4a22-b5e8-c5eb4bcfc2d4", "refuuid": "ec79c7ff-748b-4b23-86ff-ea6510888ce6", "name": "METHOTREXATE", "unii": "YL5FZ2Y5U1", "linking_id": "YL5FZ2Y5U1", "ref_pname": "METHOTREXATE", "substance_class": "reference" } }, { "uuid": "ecf99659-39d2-4688-8b3f-1537095fe17d", "amount": { "uuid": "9c60a6a2-8195-4a95-8dc7-62f81d5d9f7c" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "5e83cbf1-1cce-4dee-ab96-eec6593e0614", "refuuid": "9855f1ab-7e73-4405-a408-08530d1a6a63", "name": "VINCRISTINE", "unii": "5J49Q6B70F", "linking_id": "5J49Q6B70F", "ref_pname": "VINCRISTINE", "substance_class": "reference" } }, { "uuid": "98f2c68f-d3b2-4e11-ade2-c9e681afd8ba", "amount": { "uuid": "6eda50cd-8e08-4d9a-bfc4-3069e8b4b0e2" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "9c08c695-31bc-4b60-b304-5956d3cb7e3e", "refuuid": "9855f1ab-7e73-4405-a408-08530d1a6a63", "name": "VINCRISTINE", "unii": "5J49Q6B70F", "linking_id": "5J49Q6B70F", "ref_pname": "VINCRISTINE", "substance_class": "reference" } }, { "uuid": "85956665-87b3-42cf-8f3d-63c9b16b5c7a", "amount": { "uuid": "2df4f44e-cdcf-48f5-b46f-57edd868fd9d" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "487d46a5-6d42-439a-83aa-59bd3d3923df" ], "related_substance": { "uuid": "c04eed82-c6ab-4994-ab0c-d00e710a2e43", "refuuid": "4fba4435-771e-4450-97e9-e141bbbc818e", "name": "RIFAMPIN", "unii": "VJT6J7R4TR", "linking_id": "VJT6J7R4TR", "ref_pname": "RIFAMPIN", "substance_class": "reference" } }, { "uuid": "2b720d2e-9043-4b4a-b024-2681342ce528", "amount": { "uuid": "2cf12caf-3576-4030-8201-c8fe76003de8" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "f6cd9aa5-eb14-4ca7-b1e5-a504b6bd4891", "refuuid": "52b5c76e-d0d1-4766-914f-c9fefd813b91", "name": "SULFINPYRAZONE", "unii": "V6OFU47K3W", "linking_id": "V6OFU47K3W", "ref_pname": "SULFINPYRAZONE" } }, { "uuid": "74fbc772-5971-41a2-9d98-ada08a377f7a", "amount": { "uuid": "b92353b7-11fc-409f-85dd-4179a3b26fa9" }, "type": "INHIBITOR->TRANSPORTER", "references": [ "8c665769-7387-4430-a747-6d38b7a51ad3" ], "related_substance": { "uuid": "abfdf077-213f-4541-84bf-5ebfd4cc4394", "refuuid": "83c495f8-862a-4482-a13a-27e7cac26757", "name": "BIRICODAR", "unii": "3KG76X4KJK", "linking_id": "3KG76X4KJK", "ref_pname": "BIRICODAR", "substance_class": "reference" } }, { "uuid": "9ff0a5f2-a914-4dbd-8f63-2e579bff5457", "amount": { "uuid": "81e06948-ebe8-43a0-b124-d801327321d0" }, "type": "INHIBITOR->TARGET", "references": [ "96f4157e-cdf4-4abe-99d2-6ceff175e7c5" ], "related_substance": { "uuid": "471b05c8-2772-4f65-b6e1-8cca0d829638", "refuuid": "83c495f8-862a-4482-a13a-27e7cac26757", "name": "BIRICODAR", "unii": "3KG76X4KJK", "linking_id": "3KG76X4KJK", "ref_pname": "BIRICODAR", "substance_class": "reference" } }, { "uuid": "cd8a275f-bea1-47f6-9c78-27747465143e", "amount": { "uuid": "51650a2d-23a2-4aa9-95e1-8ea1b100468d" }, "type": "NON-INHIBITOR->TRANSPORTER", "related_substance": { "uuid": "8fb3957f-35f6-47ad-bfb0-fdb9ef1b9dba", "refuuid": "57b61e36-562a-4c45-a23c-716f0fb1d694", "name": "ENCEQUIDAR", "unii": "K4I4I996O4", "linking_id": "K4I4I996O4", "ref_pname": "ENCEQUIDAR" } }, { "uuid": "2ac388cb-802e-4d95-b2ff-0ad2378d0883", "amount": { "uuid": "6be20498-16db-4470-8863-16e42a67b29c" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "c1df5980-51a3-451b-a06a-3c469cc56570", "refuuid": "5aa3f5bd-6c2a-427e-9669-d3e463b7c108", "name": "EDATREXATE", "unii": "JT4X6Z1HRR", "linking_id": "JT4X6Z1HRR", "ref_pname": "EDATREXATE", "substance_class": "reference" } }, { "uuid": "bca2ceb1-791b-46e0-8763-c5721f1ae3a6", "amount": { "uuid": "6fe5c59c-f64c-4ee5-937a-5ae7d62051e6" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "0615a6ce-a86d-4a73-8567-119f646ab814", "refuuid": "09370865-4f05-4e9c-ae74-7d1f8c51efaa", "name": "MITOXANTRONE", "unii": "BZ114NVM5P", "linking_id": "BZ114NVM5P", "ref_pname": "MITOXANTRONE", "substance_class": "reference" } }, { "uuid": "fd51bab3-06a3-4c1f-9854-28481a039ccf", "amount": { "uuid": "d6b0c559-e89a-4616-b7b9-4f4ec065000b" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "ee5d99da-d39f-48ba-9747-3d119a1910f2", "refuuid": "d0c92950-0bc8-481d-b8f5-ebc6a43522f8", "name": "IDARUBICIN", "unii": "ZRP63D75JW", "linking_id": "ZRP63D75JW", "ref_pname": "IDARUBICIN", "substance_class": "reference" } }, { "uuid": "8742fd69-926a-4ecb-86db-b25d7f2d864e", "amount": { "uuid": "945e4435-3f12-4532-b3c1-8c91a934fbda" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "91011624-ceb5-439e-8998-9f38506864f0", "refuuid": "4f0a4a62-6657-47f4-b12d-9726d36e34c2", "name": "EPIRUBICIN", "unii": "3Z8479ZZ5X", "linking_id": "3Z8479ZZ5X", "ref_pname": "EPIRUBICIN", "substance_class": "reference" } }, { "uuid": "e5224b20-3503-449e-8b07-b0fe2b07dc33", "amount": { "uuid": "fa7503d9-7dc2-4283-a816-beed1f3f08a6" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "683a16d2-e99d-4710-a0f8-e3883255349d", "refuuid": "d7211797-c63e-4fb3-811f-c57b6a5e1146", "name": "DAUNORUBICIN", "unii": "ZS7284E0ZP", "linking_id": "ZS7284E0ZP", "ref_pname": "DAUNORUBICIN", "substance_class": "reference" } }, { "uuid": "5d73d2ef-e4b4-4809-bb77-38429e592bb8", "amount": { "uuid": "81c6d2d0-293b-4337-a9bb-0cb409b2d137" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "20466a57-9605-4835-acb0-00f3685a3551", "refuuid": "88f7c90e-8da6-40dc-9021-99709da99dc0", "name": "DOXORUBICIN", "unii": "80168379AG", "linking_id": "80168379AG", "ref_pname": "DOXORUBICIN", "substance_class": "reference" } }, { "uuid": "2acec531-639b-4351-bd46-6661fc04a7f9", "amount": { "uuid": "ccf8896b-5484-4088-9ec8-79a03d2e3e03" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "0dbe4123-1799-406a-bf41-6e055d2ff0f3", "refuuid": "06793752-39c4-4700-b642-7174f0314e3b", "name": "HYDROXYFLUTAMIDE", "unii": "31D90UKP5Y", "linking_id": "31D90UKP5Y", "ref_pname": "HYDROXYFLUTAMIDE", "substance_class": "reference" } }, { "uuid": "38c3ab07-dba7-4392-9f9f-53971da0c7d4", "amount": { "uuid": "5ffc379f-bcd6-48ff-bc1d-d9ef4af57ad3" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "231fcf0d-cba9-4aaa-9251-bcbd945e3716", "refuuid": "ceb90449-01d7-485e-b6b3-ee173f370818", "name": "FLUTAMIDE", "unii": "76W6J0943E", "linking_id": "76W6J0943E", "ref_pname": "FLUTAMIDE", "substance_class": "reference" } }, { "uuid": "00f68790-3ce9-4baa-a995-44b1010780bb", "amount": { "uuid": "813b6b0b-bbde-42ae-9984-e7f100cdf139" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "62f62acd-525a-44dc-8841-1936a43a7617", "refuuid": "34be46f4-df27-4967-b8bd-5e0d9c6b2128", "name": "VINBLASTINE", "unii": "5V9KLZ54CY", "linking_id": "5V9KLZ54CY", "ref_pname": "VINBLASTINE", "substance_class": "reference" } }, { "uuid": "ec58983d-bc0d-476a-bc54-480c2b4a3bfa", "amount": { "uuid": "40652b11-e819-43bc-ad63-df898855c439" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "8877691d-36bc-4864-86d2-b2edcba7e667", "refuuid": "8859ae53-78bb-4702-8ad9-b7fbe5b92fe4", "name": "7-ETHYL-10-HYDROXYCAMPTOTHECIN", "unii": "0H43101T0J", "linking_id": "0H43101T0J", "ref_pname": "7-ETHYL-10-HYDROXYCAMPTOTHECIN", "substance_class": "reference" } }, { "uuid": "fcf3eeec-f8d2-4269-9c06-e5c940b5c77b", "amount": { "uuid": "6e904c0f-6d8c-45e0-9970-890ce746c343" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "923bbb9f-aa9b-4776-bd60-7d55dee050eb", "refuuid": "886dff31-4a11-444c-9cb7-89075cd2565d", "name": "Irinotecan", "unii": "7673326042", "linking_id": "7673326042", "ref_pname": "Irinotecan", "substance_class": "reference" } }, { "uuid": "c8dfb99f-946c-4d59-bde3-f021bfd72ec5", "amount": { "uuid": "c0c2c082-cb5c-4e4c-bf9f-153ce6cd92d5" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "33972d7b-9841-42ec-8681-1521776ff0da", "refuuid": "7a6e1dc8-bb6c-407e-8d90-5fadfa1ccd3c", "name": "PACLITAXEL", "unii": "P88XT4IS4D", "linking_id": "P88XT4IS4D", "ref_pname": "PACLITAXEL", "substance_class": "reference" } }, { "uuid": "d9cd31da-9ffb-4634-8ae1-a7b577cf3996", "amount": { "uuid": "d9437577-db50-46ba-9335-291814dafcc8" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "21f062a6-2b83-4e54-b799-5edee9abee31" ], "related_substance": { "uuid": "08795244-efb4-48ef-a6f1-4cbd78296ec5", "refuuid": "26ab9cfe-9c78-4051-98cc-5cb6d9ec1278", "name": "RALTITREXED", "unii": "FCB9EGG971", "linking_id": "FCB9EGG971", "ref_pname": "RALTITREXED", "substance_class": "reference" } }, { "uuid": "82aff53b-4cac-4a7c-baae-64aebf782355", "amount": { "uuid": "a5ad415d-b405-48d4-9a00-737d66f36a14" }, "type": "SUBSTRATE->TRANSPORTER", "references": [ "5d547bed-252b-481c-93e7-2504b78d1349" ], "related_substance": { "uuid": "9137e0e1-19bb-4f02-b10b-ccb5e75d7bcb", "refuuid": "e0356064-bd07-4df4-99a0-71d44f390168", "name": "BILIRUBIN", "unii": "RFM9X3LJ49", "linking_id": "RFM9X3LJ49", "ref_pname": "BILIRUBIN", "substance_class": "reference" } } ], "names": [ { "uuid": "a7eed00b-aa45-40f8-98d7-6b77338f39fe", "name": "ABC29", "stdName": "ABC29", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "413db227-2365-4919-b12e-52870b4b3731" ], "display_name": false }, { "uuid": "f664148a-8951-4902-b29c-495e5f2f05a7", "name": "ABCC", "stdName": "ABCC", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "413db227-2365-4919-b12e-52870b4b3731" ], "display_name": false }, { "uuid": "59f12d20-9837-4403-a3b1-68a63486f7f0", "name": "ABCC1", "stdName": "ABCC1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "display_name": false }, { "uuid": "6a5231b5-d3ca-4f33-bb33-fd2de06eb4e1", "name": "ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 1", "stdName": "ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "display_name": false }, { "uuid": "cc86584b-7b4d-4de1-9886-ce90c3c83b9d", "name": "DKFZP686N04233", "stdName": "DKFZP686N04233", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "413db227-2365-4919-b12e-52870b4b3731" ], "display_name": false }, { "uuid": "bad4fdfa-5c66-4b98-be78-bc913e5b16c6", "name": "DKFZP781G125", "stdName": "DKFZP781G125", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "413db227-2365-4919-b12e-52870b4b3731" ], "display_name": false }, { "uuid": "e5ee94af-6a4b-48d9-ad81-1d01648ff6c3", "name": "GS-X", "stdName": "GS-X", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "413db227-2365-4919-b12e-52870b4b3731" ], "display_name": false }, { "uuid": "067f580f-f469-47a6-86d0-3cedf8c04d48", "name": "MRP", "stdName": "MRP", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "display_name": false }, { "uuid": "a4a3bbf2-6c85-47f9-949e-530e6b6f53c1", "name": "MRP-1", "stdName": "MRP-1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "07481531-4243-49fa-b49d-a52c0d77d54c" ], "display_name": true }, { "uuid": "529fdb6d-d147-4299-a78c-a0f852494f18", "name": "MRP1", "stdName": "MRP1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "display_name": false }, { "uuid": "98b65bed-801b-426e-b4c3-40baa7a60f55", "name": "MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1", "stdName": "MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "204e7aaa-a9ef-469a-ad3f-7ebc17fcef34", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "display_name": false } ], "protein": { "uuid": "92ad6dba-f6ac-4107-b9a7-0a0c27c734d1", "glycosylation": { "uuid": "2c13caad-44ee-49c1-8f91-619c27641e44", "glycosylation_type": "HUMAN", "n_glycosylation_sites": [ { "residue_index": 19, "subunit_index": 1 }, { "residue_index": 23, "subunit_index": 1 }, { "residue_index": 1006, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "52ccb9d8-a07f-48d7-b256-b1f45cdb5a43", "sequence": "MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV", "subunit_index": 1 } ], "references": [ "77f3f940-7195-4f17-9446-1db0b5ee6edb", "abc3c369-925a-4d6c-befe-e084e25f4f9a" ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "b9262afe-51a1-496a-a2ee-e9858e60e996", "name": "MOL_WEIGHT:NUMBER(CALCULATED)", "type": "amount", "value": { "uuid": "eb93c1be-84e3-49e0-b48d-70285b7f63e5", "type": "ESTIMATED", "average": 172000, "units": "Da" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "ef804b07-2c91-4184-8e33-60239b7f8217", "name": "Molecular Formula", "value": { "uuid": "9f1ff715-9be5-49d8-8d56-c2b0761a4564", "type": "ESTIMATED", "non_numeric_value": "C7803H12205N2012O2205S64" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "dce36e18-f12d-4a83-a588-57311c8f67b0" } } ] }