{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "2b7dd95a-2862-440f-9089-5d17a7fd4af2", "code": "P08912", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/P08912?sort=score", "code_system": "UNIPROT", "references": [ "78ba1170-b731-4c74-8ba7-d34eb0bf8ee2" ] }, { "uuid": "7fb419e9-ad05-4dc6-ad6a-d21d4d340db2", "code": "P08912", "type": "PRIMARY", "url": "https://pharos.nih.gov/idg/search?q=P08912+&kind=", "code_system": "PHAROS", "references": [ "78ba1170-b731-4c74-8ba7-d34eb0bf8ee2" ] }, { "uuid": "b0a2940f-4b0d-4e51-89f4-2e6a75111547", "code": "QQ0IJ5P4GV", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "5bae508a-7cdd-46ab-87ed-6af7c1acb978", "citation": "http://www.uniprot.org/uniprot/P08912", "url": "http://www.uniprot.org/uniprot/P08912", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a49742c9-d16c-47e8-88df-c846b712efd4", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "d137052f-7676-49fe-beb6-280667d03911", "citation": "http://www.uniprot.org/uniprot/P08912?sort=score", "url": "http://www.uniprot.org/uniprot/P08912?sort=score", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "78ba1170-b731-4c74-8ba7-d34eb0bf8ee2", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493393568000, "tags": [ "NOMEN" ] }, { "uuid": "6e981b1d-98bc-4b62-9f35-8d8f855a54e7", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210598Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a3d566c0-1886-47e6-bffc-a4cd21c5aaf0", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210598s000lbl.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "42c3488d-7933-4dd8-bf4a-1d7422be8f23", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210598Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "16cd0d13-6f9d-43f2-a868-db9f12ca20f8", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202450Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "0872114a-2200-41e6-aef7-fc05ffa9ab72", "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.", "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x", "doc_type": "JA", "public_domain": true }, { "uuid": "48c4d8bf-5066-483c-a5ed-876462b2e36d", "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.", "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x", "doc_type": "JA", "public_domain": true }, { "uuid": "4258fe47-ea0d-4ced-a6f1-92caee435e28", "citation": "https://en.wikipedia.org/wiki/VU-0238429", "url": "https://en.wikipedia.org/wiki/VU-0238429", "doc_type": "WIKI", "public_domain": true }, { "uuid": "6a71f8ea-474b-424d-91d1-cdd572bea0d8", "citation": "https://www.drugbank.ca/drugs/DB00572", "doc_type": "WEBSITE", "public_domain": true }, { "uuid": "a53a8eb7-57d0-4881-98e9-884570d7f84a", "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.", "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x", "doc_type": "JA", "public_domain": true }, { "uuid": "46bed06b-b4af-440d-9d2d-9e3e6075c854", "citation": "https://www.alzforum.org/therapeutics/milameline", "url": "https://www.alzforum.org/therapeutics/milameline", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e2ffbf46-b277-40c8-b156-57e146e31872", "citation": "Buckley, NOEL J., et al. \"Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.\" Molecular Pharmacology 35.4 (1989): 469-476.", "url": "https://molpharm.aspetjournals.org/content/molpharm/35/4/469.full.pdf", "doc_type": "JA", "public_domain": true }, { "uuid": "2a305633-2456-4f75-9951-871683374d38", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202450Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "30b5b82f-29f3-498c-b5ce-dcd6dd094ae3", "citation": "Lee, Min Jung, et al. \"Pharmacological characterization of DA-8010, a novel muscarinic receptor antagonist selective for urinary bladder over salivary gland.\" European Journal of Pharmacology 843 (2019): 240-250.", "url": "https://www.sciencedirect.com/science/article/pii/S0014299918306915", "doc_type": "JA", "public_domain": true }, { "uuid": "f9539de1-7fe6-4fb4-85ac-b3df0f1dab2f", "citation": "https://www.sciencedirect.com/science/article/pii/S0304395901003190", "url": "https://www.sciencedirect.com/science/article/pii/S0304395901003190", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "6e7f8142-af22-463e-9bf6-b0402d718fdd", "version": "21", "unii": "QQ0IJ5P4GV", "relationships": [ { "uuid": "c94c5dfa-10b9-4ca3-9068-8ab8d359f793", "amount": { "uuid": "882d59fb-e1b3-4e9a-bd8c-c9dbec428ede" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "5071eae8-b7f2-44e5-975f-1f06af393c89", "refuuid": "e088275a-a45c-4dfe-b41f-f49921f9c672", "name": "DOXEPIN", "unii": "5ASJ6HUZ7D", "linking_id": "5ASJ6HUZ7D", "ref_pname": "DOXEPIN" } }, { "uuid": "447008fd-5e19-4af7-8302-26f8bf8d5b34", "amount": { "uuid": "3390b64d-4ae9-4c6a-91d1-ab9ff6b3f859", "average": 4.2, "units": "NANOMOLAR" }, "qualification": "Kd", "type": "INHIBITOR->TARGET", "interaction_type": "BINDING", "references": [ "a3d566c0-1886-47e6-bffc-a4cd21c5aaf0", "42c3488d-7933-4dd8-bf4a-1d7422be8f23" ], "related_substance": { "uuid": "7c677972-f758-41e5-9122-eb1ea7b0f348", "refuuid": "9ba5a86e-eb06-4d83-bf8a-64279e729438", "name": "REVEFENACIN", "unii": "G2AE2VE07O", "linking_id": "G2AE2VE07O", "ref_pname": "REVEFENACIN" } }, { "uuid": "8bb5fb8c-43c7-41a4-82e9-efe9b35a8d8d", "amount": { "uuid": "c99331f1-9270-4470-ace8-4b38244f7283", "average": 11, "units": "NANOMOLAR" }, "comments": "THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.", "qualification": "Ki", "type": "INHIBITOR->TARGET", "interaction_type": "BINDING", "references": [ "6e981b1d-98bc-4b62-9f35-8d8f855a54e7" ], "related_substance": { "uuid": "9591965f-ba05-4cfd-80d6-06d4ccb91985", "refuuid": "a572ad37-1bc2-48a4-a9b0-1b63da9126cc", "name": "THRX-195518", "unii": "A6X64T4LZ4", "linking_id": "A6X64T4LZ4", "ref_pname": "THRX-195518" } }, { "uuid": "72861c81-1fcd-4267-ad86-85d8670679c4", "amount": { "uuid": "772ac8fb-e626-4bd8-bee0-74ee351b11f2" }, "type": "INHIBITOR->TARGET", "references": [ "6a71f8ea-474b-424d-91d1-cdd572bea0d8" ], "related_substance": { "uuid": "98591863-e53c-459e-8e26-d97826b03a7a", "refuuid": "bd1911ab-5462-408a-b78c-77083b8ba70c", "name": "ATROPINE", "unii": "7C0697DR9I", "linking_id": "7C0697DR9I", "ref_pname": "ATROPINE" } }, { "uuid": "adcac0f4-a5da-4140-b92d-a49e31f2bd3a", "amount": { "uuid": "73ad4a28-28fc-40e0-a8e9-55934b734fef" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "7f38d533-5582-4ffa-b3da-4b8a7fe56ea0", "refuuid": "ee2f2936-d51a-495b-96e0-b3fef32ae001", "name": "TOLTERODINE", "unii": "WHE7A56U7K", "linking_id": "WHE7A56U7K", "ref_pname": "TOLTERODINE" } }, { "uuid": "fe3da07c-66cb-4aee-b5a3-5e07fa5d12cb", "comments": "selective positive allosteric modulator", "type": "ACTIVATOR->TARGET", "interaction_type": "ALLOSTERIC ACTIVATOR", "references": [ "4258fe47-ea0d-4ced-a6f1-92caee435e28" ], "related_substance": { "uuid": "a8851163-c52f-43fa-b372-49f48f509acc", "refuuid": "8f38e160-034a-4c82-acac-57c0a12e5661", "name": "VU-0238429", "unii": "ZH1ZWF5Q3P", "linking_id": "ZH1ZWF5Q3P", "ref_pname": "VU-0238429" } }, { "uuid": "3376fde9-cdf2-453c-bc70-a80eb413535b", "amount": { "uuid": "ae89ceae-952f-4adb-b6eb-dd53d91417bf", "average": 0.24, "units": "NANOMOLAR" }, "qualification": "Ki", "type": "INHIBITOR->TARGET", "references": [ "2a305633-2456-4f75-9951-871683374d38" ], "related_substance": { "uuid": "de7ae1cc-6aa1-41c1-ae80-fc39af440827", "refuuid": "434aa978-93b6-44fb-91e3-0a8b1f0cded7", "name": "ACLIDINIUM", "unii": "K17VY42F6C", "linking_id": "K17VY42F6C", "ref_pname": "ACLIDINIUM" } }, { "uuid": "4c4a24c1-02f8-4f13-b080-658ef82106f8", "amount": { "uuid": "acc17f3f-cabc-47f4-ac43-1abad4a7beca", "average": 1000, "low": 1000, "units": "NANOMOLAR" }, "qualification": "Ki", "type": "NON-INHIBITOR->OFF TARGET", "interaction_type": "NON-INHIBITOR", "references": [ "0872114a-2200-41e6-aef7-fc05ffa9ab72" ], "related_substance": { "uuid": "48f0041f-0ceb-491c-8580-b1b561e8d986", "refuuid": "d8f372eb-a89e-47ec-a957-bcdb1111df0b", "name": "PALIPERIDONE", "unii": "838F01T721", "linking_id": "838F01T721", "ref_pname": "PALIPERIDONE" } }, { "uuid": "ecd9aac9-c44a-447a-8ada-5351195d8de6", "amount": { "uuid": "8a427eac-2fde-434b-a788-d704c5ce7c99", "type": "RELATIVE BINDING AFFINITY", "average": 10000, "units": "NANOMOLAR" }, "type": "NON-INHIBITOR->OFF TARGET", "references": [ "a53a8eb7-57d0-4881-98e9-884570d7f84a" ], "related_substance": { "uuid": "8583f311-a2c6-449b-a3f0-47d5b742e417", "refuuid": "95270949-f3d1-440d-8635-faa62495c858", "name": "RISPERIDONE", "unii": "L6UH7ZF8HC", "linking_id": "L6UH7ZF8HC", "ref_pname": "RISPERIDONE" } }, { "uuid": "5baec8e8-de56-49d9-8dd9-a809c3128b91", "amount": { "uuid": "d1b00f22-3431-4547-a8e2-6554700841c2", "average": 217, "high": 326, "low": 108, "units": "NANOMOLAR" }, "comments": "Membranes from transfected CHO cells", "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "BINDING", "references": [ "e2ffbf46-b277-40c8-b156-57e146e31872" ], "related_substance": { "uuid": "6c8d987c-8c6f-414d-8044-080c3416b847", "refuuid": "f23368bb-a6e5-466c-9f30-6f1a4f38ff51", "name": "METHOCTRAMINE FREE BASE", "unii": "NVJ76B897D", "linking_id": "NVJ76B897D", "ref_pname": "METHOCTRAMINE FREE BASE", "substance_class": "reference" } }, { "uuid": "f74ab400-0f2a-4de7-9152-c3be61442728", "amount": { "uuid": "1f12ad16-2037-4f45-b5db-b82cd236bcfe" }, "type": "AGONIST->TARGET", "references": [ "46bed06b-b4af-440d-9d2d-9e3e6075c854" ], "related_substance": { "uuid": "5b039083-f08b-492b-8c02-b35ae2f258be", "refuuid": "4bd4dc04-a436-468e-b182-a092daa6b727", "name": "MILAMELINE", "unii": "R9X77R42FN", "linking_id": "R9X77R42FN", "ref_pname": "MILAMELINE", "substance_class": "reference" } }, { "uuid": "24ea88ff-2a33-4a94-a5b6-ac3f8b24db93", "amount": { "uuid": "fcf15f71-5483-49fc-9014-faaa52013300" }, "type": "INHIBITOR->TARGET", "references": [ "f9539de1-7fe6-4fb4-85ac-b3df0f1dab2f" ], "related_substance": { "uuid": "a7c55dc4-eee3-4c4e-8d66-aaa666503f11", "refuuid": "31740658-2033-4e23-a2b8-9be02599583c", "name": "VEDACLIDINE", "unii": "98IW5HAV1N", "linking_id": "98IW5HAV1N", "ref_pname": "VEDACLIDINE", "substance_class": "reference" } }, { "uuid": "1f85d11c-a5a8-4862-932b-1d024dc62047", "amount": { "uuid": "eb62a3e7-240d-471c-a561-7b396efb3128", "average": 2, "high": 2.34, "low": 1.7, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "30b5b82f-29f3-498c-b5ce-dcd6dd094ae3" ], "related_substance": { "uuid": "43f39d6e-e109-4983-b0f8-7c4730c1be5a", "refuuid": "d5e47be6-acea-4ed2-9b6a-6ff65012c6ea", "name": "VELUFENACIN", "unii": "WV3E0S3IQB", "linking_id": "WV3E0S3IQB", "ref_pname": "VELUFENACIN", "substance_class": "reference" } } ], "names": [ { "uuid": "576cf6a8-ac4f-48cb-a77e-5ce1ff3e57b5", "name": "CHRM5", "stdName": "CHRM5", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "d137052f-7676-49fe-beb6-280667d03911", "a49742c9-d16c-47e8-88df-c846b712efd4" ], "display_name": false }, { "uuid": "b65de3a9-006a-4b25-ab9c-3a575cf8c074", "name": "M5", "stdName": "M5", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e2ffbf46-b277-40c8-b156-57e146e31872" ], "display_name": false }, { "uuid": "03f48ccd-ade4-456d-839e-bf41b0ae81a4", "name": "MUSCARINIC ACETYLCHOLINE RECEPTOR M5", "stdName": "MUSCARINIC ACETYLCHOLINE RECEPTOR M5", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "5bae508a-7cdd-46ab-87ed-6af7c1acb978", "a49742c9-d16c-47e8-88df-c846b712efd4" ], "display_name": true } ], "protein": { "uuid": "64629cdd-ef16-4743-9cee-4f5d886cccd3", "glycosylation": { "uuid": "00758240-24c8-4150-b09a-39e9b4774a7f", "glycosylation_type": "HUMAN", "n_glycosylation_sites": [ { "residue_index": 8, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "92cca816-4cfe-48cf-b259-78075c7a72ca", "sequence": "MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP", "subunit_index": 1 } ], "references": [ "5bae508a-7cdd-46ab-87ed-6af7c1acb978" ], "disulfide_links": [ { "sites": [ { "residue_index": 103, "subunit_index": 1 }, { "residue_index": 183, "subunit_index": 1 } ] } ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "d7f8204d-aa35-4feb-8bf2-d63c884d5d30", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "1f2c0d64-b27f-435a-b740-104651ccdd60", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "06c33a60-fd71-4fbc-9bc4-c6a4742060dd", "name": "Molecular Formula", "value": { "uuid": "d14f23ff-8889-4f5c-a2fc-1fd5cccf797f", "type": "ESTIMATED", "non_numeric_value": "C2705H4259N726O771P2S28" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "0dc1890a-c9ee-4747-a852-f656c43f80fb", "structural_modifications": [ { "uuid": "c749ec6f-3f46-4b63-b8a0-1c8c2f8c8140", "extent": "COMPLETE", "sites": [ { "residue_index": 501, "subunit_index": 1 }, { "residue_index": 505, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "e8cb1d27-eae7-4cf3-9f4e-f9c9818a33cf", "refuuid": "96bbf36a-d049-4313-9712-8608530faef7", "name": "THREONINE PHOSPHATE", "unii": "3L4WX7B1EI", "linking_id": "3L4WX7B1EI", "ref_pname": "THREONINE PHOSPHATE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" } ] } } ] }