{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "3d8305f7-a59b-4300-904d-3325a16102bb",
          "code": "G9XQ9S7T2F",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "deb8c6be-f0f8-4250-a88d-5c21f287991f",
          "citation": "https://pubchem.ncbi.nlm.nih.gov/compound/Metopimazine#section=Biological-Test-Results",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/Metopimazine",
          "doc_type": "PUBCHEM",
          "public_domain": true,
          "tags": [
            "POT"
          ]
        },
        {
          "uuid": "a6c27778-645e-4263-b87e-eea38754294d",
          "citation": "WIKI",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "ff2b6933-1324-4bca-b362-61e9b6451f41",
          "citation": "http://www.uniprot.org/uniprot/P35462",
          "url": "http://www.uniprot.org/uniprot/P35462",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "3052df7f-900f-4878-bd71-efc19eeab7cd",
          "citation": "UNIPROT",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "d0e33799-c62e-4dfc-a4df-0d567f734f4c",
          "citation": "Chiò, Adriano, Letizia Mazzini, and Gabriele Mora. \"Disease-modifying therapies in amyotrophic lateral sclerosis.\" Neuropharmacology 167 (2020): 107986.",
          "url": "https://www.sciencedirect.com/science/article/pii/S0028390820300526",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "2002ab4a-bd53-4c0d-bea1-1a8af685ee48",
          "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022192lbl.pdf",
          "doc_type": "NDA PUBLIC REVIEW",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "2eae9d86-b9b6-439e-84b6-b4bec07db5df",
          "citation": "Svenningsson, Per, et al. \"Safety and tolerability of IRL790 in Parkinson’s disease with levodopa-induced dyskinesia—a phase 1b trial.\" npj Parkinson's Disease 4.1 (2018): 35.",
          "url": "https://www.nature.com/articles/s41531-018-0071-3",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "8acd4cd6-1bde-4ece-8765-9c556db5a301",
          "citation": "https://www.drugbank.ca/drugs/DB00714#BE0000581",
          "doc_type": "WEBSITE",
          "public_domain": true
        },
        {
          "uuid": "e88b13bd-e163-4d0a-9d46-15bf6dcd46c2",
          "citation": "Wager, Travis T., et al. \"Dopamine D3/D2 receptor antagonist PF-4363467 attenuates opioid drug-seeking behavior without concomitant D2 side effects.\" ACS chemical neuroscience 8.1 (2016): 165-177.",
          "url": "https://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00297",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "POT",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "d42de5b0-4bea-499c-a543-e57ddd7f4001",
          "citation": "Attkins, Neil, et al. \"Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human.\" Xenobiotica 40.11 (2010): 730-742.",
          "url": "https://www.tandfonline.com/doi/full/10.3109/00498254.2010.514961",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "PHARMACOKINETICS"
          ]
        },
        {
          "uuid": "7752144c-7c07-42cc-8895-5494648014d1",
          "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf",
          "doc_type": "FDA APPROVED DRUG LABEL",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "b4de605c-915f-43c8-8d5e-57c2f5d0a27b",
          "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.",
          "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "71a9eb7f-6fd3-450d-beff-495e714878f6",
          "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.",
          "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "31a86c7f-d684-4bf0-8099-2b0da059f83b",
          "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf",
          "doc_type": "FDA APPROVED DRUG LABEL",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "52b3088d-46c6-4851-9478-a6db214726e7",
          "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf",
          "doc_type": "FDA APPROVED DRUG LABEL",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "ce9482a9-f209-477b-84f7-d48d6134e4bf",
          "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.",
          "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "15dcb230-631c-4248-925c-d6415ae58113",
          "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf",
          "doc_type": "FDA APPROVED DRUG LABEL",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "5b2c48e1-8441-4762-ac51-87be038c800a",
          "citation": "Feng, Meihua Rose, Joseph Loo, and Jonathan Wright. \"Disposition of the antipsychotic agent CI-1007 in rats, monkeys, dogs, and human cytochrome p450 2D6 extensive metabolizers: Species comparison and allometric scaling.\" Drug metabolism and disposition 26.10 (1998): 982-988.",
          "url": "https://dmd.aspetjournals.org/content/dmd/26/10/982.full.pdf",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "cda13951-6b73-401f-a665-cff8fe51c969",
          "citation": "WIKI",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "6be1368a-25f3-4b86-9f84-4d8c3fa59cc6",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "8fd88c00-a147-41c0-a0c8-23947e34792f",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE",
            "NOMEN"
          ]
        },
        {
          "uuid": "d1b9a629-aa2d-46c3-bedd-d08340e59597",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "052e9411-aa6b-4410-a00b-a5d63913d7fe",
          "citation": "WIKI",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "63470570-7c35-410c-a494-6cce7ca60931",
          "citation": "Attkins, N. J., et al. \"Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061.\" Xenobiotica 39.7 (2009): 523-533.",
          "url": "https://www.tandfonline.com/doi/full/10.1080/00498250902893775?casa_token=6gs8Uf1iXpgAAAAA%3A7nf-3ir6pzdZMTWvKuSZj8LMBaBK_ryfqNh8J69PsjHVPhVN2cWX9ZIkNogC5htN4hBmGIpP_kSwiw",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "040ef8d9-6e47-4a2d-a375-40f9d1cdfa18",
          "citation": "Doot, Robert K., et al. \"Selectivity of probes for PET imaging of dopamine D3 receptors.\" Neuroscience letters 691 (2019): 18-25.",
          "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123300/",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "35472149-6d3d-4cae-ad0a-2ca9c3216f40",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE",
            "NOMEN"
          ]
        },
        {
          "uuid": "2f05e75b-fb4e-4322-8cef-f592ac6f1ff6",
          "citation": "Corena-McLeod, Maria. \"Comparative pharmacology of risperidone and paliperidone.\" Drugs in R&D 15.2 (2015): 163-174.",
          "url": "https://link.springer.com/article/10.1007/s40268-015-0092-x",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "0cacf472-7e9b-43d1-98ae-086c22ea4502",
          "citation": "Doot, Robert K., et al. \"Selectivity of probes for PET imaging of dopamine D3 receptors.\" Neuroscience letters 691 (2019): 18-25.",
          "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123300/",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "931a9088-c5c8-4ec0-9710-6ecb44147e51",
          "citation": "https://jpet.aspetjournals.org/content/early/2021/07/12/jpet.121.000698",
          "url": "https://jpet.aspetjournals.org/content/early/2021/07/12/jpet.121.000698",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "684387a6-83f5-4faf-989e-c6fcf89cde39",
          "citation": "Bennacef, Idriss, et al. \"Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.\" Bioorganic & medicinal chemistry letters 19.17 (2009): 5056-5059.",
          "url": "https://d1wqtxts1xzle7.cloudfront.net/40484581/Dopamine_D-3_receptor_antagonists_The_qu20151129-16879-15j4vf8-libre.pdf?1448836054=&response-content-disposition=inline%3B+filename%3DDopamine_D3_receptor_antagonists_The_que.pdf&Expires=1665613604&Signature=PATlivX~YkEckG3GJV-BTse0jU8dGy-U6c4XZDitmrp~U~LtlHfi7qgRxWa6s8dOZl0Ayc2JA21eIqhlf5RVUOTPPt-2gwLMT7wZXIM9TLaH0AHJUH1oXpKNz1vG~~B0i1ar8dJTMSrT2y~Wq-HbNEEr4dOKPa6hlZfJF0JPG3lzUqyPtZsGd2c3A551vDxSzEdM9z-5XcoihnDPpxiFiqqMbECdMB3dJlZ9wdG-vn0MLKrvX1tqaBBbr23tZEwsjnwtZC4JIkMKuOBqZQgHEjiCTtZqAQRCW85pVgKNM-bOrPZB6hfo5DO4ZDYqhhJI0GyTxa5Lxy8u~hO2I2VkyQ__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "b384b89d-2000-4a13-88f4-8795a4eca53c",
          "citation": "stn",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "5a5d2fab-6e78-455c-8524-95c03ff07ff6",
          "citation": "Bennacef, Idriss, et al. \"Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.\" Bioorganic & medicinal chemistry letters 19.17 (2009): 5056-5059.",
          "url": "https://d1wqtxts1xzle7.cloudfront.net/40484581/Dopamine_D-3_receptor_antagonists_The_qu20151129-16879-15j4vf8-libre.pdf?1448836054=&response-content-disposition=inline%3B+filename%3DDopamine_D3_receptor_antagonists_The_que.pdf&Expires=1665613604&Signature=PATlivX~YkEckG3GJV-BTse0jU8dGy-U6c4XZDitmrp~U~LtlHfi7qgRxWa6s8dOZl0Ayc2JA21eIqhlf5RVUOTPPt-2gwLMT7wZXIM9TLaH0AHJUH1oXpKNz1vG~~B0i1ar8dJTMSrT2y~Wq-HbNEEr4dOKPa6hlZfJF0JPG3lzUqyPtZsGd2c3A551vDxSzEdM9z-5XcoihnDPpxiFiqqMbECdMB3dJlZ9wdG-vn0MLKrvX1tqaBBbr23tZEwsjnwtZC4JIkMKuOBqZQgHEjiCTtZqAQRCW85pVgKNM-bOrPZB6hfo5DO4ZDYqhhJI0GyTxa5Lxy8u~hO2I2VkyQ__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "9647ef62-02af-4043-914c-2ce9e7cad778",
          "citation": "stn",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "7961654a-7168-410a-9cc6-8130c400b018",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "5c0d6559-144c-4c92-a9df-a2a25a888505",
          "citation": "WIK",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "4473966c-f7a2-4fe1-b435-622529f7e3f8",
          "citation": "Shapiro, David A., et al. \"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.\" Neuropsychopharmacology 28.8 (2003): 1400-1411.",
          "url": "https://www.nature.com/articles/1300203",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "f73a7eba-cdfe-40ce-ae7a-7f5be088fcda",
          "citation": "https://go.drugbank.com/drugs/DB12061",
          "url": "https://go.drugbank.com/drugs/DB12061",
          "doc_type": "DRUG BANK",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "f0cfcb0f-11d9-44c5-95ff-6835ef36af7b",
          "citation": "https://drugs.ncats.io/drug/7SNB18Q89D",
          "url": "https://drugs.ncats.io/drug/7SNB18Q89D",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "429a246f-6e70-427c-b985-6506a1e17a34",
          "citation": "WIKI",
          "doc_type": "WIKI",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "fce9f5e1-fd1b-4cdc-a03e-cc5d20edb0ff",
          "citation": "Nichols, David E., et al. \"Lysergamides of isomeric 2, 4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N, N-diethyllysergamide (LSD).\" Journal of Medicinal Chemistry 45.19 (2002): 4344-4349.",
          "url": "https://pubs.acs.org/doi/pdf/10.1021/jm020153s",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "4269213d-eb50-4465-97a2-c290e824586a",
          "citation": "https://drugs.ncats.io/drug/419A0R564U",
          "url": "https://drugs.ncats.io/drug/419A0R564U",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "71a6fb18-e795-4b2c-b025-2f1c116842ad",
          "citation": "https://go.drugbank.com/drugs/DB09223",
          "url": "https://go.drugbank.com/drugs/DB09223",
          "doc_type": "DRUG BANK",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "de3d52c7-a1a1-4b55-9ea1-8cfadcf391d1",
          "citation": "Bourne, James A. \"SCH 23390: the first selective dopamine D1‐like receptor antagonist.\" CNS drug reviews 7.4 (2001): 399-414.",
          "url": "https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00207.x?sid=nlm%3Apubmed",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "5ffc24eb-a826-401d-828b-29a2f9e37378",
          "citation": "Bourne, James A. \"SCH 23390: the first selective dopamine D1‐like receptor antagonist.\" CNS drug reviews 7.4 (2001): 399-414.",
          "url": "https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00207.x?sid=nlm%3Apubmed",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "93cbf858-0da0-4af1-850b-5d63304b913d",
          "citation": "Bourne, James A. \"SCH 23390: the first selective dopamine D1‐like receptor antagonist.\" CNS drug reviews 7.4 (2001): 399-414.",
          "url": "https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3458.2001.tb00207.x?sid=nlm%3Apubmed",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "ecee770b-503e-410d-ba56-8075aa6a3661",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "044a2f69-48c4-40a8-b819-26ac040d934a",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "a98f13f0-dc55-4a68-ad39-74c161d27375",
      "version": "74",
      "unii": "G9XQ9S7T2F",
      "relationships": [
        {
          "uuid": "ad80eb6b-4a83-4d93-a367-c5cafa54d09b",
          "amount": {
            "uuid": "e3e0feac-1314-4569-8a60-bdc367d578bf",
            "average": 12,
            "units": "NANOMOLAR"
          },
          "comments": "Emax 82% Transfected CHO cells",
          "qualification": "EC50",
          "type": "AGONIST->TARGET",
          "references": [
            "8acd4cd6-1bde-4ece-8765-9c556db5a301"
          ],
          "related_substance": {
            "uuid": "122d8f7b-153c-4338-a1f5-b7298d3da083",
            "refuuid": "d5382a9f-4b7e-432d-bf4d-03a5473c8f22",
            "name": "APOMORPHINE",
            "unii": "N21FAR7B4S",
            "linking_id": "N21FAR7B4S",
            "ref_pname": "APOMORPHINE"
          }
        },
        {
          "uuid": "c25bc231-6ef9-40b6-bedf-91588febd96e",
          "amount": {
            "uuid": "987a9927-a8bf-44f8-bead-c93f5aecec79"
          },
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "189bb8ea-8264-4c9c-a5fa-dda9bc5cb7c6",
            "refuuid": "a3cbd3a3-7846-4771-b0d0-7c6b4441cf8d",
            "name": "PERGOLIDE",
            "unii": "24MJ822NZ9",
            "linking_id": "24MJ822NZ9",
            "ref_pname": "PERGOLIDE"
          }
        },
        {
          "uuid": "8d703844-6d1a-40ff-ae8d-f96bb480f9de",
          "amount": {
            "uuid": "74f0bc95-3bde-4248-8db0-0671d914bfd4"
          },
          "type": "PARTIAL AGONIST->TARGET",
          "related_substance": {
            "uuid": "92404389-3957-497c-af93-f55cbc234754",
            "refuuid": "290d9815-8602-4636-ab28-7497ef98895b",
            "name": "Brilaroxazine",
            "unii": "X8L60BA01I",
            "linking_id": "X8L60BA01I",
            "ref_pname": "Brilaroxazine"
          }
        },
        {
          "uuid": "d8f3894e-c852-437e-9045-fc7546771fe3",
          "amount": {
            "uuid": "4df514b0-972d-4654-82ed-18bcdcddda47",
            "average": 3.2,
            "units": "NANOMOLAR"
          },
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "7aad27bb-37db-4418-af94-1f8d18b7a33e",
            "refuuid": "6fca0332-91d4-44db-b125-81cc3c1639ea",
            "name": "SB-773812",
            "unii": "ZNP5SNF9FY",
            "linking_id": "ZNP5SNF9FY",
            "ref_pname": "SB-773812"
          }
        },
        {
          "uuid": "48ae1463-e033-423f-8d06-489c483f6914",
          "amount": {
            "uuid": "0e7b97fe-396d-4bb1-88d2-8472eb70a5e3"
          },
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "ba89a03f-bc68-41ee-a245-aea11cf3d434",
            "refuuid": "b1f67d7b-63e2-4936-916e-9adc6a636638",
            "name": "GSK-598809",
            "unii": "Y5OZ63HC3V",
            "linking_id": "Y5OZ63HC3V",
            "ref_pname": "GSK-598809"
          }
        },
        {
          "uuid": "36802c20-b996-4873-acb2-0c80d31952a6",
          "amount": {
            "uuid": "e7c05e19-17a6-46c1-8126-f63c103b59fb",
            "average": 90,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "references": [
            "2eae9d86-b9b6-439e-84b6-b4bec07db5df"
          ],
          "related_substance": {
            "uuid": "088a7140-6c7c-45c5-9626-9aa42e75431a",
            "refuuid": "45dab35e-6d69-4b70-bec8-d58b5c11f8dc",
            "name": "MESDOPETAM",
            "unii": "HD4QV8GX26",
            "linking_id": "HD4QV8GX26",
            "ref_pname": "MESDOPETAM"
          }
        },
        {
          "uuid": "ccb2164a-bcc2-4ea7-9cfe-a38b85ad6c75",
          "type": "PARTIAL AGONIST->TARGET",
          "related_substance": {
            "uuid": "cf9006dc-1f1a-43eb-9d09-8100ccf6178d",
            "refuuid": "731f67a1-c8e1-47fb-8643-d7f92f761216",
            "name": "BP-14979",
            "unii": "XN7HA74WB0",
            "linking_id": "XN7HA74WB0",
            "ref_pname": "BP-14979"
          }
        },
        {
          "uuid": "afb0b9f2-367f-4c35-aa23-21099bbed736",
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "351cf606-4a4d-49a4-88bb-a2f2973f0983",
            "refuuid": "42309f06-bb6c-4965-90ab-debd7c516554",
            "name": "ROPINIROLE",
            "unii": "030PYR8953",
            "linking_id": "030PYR8953",
            "ref_pname": "ROPINIROLE"
          }
        },
        {
          "uuid": "23690cc1-5782-4c13-bf09-edbbe2640ec1",
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "42bffd00-7a36-434b-9e55-974fbcbe35c5",
            "refuuid": "23ecdee4-0740-40b6-b006-395ed0d40ac6",
            "name": "ROTIGOTINE",
            "unii": "87T4T8BO2E",
            "linking_id": "87T4T8BO2E",
            "ref_pname": "ROTIGOTINE"
          }
        },
        {
          "uuid": "d4d446dc-7013-45ec-a245-41fc28670432",
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "d20c9bfc-d455-422e-8b16-4175e6b05d75",
            "refuuid": "4dae9454-8311-4528-8b18-4d4a3f4e6d32",
            "name": "PRAMIPEXOLE",
            "unii": "83619PEU5T",
            "linking_id": "83619PEU5T",
            "ref_pname": "PRAMIPEXOLE"
          }
        },
        {
          "uuid": "aa9575ff-ae2a-479c-9bbc-2c190aa4c727",
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "7671e62f-9aea-4a26-abaf-e01e365a137b",
            "refuuid": "74eb96da-1f5b-4bad-9687-8a221557fb5a",
            "name": "BROMOCRIPTINE",
            "unii": "3A64E3G5ZO",
            "linking_id": "3A64E3G5ZO",
            "ref_pname": "BROMOCRIPTINE"
          }
        },
        {
          "uuid": "35d33252-e95f-418e-a221-1878b8d1fc9c",
          "amount": {
            "uuid": "1cdcb7b7-4923-4bd0-8549-fe6614af658d",
            "average": 0.085,
            "units": "NANOMOLAR"
          },
          "comments": "Most of the clinically used antipsychotics display fairly high affinity for D3 receptors in vitro, they lack significant D3 receptor binding in vivo. They also do not occupy D3 receptors in schizophrenic patients at clinically-relevant doses, despite having significant and expected D2 receptor occupancy. The lack of in vivo D3 receptor occupancy of currently used antipsychotics may be due to their inability to displace endogenous DA from these sites; especially since DA has approximately 20- fold higher affinity for D3 vs D2 receptors and D3 (but not D2) receptors exist predominantly in a high affinity state for DA”",
          "qualification": "Ki",
          "type": "PARTIAL AGONIST->TARGET",
          "related_substance": {
            "uuid": "0680955e-51c1-4d17-9d8f-968fff0f4221",
            "refuuid": "c2b826fe-75d5-4d80-b36a-3bec1d7c5e24",
            "name": "CARIPRAZINE",
            "unii": "F6RJL8B278",
            "linking_id": "F6RJL8B278",
            "ref_pname": "CARIPRAZINE"
          }
        },
        {
          "uuid": "a60abfbd-8eb0-484d-bddd-1c47dfc207f2",
          "type": "RADIOLIGAND->TARGET",
          "related_substance": {
            "uuid": "6faae831-29b5-4c26-a8ca-4b4c26d32e9e",
            "refuuid": "f2ef2bf9-0556-48dd-ab49-54a0e5f1692b",
            "name": "NAXAGOLIDE C-11",
            "unii": "PJ3R40IQ7L",
            "linking_id": "PJ3R40IQ7L",
            "ref_pname": "NAXAGOLIDE C-11"
          }
        },
        {
          "uuid": "61472102-d648-4ece-95ad-bf52032e4cce",
          "amount": {
            "uuid": "d1c6c108-8818-4132-8170-7a438fca6a4e",
            "average": 7.1,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "interaction_type": "MAJOR",
          "references": [
            "2002ab4a-bd53-4c0d-bea1-1a8af685ee48"
          ],
          "related_substance": {
            "uuid": "776a5fa6-a98b-44ef-a77b-e2d4f3a7e977",
            "refuuid": "f1476505-8361-4080-8a97-c6b9a0fb89ed",
            "name": "ILOPERIDONE",
            "unii": "VPO7KJ050N",
            "linking_id": "VPO7KJ050N",
            "ref_pname": "ILOPERIDONE"
          }
        },
        {
          "uuid": "ad7a80a6-39e7-417c-b68b-e7125c9eb9ee",
          "amount": {
            "uuid": "c129bf1a-5af7-442f-9075-b1d0e7c9a95c",
            "type": "RELATIVE BINDING AFFINITY",
            "average": 2.4,
            "units": "NANOMOLAR",
            "non_numeric_value": "Dose 400-800mg"
          },
          "qualification": "Ki",
          "type": "ANTAGONIST->TARGET",
          "interaction_type": "ANTAGONIST",
          "references": [
            "31a86c7f-d684-4bf0-8099-2b0da059f83b"
          ],
          "related_substance": {
            "uuid": "fad765ab-aeaf-40aa-986e-c7467829642b",
            "refuuid": "95bb2237-a7ee-4915-9473-84238cba0854",
            "name": "AMISULPRIDE",
            "unii": "8110R61I4U",
            "linking_id": "8110R61I4U",
            "ref_pname": "AMISULPRIDE"
          }
        },
        {
          "uuid": "ea564340-723d-4745-a3bb-8876f20130e1",
          "type": "AGONIST->TARGET",
          "references": [
            "e88b13bd-e163-4d0a-9d46-15bf6dcd46c2",
            "d42de5b0-4bea-499c-a543-e57ddd7f4001"
          ],
          "related_substance": {
            "uuid": "c80844ae-874a-4ec4-bcb9-996a199adcae",
            "refuuid": "563d642b-40d7-4202-9973-8de501e4d108",
            "name": "PF-592379",
            "unii": "66B7UY5K7I",
            "linking_id": "66B7UY5K7I",
            "ref_pname": "PF-592379"
          }
        },
        {
          "uuid": "f5a8262b-c373-4053-b197-65a6c353ea66",
          "type": "INHIBITOR->TARGET",
          "references": [
            "deb8c6be-f0f8-4250-a88d-5c21f287991f"
          ],
          "related_substance": {
            "uuid": "a717bc73-68bf-42e3-9cc6-ecb6ba9bf8ed",
            "refuuid": "9f2aa717-4057-41e3-b056-8bc81935a644",
            "name": "METOPIMAZINE",
            "unii": "238S75V9AV",
            "linking_id": "238S75V9AV",
            "ref_pname": "METOPIMAZINE"
          }
        },
        {
          "uuid": "7a0d12c3-972d-4e6c-b25b-abbb508013b8",
          "type": "AGONIST->TARGET",
          "interaction_type": "PARTIAL AGONIST",
          "references": [
            "5b2c48e1-8441-4762-ac51-87be038c800a"
          ],
          "related_substance": {
            "uuid": "248a7a95-b224-426d-b07a-8328412f5df2",
            "refuuid": "6afb11d5-7bc9-4ec9-8969-9fdab4f484bd",
            "name": "CI-1007",
            "unii": "Z5XDS9Z25L",
            "linking_id": "Z5XDS9Z25L",
            "ref_pname": "CI-1007"
          }
        },
        {
          "uuid": "2a142b34-0d22-4bd7-a771-0a9f967bc3a5",
          "amount": {
            "uuid": "d9652e57-2b67-4bc9-84cf-bba9c45257ce",
            "average": 5.5,
            "high": 7.5,
            "low": 3.5,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "interaction_type": "INHIBITOR ",
          "references": [
            "ce9482a9-f209-477b-84f7-d48d6134e4bf"
          ],
          "related_substance": {
            "uuid": "ec4cb4ce-08f1-40d5-864e-76340b0f6bdd",
            "refuuid": "d8f372eb-a89e-47ec-a957-bcdb1111df0b",
            "name": "PALIPERIDONE",
            "unii": "838F01T721",
            "linking_id": "838F01T721",
            "ref_pname": "PALIPERIDONE"
          }
        },
        {
          "uuid": "43c17eef-20ef-433c-8531-8f563ce77e21",
          "amount": {
            "uuid": "fb4e69ea-7815-4200-9346-f04a12f42e3b",
            "average": 13,
            "high": 18,
            "low": 8,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "WEAK INHIBITOR->TARGET",
          "interaction_type": "INHIBITOR ",
          "references": [
            "2f05e75b-fb4e-4322-8cef-f592ac6f1ff6"
          ],
          "related_substance": {
            "uuid": "785dd991-3394-41fc-9f44-7ad7d8840105",
            "refuuid": "95270949-f3d1-440d-8635-faa62495c858",
            "name": "RISPERIDONE",
            "unii": "L6UH7ZF8HC",
            "linking_id": "L6UH7ZF8HC",
            "ref_pname": "RISPERIDONE"
          }
        },
        {
          "uuid": "61007180-15a9-4ce0-a0d7-f48dc078caa7",
          "amount": {
            "uuid": "5f9d2553-7f10-4210-9b6e-c52796b79d35"
          },
          "type": "INHIBITOR->TARGET",
          "interaction_type": "ANTAGONIST",
          "references": [
            "429a246f-6e70-427c-b985-6506a1e17a34"
          ],
          "related_substance": {
            "uuid": "8046ae55-fc2c-4d38-853c-8cf73964d27d",
            "refuuid": "11dfefd8-1b99-41dc-900a-021280e48497",
            "name": "SB-277011",
            "unii": "CHW57ND47C",
            "linking_id": "CHW57ND47C",
            "ref_pname": "SB-277011"
          }
        },
        {
          "uuid": "fe4503a1-0105-4b67-bdf3-08451ce6235b",
          "amount": {
            "uuid": "2fb2c187-787e-443a-8c7c-56212c8843dc"
          },
          "type": "AGONIST->TARGET",
          "references": [
            "7961654a-7168-410a-9cc6-8130c400b018"
          ],
          "related_substance": {
            "uuid": "3fbc166d-9148-42a0-aa53-73a824e85d0d",
            "refuuid": "f51c196c-6cf2-4e95-a3ea-435b44b0bd57",
            "name": "6-FLUORO-DMT",
            "unii": "J4CZH8D9EN",
            "linking_id": "J4CZH8D9EN",
            "ref_pname": "6-FLUORO-DMT"
          }
        },
        {
          "uuid": "9c4cf98c-5da6-410c-bfdc-4a68e3d2cf15",
          "amount": {
            "uuid": "cba3f08e-4fc0-42b9-a546-c93b1e38da40"
          },
          "type": "AGONIST->TARGET",
          "references": [
            "052e9411-aa6b-4410-a00b-a5d63913d7fe"
          ],
          "related_substance": {
            "uuid": "ce5b5b69-b40c-489d-ad6c-59d912db08a7",
            "refuuid": "b714e0ee-d080-4552-924e-a8a46a576f43",
            "name": "DINOXYLINE",
            "unii": "9T7B8CV47A",
            "linking_id": "9T7B8CV47A",
            "ref_pname": "DINOXYLINE"
          }
        },
        {
          "uuid": "9e20aa4d-cd23-46b0-ad9b-ed7a1b4ae873",
          "amount": {
            "uuid": "24d3a4e0-edcd-475c-a411-c6214f532db0",
            "average": 0.17,
            "units": "NANOMOLAR"
          },
          "comments": " D3-selective radiotracer.",
          "qualification": "Ki",
          "type": "RADIOLIGAND->TARGET",
          "references": [
            "040ef8d9-6e47-4a2d-a375-40f9d1cdfa18"
          ],
          "related_substance": {
            "uuid": "e370a7e5-fadf-4ae4-b0ac-5e0ed1be65c9",
            "refuuid": "a644f0af-6ff8-44e9-af74-b34a7362202a",
            "name": "FLUORTRIOPRIDE F-18",
            "unii": "94W3VUC3ZF",
            "linking_id": "94W3VUC3ZF",
            "ref_pname": "FLUORTRIOPRIDE F-18",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "b9cf01e8-e625-4ea4-b204-1393be7991fc",
          "amount": {
            "uuid": "4898e0e9-1f17-4611-9c7f-7c1f3c0f036a"
          },
          "type": "AGONIST->TARGET",
          "references": [
            "35472149-6d3d-4cae-ad0a-2ca9c3216f40"
          ],
          "related_substance": {
            "uuid": "041415c0-1bd7-4b34-9605-3dc3f39100db",
            "refuuid": "5af17931-7d74-4f61-948c-8f61e2a8f3b3",
            "name": "8-OH-PBZI",
            "unii": "B8GYQ9JV5F",
            "linking_id": "B8GYQ9JV5F",
            "ref_pname": "8-OH-PBZI"
          }
        },
        {
          "uuid": "68b4eb05-c3ce-4700-8eec-b28134f40576",
          "amount": {
            "uuid": "eb829c33-b24c-4be7-8ce3-d840638bcd27"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "d0e33799-c62e-4dfc-a4df-0d567f734f4c"
          ],
          "related_substance": {
            "uuid": "9a5e1c7d-a00b-43e9-aef0-0073132e1f96",
            "refuuid": "853e38c8-ffda-4379-bfb6-e8bf16b17b6a",
            "name": "PIMOZIDE",
            "unii": "1HIZ4DL86F",
            "linking_id": "1HIZ4DL86F",
            "ref_pname": "PIMOZIDE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "4bcf61cd-4694-4bf1-825b-5856aa0825ce",
          "amount": {
            "uuid": "6982947a-f6cb-40c7-b6b0-c350eb3f8ea6"
          },
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "27dfc456-bfe6-442c-88f4-b1840cc87fcc",
            "refuuid": "9e0859c7-5014-4c51-a734-ffd7fd412a05",
            "name": "CORYDALMINE, (-)-",
            "unii": "DV8DX4568D",
            "linking_id": "DV8DX4568D",
            "ref_pname": "CORYDALMINE, (-)-"
          }
        },
        {
          "uuid": "8d95475a-6daa-4c16-a300-f47649550928",
          "amount": {
            "uuid": "d5214917-21cc-4b1b-86b0-35f93a95cb43",
            "average": 15,
            "units": "NANOMOLAR"
          },
          "comments": "A potent and highly selective agonist for the dopamine D3 receptor.",
          "qualification": "EC50",
          "type": "AGONIST->TARGET",
          "references": [
            "63470570-7c35-410c-a494-6cce7ca60931"
          ],
          "related_substance": {
            "uuid": "73f950d5-5fe2-41a6-bc1d-7ab29586ac55",
            "refuuid": "25e05feb-2a49-4488-befb-3abb714c1cd2",
            "name": "PF-219061",
            "unii": "ZK5ZP8L5S2",
            "linking_id": "ZK5ZP8L5S2",
            "ref_pname": "PF-219061"
          }
        },
        {
          "uuid": "cee3997d-5d7b-4d05-b620-aa3564f49d8d",
          "amount": {
            "uuid": "892592e9-5eaf-4120-8687-5fcdb45e1034",
            "average": 3.5,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "references": [
            "0cacf472-7e9b-43d1-98ae-086c22ea4502"
          ],
          "related_substance": {
            "uuid": "318c0ca2-c8f6-4e0f-83bf-eb5ce4387b4c",
            "refuuid": "60bb5373-f75c-4688-bece-689e121085f0",
            "name": "RACLOPRIDE",
            "unii": "430K3SOZ7G",
            "linking_id": "430K3SOZ7G",
            "ref_pname": "RACLOPRIDE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "3bba0b37-00ee-442e-9f04-12978f630c02",
          "amount": {
            "uuid": "0dd0a394-7e86-4762-89f8-4770f807df6a"
          },
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "64243239-3082-415b-b993-148d5e8366cc",
            "refuuid": "6ee93f49-30dd-4dc0-8a7f-3fa244561391",
            "name": "3-(2-oxo-3-{2-[4-(trifluoromethyl)piperidin-1-yl]ethyl}imidazolidin-1-yl)benzonitrile",
            "unii": "8K5G4U34CU",
            "linking_id": "8K5G4U34CU",
            "ref_pname": "3-(2-oxo-3-{2-[4-(trifluoromethyl)piperidin-1-yl]ethyl}imidazolidin-1-yl)benzonitrile",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "b5ada9c7-ef1d-49e7-815a-8d354ddd9b5e",
          "amount": {
            "uuid": "a242cc88-22ad-4be3-b951-caca8b2f1d17"
          },
          "comments": "Did not image D3 receptors.",
          "type": "RADIOLIGAND->TARGET",
          "references": [
            "5a5d2fab-6e78-455c-8524-95c03ff07ff6",
            "9647ef62-02af-4043-914c-2ce9e7cad778"
          ],
          "related_substance": {
            "uuid": "96c5c971-78e6-4aeb-a775-53b24e93256b",
            "refuuid": "7efd2ba1-a762-47c9-9035-94a18beaa119",
            "name": "3-[2-Oxo-3-[2-[4-(trifluoromethyl)-1-piperidinyl]ethyl]-1-imidazolidinyl]benzonitrile-cyano-11C",
            "unii": "C2PJP69BQR",
            "linking_id": "C2PJP69BQR",
            "ref_pname": "3-[2-Oxo-3-[2-[4-(trifluoromethyl)-1-piperidinyl]ethyl]-1-imidazolidinyl]benzonitrile-cyano-11C",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "0355dc74-8545-428f-b98e-9cc1201f454c",
          "amount": {
            "uuid": "4fb62370-1ee6-4abe-85ee-be0ab38ae274"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "931a9088-c5c8-4ec0-9710-6ecb44147e51"
          ],
          "related_substance": {
            "uuid": "7c1cb4db-67b8-42f5-a4e4-15d31893a6e3",
            "refuuid": "59346899-cf62-4a03-8574-a706654ef917",
            "name": "TRAZPIROBEN",
            "unii": "FH87H57Q4Y",
            "linking_id": "FH87H57Q4Y",
            "ref_pname": "TRAZPIROBEN",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "e74fa25c-08b1-40f5-93a5-1f9e5dba2e17",
          "type": "INHIBITOR->TARGET",
          "interaction_type": "ANTAGONIST",
          "references": [
            "a6c27778-645e-4263-b87e-eea38754294d"
          ],
          "related_substance": {
            "uuid": "30ccc14a-ae72-412f-b83c-e2cd21821768",
            "refuuid": "6da14dc0-0741-4dee-bf23-259b32b38404",
            "name": "DESMETHOXYFALLYPRIDE",
            "unii": "CJD4EF9EME",
            "linking_id": "CJD4EF9EME",
            "ref_pname": "DESMETHOXYFALLYPRIDE"
          }
        },
        {
          "uuid": "cdb8d244-ace3-44ac-926c-7393bb010b3a",
          "amount": {
            "uuid": "e4ee9393-19a0-4816-b9b9-765a0091cebb"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "4269213d-eb50-4465-97a2-c290e824586a"
          ],
          "related_substance": {
            "uuid": "65393ce0-1d33-4a9e-b105-f263a8aa5f09",
            "refuuid": "458f966c-d4da-4fdb-b056-bcb4d135a15e",
            "name": "ELOPIPRAZOLE",
            "unii": "419A0R564U",
            "linking_id": "419A0R564U",
            "ref_pname": "ELOPIPRAZOLE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "427dbfe0-af19-4d0d-8eca-a549f882c61e",
          "amount": {
            "uuid": "f809ad52-0880-4ea8-8120-827f98054d2b",
            "average": 2.3
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "d2380f73-040f-406a-bf0e-86802c509c23",
            "refuuid": "44113624-19ec-4631-951f-e3a91606efb8",
            "name": "BROMPERIDOL",
            "unii": "LYH6F7I22E",
            "linking_id": "LYH6F7I22E",
            "ref_pname": "BROMPERIDOL",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "8218555b-5bc6-479e-94ad-9dbb26f75c33",
          "amount": {
            "uuid": "713da550-b9e9-4add-86ff-a326e417dcf4",
            "average": 27,
            "high": 33,
            "low": 21,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "LIGAND->OFF TARGET",
          "interaction_type": "BINDING",
          "references": [
            "fce9f5e1-fd1b-4cdc-a03e-cc5d20edb0ff"
          ],
          "related_substance": {
            "uuid": "ba3efe73-b28a-4bf7-994d-7a1f395f2129",
            "refuuid": "47838978-2214-4228-a38b-9ed5b1b283a3",
            "name": "LYSERGIDE",
            "unii": "8NA5SWF92O",
            "linking_id": "8NA5SWF92O",
            "ref_pname": "LYSERGIDE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "25213c57-8a68-4e77-b508-9ccd25828a70",
          "amount": {
            "uuid": "c5cce43c-bd04-4f01-a9ad-57be9f100d17"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "71a6fb18-e795-4b2c-b025-2f1c116842ad"
          ],
          "related_substance": {
            "uuid": "29c77876-e107-414d-8308-68dc69d197cb",
            "refuuid": "d0fa9211-2b23-4b76-be8f-760f995aaf7f",
            "name": "BLONANSERIN",
            "unii": "AQ316B4F8C",
            "linking_id": "AQ316B4F8C",
            "ref_pname": "BLONANSERIN",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "9d263c7d-44bc-4089-ae20-e54b9d9fc6fd",
          "amount": {
            "uuid": "b55c74af-671f-442d-afc6-af9264a57e45"
          },
          "type": "INHIBITOR->TARGET",
          "related_substance": {
            "uuid": "91a26b2d-6bf5-4122-9121-ba443dce85d3",
            "refuuid": "c8be447d-d74f-4ac5-9f25-a45736d8c5cc",
            "name": "F-17464 FREE BASE",
            "unii": "TDB64DDB5X",
            "linking_id": "TDB64DDB5X",
            "ref_pname": "F-17464 FREE BASE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "abb9be71-a012-49a0-bdc9-6f870791c11c",
          "amount": {
            "uuid": "485a441d-8170-4fa8-b9cf-c5549c61f22a",
            "average": 1,
            "high": 1.4,
            "low": 0.6,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "PARTIAL AGONIST->TARGET",
          "references": [
            "4473966c-f7a2-4fe1-b435-622529f7e3f8"
          ],
          "related_substance": {
            "uuid": "1e23d681-9cfc-4538-b5e0-3f3530202d38",
            "refuuid": "c193f733-fa48-4704-bbca-957a3c6dff6c",
            "name": "ARIPIPRAZOLE",
            "unii": "82VFR53I78",
            "linking_id": "82VFR53I78",
            "ref_pname": "ARIPIPRAZOLE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "0deaa72a-9d8b-4ec8-a2e6-24e276e6c95d",
          "amount": {
            "uuid": "939a8df0-b8ed-4a6a-9872-894d6891c720"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "f0cfcb0f-11d9-44c5-95ff-6835ef36af7b"
          ],
          "related_substance": {
            "uuid": "cb52feaa-d51e-4a71-bd94-a34d9f1c8404",
            "refuuid": "df9ef20c-25d3-4a09-b6f2-c25302bebb60",
            "name": "ADOPRAZINE",
            "unii": "7SNB18Q89D",
            "linking_id": "7SNB18Q89D",
            "ref_pname": "ADOPRAZINE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "8642fba6-dcd2-4799-a0b7-ff1261ae246c",
          "amount": {
            "uuid": "9f377186-b555-4e2e-bce2-cdb7bef38dd7"
          },
          "type": "RADIOLIGAND->TARGET",
          "related_substance": {
            "uuid": "2e791352-4290-4169-999b-ee2c45c1c517",
            "refuuid": "37736895-d413-4eed-8cea-956919705d3f",
            "name": "IOLOPRIDE I-123",
            "unii": "5E76SOQ99K",
            "linking_id": "5E76SOQ99K",
            "ref_pname": "IOLOPRIDE I-123",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "28e9104f-e93f-4438-a155-4f6d094553ac",
          "amount": {
            "uuid": "a1c9e367-9ed3-4169-824c-1129db24762a"
          },
          "type": "PARTIAL AGONIST->TARGET",
          "references": [
            "f73a7eba-cdfe-40ce-ae7a-7f5be088fcda"
          ],
          "related_substance": {
            "uuid": "f37c556c-3df4-4e7b-a650-004ee94c6469",
            "refuuid": "fca1e40b-2e85-4ae2-957a-0c470db06eba",
            "name": "PARDOPRUNOX",
            "unii": "5R72CHP32S",
            "linking_id": "5R72CHP32S",
            "ref_pname": "PARDOPRUNOX",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "2be70344-0d07-4874-9a22-4e267f162406",
          "amount": {
            "uuid": "8ea78af0-46ee-4ef9-8f0b-52e475f69d3d"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "ecee770b-503e-410d-ba56-8075aa6a3661"
          ],
          "related_substance": {
            "uuid": "5e66087d-e599-4078-9ea2-eaba74d515a2",
            "refuuid": "a8d38b50-13f5-4a24-9606-9c3aea20eb17",
            "name": "N-[(3R)-4-[4-(3-Chloro-5-ethyl-2-methoxyphenyl)-1-piperazinyl]-3-hydroxybutyl]-1H-indole-2-carboxamide",
            "unii": "45L365B7XN",
            "linking_id": "45L365B7XN",
            "ref_pname": "N-[(3R)-4-[4-(3-Chloro-5-ethyl-2-methoxyphenyl)-1-piperazinyl]-3-hydroxybutyl]-1H-indole-2-carboxamide",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "1594e016-70b1-4942-9f90-0b13608a499b",
          "amount": {
            "uuid": "8cb12964-bc14-4279-ac82-7534dd9801c1",
            "average": 4,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "AGONIST->TARGET",
          "references": [
            "93cbf858-0da0-4af1-850b-5d63304b913d"
          ],
          "related_substance": {
            "uuid": "86612814-7899-4cd0-b037-b6fe27e56783",
            "refuuid": "11cfc6b9-4651-4a5c-98b9-284d8fbe2b50",
            "name": "DOPAMINE",
            "unii": "VTD58H1Z2X",
            "linking_id": "VTD58H1Z2X",
            "ref_pname": "DOPAMINE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "38e39c2c-ff35-4127-bed6-9bdce97004d0",
          "amount": {
            "uuid": "3657b574-2fbc-43a8-84da-14f6c9476e2f",
            "average": 0.8,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->OFF-TARGET",
          "references": [
            "de3d52c7-a1a1-4b55-9ea1-8cfadcf391d1"
          ],
          "related_substance": {
            "uuid": "f83d6ffc-a67f-4361-8dd9-913605d7bfe2",
            "refuuid": "13369292-c650-4ac4-be6a-dadb9d87a173",
            "name": "SCH-23390",
            "unii": "UGT5535REQ",
            "linking_id": "UGT5535REQ",
            "ref_pname": "SCH-23390",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "dcf4d17b-4280-4522-99af-2c7d95c2342e",
          "amount": {
            "uuid": "c05ccc6b-8662-40fb-82e7-a1dd76a23d4b",
            "average": 7,
            "units": "NANOMOLAR"
          },
          "qualification": "Ki",
          "type": "INHIBITOR->TARGET",
          "references": [
            "5ffc24eb-a826-401d-828b-29a2f9e37378"
          ],
          "related_substance": {
            "uuid": "f462613e-0892-4b6f-825d-d648411775bc",
            "refuuid": "cb034a38-8a43-4112-9760-cae598710d66",
            "name": "HALOPERIDOL",
            "unii": "J6292F8L3D",
            "linking_id": "J6292F8L3D",
            "ref_pname": "HALOPERIDOL",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "8c256708-65cb-4e59-a847-adf70e5cd5af",
          "name": "D(3) DOPAMINE RECEPTOR",
          "stdName": "D(3) DOPAMINE RECEPTOR",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "3052df7f-900f-4878-bd71-efc19eeab7cd",
            "ff2b6933-1324-4bca-b362-61e9b6451f41"
          ],
          "display_name": true
        },
        {
          "uuid": "e5e59c49-6e37-4f2f-8c31-9caf518039f8",
          "name": "D3",
          "stdName": "D3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "ff2b6933-1324-4bca-b362-61e9b6451f41"
          ],
          "display_name": false
        },
        {
          "uuid": "c4813480-ccb8-4cb5-bc53-d894212cac07",
          "name": "D3R",
          "stdName": "D3R",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "3052df7f-900f-4878-bd71-efc19eeab7cd"
          ],
          "display_name": false
        },
        {
          "uuid": "b0d4ed22-1822-a433-0e38-67df5b51292b",
          "name": "DOPAMINE D3 RECEPTOR",
          "stdName": "DOPAMINE D3 RECEPTOR",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "ff2b6933-1324-4bca-b362-61e9b6451f41"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "8bd96abb-2f2b-4253-a3c0-3fbdf13fb232",
        "glycosylation": {
          "uuid": "4b537772-fbe0-4d27-a3dc-1586f8d8b92f",
          "glycosylation_type": "HUMAN",
          "n_glycosylation_sites": [
            {
              "residue_index": 12,
              "subunit_index": 1
            },
            {
              "residue_index": 19,
              "subunit_index": 1
            },
            {
              "residue_index": 97,
              "subunit_index": 1
            },
            {
              "residue_index": 173,
              "subunit_index": 1
            }
          ]
        },
        "subunits": [
          {
            "uuid": "8102de92-ecfd-4cf4-bbbf-0b6e3dff9f22",
            "sequence": "MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC",
            "subunit_index": 1
          }
        ],
        "references": [
          "ff2b6933-1324-4bca-b362-61e9b6451f41"
        ],
        "disulfide_links": [
          {
            "sites": [
              {
                "residue_index": 103,
                "subunit_index": 1
              },
              {
                "residue_index": 181,
                "subunit_index": 1
              }
            ]
          },
          {
            "sites": [
              {
                "residue_index": 355,
                "subunit_index": 1
              },
              {
                "residue_index": 358,
                "subunit_index": 1
              }
            ]
          }
        ],
        "protein_sub_type": "",
        "protein_type": "RECEPTOR",
        "sequence_origin": "HUMAN",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "33835df8-9314-4f4c-b6de-ed4f5a8ccfcc",
          "name": "MOL_WEIGHT",
          "type": "amount",
          "value": {
            "uuid": "8d9aec52-4fb1-46b8-87f8-f45d00314245",
            "units": "DA"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "282c47c8-dd07-4a99-80f9-f7d4ec84fbdb",
          "name": "Molecular Formula",
          "value": {
            "uuid": "4c3eb3c9-9ff4-426f-95a6-0a8050a42e0c",
            "type": "ESTIMATED",
            "non_numeric_value": "C1998H3147N531O552S24"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "3bb82ec3-bfed-41bc-a6b7-0b21214ef241"
      }
    }
  ]
}