{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "68f49419-d126-473c-8dd1-72272ad84b39",
          "code": "1314-23-4",
          "type": "PRIMARY",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=1314-23-4",
          "code_system": "CAS",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b",
            "71f74e6a-c654-4a6b-a321-a7d48a2b2ab0"
          ]
        },
        {
          "uuid": "2697afdd-8376-44b4-b7c8-0babd5d42e61",
          "code": "C028541",
          "type": "PRIMARY",
          "url": "http://www.ncbi.nlm.nih.gov/mesh/67028541",
          "code_system": "MESH",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "4255f568-43c6-489c-b738-9fece78de6aa",
          "code": "ZIRCONIUM DIOXIDE",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/Zirconium_dioxide",
          "code_system": "WIKIPEDIA",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "abb7e8f6-b628-49bc-a4a0-99f54409f860",
          "code": "21 CFR 176.170",
          "comments": "PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS|Subpart B--Substances for Use Only as Components of Paper and Paperboard|Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=176.170",
          "code_system": "CFR",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "42885425-2056-4914-bf45-68746d7ea6c5",
          "code": "39972",
          "comments": "RxNorm",
          "type": "PRIMARY",
          "url": "https://rxnav.nlm.nih.gov/REST/rxcui/39972/allProperties.xml?prop=all",
          "code_system": "RXCUI",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "100437bd-e776-44ca-b08c-38fa6dc8ae5a",
          "code": "m11650",
          "comments": "Merck Index",
          "type": "PRIMARY",
          "url": "https://merckindex.rsc.org/monographs/m11650?q=authorize",
          "code_system": "MERCK INDEX",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "28939fbe-2f25-4501-b1a0-b9a00d2510e7",
          "code": "SUB15766MIG",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "79f4038a-cbb5-4898-abc7-265026eac5d6",
          "code": "6452892",
          "type": "PRIMARY",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/6452892",
          "code_system": "PUBCHEM",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "c75cc65b-9f81-46ac-b209-26bb5d7e868e",
          "code": "215-227-2",
          "type": "PRIMARY",
          "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.013.844",
          "code_system": "ECHA (EC/EINECS)",
          "references": [
            "819530b1-2e88-4a1c-b508-c69fc727ba7b"
          ]
        },
        {
          "uuid": "563f69a5-3cde-6bde-d274-cc76e46ff854",
          "code": "DTXSID1042520",
          "type": "PRIMARY",
          "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID1042520",
          "code_system": "EPA CompTox",
          "references": [
            "8ecfeba7-295e-d913-2391-8a13a5b6ce43"
          ]
        },
        {
          "uuid": "467ecf4e-d8ec-42ef-9079-25aef5c3f570",
          "code": "S38N85C5G0",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "e4f791bd-21fe-b6b2-b101-b986b4512405",
          "code": "S38N85C5G0",
          "type": "PRIMARY",
          "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=S38N85C5G0",
          "code_system": "DAILYMED",
          "references": [
            "00443e0c-bb21-c3f8-691f-8c1c1d8d6c2c"
          ]
        },
        {
          "uuid": "0ab04c5e-7bb2-ea4f-e615-0ae443e3698f",
          "code": "100000076777",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "d6ee4cd2-bf59-2824-1314-544cbd19a368"
          ]
        },
        {
          "uuid": "3cca554e-4e5d-b0ca-fc2d-448805b9d3b0",
          "code": "12958",
          "type": "PRIMARY",
          "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=12958",
          "code_system": "NSC",
          "references": [
            "9753d3f8-2b0f-c6c4-68f0-b395ad9feb97"
          ]
        }
      ],
      "relationships": [
        {
          "uuid": "ee8ba3e3-e293-43d8-b1bf-97f5a1a8607c",
          "type": "ACTIVE MOIETY",
          "related_substance": {
            "uuid": "55f2a5e5-5bfc-4675-8f63-269b50f7654c",
            "refuuid": "7c66fed8-8f53-4858-a236-753790159de3",
            "name": "ZIRCONIUM OXIDE",
            "unii": "S38N85C5G0",
            "linking_id": "S38N85C5G0",
            "ref_pname": "ZIRCONIUM OXIDE",
            "substance_class": "reference"
          }
        }
      ],
      "substance_class": "chemical",
      "names": [
        {
          "uuid": "7a88a6d5-9ca0-4070-85fe-87f85eddd45a",
          "name": "NSC-12958",
          "stdName": "NSC-12958",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "061e2053-d861-471f-8d6b-629987c702d8",
            "095501dc-1d01-47c3-ba6f-4fcba2addd4b"
          ],
          "display_name": false
        },
        {
          "uuid": "4c991fd1-4589-47a4-b185-a561c779d1f4",
          "name": "ZIRCONIA",
          "stdName": "ZIRCONIA",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "061e2053-d861-471f-8d6b-629987c702d8",
            "0eca2877-d24d-4d47-97ca-bba5ff5906dd"
          ],
          "display_name": false
        },
        {
          "uuid": "8c9c59d7-1edf-43d4-977c-d00dc3bc0194",
          "name": "ZIRCONIUM DIOXIDE",
          "stdName": "ZIRCONIUM DIOXIDE",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": true,
          "references": [
            "8a720521-6690-4b71-b5ab-62d1763500df",
            "061e2053-d861-471f-8d6b-629987c702d8",
            "14412795-f9e3-46af-ac4e-c940380da4fd",
            "6f115612-df04-4689-99a5-e11983bf676b",
            "d97803c2-7f26-4523-99d0-dca87efe87ff",
            "74654cd9-0888-4d9a-b457-3e9e556853c2",
            "5249e34c-a1bd-4e3e-ab29-694d58f010af"
          ],
          "display_name": false,
          "domains": [
            "cosmetic"
          ],
          "name_orgs": [
            {
              "uuid": "122fd470-45fa-4de8-8f3b-471f957daaa9",
              "name_org": "INCI"
            }
          ]
        },
        {
          "uuid": "f74c2d90-cdb6-479b-9f46-23bd33206103",
          "name": "ZIRCONIUM OXIDE",
          "stdName": "ZIRCONIUM OXIDE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1c466d85-7a46-4843-adae-d62b1507137c",
            "061e2053-d861-471f-8d6b-629987c702d8",
            "da20afee-e957-412c-a7a4-a86911b41a79",
            "da5d483f-8b06-45e6-800e-cfe28e3dc8dc",
            "5e486bf8-3b80-47c1-bc31-399d4fd3fb49"
          ],
          "display_name": true
        },
        {
          "uuid": "6b159307-6635-479d-826b-4763503e9e3d",
          "name": "ZIRCONIUM OXIDE [MI]",
          "stdName": "ZIRCONIUM OXIDE [MI]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1c466d85-7a46-4843-adae-d62b1507137c",
            "061e2053-d861-471f-8d6b-629987c702d8"
          ],
          "display_name": false
        },
        {
          "uuid": "5c054e31-2e1f-2aff-c4b7-2dd4f5ee0819",
          "name": "Zirconium dioxide [WHO-DD]",
          "stdName": "ZIRCONIUM DIOXIDE [WHO-DD]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "bcfafc5a-42cd-77f8-1a90-ebc74702c6f6"
          ],
          "display_name": false
        }
      ],
      "references": [
        {
          "uuid": "8a720521-6690-4b71-b5ab-62d1763500df",
          "citation": "MERCK",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "d97803c2-7f26-4523-99d0-dca87efe87ff",
          "citation": "DL",
          "doc_type": "MERCK INDEX",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "da20afee-e957-412c-a7a4-a86911b41a79",
          "citation": "MERCK 14TH",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "da5d483f-8b06-45e6-800e-cfe28e3dc8dc",
          "citation": "OTC",
          "doc_type": "MERCK INDEX",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "1c466d85-7a46-4843-adae-d62b1507137c",
          "citation": "MERCK INDEX",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "061e2053-d861-471f-8d6b-629987c702d8",
          "citation": "MERCK INDEX",
          "doc_type": "MERCK INDEX",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "5249e34c-a1bd-4e3e-ab29-694d58f010af",
          "citation": "PCPC",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "74654cd9-0888-4d9a-b457-3e9e556853c2",
          "citation": "WHO-DD",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "0eca2877-d24d-4d47-97ca-bba5ff5906dd",
          "citation": "STN",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "095501dc-1d01-47c3-ba6f-4fcba2addd4b",
          "citation": "CHEMID",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "819530b1-2e88-4a1c-b508-c69fc727ba7b",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390518000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "f4e02a32-09dd-42a0-9bae-015b2483a969",
          "citation": "SRS import [S38N85C5G0]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=S38N85C5G0",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390518000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "5e486bf8-3b80-47c1-bc31-399d4fd3fb49",
          "citation": "ZIRCONIUM OXIDE [MI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "14412795-f9e3-46af-ac4e-c940380da4fd",
          "citation": "ZIRCONIUM DIOXIDE [INCI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "6f115612-df04-4689-99a5-e11983bf676b",
          "citation": "ZIRCONIUM DIOXIDE [WHO-DD]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "a3cc2c91-6f39-1c15-45f0-6a5db9415101",
          "citation": "WEBSITE",
          "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=1314-23-4",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "71f74e6a-c654-4a6b-a321-a7d48a2b2ab0",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "9753d3f8-2b0f-c6c4-68f0-b395ad9feb97",
          "citation": "NCI",
          "doc_type": "NCI DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "bcfafc5a-42cd-77f8-1a90-ebc74702c6f6",
          "citation": "WHO-DD",
          "doc_type": "WHO DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "00443e0c-bb21-c3f8-691f-8c1c1d8d6c2c",
          "citation": "DailyMed",
          "doc_type": "DAILYMED",
          "public_domain": true
        },
        {
          "uuid": "8ecfeba7-295e-d913-2391-8a13a5b6ce43",
          "citation": "EPA CompTox",
          "doc_type": "EPA",
          "public_domain": true
        },
        {
          "uuid": "d6ee4cd2-bf59-2824-1314-544cbd19a368",
          "citation": "EU-SRS",
          "doc_type": "EMA LIST",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "moieties": [
        {
          "uuid": "a0611bca-5ba0-4a49-99d6-3b0b37795f9c",
          "id": "a0611bca-5ba0-4a49-99d6-3b0b37795f9c",
          "molfile": "\n  Marvin  01132108202D          \n\n  1  0  0  0  0  0            999 V2000\n   -1.7500   -1.4333    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0\nM  CHG  1   1  -1\nM  END",
          "smiles": "[OH-]",
          "formula": "HO",
          "atropisomerism": "No",
          "charge": -1,
          "count": 2,
          "stereochemistry": "ACHIRAL",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 2,
            "units": "MOL RATIO",
            "uuid": "9af6b7ba-b27c-47a3-ad0a-8ac446e20a47"
          },
          "defined_stereo": 0,
          "ez_centers": 0,
          "molecular_weight": "17.0073",
          "optical_activity": "NONE",
          "stereo_centers": 0
        },
        {
          "uuid": "66cb554c-b812-4358-818d-72794289d736",
          "id": "66cb554c-b812-4358-818d-72794289d736",
          "molfile": "\n  Marvin  01132105212D          \n\n  1  0  0  0  0  0            999 V2000\n   -3.4000   -1.4333    0.0000 Zr  0  0  0  0  0  0  0  0  0  0  0  0\nM  CHG  1   1   4\nM  END",
          "smiles": "[Zr+4]",
          "formula": "Zr",
          "atropisomerism": "No",
          "charge": 4,
          "count": 1,
          "stereochemistry": "ACHIRAL",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "c439ad04-5e73-42a8-ba52-c161252fa62c"
          },
          "defined_stereo": 0,
          "ez_centers": 0,
          "molecular_weight": "91.2236",
          "optical_activity": "NONE",
          "stereo_centers": 0
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "7c66fed8-8f53-4858-a236-753790159de3",
      "version": "11",
      "structure": {
        "id": "a086ad3f-0a7e-4f22-8110-e6e18a55fcd2",
        "molfile": "\n  Marvin  01132108202D          \n\n  3  0  0  0  0  0            999 V2000\n   -3.4000   -1.4333    0.0000 Zr  0  0  0  0  0  0  0  0  0  0  0  0\n   -1.7500   -1.4333    0.0000 O   0  6  0  0  0  0  0  0  0  0  0  0\n   -1.7500   -1.4333    0.0000 O   0  6  0  0  0  0  0  0  0  0  0  0\nM  CHG  3   1   4   2  -2   3  -2\nM  STY  1   1 MUL\nM  SCN  1   1 HT \nM  SAL   1  2   2   3\nM  SPA   1  1   2\nM  SDI   1  4   -2.1700   -1.8533   -2.1700   -1.0133\nM  SDI   1  4   -1.3300   -1.0133   -1.3300   -1.8533\nM  SMT   1 2\nM  END",
        "smiles": "[O-2].[O-2].[Zr+4]",
        "formula": "2O.Zr",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ACHIRAL",
        "defined_stereo": 0,
        "ez_centers": 0,
        "molecular_weight": "123.2225",
        "optical_activity": "NONE",
        "references": [
          "8a720521-6690-4b71-b5ab-62d1763500df",
          "f4e02a32-09dd-42a0-9bae-015b2483a969"
        ],
        "stereo_centers": 0
      },
      "unii": "S38N85C5G0"
    }
  ]
}