{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-09-09",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "406fed25-dc3b-6f12-2cb2-0941905df58e",
          "code": "667618",
          "comments": "ORPHAN DRUG|Designated|Treatment of Duchenne Muscular Dystrophy",
          "type": "PRIMARY",
          "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=667618",
          "code_system": "FDA ORPHAN DRUG"
        },
        {
          "uuid": "a814d951-ddda-4d35-8221-aea29be27950",
          "code": "Q6ZMU5",
          "type": "PRIMARY",
          "url": "https://www.uniprot.org/uniprot/Q6ZMU5",
          "code_system": "UNIPROT"
        },
        {
          "uuid": "772f7437-bae5-4858-b7bc-c8e26abfe984",
          "code": "GPU59XZ1PZ",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "64e01f97-4868-3941-8209-1aa4daee920b",
          "citation": "https://www.uniprot.org/uniprot/Q6ZMU5",
          "url": "https://www.uniprot.org/uniprot/Q6ZMU5",
          "doc_type": "UNIPROT",
          "public_domain": true
        },
        {
          "uuid": "f45c6605-014d-621e-4f78-da13505ef278",
          "citation": "Gushchina, Liubov V., et al. \"Treatment with recombinant human MG53 protein increases membrane integrity in a mouse model of limb girdle muscular dystrophy 2B.\" Molecular Therapy 25.10 (2017): 2360-2371.",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "7e423753-972e-41a6-a348-fe9bc65940e0",
      "version": "8",
      "unii": "GPU59XZ1PZ",
      "relationships": [
        {
          "uuid": "88051517-210a-447f-aeed-fa0bab2ee8e7",
          "amount": {
            "uuid": "854b4b96-e891-4b1f-ac27-6a09392d9ee8"
          },
          "type": "ACTIVE MOIETY",
          "references": [
            "f45c6605-014d-621e-4f78-da13505ef278"
          ],
          "related_substance": {
            "uuid": "1f73f504-09eb-4101-8d1d-82d9953855b8",
            "refuuid": "7e423753-972e-41a6-a348-fe9bc65940e0",
            "name": "Mitsugumin-53",
            "unii": "GPU59XZ1PZ",
            "linking_id": "GPU59XZ1PZ",
            "ref_pname": "Mitsugumin-53",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "c3ce0041-5943-05c3-ec0a-acadb5db4d95",
          "name": "MG53",
          "stdName": "MG53",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "64e01f97-4868-3941-8209-1aa4daee920b"
          ],
          "display_name": false
        },
        {
          "uuid": "d0b946f1-79f0-ac02-1791-5a6061adf132",
          "name": "Mitsugumin-53",
          "stdName": "MITSUGUMIN-53",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "64e01f97-4868-3941-8209-1aa4daee920b"
          ],
          "display_name": true
        },
        {
          "uuid": "60dcac36-5991-1cdd-0f30-7fa0034e64e6",
          "name": "RECOMBINANT HUMAN MG53 PROTEIN",
          "stdName": "RECOMBINANT HUMAN MG53 PROTEIN",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f45c6605-014d-621e-4f78-da13505ef278"
          ],
          "display_name": false
        },
        {
          "uuid": "e2c6fb0e-b000-41b3-b655-72152ee27da7",
          "name": "TRIM72 expressed protein",
          "stdName": "TRIM72 EXPRESSED PROTEIN",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "64e01f97-4868-3941-8209-1aa4daee920b"
          ],
          "display_name": false
        },
        {
          "uuid": "c61d5d20-502d-b72e-1a69-93f075a06897",
          "name": "Tripartite motif-containing protein 72",
          "stdName": "TRIPARTITE MOTIF-CONTAINING PROTEIN 72",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "64e01f97-4868-3941-8209-1aa4daee920b"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "514bd62e-3b0b-44f5-abae-d201305e09e1",
        "glycosylation": {
          "uuid": "181dba55-4fcc-479a-a5ac-968a1bbc7586"
        },
        "subunits": [
          {
            "uuid": "9bdb85a9-5fef-4c85-bc3e-75eb7639cebc",
            "sequence": "MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA",
            "subunit_index": 1
          },
          {
            "uuid": "d75101bf-ab89-4191-9691-ed7bf1158d53",
            "sequence": "MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA",
            "subunit_index": 2
          }
        ],
        "references": [
          "64e01f97-4868-3941-8209-1aa4daee920b"
        ],
        "disulfide_links": [
          {
            "sites": [
              {
                "residue_index": 242,
                "subunit_index": 1
              },
              {
                "residue_index": 242,
                "subunit_index": 2
              }
            ]
          }
        ],
        "protein_sub_type": "",
        "sequence_origin": "HUMAN",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "6c7947f8-d4aa-447a-87f4-85e8c4b7cf2a",
          "name": "MOL_WEIGHT:NUMBER(CALCULATED)",
          "type": "amount",
          "value": {
            "uuid": "73f9ff00-5a1a-41d9-b184-e2c2ce9e24c4",
            "type": "ESTIMATED",
            "average": 105000,
            "units": "Da"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "05b467ec-c865-451b-b35b-caa5bf7dfac3",
          "name": "Molecular Formula",
          "value": {
            "uuid": "b6885750-5c4e-4c62-b427-a0425a7dd2a2",
            "type": "ESTIMATED",
            "non_numeric_value": "C4658H7426N1344O1358S46"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "5d149a3a-4a19-4ec3-9152-b66f213df00d",
        "structural_modifications": [
          {
            "uuid": "fb3ffa3a-b3c3-46a2-bf95-196b294c51f3",
            "extent": "Unspecified",
            "sites": [
              {
                "residue_index": 144,
                "subunit_index": 1
              },
              {
                "residue_index": 144,
                "subunit_index": 2
              }
            ],
            "location_type": "SITE_SPECIFIC",
            "molecular_fragment": {
              "uuid": "ec506207-f039-4458-963a-84de33d00ed6",
              "refuuid": "a645e10c-c50d-4e71-8805-a772b3ce4728",
              "name": "S-NITROSOCYSTEINE",
              "unii": "926P2322P4",
              "linking_id": "926P2322P4",
              "ref_pname": "S-NITROSOCYSTEINE",
              "substance_class": "reference"
            },
            "residue_modified": "C",
            "structural_modification_type": "AMINO_ACID_SUBSTITUTION"
          }
        ]
      }
    }
  ]
}