{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2026-09-09", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "bf1cb922-d7b8-4827-bbfa-f4b066c253fb", "code": "Q96EB6", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/Q96EB6", "code_system": "UNIPROT", "references": [ "e249aa98-ced4-4feb-b2d6-39c49d94a315" ] }, { "uuid": "5e3d3148-952c-4648-b46e-4e6c560f7fb4", "code": "R8FS417W9N", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad", "citation": "UNIPROT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "2437eb9f-dc5d-4ffb-bc3f-82b16899a0f0", "citation": "PCPC-DB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e249aa98-ced4-4feb-b2d6-39c49d94a315", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493392748000, "tags": [ "NOMEN" ] }, { "uuid": "d98d297a-38ec-4880-b238-ebd88db9a8ab", "citation": "SRS import [R8FS417W9N]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=R8FS417W9N", "doc_type": "SRS", "public_domain": true, "document_date": 1493392748000, "tags": [ "NOMEN" ] }, { "uuid": "0a1a665b-cd61-432a-9fb7-871f43e44caf", "citation": "RH-POLYPEPTIDE-66 [INCI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "09d16f49-6957-4afd-9a70-9655d5bd13a4", "citation": "Zheng, Wenhao, et al. \"Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.\" International immunopharmacology 45 (2017): 135-147.", "url": "https://www.sciencedirect.com/science/article/pii/S1567576917300644", "doc_type": "JA", "public_domain": true }, { "uuid": "acbb3e7a-bb39-4db6-beb7-c67f9175c3eb", "citation": "WIKI", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c679a25a-debe-4964-bd8c-80d97aaec6b1", "citation": "OMT 28", "url": "https://adisinsight.springer.com/drugs/800049040", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "f7eca9b6-10d5-45c3-8959-5843dbf24234", "citation": "https://en.wikipedia.org/wiki/STAC-9", "url": "https://en.wikipedia.org/wiki/STAC-9", "doc_type": "WIKI", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "5424295a-c2bd-45d0-8497-9542210bce04", "citation": "https://en.wikipedia.org/wiki/SRT-3025", "url": "https://en.wikipedia.org/wiki/SRT-3025", "doc_type": "WIKI", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a389b2f7-ab1d-4424-bb8c-43a0ef8afd19", "citation": "WIKI", "url": "https://en.wikipedia.org/wiki/SRT-1460", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c0b21a36-bd48-4422-bc89-fffceafe4f3d", "citation": "WIKI", "url": "https://en.wikipedia.org/wiki/SRT-1460", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "442b6b81-bb40-4265-aa07-321779387b6e", "citation": "WIKI", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a5262aca-7087-45bc-a42c-b5e333287ea9", "citation": "WIKI", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "1b857045-b153-4a45-a9ca-fd9838eda383", "version": "14", "unii": "R8FS417W9N", "relationships": [ { "uuid": "b190b00a-0a94-40c2-9d4f-9d5b4906f17e", "type": "ACTIVATOR->TARGET", "related_substance": { "uuid": "6d5dfd87-f5c4-4ca7-8364-456cd656a0de", "refuuid": "9679b18f-9f08-41f3-bc8d-884e6bc5adfa", "name": "SRT-2104", "unii": "4521NR0J09", "linking_id": "4521NR0J09", "ref_pname": "SRT-2104" } }, { "uuid": "076254f3-16cf-422a-a553-6d4fbe8287fd", "amount": { "uuid": "f732bc79-1b9c-4978-a2dc-c452c3db6e67" }, "type": "ACTIVATOR->TARGET", "references": [ "c0b21a36-bd48-4422-bc89-fffceafe4f3d" ], "related_substance": { "uuid": "e3736a2b-7dd1-45f6-aab7-6fa62bfabb82", "refuuid": "74f81060-92da-4985-be31-7c7d50642a35", "name": "SRT-1460", "unii": "FN6D3F3HTG", "linking_id": "FN6D3F3HTG", "ref_pname": "SRT-1460" } }, { "uuid": "a0953f7e-672e-4a81-84d8-9411a6754687", "amount": { "uuid": "64784d90-daab-42b2-9b4e-458e6d019017" }, "type": "ACTIVATOR->TARGET", "references": [ "acbb3e7a-bb39-4db6-beb7-c67f9175c3eb" ], "related_substance": { "uuid": "672f7cde-2068-4357-b079-5c8b8c9f650c", "refuuid": "f39729bc-a203-45ee-8acc-9b56c236dee1", "name": "SRT-2183", "unii": "6FKU9G9CX6", "linking_id": "6FKU9G9CX6", "ref_pname": "SRT-2183" } }, { "uuid": "406967f2-c382-443e-b167-249dfd2d97e5", "amount": { "uuid": "1b62eeaa-a3ab-4b81-a092-dd302f145349" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "6782b173-00ca-42dc-bf58-1039c9335550", "refuuid": "f87e0b64-57a9-46e0-846d-bf485cb1cf76", "name": "SELISISTAT", "unii": "L19ECD5014", "linking_id": "L19ECD5014", "ref_pname": "SELISISTAT", "substance_class": "reference" } }, { "uuid": "e340c72f-7d5a-493a-bc4f-d31456b1c5cd", "amount": { "uuid": "b3832694-448f-45e5-a1c6-dba557b07bae" }, "comments": "Increases expression of SIRT1.", "type": "ACTIVATOR->TARGET", "references": [ "09d16f49-6957-4afd-9a70-9655d5bd13a4" ], "related_substance": { "uuid": "304a66f0-7f6f-4163-a8b1-553e27fb7166", "refuuid": "0a6fe9a3-3c76-4262-b977-85495e9f143b", "name": "FISETIN", "unii": "OO2ABO9578", "linking_id": "OO2ABO9578", "ref_pname": "FISETIN", "substance_class": "reference" } }, { "uuid": "6cb76b4e-faad-470e-bb50-7517fe16cde9", "amount": { "uuid": "67716992-5e83-40a3-936e-80d54a0780fd" }, "type": "ACTIVATOR->TARGET", "references": [ "f7eca9b6-10d5-45c3-8959-5843dbf24234" ], "related_substance": { "uuid": "2acb60a8-119d-49d2-8a5c-492307db40f7", "refuuid": "8ef80f34-2fb3-4cb0-9ad0-cc34dc571211", "name": "STAC-9", "unii": "MG7TTL8YCY", "linking_id": "MG7TTL8YCY", "ref_pname": "STAC-9", "substance_class": "reference" } }, { "uuid": "0bffcd66-c4d2-4f86-b28e-52882faf7bcc", "amount": { "uuid": "0cc04b30-f6e4-4116-b1e0-cb11b6225d5a" }, "type": "ACTIVATOR->TARGET", "references": [ "5424295a-c2bd-45d0-8497-9542210bce04" ], "related_substance": { "uuid": "f6a55d93-8d3c-42e0-813a-1e537cbcc75f", "refuuid": "f5c0079c-6c3a-40df-a440-f865dde67cf7", "name": "SRT-3025", "unii": "L4WQ6846SR", "linking_id": "L4WQ6846SR", "ref_pname": "SRT-3025", "substance_class": "reference" } } ], "names": [ { "uuid": "3a02d58f-c9eb-4cfe-9be8-3c595adc8c56", "name": "HSIR2", "stdName": "HSIR2", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "bc2b0235-54b8-464c-be36-e1f37024d80b", "name": "HSIRT1", "stdName": "HSIRT1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "69cb7b92-e8f5-4abf-93b2-387c899996e3", "name": "HUMAN NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1", "stdName": "HUMAN NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "f35ea2fa-fb30-4613-bfc4-4071051f4c37", "name": "NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1", "stdName": "NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": true }, { "uuid": "b820cbd9-d133-4eb7-a36e-34fb7c012748", "name": "NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 (HUMAN)", "stdName": "NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 (HUMAN)", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "1207016e-7aff-4af3-a2fa-3b84cd4e82f1", "name": "REGULATORY PROTEIN SIR2 HOMOLOG 1", "stdName": "REGULATORY PROTEIN SIR2 HOMOLOG 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "4a95a18f-aa26-461c-9454-0ee234687183", "name": "RH-POLYPEPTIDE-66", "stdName": "RH-POLYPEPTIDE-66", "type": "of", "languages": [ "en" ], "preferred": true, "references": [ "2437eb9f-dc5d-4ffb-bc3f-82b16899a0f0", "0a1a665b-cd61-432a-9fb7-871f43e44caf", "cc64fb40-972c-4cd7-921d-cbf12dd41abb" ], "display_name": false, "domains": [ "cosmetic" ], "name_orgs": [ { "uuid": "d73c2c75-f9b1-41fa-a706-9b395a1ae6a7", "name_org": "INCI" } ] }, { "uuid": "380511ba-5f8e-4d71-a071-dc4169764255", "name": "SIR2-LIKE PROTEIN 1", "stdName": "SIR2-LIKE PROTEIN 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc64fb40-972c-4cd7-921d-cbf12dd41abb", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "display_name": false }, { "uuid": "0e12879b-2ae4-4731-8eab-dd2f325b24b5", "name": "SIRT 1", "stdName": "SIRT 1", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "2437eb9f-dc5d-4ffb-bc3f-82b16899a0f0", "cc64fb40-972c-4cd7-921d-cbf12dd41abb" ], "display_name": false } ], "protein": { "uuid": "e2d5493b-4ccf-47d3-8040-d4ff4c35da13", "glycosylation": { "uuid": "5de9c744-61af-43e8-8a10-893e6a95a2ea", "n_glycosylation_sites": [ { "residue_index": 1, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "11a8f9b0-5e6f-4c34-a287-b983b063a090", "sequence": "ADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS", "subunit_index": 1 } ], "references": [ "d98d297a-38ec-4880-b238-ebd88db9a8ab", "e1e7e8cb-0191-4eb7-90e5-8da20cfe35ad" ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "b245a104-ba47-4174-86c1-15b99bca123b", "name": "MOL_WEIGHT:NUMBER(CALCULATED)", "type": "amount", "value": { "uuid": "ecb0088d-65a3-4480-89e4-c2b957f364bf", "type": "ESTIMATED", "average": 81500, "units": "Da" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "5a13b1ca-da2a-42d4-9fda-1a1a83682113", "name": "Molecular Formula", "value": { "uuid": "eea01223-9540-4438-8be5-ed051777bfc3", "type": "ESTIMATED", "non_numeric_value": "C3544H5547N985O1167S28" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "c932a2a6-865b-4e0c-8291-4faa7b7dc58b" } } ] }