{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2026-09-09", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "857c4bbd-6ffe-4d3d-976b-0cfffcf77825", "code": "93585-89-8", "type": "ALTERNATIVE", "url": "https://commonchemistry.cas.org/detail?cas_rn=93585-89-8", "code_system": "CAS", "references": [ "b8766ee3-9943-43c0-88cb-1380018a59e5" ] }, { "uuid": "ab64f9dd-0d8e-404c-a17d-949650125fd4", "code": "105186-99-0", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=105186-99-0", "code_system": "CAS", "references": [ "b8766ee3-9943-43c0-88cb-1380018a59e5" ] }, { "uuid": "ed0a5a00-e243-4ef2-ad79-b5b12068c100", "code": "121494106", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/121494106", "code_system": "PUBCHEM", "references": [ "b8766ee3-9943-43c0-88cb-1380018a59e5" ] }, { "uuid": "3b467716-b1d5-0a56-f52a-dcfccbe7eaa1", "code": "DTXSID00239474", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID00239474", "code_system": "EPA CompTox", "references": [ "193c6248-d6d0-0b66-2019-46b0c2a9b7fe" ] }, { "uuid": "f082e7ef-8a58-4761-8b4a-501087ac79ed", "code": "UH1S6NFW5D", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "a76a0c30-720c-e0ba-e6c1-1c9a29dc7d57", "code": "300000047868", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "4720e0bc-cead-8835-6307-fb68b7ec0cb2" ] } ], "substance_class": "protein", "references": [ { "uuid": "3ecf24f0-ba7b-4afe-bb12-7e7f4f2e2219", "citation": "FDA_SRS", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "2a219453-3f38-40a0-ada1-65494b990267", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "107a4ad1-2b73-4145-834e-5ee66886588d", "citation": "UNIPROT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "613828df-02c2-4af1-a578-b04f774b6b10", "citation": "PCPC-DB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e700445a-d2cb-45f2-93a7-14dadd3c3a13", "citation": "STN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "b8766ee3-9943-43c0-88cb-1380018a59e5", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493392302000, "tags": [ "NOMEN" ] }, { "uuid": "9b6d862e-8257-4139-92bc-ca62dc8eb98b", "citation": "SRS import [UH1S6NFW5D]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=UH1S6NFW5D", "doc_type": "SRS", "public_domain": true, "document_date": 1493392302000, "tags": [ "NOMEN" ] }, { "uuid": "d1b64d82-9c2b-4725-bfa7-c32528b69d25", "citation": "RH-POLYPEPTIDE-19 [INCI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "193c6248-d6d0-0b66-2019-46b0c2a9b7fe", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=93585-89-8", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "741bdf0f-9062-494e-bc50-8cd51edd01c8", "citation": " Regenerative MedicineVol. 13, No. 6 Research Article, 21 Aug 2018https://doi.org/10.2217/rme-2018-0085", "url": "https://www.futuremedicine.com/doi/10.2217/rme-2018-0085", "doc_type": "JA", "public_domain": true }, { "uuid": "9a85794d-eb93-47ea-a8df-a54cb97f2262", "citation": "Sloan‐Lancaster, Joanne, et al. \"Evaluation of the safety, pharmacokinetics, pharmacodynamics, and efficacy after single and multiple dosings of LY3016859 in healthy subjects and patients with diabetic nephropathy.\" Clinical pharmacology in drug development 7.7 (2018): 759-772.", "url": "https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.436", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e5fef173-86e3-457e-b5b0-483e6ea774c3", "citation": "Sloan‐Lancaster, Joanne, et al. \"Evaluation of the safety, pharmacokinetics, pharmacodynamics, and efficacy after single and multiple dosings of LY3016859 in healthy subjects and patients with diabetic nephropathy.\" Clinical pharmacology in drug development 7.7 (2018): 759-772.", "url": "https://accp1.onlinelibrary.wiley.com/doi/full/10.1002/cpdd.436", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "4720e0bc-cead-8835-6307-fb68b7ec0cb2", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "e9acc8c5-9c89-4fc1-9d1b-88ff541f2511", "version": "8", "unii": "UH1S6NFW5D", "relationships": [ { "uuid": "50931f91-19f7-45c3-ac64-20279e739aa9", "amount": { "uuid": "670a9231-f591-4514-b774-46e4726c927f" }, "comments": "Binds to key residues in the C‐terminal regions of TGF‐α and epiregulin, preventing their binding to the EGFR. Engagement of the 2 targets by LY results in internalization of the transmembrane precursors and neutralization of the activity of the mature ligands in vitro.", "type": "INHIBITOR->TARGET", "references": [ "9a85794d-eb93-47ea-a8df-a54cb97f2262" ], "related_substance": { "uuid": "7d0b608b-9329-44b6-b651-ebcf9e6c3a17", "refuuid": "8d4308a2-bf54-4185-8255-fc8023f220a9", "name": "Fepixnebart", "unii": "FP2PL0HRK8", "linking_id": "FP2PL0HRK8", "ref_pname": "Fepixnebart" } }, { "uuid": "1ee45185-fda3-4d43-949b-c13746c50dab", "amount": { "uuid": "a11749d7-beaa-4102-b1fa-2b6e5f34d692", "average": 0.44, "units": "pg/mg" }, "type": "PARENT->CONSTITUENT ALWAYS PRESENT", "references": [ "741bdf0f-9062-494e-bc50-8cd51edd01c8" ], "related_substance": { "uuid": "0022012d-999a-4bdf-b1ef-87f6514ba40c", "refuuid": "c74772c6-68e4-4b06-bc43-7a6e50970716", "name": "ALLOGENEIC HUMAN AMNION/CHORION MEMBRANE", "unii": "BA5V83N5BZ", "linking_id": "BA5V83N5BZ", "ref_pname": "ALLOGENEIC HUMAN AMNION/CHORION MEMBRANE", "substance_class": "reference" } } ], "names": [ { "uuid": "7fcf874f-a79e-4d6d-8060-0a41b843c79c", "name": "EGF-LIKE TGF", "stdName": "EGF-LIKE TGF", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "c4806053-6d3c-49fc-a845-8fc6b20d4888", "name": "ETGF", "stdName": "ETGF", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "82c6b2b3-2c8b-4a16-be0f-813952250637", "name": "HUMAN TRANSFORMING GROWTH FACTOR .ALPHA.", "stdName": "HUMAN TRANSFORMING GROWTH FACTOR .ALPHA.", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "3ecf24f0-ba7b-4afe-bb12-7e7f4f2e2219", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "d4fcb8d4-269e-4f0a-bd33-c192771df1d7", "name": "NEXPURE BIO TGFA", "stdName": "NEXPURE BIO TGFA", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "613828df-02c2-4af1-a578-b04f774b6b10", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "ba573740-631c-4a14-bb85-c132a4d06ecd", "name": "RH-POLYPEPTIDE-19", "stdName": "RH-POLYPEPTIDE-19", "type": "of", "languages": [ "en" ], "preferred": true, "references": [ "d1b64d82-9c2b-4725-bfa7-c32528b69d25", "613828df-02c2-4af1-a578-b04f774b6b10", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false, "domains": [ "cosmetic" ], "name_orgs": [ { "uuid": "5edc15a2-d1a7-4398-8619-9f8432dca621", "name_org": "INCI" } ] }, { "uuid": "98d2a359-2746-4ec9-bfde-34620dc3fcb4", "name": "TGF TYPE 1", "stdName": "TGF TYPE 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "9361cdbb-51bd-4bb9-8f4f-e831de720d2c", "name": "TGF-.ALPHA.", "stdName": "TGF-.ALPHA.", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "3523379a-a6d6-41f5-95fa-b77e09813637", "name": "TRANSFORMING GROWTH FACTOR .ALPHA.", "stdName": "TRANSFORMING GROWTH FACTOR .ALPHA.", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "a9eced41-b443-46fa-aee2-62a7b1a44efe", "name": "TRANSFORMING GROWTH FACTOR .ALPHA. (HUMAN)", "stdName": "TRANSFORMING GROWTH FACTOR .ALPHA. (HUMAN)", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "3ecf24f0-ba7b-4afe-bb12-7e7f4f2e2219", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": true }, { "uuid": "16f262ed-008b-4686-996f-ac4e04d698a7", "name": "TRANSFORMING GROWTH FACTOR .ALPHA. (RAT), 7-L-ASPARTIC ACID-15-L-PHENYLALANINE-28-L-ASPARTIC ACID-41-L-ALANINE-", "stdName": "TRANSFORMING GROWTH FACTOR .ALPHA. (RAT), 7-L-ASPARTIC ACID-15-L-PHENYLALANINE-28-L-ASPARTIC ACID-41-L-ALANINE-", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e700445a-d2cb-45f2-93a7-14dadd3c3a13", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false }, { "uuid": "41658686-568c-4ea9-9f55-2ea015681cac", "name": "VAL-VAL-SER-HIS-PHE-ASN-ASP-CYS-PRO-ASP-SER-HIS-THR-GLN-PHE-CYS-PHE-HIS-GLY-THR-CYS-ARG-PHE-LEU-VAL-GLN-GLU-ASP-LYS-PRO-ALA-CYS-VAL-CYS-HIS-SER-GLY-TYR-VAL-GLY-ALA-ARG-CYS-GLU-HIS-ALA-ASP-LEU-LEU-ALA", "stdName": "VAL-VAL-SER-HIS-PHE-ASN-ASP-CYS-PRO-ASP-SER-HIS-THR-GLN-PHE-CYS-PHE-HIS-GLY-THR-CYS-ARG-PHE-LEU-VAL-GLN-GLU-ASP-LYS-PRO-ALA-CYS-VAL-CYS-HIS-SER-GLY-TYR-VAL-GLY-ALA-ARG-CYS-GLU-HIS-ALA-ASP-LEU-LEU-ALA", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "3ecf24f0-ba7b-4afe-bb12-7e7f4f2e2219", "2a219453-3f38-40a0-ada1-65494b990267" ], "display_name": false } ], "protein": { "uuid": "e3771a69-69fe-4cf9-accd-980bb8f3a87b", "glycosylation": { "uuid": "d2dc020a-d39a-4f14-9215-40359de6191e" }, "subunits": [ { "uuid": "d6061351-93a7-4e8f-b21d-0034fe451047", "sequence": "VVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLA", "subunit_index": 1 } ], "references": [ "107a4ad1-2b73-4145-834e-5ee66886588d", "9b6d862e-8257-4139-92bc-ca62dc8eb98b" ], "disulfide_links": [ { "sites": [ { "residue_index": 8, "subunit_index": 1 }, { "residue_index": 21, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 16, "subunit_index": 1 }, { "residue_index": 32, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 34, "subunit_index": 1 }, { "residue_index": 43, "subunit_index": 1 } ] } ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "540a75e8-2d3f-4c5a-ba0b-9bdb5f5acc33", "name": "MOL_WEIGHT:NUMBER(CALCULATED)", "type": "amount", "value": { "uuid": "c6fed6b6-effb-4411-9cf7-12b9e3476ff9", "type": "ESTIMATED", "average": 5550, "units": "Da" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "9a3cee24-4338-4414-b425-a22f781d36ad", "name": "Molecular Formula", "value": { "uuid": "f24a4ca2-c182-40e1-9d94-50654b9dfc45", "type": "ESTIMATED", "non_numeric_value": "C239H353N70O72S6" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "aa45c0b4-8b36-49ef-98d9-6eab355b39d7" } } ] }