{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-09-09",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "29464522-0cb8-4fa4-b8aa-6bb9128ec7fb",
          "code": "P49773",
          "type": "PRIMARY",
          "url": "http://www.uniprot.org/uniprot/P49773",
          "code_system": "UNIPROT",
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ]
        },
        {
          "uuid": "d6bec003-235a-4b72-b140-3b6417ffc7bf",
          "code": "HINT1",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/HINT1",
          "code_system": "WIKIPEDIA",
          "references": [
            "26b34a36-1363-5784-6479-2d61a958b703"
          ]
        },
        {
          "uuid": "a64aac40-8790-425e-b1a0-baaace721202",
          "code": "TUU1WM80MU",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "958063a6-6b47-3495-2132-fd746e9f53b2",
          "citation": "208341ORIG1S000 CLINICAL PHARMACOLOGY AND BIOPHARMACEUTICS REVIEW(S)",
          "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208341Orig1s000ClinPharmR.pdf",
          "doc_type": "NDA PUBLIC REVIEW",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "CLIN"
          ]
        },
        {
          "uuid": "44821a48-7c57-e9de-930b-b89081af8a17",
          "citation": "P49773",
          "url": "http://www.uniprot.org/uniprot/P49773",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "26b34a36-1363-5784-6479-2d61a958b703",
          "citation": "HINT1",
          "url": "HINT1",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "ac04c42c-cdf0-411f-9a83-d8a1717f726a",
      "version": "6",
      "unii": "TUU1WM80MU",
      "relationships": [
        {
          "uuid": "c9244606-3a5c-43b9-a7c0-1a565217882e",
          "type": "SUBSTRATE->METABOLIC ENZYME",
          "references": [
            "958063a6-6b47-3495-2132-fd746e9f53b2"
          ],
          "related_substance": {
            "uuid": "ab225869-e2bc-420b-b247-0ff629db0c2c",
            "refuuid": "cd5d3938-c608-4626-a031-383010838742",
            "name": "GS-566500",
            "unii": "8C9Y1F217H",
            "linking_id": "8C9Y1F217H",
            "ref_pname": "GS-566500",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "8ffe09a2-794e-4e86-b8ee-15b9fa06b916",
          "name": "ADENOSINE 5'-MONOPHOSPHORAMIDASE",
          "stdName": "ADENOSINE 5'-MONOPHOSPHORAMIDASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "2ebde860-03d5-4f8f-8130-e8d3b7d9a51f",
          "name": "HINT",
          "stdName": "HINT",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "8ef31870-b289-4d1e-b43b-279edd73ff72",
          "name": "HINT1",
          "stdName": "HINT1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "aaba7aee-ad79-403e-94ea-6ec6f64cc282",
          "name": "HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1",
          "stdName": "HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": true
        },
        {
          "uuid": "c6c17ce9-9306-4d88-9b61-feefe99820cc",
          "name": "PKCI-1",
          "stdName": "PKCI-1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "0a719346-ac25-4106-a311-9ae1fe262bc8",
          "name": "PKCI1",
          "stdName": "PKCI1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "737f3310-d64e-4b97-ac23-35a5ab5a0947",
          "name": "PRKCNH1",
          "stdName": "PRKCNH1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "351af1b4-df82-4039-8fa0-d5f58e804a2b",
          "name": "PROTEIN KINASE C INHIBITOR 1",
          "stdName": "PROTEIN KINASE C INHIBITOR 1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        },
        {
          "uuid": "f5b7da37-c47d-4042-9663-ec044c85d6cb",
          "name": "PROTEIN KINASE C-INTERACTING PROTEIN 1",
          "stdName": "PROTEIN KINASE C-INTERACTING PROTEIN 1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "44821a48-7c57-e9de-930b-b89081af8a17"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "d5cb3c36-e7fa-44d2-8153-27bd052f07c3",
        "glycosylation": {
          "uuid": "5076d98f-78a5-43aa-83b2-66c105c881af"
        },
        "subunits": [
          {
            "uuid": "7f6668d5-56c8-4e10-aa4e-62e1d5ede0d8",
            "sequence": "ADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG",
            "subunit_index": 1
          },
          {
            "uuid": "b2a0d0bf-a8f7-427b-993a-acd51c54f1d4",
            "sequence": "ADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG",
            "subunit_index": 2
          }
        ],
        "references": [
          "44821a48-7c57-e9de-930b-b89081af8a17"
        ],
        "protein_sub_type": "",
        "protein_type": "ENZYME",
        "sequence_origin": "HUMAN",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "c2f607dd-2829-423b-b339-712acec59a70",
          "name": "MOL_WEIGHT:NUMBER(CALCULATED)",
          "type": "amount",
          "value": {
            "uuid": "825d13d4-7116-40a5-8886-1381dd50092d",
            "type": "ESTIMATED",
            "average": 27300,
            "units": "Da"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "4202857e-5d6e-4df9-852b-0ec08654277d",
          "name": "Molecular Formula",
          "value": {
            "uuid": "232b9c51-4b88-4657-ab4f-b56cd61ef917",
            "type": "ESTIMATED",
            "non_numeric_value": "C1218H1926N346O350S10"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "83217d13-548b-4aae-addb-e6241b993d37",
        "structural_modifications": [
          {
            "uuid": "2cd92a10-d037-48c0-85ab-34945cfe5d88",
            "sites": [
              {
                "residue_index": 44,
                "subunit_index": 1
              },
              {
                "residue_index": 71,
                "subunit_index": 1
              },
              {
                "residue_index": 44,
                "subunit_index": 2
              },
              {
                "residue_index": 71,
                "subunit_index": 2
              }
            ],
            "location_type": "SITE_SPECIFIC",
            "molecular_fragment": {
              "uuid": "758a6108-4bac-4610-aea8-7a1dece3eb30",
              "refuuid": "b6eb2edb-1b4d-46ad-92ad-a43f0f545926",
              "name": "DEXFOSFOSERINE",
              "unii": "VI4F0K069V",
              "linking_id": "VI4F0K069V",
              "ref_pname": "DEXFOSFOSERINE",
              "substance_class": "reference"
            },
            "structural_modification_type": "AMINO_ACID_SUBSTITUTION"
          }
        ]
      }
    }
  ]
}