{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "87ba9929-9919-4d1b-b091-0e31e36cf7c3", "code": "HR7SSL4L4D", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "31d6ddac-76bc-426f-96ea-46e58bbb575b", "citation": "http://www.uniprot.org/uniprot/Q04912", "url": "http://www.uniprot.org/uniprot/Q04912", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "94a1dafd-0056-45cf-b043-e13c43dea042", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "62bf8a2c-62c0-4409-a28c-dd845a255a5b", "citation": "https://www.sciencedirect.com/topics/medicine-and-dentistry/merestinib", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/merestinib", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "edbe2ed6-f565-4ad9-81c2-14c9a9e00511", "citation": "Carboni, Joan M., et al. \"BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.\" Molecular cancer therapeutics 8.12 (2009): 3341-3349.", "url": "https://watermark.silverchair.com/3341.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA1cwggNTBgkqhkiG9w0BBwagggNEMIIDQAIBADCCAzkGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMBEqB1dt7IpFPQC7UAgEQgIIDCpRZGIaE_g4UXq48Y5JKULSOvbF8_VusnG_9io-mao44nO1tP4ZwoKgjprMG1aRPjmSCqYlXHq508Itdbo6haWxT1P868yzPqIKMx5aAfsvwdeLiu9dRsS8cQX3cD0kZMKdokNFWdLN652OBk-jb6rEnEvQxTFQn8iIxDEVEVXivQxEn1hk9O3Fkdi-9AaQ3sCNLJruCG8Rrmr6iyZfAkud7RAAQF-AHcc19mtNxO_XMnQtfnsOf2T--mo8r4Ib9hFOlHzHWDwqks5VMkaRebacsZVi0Rh4etMrDCxTCaewU_gAE9o0KM1fity6ubZlSzMCHgBj4RpJNyw9upaW3rTN3HDlER_j5y1jh4Ur2S4Fbd08EZfDuGkmYM2QxcMolOzT2UaCBkL9gO6cdaP59y8AVuKDX2Rq_ihHmMtHt5JZ02-_O4E0Jb3SvqLotua37s_2rEnc8bVEtQQTXX-7UZJiAgM0bUTABpkI2130NVZlrpw_v3C6y8p6Oo86HiQWYqrBLDsJ4iLWLjMWfB76jehk39vORvZP3eIZ-UWlZOhGnMi9Gbz981aXRDFwWB6EYkJfil6Rk2bFOj3rw-CA5g329Atunjt5ehVGWnge-8dMffhQ-UoVDEn1HcTls493kJKqVqJT6yIUZ0f94HHOip2q6mOuBBxGHCD_Y-Cml296jbDal8DVu66gJpOomfn8fvVLPYwfZZ2Ku0sIr4JA2fnJe2PtDcv3h-TitmbO0JmXKjhbvUqa45eW915hwr4Xxjcmh5MXaoYPwTrFrrqHqrxEuPpMcbxRVwApooEiRPlTT6r6L8gGNEaetCtoKvXD5cd_crUK1INbklis2BYLfHaeeRcl9UaXtSItma1RU_xmLwNu3jBG5P3N1pgtBqGjsH8vdUKzfwIrmJdvrUeLMwM6WyeGQdckmEeTq6Vz_Il9xOzPrilfIx4CSNXFkpl9SsKAAglsU54PZQTY3tZiB-pUdFzXpeMJbi5BD9poSloeROVOQ0SXgX8wp7xl02W87ltOjLukRw3DIjok", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "b8d32ef9-7fd1-4ad4-ae06-335986cc1280", "version": "8", "unii": "HR7SSL4L4D", "relationships": [ { "uuid": "5adfebbd-4c9f-4eb2-a5fb-8a96ad6dc3bf", "amount": { "uuid": "df7a43da-d423-44c7-af97-bb1468821f72", "average": 44, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->OFF-TARGET", "references": [ "edbe2ed6-f565-4ad9-81c2-14c9a9e00511" ], "related_substance": { "uuid": "5817d033-6bc9-49a8-8abe-2dba3cd261dc", "refuuid": "4027a105-8634-492d-9bdb-f1ce143d6273", "name": "BMS-754807", "unii": "W9E3353E8J", "linking_id": "W9E3353E8J", "ref_pname": "BMS-754807", "substance_class": "reference" } }, { "uuid": "8c051276-8b2e-4b9d-8d04-fabe81fa8d58", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "b2eef6e8-4584-440f-abf5-bb563768f176", "refuuid": "61123f13-17d7-432f-921c-a1edeedb7686", "name": "GLESATINIB", "unii": "7Q29OXD98N", "linking_id": "7Q29OXD98N", "ref_pname": "GLESATINIB" } }, { "uuid": "76dce1c8-e508-4637-b262-6c300aa1c0b0", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "5d80237c-c80d-4cd9-9119-682f4938604a", "refuuid": "b4565c03-5189-4d57-a7ec-c1e2c094400f", "name": "NARNATUMAB", "unii": "R42YK40U9M", "linking_id": "R42YK40U9M", "ref_pname": "NARNATUMAB" } }, { "uuid": "8dff7dde-3d49-4187-b8e7-27d813b9fffe", "amount": { "uuid": "1e7500a7-13d7-4b56-bf67-e77a4cba1f75" }, "type": "INHIBITOR->TARGET", "references": [ "62bf8a2c-62c0-4409-a28c-dd845a255a5b" ], "related_substance": { "uuid": "7b75f399-f9e2-4302-a96b-22e95dea2fb6", "refuuid": "5b5254a5-792a-4526-8307-de72b0ba7cb9", "name": "MERESTINIB", "unii": "5OGS5K699E", "linking_id": "5OGS5K699E", "ref_pname": "MERESTINIB", "substance_class": "reference" } } ], "names": [ { "uuid": "fa8d2b7c-927c-119f-44a3-cca6ee961746", "name": "CD136", "stdName": "CD136", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false }, { "uuid": "1de1bb2e-821a-f4bb-67d5-f5c2ff70b15a", "name": "CDW136", "stdName": "CDW136", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false }, { "uuid": "352c98b6-6b47-4dfc-a2b2-6a8b5de96049", "name": "MACROPHAGE-STIMULATING PROTEIN RECEPTOR", "stdName": "MACROPHAGE-STIMULATING PROTEIN RECEPTOR", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "94a1dafd-0056-45cf-b043-e13c43dea042", "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": true }, { "uuid": "bc9a4fd7-e05c-0374-d7aa-906d31b414e6", "name": "P185-RON", "stdName": "P185-RON", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false }, { "uuid": "150125fd-d7bd-8db3-628f-86edb1f50b7c", "name": "PROTEIN-TYROSINE KINASE 8", "stdName": "PROTEIN-TYROSINE KINASE 8", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false }, { "uuid": "254dbb38-2941-0d5d-02ca-d87cad1471fd", "name": "PTK8", "stdName": "PTK8", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false }, { "uuid": "ce9e66da-6e59-2c54-e04b-97174b839fd1", "name": "RON", "stdName": "RON", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "display_name": false } ], "protein": { "uuid": "d1edb9cd-75c3-4fa7-aa47-19b6435e8147", "glycosylation": { "uuid": "fb87e763-e99f-44fc-9c13-140fe4baf631", "glycosylation_type": "HUMAN", "n_glycosylation_sites": [ { "residue_index": 42, "subunit_index": 1 }, { "residue_index": 395, "subunit_index": 1 }, { "residue_index": 434, "subunit_index": 1 }, { "residue_index": 464, "subunit_index": 1 }, { "residue_index": 630, "subunit_index": 1 }, { "residue_index": 696, "subunit_index": 1 }, { "residue_index": 817, "subunit_index": 1 }, { "residue_index": 873, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "9c4f84ae-f064-47db-bf5a-16c4668f5ce4", "sequence": "EDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT", "subunit_index": 1 }, { "uuid": "9352a3d3-62c9-401c-aedd-76e819ef6139", "sequence": "EDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAP", "subunit_index": 2 }, { "uuid": "fc63bc5a-1958-491a-b4a6-52113a07459d", "sequence": "GAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT", "subunit_index": 3 } ], "references": [ "31d6ddac-76bc-426f-96ea-46e58bbb575b" ], "disulfide_links": [ { "sites": [ { "residue_index": 77, "subunit_index": 1 }, { "residue_index": 80, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 83, "subunit_index": 1 }, { "residue_index": 138, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 111, "subunit_index": 1 }, { "residue_index": 119, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 150, "subunit_index": 1 }, { "residue_index": 153, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 276, "subunit_index": 1 }, { "residue_index": 343, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 361, "subunit_index": 1 }, { "residue_index": 383, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 362, "subunit_index": 1 }, { "residue_index": 398, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 503, "subunit_index": 1 }, { "residue_index": 521, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 509, "subunit_index": 1 }, { "residue_index": 543, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 512, "subunit_index": 1 }, { "residue_index": 528, "subunit_index": 1 } ] }, { "sites": [ { "residue_index": 524, "subunit_index": 1 }, { "residue_index": 534, "subunit_index": 1 } ] } ], "protein_sub_type": "", "sequence_origin": "HUMAN", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "1213a64b-1560-4c86-a6cd-143c629ebcf1", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "3d2e0135-6071-4835-986b-6d739986c987", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "12eff1a4-9ae0-4d16-a7b8-cf1fb25fefa6", "name": "Molecular Formula", "value": { "uuid": "2b8c6f1f-ba25-43ae-8305-3487045fc123", "type": "ESTIMATED", "non_numeric_value": "C13310H20744N3704O3888P4S128" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "ba726beb-e38b-41af-a5f4-173d5d773a2c", "structural_modifications": [ { "uuid": "e2cdf62b-7427-4b15-bdf0-adf96d252ee3", "extent": "COMPLETE", "sites": [ { "residue_index": 1214, "subunit_index": 1 }, { "residue_index": 1215, "subunit_index": 1 }, { "residue_index": 1329, "subunit_index": 1 }, { "residue_index": 1336, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "b6a410ee-7714-4591-9c6e-fb855e72d8ae", "refuuid": "6534bbf5-6eb4-4a29-aba8-46e6ed9c50bd", "name": "TYROSINE O-PHOSPHATE", "unii": "2R86C98KDX", "linking_id": "2R86C98KDX", "ref_pname": "TYROSINE O-PHOSPHATE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" } ] } } ] }