{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "ef0eeccb-abaa-47e2-81be-9f948c47816e", "code": "P21589", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/P21589?sort=score", "code_system": "UNIPROT", "references": [ "41ef8b39-0674-49e2-a81a-0484e9039436" ] }, { "uuid": "4844de71-0534-4e12-ba4c-273baba27632", "code": "P21589", "type": "PRIMARY", "url": "https://pharos.nih.gov/idg/search?q=P21589", "code_system": "PHAROS", "references": [ "41ef8b39-0674-49e2-a81a-0484e9039436" ] }, { "uuid": "cfb45671-2bc8-4983-aa86-67f1cdb7dac9", "code": "9027-73-0", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=9027-73-0", "code_system": "CAS", "references": [ "41ef8b39-0674-49e2-a81a-0484e9039436", "b0fb0179-785b-4235-a425-39a0110c345b" ] }, { "uuid": "1dfb64b0-3c5f-48a9-bba3-4ba7e64e13ba", "code": "21 CFR 862.1520", "comments": "PART 862 -- CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES|Subpart B--Clinical Chemistry Test Systems|Sec. 862.1520 5'-Nucleotidase test system.", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=862.1520", "code_system": "CFR", "references": [ "41ef8b39-0674-49e2-a81a-0484e9039436" ] }, { "uuid": "ee3eb417-a2c2-40fd-fb34-32d293b34ace", "code": "1689-9", "comments": "LOINC|ACTIVE|CHEM|Amnio fld|5'-Nucleotidase [Enzymatic activity/volume] in Amniotic fluid", "type": "PRIMARY", "url": "https://loinc.org/1689-9/", "code_system": "LOINC", "references": [ "b8e969b2-6d83-899a-42a8-703cbd2e39ad" ] }, { "uuid": "29e97429-803c-bbbf-8b15-aefbc2f129ee", "code": "1690-7", "comments": "LOINC|ACTIVE|CHEM|Ser/Plas|5'-Nucleotidase [Enzymatic activity/volume] in Serum or Plasma", "type": "PRIMARY", "url": "https://loinc.org/1690-7/", "code_system": "LOINC", "references": [ "b8e969b2-6d83-899a-42a8-703cbd2e39ad" ] }, { "uuid": "d8afb671-c121-4546-a535-a5af997e618b", "code": "T8635M4C7O", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "bd56549f-061d-4ef1-ad61-a0adb8b98b2c", "citation": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158132", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C158132", "doc_type": "NCI THESAURUS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "8ece7a8c-970c-4659-9e64-a8152028d427", "citation": "http://www.uniprot.org/uniprot/P21589?sort=score", "url": "http://www.uniprot.org/uniprot/P21589?sort=score", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "a68d3545-57bb-4e8f-9b40-ab8d37d619e4", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "13e14d1e-66f7-4346-acdb-e419d3f6bceb", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "db4d36c6-c4b6-44ac-bf9e-549f28370c0d", "citation": "http://www.uniprot.org/uniprot/P21589", "url": "http://www.uniprot.org/uniprot/P21589", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "41ef8b39-0674-49e2-a81a-0484e9039436", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493393384000, "tags": [ "NOMEN" ] }, { "uuid": "7e16db33-dd37-4bed-9471-3cade52cefca", "citation": "SRS import [T8635M4C7O]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=T8635M4C7O", "doc_type": "SRS", "public_domain": true, "document_date": 1493393384000, "tags": [ "NOMEN" ] }, { "uuid": "b8e969b2-6d83-899a-42a8-703cbd2e39ad", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "b0fb0179-785b-4235-a425-39a0110c345b", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "8c90a341-07e7-4a43-88ca-7e46eb2e332b", "citation": "Lawson, Kenneth V., et al. \"Discovery of AB680: a potent and selective inhibitor of CD73.\" Journal of Medicinal Chemistry 63.20 (2020): 11448-11468.", "url": "https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00525", "doc_type": "JA", "public_domain": true }, { "uuid": "21146547-7110-46d6-bf83-356310130768", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "199cea50-829d-4b52-b547-cbe99923ec67", "citation": "List 131", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9f184e17-8d87-421c-81c1-f9b3831da2aa", "citation": "INN P129", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl129.pdf?sfvrsn=678fceea_3&download=true", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "b8ca51c6-4784-4039-a5cf-728e507955c4", "citation": "List 132", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl132.pdf", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "25dfb144-1c87-4e39-99d4-239482dc70ff", "version": "43", "unii": "T8635M4C7O", "relationships": [ { "uuid": "5bf181cc-26c2-4a7c-865a-66bd32a5d693", "comments": "Targets and binds to CD73, leading to clustering and internalization of CD73. This prevents CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine and decreases the amount of free adenosine. This prevents adenosine-mediated suppression of lymphocyte activity and increases the activity of CD8-positive effector cells. This also activates macrophages, and reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes.", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "3380d52d-214b-4279-aab3-3302885e93c0", "refuuid": "6fa0d999-07b8-4c62-b66b-237240111999", "name": "BMS-986179", "unii": "7PO9B4VQ1U", "linking_id": "7PO9B4VQ1U", "ref_pname": "BMS-986179" } }, { "uuid": "62196c56-e90a-49e0-815b-c877ed7d943c", "amount": { "uuid": "863ea2c0-33ea-48a0-a42a-39b8392464c8" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "def9f7ab-3d0d-4098-8964-3dd293bf1a9e", "refuuid": "4390d914-1598-4665-b32c-3794329da1a8", "name": "ULILEDLIMAB", "unii": "3OX1DBR75G", "linking_id": "3OX1DBR75G", "ref_pname": "ULILEDLIMAB" } }, { "uuid": "98458a62-5770-4773-aefc-de1707a8e94a", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "a752c519-248c-48ce-9270-e9d82f7895e3", "refuuid": "26ed8881-c819-4afe-b08e-51df96951f83", "name": "OLECLUMAB", "unii": "5CRY01URYQ", "linking_id": "5CRY01URYQ", "ref_pname": "OLECLUMAB" } }, { "uuid": "8ea8e7df-dd2a-4b87-b521-d9679f1db99c", "type": "PARENT->INNOVATOR", "related_substance": { "uuid": "48abdf92-1c1e-4062-add4-60330499acf4", "refuuid": "26ed8881-c819-4afe-b08e-51df96951f83", "name": "OLECLUMAB", "unii": "5CRY01URYQ", "linking_id": "5CRY01URYQ", "ref_pname": "OLECLUMAB" } }, { "uuid": "278b94e0-4d9e-460f-b183-bca93daa9671", "type": "INHIBITOR->TARGET", "references": [ "bd56549f-061d-4ef1-ad61-a0adb8b98b2c" ], "related_substance": { "uuid": "5e62173d-5215-49c8-bc76-2ae9fec37f6e", "refuuid": "26df9b53-61cc-42ca-8b03-64f1b2bd8754", "name": "NZV-930", "unii": "2M0F9Q9SZ2", "linking_id": "2M0F9Q9SZ2", "ref_pname": "NZV-930" } }, { "uuid": "1cf2ee7f-7af1-4fa9-954f-371fe4d7743e", "amount": { "uuid": "b30e7ee0-a9f0-4eb7-a327-1d9f7ecccf8c", "average": 0.043, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "8c90a341-07e7-4a43-88ca-7e46eb2e332b" ], "related_substance": { "uuid": "48ca9c41-8610-467f-abe2-1c6176d53239", "refuuid": "80760e79-f315-4e31-b041-1ea1c4df8bd0", "name": "QUEMLICLUSTAT", "unii": "J6K8WSV73A", "linking_id": "J6K8WSV73A", "ref_pname": "QUEMLICLUSTAT" } }, { "uuid": "50ba6bad-8c52-4b67-9fa5-af4387093d70", "amount": { "uuid": "168812da-bd56-4bd5-8c43-76ece7ad76e2" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "497e4ba8-6573-4e0d-b159-bf35c326935c", "refuuid": "302cadab-2b69-4779-8c19-d5c50757e552", "name": "LY-3475070", "unii": "AKA9175T4N", "linking_id": "AKA9175T4N", "ref_pname": "LY-3475070" } }, { "uuid": "7384f27a-1b16-4d6a-9e78-065e43928f77", "amount": { "uuid": "354a5fbb-942c-489e-9770-88c0c216c68d" }, "comments": "In vitro and in vivo pharmacology studies show INCA00186 to be a potent binder and inhibitor\nof CD73 function", "type": "INHIBITOR->TARGET", "interaction_type": "IN-VITRO, IN-VIVO", "references": [ "9f184e17-8d87-421c-81c1-f9b3831da2aa" ], "related_substance": { "uuid": "97d70afd-c82b-40a8-8cb4-bb1818a21484", "refuuid": "644b42ae-7a19-4b2f-8435-34a96a720c59", "name": "Uprevstobart", "unii": "BH6FYV3BSC", "linking_id": "BH6FYV3BSC", "ref_pname": "Uprevstobart" } }, { "uuid": "0b316dd6-7bed-4af4-9e40-8a63d874b449", "amount": { "uuid": "89bf134f-543b-4538-82ec-3af32d37f5f9" }, "type": "INHIBITOR->TARGET", "interaction_type": "IN-VITRO, IN-VIVO", "references": [ "21146547-7110-46d6-bf83-356310130768" ], "related_substance": { "uuid": "ce37867a-93da-440d-8cdb-4cd6319c9956", "refuuid": "0fd7e579-77a4-4680-9699-8c6f61e26a7e", "name": "ORIC-533 FREE BASE", "unii": "7R3R8M6TAV", "linking_id": "7R3R8M6TAV", "ref_pname": "ORIC-533 FREE BASE" } }, { "uuid": "febea3a1-fbe2-4de9-b832-b594b86cf7c3", "amount": { "uuid": "b718571a-c5d9-4df5-ad0c-0ceeaacf1117" }, "type": "INHIBITOR->TARGET", "references": [ "199cea50-829d-4b52-b547-cbe99923ec67" ], "related_substance": { "uuid": "804ef5f6-0e90-4a0a-af5b-68c57eb97ba9", "refuuid": "7485efe8-20aa-4b75-962e-34d494757209", "name": "Mavrostobart", "unii": "HT4MAJ8SLE", "linking_id": "HT4MAJ8SLE", "ref_pname": "Mavrostobart", "substance_class": "reference" } }, { "uuid": "91fa20a8-b4bd-4149-9c14-9dc0648a8746", "amount": { "uuid": "c94a25c8-aaa7-4caf-8398-54d9750a302a" }, "type": "LIGAND->TARGET", "references": [ "b8ca51c6-4784-4039-a5cf-728e507955c4" ], "related_substance": { "uuid": "ceac1968-4fce-4175-8fd7-2729100025c3", "refuuid": "b720e594-d970-4e30-99bb-bd89abbb4929", "name": "Ledostomig", "unii": "F9U3H6DB73", "linking_id": "F9U3H6DB73", "ref_pname": "Ledostomig", "substance_class": "reference" } } ], "names": [ { "uuid": "96fc24d2-4f7a-4d74-b0c3-4310b023eb46", "name": "5'-MONONUCLEOTIDASE", "stdName": "5'-MONONUCLEOTIDASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "13e14d1e-66f7-4346-acdb-e419d3f6bceb", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "efc40a55-3770-4c56-ad65-90e2385149ff", "name": "5'-NT", "stdName": "5'-NT", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ece7a8c-970c-4659-9e64-a8152028d427", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "58b36976-1dbb-45c1-8a63-0b5ee8cb5a40", "name": "5'-NUCLEOTIDASE", "stdName": "5'-NUCLEOTIDASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "db4d36c6-c4b6-44ac-bf9e-549f28370c0d", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": true }, { "uuid": "8663f0b7-eab3-4cf2-908b-c4cd23e22c31", "name": "CD73", "stdName": "CD73", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ece7a8c-970c-4659-9e64-a8152028d427", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "cdf73525-6c49-42ea-b19c-d47f8f36e9a1", "name": "E.C. 3.1.3.5", "stdName": "E.C. 3.1.3.5", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "13e14d1e-66f7-4346-acdb-e419d3f6bceb", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "2cfea9b2-6c29-415d-946e-7a08bdf69ddb", "name": "ECTO-5'-NUCLEOTIDASE", "stdName": "ECTO-5'-NUCLEOTIDASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ece7a8c-970c-4659-9e64-a8152028d427", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "fb3c7c75-e35c-494a-90f3-c5b9a42524d1", "name": "NT5", "stdName": "NT5", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ece7a8c-970c-4659-9e64-a8152028d427", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "fb79bf75-732b-44b0-a859-c12b68257f1e", "name": "NTE", "stdName": "NTE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ece7a8c-970c-4659-9e64-a8152028d427", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false }, { "uuid": "fd8e5d89-0620-4177-a3ff-730f385fde3c", "name": "NUCLEOTIDE PHOSPHOMONOESTERASE", "stdName": "NUCLEOTIDE PHOSPHOMONOESTERASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "13e14d1e-66f7-4346-acdb-e419d3f6bceb", "a68d3545-57bb-4e8f-9b40-ab8d37d619e4" ], "display_name": false } ], "protein": { "uuid": "fb84b501-d3f7-46db-8be7-f2bac92dbbc8", "glycosylation": { "uuid": "4fdedd36-3fea-430d-9198-af60e8a431b3", "glycosylation_type": "HUMAN", "n_glycosylation_sites": [ { "residue_index": 27, "subunit_index": 1 }, { "residue_index": 285, "subunit_index": 1 }, { "residue_index": 307, "subunit_index": 1 }, { "residue_index": 377, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "f2c97900-24aa-4579-a0b1-80c30933bbdc", "sequence": "WELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS", "subunit_index": 1 } ], "references": [ "db4d36c6-c4b6-44ac-bf9e-549f28370c0d", "7e16db33-dd37-4bed-9471-3cade52cefca" ], "disulfide_links": [ { "sites": [ { "residue_index": 25, "subunit_index": 1 }, { "residue_index": 31, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 327, "subunit_index": 1 }, { "residue_index": 332, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 339, "subunit_index": 1 }, { "residue_index": 361, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 450, "subunit_index": 1 }, { "residue_index": 453, "subunit_index": 1 } ] } ], "protein_sub_type": "", "protein_type": "ENZYME", "sequence_origin": "HUMAN", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "cfd6b193-dae4-4843-bd1d-943ad1e9475f", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "76a383c5-3ec1-4283-8420-2bbf98118d4a", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "cb3ccf7e-2a0c-4f48-bc11-28024544723f" } } ] }