{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "dd058cc0-0f84-4934-b8e7-89d8106c13b1", "code": "P04150", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/P04150?sort=score", "code_system": "UNIPROT", "references": [ "f6574c8a-9380-40f6-ba03-90e2e672b078" ] }, { "uuid": "5a0dff88-07f8-4864-a8f5-4b83ba00ea57", "code": "P04150", "type": "PRIMARY", "url": "https://pharos.nih.gov/idg/search?q=P04150", "code_system": "PHAROS", "references": [ "f6574c8a-9380-40f6-ba03-90e2e672b078" ] }, { "uuid": "ecfa4a94-78ff-4f93-935f-c3ce6c10edb5", "code": "FZW85LW99M", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "af6c2f33-99bc-4b8b-bb09-ed479c88f1ed", "citation": "BIOORG MED CHEM. 2011 DEC 15;19(24):7374-86. DOI: 10.1016/J.BMC.2011.10.054. EPUB 2011 OCT 24.", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22079253", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "POT" ] }, { "uuid": "6a510a7c-1854-40df-8ea5-6c3339f24cd9", "citation": "http://www.uniprot.org/uniprot/P04150", "url": "http://www.uniprot.org/uniprot/P04150", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "45cf4b83-b6f4-440c-9006-3a176e680e12", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "0e13f086-530b-420c-a912-4da9e89174fa", "citation": "http://www.uniprot.org/uniprot/P04150?sort=score", "url": "http://www.uniprot.org/uniprot/P04150?sort=score", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "f6574c8a-9380-40f6-ba03-90e2e672b078", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493393565000, "tags": [ "NOMEN" ] }, { "uuid": "6cf1a247-12c9-8053-c24d-4f32058ec2b1", "citation": "EUR J ENDOCRINOL, 151(3), 397-406 (2004)", "url": "http://www.eje-online.org/content/151/3/397.full.pdf+html", "doc_type": "JA", "public_domain": true, "tags": [ "POT" ] }, { "uuid": "01607bbc-2b0c-a8ce-952c-913d5aa7ba11", "citation": "208684ORIG1S000 208685ORIG1S000 PHARMACOLOGY REVIEW(S)", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208684,208685Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "NOMEN", "POT" ] }, { "uuid": "5b55f656-bba8-47aa-8e12-0476f4679000", "citation": "Stock, Thomas, et al. \"Improved disease activity with fosdagrocorat (PF‐04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study.\" International journal of rheumatic diseases (2017).", "url": "http://onlinelibrary.wiley.com/doi/10.1111/1756-185X.13053/full", "doc_type": "JA", "public_domain": true }, { "uuid": "bbebc5da-767e-4ab9-ac58-d4b071cc8c17", "citation": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/addendum-stembook2018-202210.pdf?sfvrsn=842c90_3&download=true", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/addendum-stembook2018-202210.pdf?sfvrsn=842c90_3&download=true", "doc_type": "INN_LIST", "public_domain": true }, { "uuid": "975174d7-7ff3-438b-8327-c6a4dfe825ad", "citation": "https://patents.google.com/patent/US20090111781A1/en", "url": "https://patents.google.com/patent/US20090111781A1/en", "doc_type": "PATENT", "public_domain": true }, { "uuid": "069d16e0-cb45-452a-9fca-b2b1e21d0d78", "citation": "https://adisinsight.springer.com/drugs/800027868", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "5c30fa21-0787-4740-a404-cbad77c53466", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208684,208685Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "56549fa6-eeab-4f12-a6ca-1ecd241a5446", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208684,208685Orig1s000PharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c53f5a90-c05e-426f-8eb5-07254dc0a816", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/209627Orig1s000MultidisciplineR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "de1b5cd9-920b-451d-938d-e7c589bcc2a1", "citation": "https://www.medchemexpress.com/AZD2906.html", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "d7c81088-6fda-4f20-967b-4480faf2e8b4", "citation": "British Journal of Pharmacology, 169: 1389?1403. doi: 10.1111/bph.12232", "doc_type": "JA", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "a42537cc-8e7b-48e7-adbc-c555b9e2cda7", "citation": "Crooke, Stanley T., et al. \"The effects of 2′-O-methoxyethyl oligonucleotides on renal function in humans.\" nucleic acid therapeutics 28.1 (2018): 10-22.", "url": "https://www.liebertpub.com/doi/full/10.1089/nat.2017.0693", "doc_type": "JA", "public_domain": true, "tags": [ "CLIN", "NOMEN", "PUBLIC_DOMAIN_RELEASE", "POT" ] }, { "uuid": "5d033aa4-f2f9-4aca-b8a3-8740dca6b40d", "citation": "Clark, Robin D., et al. \"1H-Pyrazolo [3, 4-g] hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.\" Bioorganic & medicinal chemistry letters 18.4 (2008): 1312-1317.", "url": "https://www.sciencedirect.com/science/article/pii/S0960894X12013650", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "21c37992-c47d-44e5-94d9-a8927b049173", "citation": "https://www.drugbank.ca/drugs/DB00394", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "209a9376-1029-4b47-9b16-77da1d556a0a", "citation": "Huang, Yangjie, et al. \"The synthesis and structural requirements for measuring glucocorticoid receptor expression in vivo with (±)-11C-YJH08 PET.\" Journal of Nuclear Medicine 62.5 (2021): 723-731.", "url": "https://jnm.snmjournals.org/content/jnumed/62/5/723.full.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e8718460-57ac-4c2f-ad38-ad17ad5a7011", "citation": "WIKI", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "de02bdab-ba85-43f4-8964-852f0f38ae78", "citation": "WIKI", "doc_type": "WIKI", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "be42f010-bdfd-4d11-a03f-c421b5e23a45", "citation": "INN PL 127", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl127.pdf", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "bff9dae3-d5bf-4906-9ecb-71dcfc6ae500", "citation": "https://medkoo.com/products/51872", "url": "https://medkoo.com/products/51872", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c53bcecd-49e6-4b97-a028-f3daf69203f6", "citation": "Dazucorilant - Corcept Therapeutics", "url": "https://adisinsight.springer.com/drugs/800057468", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "6268fd08-fff2-4aea-aa73-f1f093d48c98", "citation": "INN Proposed List 116", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL116.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "12742113-6c22-4f89-ab30-d16b750baa34", "citation": "P125", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "b658fc9d-4d4c-4d57-893e-c847ab8e2bc2", "citation": "https://www.drugbank.ca/drugs/DB01410", "doc_type": "WEBSITE", "public_domain": true }, { "uuid": "c847e539-c0c4-414a-859c-1dcfc38b88f0", "citation": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "url": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "doc_type": "ASSAY REFERENCE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "d45262b1-c79c-4fb4-b6e8-80777b32d100", "citation": "https://www.drugbank.ca/drugs/DB01410", "doc_type": "WEBSITE", "public_domain": true }, { "uuid": "5399b9a8-d4d0-4ee6-9c66-669eb437e205", "citation": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "url": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "doc_type": "ASSAY REFERENCE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "0152cd31-af0e-4faa-bf91-527b131044b3", "citation": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "url": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "doc_type": "ASSAY REFERENCE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "91079de4-4bf7-48cd-807e-aa0123ebd00f", "citation": "https://medkoo.com/products/51872", "url": "https://medkoo.com/products/51872", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "6effc4a2-3df6-4aa2-a72b-a000822c3b9a", "citation": "https://www.drugbank.ca/drugs/DB01410", "doc_type": "WEBSITE", "public_domain": true }, { "uuid": "348a5e65-99ea-4f50-8905-4673951fd7ab", "citation": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "url": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "doc_type": "ASSAY REFERENCE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "33943c79-53b8-4c96-a15d-04092cab6c7c", "citation": "https://drugs.ncats.io/drug/LT69WY1J6D", "url": "https://drugs.ncats.io/drug/LT69WY1J6D", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "f41e3512-ad36-4d48-ba8b-47114f11f43d", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208684s000,208685s000lbl.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "26a95c47-2f34-4ff3-ae5b-e1e63babfada", "citation": "INN PL 127", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl127.pdf", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "778b3456-e515-477b-9666-47357487a118", "citation": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "url": "https://www.eurofinsdiscovery.com/catalogmanagement/viewItem/469", "doc_type": "ASSAY REFERENCE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a2489b8e-5a02-4f24-97d3-f52575ef187b", "citation": "https://en.wikipedia.org/wiki/Prednisolone", "doc_type": "WIKI", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "78c1008d-c95f-4462-be19-f9612c97b55f", "version": "74", "unii": "FZW85LW99M", "relationships": [ { "uuid": "88f64bdb-40ad-4039-9a53-0c23cea2913b", "amount": { "uuid": "5327bb85-443f-4206-a76a-201c6d122cff" }, "type": "AGONIST->TARGET", "references": [ "21c37992-c47d-44e5-94d9-a8927b049173" ], "related_substance": { "uuid": "95642041-d32e-4d70-a05b-b65f4cb9d85c", "refuuid": "7dfdb616-6568-4190-9cf7-aaa04efb7a52", "name": "BECLOMETHASONE DIPROPIONATE", "unii": "5B307S63B2", "linking_id": "5B307S63B2", "ref_pname": "BECLOMETHASONE DIPROPIONATE" } }, { "uuid": "0a647be2-2204-461c-8e91-0aa309752b7f", "type": "AGONIST->TARGET", "related_substance": { "uuid": "16db5658-d222-4bfd-a74c-0dc0b6219e23", "refuuid": "b359be25-28dd-44d3-a14b-f815f119b21a", "name": "BMS-791826", "unii": "60BN6CDL0K", "linking_id": "60BN6CDL0K", "ref_pname": "BMS-791826" } }, { "uuid": "ba9c98b1-3d7a-4a4c-8e07-c7be8653fc81", "amount": { "uuid": "4f5824a7-5188-4985-8a80-99148fd68b75" }, "type": "AGONIST->TARGET", "references": [ "a2489b8e-5a02-4f24-97d3-f52575ef187b" ], "related_substance": { "uuid": "57d1bd4e-d20d-4fb4-b5dc-ac0414524880", "refuuid": "9646220b-4066-4271-9435-e166e3075d55", "name": "Prednisolone", "unii": "9PHQ9Y1OLM", "linking_id": "9PHQ9Y1OLM", "ref_pname": "Prednisolone" } }, { "uuid": "61cf0465-7dc8-40b0-a304-50791d7bda0e", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "9ab38db3-adf7-41e7-ab99-4d1080f28052", "refuuid": "9ad497f2-1464-48ef-8cbd-4705619bb7dd", "name": "EXICORILANT", "unii": "GTB859B7K8", "linking_id": "GTB859B7K8", "ref_pname": "EXICORILANT" } }, { "uuid": "badea0e4-e326-4013-a877-9b7ea9dc6ba8", "amount": { "uuid": "b16d1d9c-9bb2-4ea1-8766-bad2cea1c58d", "average": 10, "units": "NANOMOLAR" }, "qualification": "Ki", "type": "AGONIST->TARGET", "interaction_type": "BINDING", "references": [ "56549fa6-eeab-4f12-a6ca-1ecd241a5446" ], "related_substance": { "uuid": "51e9fc29-eb15-4e96-896f-4f48973600fd", "refuuid": "4bf08b6d-ba68-4bf1-90d0-29f044562a27", "name": "21-Desacetyldeflazacort", "unii": "T1LWN33J2P", "linking_id": "T1LWN33J2P", "ref_pname": "21-Desacetyldeflazacort", "substance_class": "reference" } }, { "uuid": "96a62a34-35f0-4313-b364-2bc7a009163e", "amount": { "uuid": "65561b3f-1060-47d0-8949-37008789a997" }, "type": "PARTIAL AGONIST->TARGET", "references": [ "5b55f656-bba8-47aa-8e12-0476f4679000" ], "related_substance": { "uuid": "73056b30-6c1f-4399-a9ca-663293807c51", "refuuid": "0002f7ba-e0bc-40f4-a8d0-e7319124bfd9", "name": "DAGROCORAT", "unii": "OPM23UN90U", "linking_id": "OPM23UN90U", "ref_pname": "DAGROCORAT" } }, { "uuid": "859be802-5d1d-4ed5-999f-1d08dfbe95ad", "type": "AGONIST->TARGET", "related_substance": { "uuid": "b6bbf54c-8619-4414-bfbe-5b239b53573f", "refuuid": "78b8ddbe-ab86-49b9-a13d-dd103b0ab301", "name": "Hydrocortisone", "unii": "WI4X0X7BPJ", "linking_id": "WI4X0X7BPJ", "ref_pname": "Hydrocortisone" } }, { "uuid": "a35dfc7b-d68e-4a10-95de-73fe0e87049c", "amount": { "uuid": "d4c2cdf4-034a-433a-88ce-0e00246c02ef", "average": 4.37, "units": "NANOMOLAR", "non_numeric_value": "Emax = 1.28" }, "comments": "Luciferase transactivation assay in CV-1 (African green monkey kidney) cells transfected with hGR.alpha. expression vectors", "qualification": "EC50", "type": "AGONIST->TARGET", "interaction_type": "AGONIST", "references": [ "6cf1a247-12c9-8053-c24d-4f32058ec2b1", "01607bbc-2b0c-a8ce-952c-913d5aa7ba11" ], "related_substance": { "uuid": "52e1560f-c809-4bcb-a3ac-308618351342", "refuuid": "4bf08b6d-ba68-4bf1-90d0-29f044562a27", "name": "21-Desacetyldeflazacort", "unii": "T1LWN33J2P", "linking_id": "T1LWN33J2P", "ref_pname": "21-Desacetyldeflazacort", "substance_class": "reference" } }, { "uuid": "49651626-628c-4fd0-803b-26b30620d701", "type": "AGONIST->TARGET", "related_substance": { "uuid": "0adc6652-00e8-42c9-95f9-7eb4a3b74c71", "refuuid": "7f13e550-1afc-47ea-a7d1-8ce1f9b807af", "name": "HALOBETASOL PROPIONATE", "unii": "91A0K1TY3Z", "linking_id": "91A0K1TY3Z", "ref_pname": "HALOBETASOL PROPIONATE" } }, { "uuid": "cf14d853-3e7e-4941-9605-ac7dd5bd0073", "amount": { "uuid": "3131d705-5450-4fb5-9b4e-b63a902e63e6" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "ee82a60b-2741-4a8f-a9df-f5c8dd64eb36", "refuuid": "37aa650f-7088-4fc8-8742-f94529421d87", "name": "ORIC-101", "unii": "VI6E2D3CYP", "linking_id": "VI6E2D3CYP", "ref_pname": "ORIC-101" } }, { "uuid": "3bbe7f8f-b064-48a1-815c-3e6e012bb090", "amount": { "uuid": "1fc5452d-5ccd-480a-9f29-c1d53b2717da", "average": 4.68, "units": "NANOMOLAR" }, "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "c53f5a90-c05e-426f-8eb5-07254dc0a816" ], "related_substance": { "uuid": "f25e325b-1db6-433b-95ea-b69fa770206a", "refuuid": "9cb09e99-4ec7-45ba-bc70-91f09cbcd733", "name": "SEGESTERONE ACETATE", "unii": "9AMX4Q13CC", "linking_id": "9AMX4Q13CC", "ref_pname": "SEGESTERONE ACETATE" } }, { "uuid": "6f66a7cd-536a-4efe-868a-c57a6f8b62d6", "type": "AGONIST->TARGET", "related_substance": { "uuid": "b07e3b5c-8b1e-4ce4-aa1d-1ee272126b62", "refuuid": "821de401-88af-4dc8-9370-23deba10c05b", "name": "ALCLOMETASONE", "unii": "136H45TB7B", "linking_id": "136H45TB7B", "ref_pname": "ALCLOMETASONE", "substance_class": "reference" } }, { "uuid": "d9c8d10b-3843-4058-a277-08cd65ec10e3", "amount": { "uuid": "ad99aac8-86b3-42aa-ae98-8c6d5775784e" }, "type": "INHIBITOR->TARGET", "references": [ "f41e3512-ad36-4d48-ba8b-47114f11f43d" ], "related_substance": { "uuid": "8ad65d8d-4db3-42c2-9b6c-c6642545b073", "refuuid": "61faf6d1-a077-4006-b96e-09d144e8540c", "name": "Deflazacort", "unii": "KR5YZ6AE4B", "linking_id": "KR5YZ6AE4B", "ref_pname": "Deflazacort" } }, { "uuid": "a15fe8c3-6de8-4742-b8c6-b8cbcf4471d3", "type": "AGONIST->TARGET", "related_substance": { "uuid": "5e8f0a67-1176-4ef1-a261-5edc22f5d4d8", "refuuid": "a98e7a30-61cc-4956-9379-4189ba5e6d29", "name": "FLUNISOLIDE", "unii": "QK4DYS664X", "linking_id": "QK4DYS664X", "ref_pname": "FLUNISOLIDE", "substance_class": "reference" } }, { "uuid": "59307f71-88c6-4d5f-b7f7-b75175a12ff6", "type": "AGONIST->TARGET", "related_substance": { "uuid": "9991c546-f126-4b10-a4fc-316603ce415f", "refuuid": "c67b2ccf-d599-4d54-85a0-f7a83bb108b8", "name": "FLUOCINOLONE ACETONIDE", "unii": "0CD5FD6S2M", "linking_id": "0CD5FD6S2M", "ref_pname": "FLUOCINOLONE ACETONIDE", "substance_class": "reference" } }, { "uuid": "c6778968-2935-427b-b69c-90837d92d4a3", "type": "AGONIST->TARGET", "related_substance": { "uuid": "0a569141-0bc3-4d81-a46b-1fdf29edee5a", "refuuid": "69384e74-0b6e-4a6d-a9ce-70f28fc2b3a0", "name": "FLUOROMETHOLONE", "unii": "SV0CSG527L", "linking_id": "SV0CSG527L", "ref_pname": "FLUOROMETHOLONE", "substance_class": "reference" } }, { "uuid": "60427d5b-58f4-4704-8eb3-67842ae24cb3", "type": "AGONIST->TARGET", "related_substance": { "uuid": "db26a283-2036-413b-a128-00558541ce26", "refuuid": "1dbe0277-3dd3-4de1-a222-56da4fc12977", "name": "FLURANDRENOLIDE", "unii": "8EUL29XUQT", "linking_id": "8EUL29XUQT", "ref_pname": "FLURANDRENOLIDE", "substance_class": "reference" } }, { "uuid": "e5777d3d-a7d7-4a0a-95bc-d0d264ee437c", "amount": { "uuid": "61ccda98-68f0-4807-8b84-5279f517a896" }, "type": "AGONIST->TARGET", "references": [ "b658fc9d-4d4c-4d57-893e-c847ab8e2bc2" ], "related_substance": { "uuid": "f4f708ec-b3bf-4848-b219-c0a82bdee213", "refuuid": "38d80282-c6d2-4c7e-ab7c-aa64be413326", "name": "Fluticasone Propionate", "unii": "O2GMZ0LF5W", "linking_id": "O2GMZ0LF5W", "ref_pname": "Fluticasone Propionate", "substance_class": "reference" } }, { "uuid": "a624fb4e-a2ed-4c88-8ca6-ea6cc8f7fbee", "type": "AGONIST->TARGET", "related_substance": { "uuid": "f01ed480-e7fb-4bae-a531-04df81c76d6a", "refuuid": "a3a5dbcf-fad7-4553-8849-0c6a1b7a3e95", "name": "MEDRYSONE", "unii": "D2UFC189XF", "linking_id": "D2UFC189XF", "ref_pname": "MEDRYSONE", "substance_class": "reference" } }, { "uuid": "5b66b9de-64e7-46f0-a310-d057409cbbf6", "type": "AGONIST->TARGET", "related_substance": { "uuid": "0297d746-5164-4438-9a15-75c65feb9653", "refuuid": "06dae634-2566-4002-9c1d-e7076abc94c8", "name": "PARAMETHASONE", "unii": "VFC6ZX3584", "linking_id": "VFC6ZX3584", "ref_pname": "PARAMETHASONE", "substance_class": "reference" } }, { "uuid": "98132a8d-0420-45c6-ba9c-aa79c772a73d", "type": "AGONIST->TARGET", "related_substance": { "uuid": "a2768d3f-3587-47a2-8c7e-cfa1de61a665", "refuuid": "7334a535-ca4d-4faf-9d3c-19e012d116e4", "name": "RIMEXOLONE", "unii": "O7M2E4264D", "linking_id": "O7M2E4264D", "ref_pname": "RIMEXOLONE", "substance_class": "reference" } }, { "uuid": "9cee9fa8-9c0e-4db8-a6f4-5a14a74f6eee", "amount": { "uuid": "fe160c29-d839-4eb1-8c04-6941c7dcbed5", "average": 1.8, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "AGONIST->TARGET", "interaction_type": "BINDING", "references": [ "6effc4a2-3df6-4aa2-a72b-a000822c3b9a", "348a5e65-99ea-4f50-8905-4673951fd7ab" ], "related_substance": { "uuid": "e56a6767-3801-4ffb-a59b-7cc4cde736fc", "refuuid": "a4869e0d-fd91-4cb7-8e54-401995cd3e67", "name": "TRIAMCINOLONE", "unii": "1ZK20VI6TY", "linking_id": "1ZK20VI6TY", "ref_pname": "TRIAMCINOLONE", "substance_class": "reference" } }, { "uuid": "7d6f0b8e-41bf-4840-8616-535ec5661997", "type": "AGONIST->TARGET", "references": [ "069d16e0-cb45-452a-9fca-b2b1e21d0d78" ], "related_substance": { "uuid": "bfc73e99-66e1-4bda-8298-84c12d08aa8a", "refuuid": "6a0ab9ac-58d3-4b4c-97b6-0a1abe4ce9d7", "name": "SUN-597", "unii": "P789X65VWC", "linking_id": "P789X65VWC", "ref_pname": "SUN-597" } }, { "uuid": "7aeb8eb0-139e-403d-a78c-2afe2a5ae1a7", "amount": { "uuid": "c3800fc3-7d82-4e9b-a306-7f5c75a3b72f", "average": 0.45, "high": 0.52, "low": 0.38, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "975174d7-7ff3-438b-8327-c6a4dfe825ad" ], "related_substance": { "uuid": "7bf6410b-d128-4d51-96c5-cf505c4f9030", "refuuid": "8e3361f8-e4df-42b6-8ecb-7dc6096f441f", "name": "CYMIPRISTONE", "unii": "56J566JLR6", "linking_id": "56J566JLR6", "ref_pname": "CYMIPRISTONE" } }, { "uuid": "4cdf1ac2-3a3b-4bd7-92d0-a2b3721bbd33", "amount": { "uuid": "f218baa8-5489-4a37-ae86-b85c50a69623" }, "type": "AGONIST->TARGET", "references": [ "d45262b1-c79c-4fb4-b6e8-80777b32d100" ], "related_substance": { "uuid": "13d315c2-88b6-4ce5-bcc1-5e6748811507", "refuuid": "3de1ca66-a287-499e-904b-f69971f96a3e", "name": "CICLESONIDE", "unii": "S59502J185", "linking_id": "S59502J185", "ref_pname": "CICLESONIDE", "substance_class": "reference" } }, { "uuid": "fb69b617-3031-44f2-9c05-e31d8cb64759", "amount": { "uuid": "774f0660-3b29-4a67-ad3e-2e5bbf937100", "average": 1.736, "units": "MICROMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "BINDING", "references": [ "0152cd31-af0e-4faa-bf91-527b131044b3" ], "related_substance": { "uuid": "1b4481ab-b4df-43a8-8afc-8ddd92c1cbbc", "refuuid": "dbe30db9-e2f7-42a1-897d-344c3d8f9272", "name": "ESTRADIOL", "unii": "4TI98Z838E", "linking_id": "4TI98Z838E", "ref_pname": "ESTRADIOL", "substance_class": "reference" } }, { "uuid": "df9f5b12-d415-42c0-b686-2173fa7c2069", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "5583effb-9226-4d68-bf11-da9eef89a73a", "refuuid": "cda285c0-2f83-4630-b38a-96a03beff434", "name": "ULIPRISTAL", "unii": "6J5J15Q2X8", "linking_id": "6J5J15Q2X8", "ref_pname": "ULIPRISTAL" } }, { "uuid": "09cce03b-6d8b-4cfd-9199-7a580f193dd2", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "528d2b72-30e2-4dd0-8eb4-a59cdfc8c1ee", "refuuid": "b8489f69-313b-4560-a525-3be23b3aafdc", "name": "MIRICORILANT", "unii": "311Y5GV21M", "linking_id": "311Y5GV21M", "ref_pname": "MIRICORILANT" } }, { "uuid": "805ea457-fbd5-43aa-be2d-23c31979455f", "amount": { "uuid": "a368fc2c-42b5-4428-9965-d4895bc60dcd", "average": 69, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "AGONIST->TARGET", "interaction_type": "BINDING", "references": [ "5399b9a8-d4d0-4ee6-9c66-669eb437e205" ], "related_substance": { "uuid": "5e5ea0a4-561b-43d9-999a-42c17a3c5b59", "refuuid": "7545274c-75cc-47ff-b51b-387c92d4e188", "name": "Progesterone", "unii": "4G7DS2Q64Y", "linking_id": "4G7DS2Q64Y", "ref_pname": "Progesterone", "substance_class": "reference" } }, { "uuid": "f547dc18-1f59-42a3-b479-2c7249d85429", "amount": { "uuid": "a4855504-5f01-4e22-8998-27e54a6b1b96", "low": 1, "units": "MICROMOLAR" }, "comments": "6β-OH-21-desDFZ exhibited minimal binding to the human glucocorticoid receptor (<15%) at concentration up to 1 μM.", "qualification": "Ki", "type": "INHIBITOR->TARGET", "interaction_type": "MINOR", "references": [ "5c30fa21-0787-4740-a404-cbad77c53466" ], "related_substance": { "uuid": "e79223d8-6e97-4936-9558-b46766861b2d", "refuuid": "2a89fb73-2043-4c3f-bb7f-e2782b1b0a38", "name": "6BETA-HYDROXY-21-DESACETYL DEFLAZACORT", "unii": "L93L6AWV7W", "linking_id": "L93L6AWV7W", "ref_pname": "6BETA-HYDROXY-21-DESACETYL DEFLAZACORT" } }, { "uuid": "b0a5c7e1-77db-4b2e-9f68-5c6a6f716762", "amount": { "uuid": "05cead32-ac23-42b4-b078-7812da678a92", "average": 0.9, "units": "NANOMOLAR" }, "qualification": "Ki", "type": "INHIBITOR->TARGET", "references": [ "5d033aa4-f2f9-4aca-b8a3-8740dca6b40d" ], "related_substance": { "uuid": "4ee9c1e7-7394-429b-baaf-8613ba193d6b", "refuuid": "5166004c-3b7b-48a5-bab8-213000f92cce", "name": "CORT-108297", "unii": "A17W0640NB", "linking_id": "A17W0640NB", "ref_pname": "CORT-108297" } }, { "uuid": "b0e42452-ec89-4f69-93f4-3ffbb376635d", "type": "PARTIAL AGONIST->TARGET", "references": [ "af6c2f33-99bc-4b8b-bb09-ed479c88f1ed" ], "related_substance": { "uuid": "7a006901-822a-4513-add1-8c2c79f777e1", "refuuid": "cb342207-3dfa-4887-a013-47438c08ec63", "name": "MK-5932", "unii": "8WW8T70RDC", "linking_id": "8WW8T70RDC", "ref_pname": "MK-5932" } }, { "uuid": "ba1a427b-4c6b-4ffc-bf97-a046082046bc", "type": "AGONIST->TARGET", "references": [ "d7c81088-6fda-4f20-967b-4480faf2e8b4" ], "related_substance": { "uuid": "25c96bbb-eeec-4714-81c9-88fbcccbaf56", "refuuid": "cb8157c3-1a7e-4062-ab46-791749d27c6f", "name": "GW-870086", "unii": "O891A2A3ZU", "linking_id": "O891A2A3ZU", "ref_pname": "GW-870086" } }, { "uuid": "9c95f212-71f4-4b71-8fc0-a6a746df673a", "amount": { "uuid": "8e0b5f4d-ddbc-4952-b603-2915d73bc179" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "d79e3a31-f206-46be-be8e-51b6576d1b04", "refuuid": "c53c1ffe-e41a-43ec-a54b-f2129ae134e2", "name": "MAPRACORAT", "unii": "145V79YBVP", "linking_id": "145V79YBVP", "ref_pname": "MAPRACORAT", "substance_class": "reference" } }, { "uuid": "20098ad2-f294-46af-9a30-aea8bd803040", "amount": { "uuid": "c7516e12-6926-47c0-8d71-049f2d004cbe", "average": 0.15, "units": "NANOMOLAR" }, "qualification": "Ki", "type": "INHIBITOR->TARGET", "references": [ "91079de4-4bf7-48cd-807e-aa0123ebd00f" ], "related_substance": { "uuid": "2ca6f386-8001-47eb-85f9-3d468f9b1cee", "refuuid": "fbb78813-1668-4436-a3c6-642a4106213f", "name": "Nenocorilant", "unii": "MV83V7AT2Z", "linking_id": "MV83V7AT2Z", "ref_pname": "Nenocorilant", "substance_class": "reference" } }, { "uuid": "b602ee64-1673-454e-a055-0ab8f9fe42ba", "amount": { "uuid": "b717c7c4-690c-43aa-b355-183eaac39a99" }, "type": "AGONIST->TARGET", "references": [ "bbebc5da-767e-4ab9-ac58-d4b071cc8c17" ], "related_substance": { "uuid": "56ee2241-bcbb-447e-845a-e06d63103897", "refuuid": "a4613207-28d2-4edf-8962-8e44eb95b0cc", "name": "TOMICORAT", "unii": "J05S86ZS6R", "linking_id": "J05S86ZS6R", "ref_pname": "TOMICORAT", "substance_class": "reference" } }, { "uuid": "d0aa6cd0-fa81-4d7c-b499-c0f6cb8218cd", "amount": { "uuid": "c56268d0-0a7a-447e-b99a-b16d8b89c1d9" }, "type": "INHIBITOR->TARGET", "references": [ "c53bcecd-49e6-4b97-a028-f3daf69203f6" ], "related_substance": { "uuid": "ead53ac4-e3a2-4b9d-b4f7-31914b914cc4", "refuuid": "67f56852-f58b-4979-a31e-b63821ee86cc", "name": "Dazucorilant", "unii": "HR4RD5RBJ6", "linking_id": "HR4RD5RBJ6", "ref_pname": "Dazucorilant", "substance_class": "reference" } }, { "uuid": "f8a0920c-8b98-46bc-9e44-db65b2d8615c", "amount": { "uuid": "33567987-9165-4e1a-b3be-684853c5e325" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "28cc1c16-c517-4010-9f47-eff1b4d49546", "refuuid": "f31c7acb-45b8-4c94-85df-4fe4365a62a8", "name": "CLOBETASOL", "unii": "ADN79D536H", "linking_id": "ADN79D536H", "ref_pname": "CLOBETASOL", "substance_class": "reference" } }, { "uuid": "d6fd0c8d-f4a6-4397-80d0-72337c16da83", "amount": { "uuid": "9ed80cb5-7daa-4363-a523-572524869a00" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "27255bc4-2537-4010-bd65-8dd40dd6f0c9", "refuuid": "9be9b304-c12f-4dd3-8405-dae7012aa77a", "name": "Mizacorat", "unii": "GGK40O1O85", "linking_id": "GGK40O1O85", "ref_pname": "Mizacorat", "substance_class": "reference" } }, { "uuid": "487ab0df-7f97-47b7-9052-f5560075ffcb", "amount": { "uuid": "cf93934e-5085-4651-8fbb-7810f0590767" }, "comments": "Selective Nonsteroidal Glucocorticoid Receptor Modulator", "type": "AGONIST->TARGET", "related_substance": { "uuid": "24f8092a-212a-4cc7-bc44-dfeb3de0bb61", "refuuid": "1429f586-003d-4cc4-b5fd-6a408ed7a91d", "name": "AZD-5423", "unii": "641H0Q518W", "linking_id": "641H0Q518W", "ref_pname": "AZD-5423", "substance_class": "reference" } }, { "uuid": "95ef9833-dee7-4f12-a698-e6c2197519dc", "amount": { "uuid": "4e151ebd-6587-418b-a744-565a203f1854", "units": "NANOMOLAR" }, "comments": "LPS-induced TNF-α release in peripheral blood mononuclear cells. Efficacy, maximum response relative to Dexamethasone (100%)=75%", "type": "AGONIST->TARGET", "related_substance": { "uuid": "d9cfd4d9-0cbc-4c8a-93a2-228f31972f2c", "refuuid": "822700b8-7c14-498d-9caf-86dc584f6d13", "name": "VELSECORAT", "unii": "P30N0911C2", "linking_id": "P30N0911C2", "ref_pname": "VELSECORAT", "substance_class": "reference" } }, { "uuid": "f2b4bd88-6f0c-460a-b16b-cd563b9b8779", "amount": { "uuid": "4761c0da-af2f-48dd-882c-2daae13b52f7" }, "type": "INHIBITOR->TARGET", "references": [ "6268fd08-fff2-4aea-aa73-f1f093d48c98" ], "related_substance": { "uuid": "c2c637e1-b137-4110-90bc-2db3ab0a9ebd", "refuuid": "cbc02304-8db4-4090-b39e-4d473044913a", "name": "RELACORILANT", "unii": "2158753C7E", "linking_id": "2158753C7E", "ref_pname": "RELACORILANT", "substance_class": "reference" } }, { "uuid": "fb1ec6fc-e5a3-45e1-a7e6-a60ec8a24bf0", "amount": { "uuid": "c83f5e52-6e0f-4966-ab2b-77e1763bd0ad" }, "type": "INHIBITOR->TARGET", "references": [ "12742113-6c22-4f89-ab30-d16b750baa34" ], "related_substance": { "uuid": "aa642ab6-10e8-4aae-8f8b-d35f1b8e47d4", "refuuid": "53fc67f9-4bfb-4020-80c9-fd5902107d7b", "name": "ZAVACORILANT", "unii": "74XPH8W9F6", "linking_id": "74XPH8W9F6", "ref_pname": "ZAVACORILANT", "substance_class": "reference" } }, { "uuid": "5fab221d-9ca5-4b09-aed7-4942b4cafa99", "amount": { "uuid": "bdc95680-f10e-4107-91db-20c3b295c834" }, "type": "AGONIST->TARGET", "references": [ "de1b5cd9-920b-451d-938d-e7c589bcc2a1" ], "related_substance": { "uuid": "93325754-767d-4b8b-b787-f61feb6820ae", "refuuid": "a90faf30-618c-461b-b287-7e0c1d75e846", "name": "AZD-2906", "unii": "SN8JN2RU5L", "linking_id": "SN8JN2RU5L", "ref_pname": "AZD-2906", "substance_class": "reference" } }, { "uuid": "80ee5fed-fca4-4ca1-907a-a7f2d8df362b", "amount": { "uuid": "bcaf6f02-2060-4a4a-b588-83485ce72c8b" }, "type": "MODULATOR->TARGET", "references": [ "26a95c47-2f34-4ff3-ae5b-e1e63babfada" ], "related_substance": { "uuid": "22b2080c-cb4d-4633-a664-dc2bf1a033d9", "refuuid": "41e73e14-eee3-eeaa-9f1a-d1fc94f7d6e2", "name": "Adalimumab Fosimdesonide", "unii": "FWC6IWT3EH", "linking_id": "FWC6IWT3EH", "ref_pname": "Adalimumab Fosimdesonide", "substance_class": "reference" } }, { "uuid": "ae3e3904-b2b5-4193-8afb-590cc4c2d9f3", "amount": { "uuid": "6223165d-c818-4ed5-9261-3c2f1dd4a889", "average": 0.19, "units": "NANOMOLAR" }, "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "33943c79-53b8-4c96-a15d-04092cab6c7c" ], "related_substance": { "uuid": "a3c3d166-b6ec-4f52-a4d5-8ac6ebe8e828", "refuuid": "6536c38d-f232-4181-a4bf-b70ba251a5af", "name": "CLOBETASONE", "unii": "LT69WY1J6D", "linking_id": "LT69WY1J6D", "ref_pname": "CLOBETASONE", "substance_class": "reference" } }, { "uuid": "c61a0391-c5a6-4906-88f4-6726bf4909a3", "amount": { "uuid": "f51a8828-65c2-4f73-92f7-526188d7e244", "average": 1.5, "units": "NANOMOLAR" }, "qualification": "Kd", "type": "RADIOLIGAND->TARGET", "references": [ "778b3456-e515-477b-9666-47357487a118" ], "related_substance": { "uuid": "65ea0e2f-2f3b-4066-b2e6-aabb68da60d3", "refuuid": "6fd91f4a-8267-4528-9e90-8306a9540d2c", "name": "Dexamethasone H-3", "unii": "5LQB9UHQ45", "linking_id": "5LQB9UHQ45", "ref_pname": "Dexamethasone H-3", "substance_class": "reference" } }, { "uuid": "6e55edf2-2678-4751-abac-2442bebf165d", "amount": { "uuid": "e44b782c-002c-4ada-890f-10bd9bbc6d2c" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "f1b12d7d-ee05-44a6-9eb6-584156a505cf", "refuuid": "6fa7dacc-c7ba-431c-af21-990f0b0aa439", "name": "TORIPRISTONE", "unii": "711D76P884", "linking_id": "711D76P884", "ref_pname": "TORIPRISTONE", "substance_class": "reference" } }, { "uuid": "a52f87d3-7a16-4c1b-a4d3-7bb1298cf03e", "amount": { "uuid": "dfa36bd3-862a-4e67-848f-b1ffa54279b6", "average": 3, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "BINDING", "references": [ "c847e539-c0c4-414a-859c-1dcfc38b88f0" ], "related_substance": { "uuid": "c7419221-ddf4-42e7-949d-6c0c51e311af", "refuuid": "681b3b7c-2a18-442f-a215-5105a536d929", "name": "DEXAMETHASONE", "unii": "7S5I7G3JQL", "linking_id": "7S5I7G3JQL", "ref_pname": "DEXAMETHASONE", "substance_class": "reference" } }, { "uuid": "3295aa8a-eacf-436f-95a8-bbedf1e87b20", "amount": { "uuid": "f879f276-92ad-4b76-adac-493e19635e66" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "edfb14dd-e549-43a5-85d9-83175a4372c1", "refuuid": "1cbbd8c6-7c34-4bb5-b1c4-965666a37e80", "name": "DEXBUDESONIDE", "unii": "2HI1006KPH", "linking_id": "2HI1006KPH", "ref_pname": "DEXBUDESONIDE", "substance_class": "reference" } }, { "uuid": "7ac90db4-623a-47f1-ac2a-b0ca2e4d7b58", "amount": { "uuid": "f1ebca25-fe32-4497-b186-50c901444bba" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "84c2761f-c81d-4317-a38a-708ecfcb4e24", "refuuid": "7b4c8fe3-8c3b-457c-8fec-1bc3866817fa", "name": "LOTEPREDNOL ETABONATE", "unii": "YEH1EZ96K6", "linking_id": "YEH1EZ96K6", "ref_pname": "LOTEPREDNOL ETABONATE", "substance_class": "reference" } }, { "uuid": "de46bcfc-c771-4880-a893-9b0fb79958d2", "amount": { "uuid": "3476925f-6e79-4477-b231-57ad32dc0632" }, "comments": "25-30 times more potent than cortisol", "type": "AGONIST->TARGET", "related_substance": { "uuid": "d32869f6-c707-4c3c-9547-1955e8a33016", "refuuid": "4b050162-bdeb-44a1-9e95-9fdd674df7a3", "name": "BETAMETHASONE", "unii": "9842X06Q6M", "linking_id": "9842X06Q6M", "ref_pname": "BETAMETHASONE", "substance_class": "reference" } } ], "names": [ { "uuid": "186cdcb1-37b2-4af2-abdc-21847739f2cf", "name": "GLUCOCORTICOID RECEPTOR", "stdName": "GLUCOCORTICOID RECEPTOR", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "45cf4b83-b6f4-440c-9006-3a176e680e12", "6a510a7c-1854-40df-8ea5-6c3339f24cd9" ], "display_name": true }, { "uuid": "f68feea4-a50b-460c-ad31-5514175fe8fd", "name": "GR", "stdName": "GR", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0e13f086-530b-420c-a912-4da9e89174fa", "45cf4b83-b6f4-440c-9006-3a176e680e12" ], "display_name": false }, { "uuid": "f5ea69ba-cd5e-4f52-98dc-5dd1aa69ee34", "name": "GRL", "stdName": "GRL", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0e13f086-530b-420c-a912-4da9e89174fa", "45cf4b83-b6f4-440c-9006-3a176e680e12" ], "display_name": false }, { "uuid": "b3bcda3a-83c3-47b5-a5b0-f06c64ea8d89", "name": "NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1", "stdName": "NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0e13f086-530b-420c-a912-4da9e89174fa", "45cf4b83-b6f4-440c-9006-3a176e680e12" ], "display_name": false } ], "protein": { "uuid": "80c46824-2387-4324-8be7-ba16a60f56c7", "glycosylation": { "uuid": "3bba5de5-33fe-4242-8344-52b1ae08b9fe" }, "subunits": [ { "uuid": "64e891f8-030a-4cf8-8d99-0c90e5e9dbfb", "sequence": "MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK", "subunit_index": 1 } ], "references": [ "6a510a7c-1854-40df-8ea5-6c3339f24cd9" ], "other_links": [ { "uuid": "00f52f0f-9b90-4cf9-93fa-132e5c14fd88", "sites": [ { "residue_index": 421, "subunit_index": 1 }, { "residue_index": 424, "subunit_index": 1 }, { "residue_index": 438, "subunit_index": 1 }, { "residue_index": 441, "subunit_index": 1 } ], "linkage_type": "COORDINATION COMPOUND" }, { "uuid": "dbb3af94-9bef-4ed5-8b9f-aa13e95ad69c", "sites": [ { "residue_index": 457, "subunit_index": 1 }, { "residue_index": 463, "subunit_index": 1 }, { "residue_index": 473, "subunit_index": 1 }, { "residue_index": 476, "subunit_index": 1 } ], "linkage_type": "COORDINATION COMPOUND" } ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "736c3714-a9e5-463f-99b1-6d2dd3ab2991", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "f788506d-77fb-43a2-a02f-4c36860ef5f9", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "b801eece-c29c-4daa-9450-9b8bf1ae75e0", "structural_modifications": [ { "uuid": "70ab2f0f-0590-44ca-a129-2a991ccaa71c", "extent": "COMPLETE", "sites": [ { "residue_index": 113, "subunit_index": 1 }, { "residue_index": 134, "subunit_index": 1 }, { "residue_index": 141, "subunit_index": 1 }, { "residue_index": 203, "subunit_index": 1 }, { "residue_index": 211, "subunit_index": 1 }, { "residue_index": 226, "subunit_index": 1 }, { "residue_index": 267, "subunit_index": 1 }, { "residue_index": 404, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "47c6e67a-d395-47f4-8ace-85835bce69a2", "refuuid": "b6eb2edb-1b4d-46ad-92ad-a43f0f545926", "name": "DEXFOSFOSERINE", "unii": "VI4F0K069V", "linking_id": "VI4F0K069V", "ref_pname": "DEXFOSFOSERINE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" }, { "uuid": "69e9ab59-3a40-4b8e-a530-fb0909aeb16a", "extent": "COMPLETE", "sites": [ { "residue_index": 480, "subunit_index": 1 }, { "residue_index": 492, "subunit_index": 1 }, { "residue_index": 494, "subunit_index": 1 }, { "residue_index": 495, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "f373bf47-d39b-4252-a2e8-b0fa3656ead1", "refuuid": "a19dd859-34dc-4b9e-9a9a-423796569bac", "name": "N6-ACETYLLYSINE", "unii": "470AD5VY1X", "linking_id": "470AD5VY1X", "ref_pname": "N6-ACETYLLYSINE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" }, { "uuid": "dad64379-dc64-407a-a356-bde4de151013", "sites": [ { "residue_index": 421, "subunit_index": 1 }, { "residue_index": 424, "subunit_index": 1 }, { "residue_index": 438, "subunit_index": 1 }, { "residue_index": 441, "subunit_index": 1 } ], "location_type": "SITE_SPECIFIC", "molecular_fragment": { "uuid": "cace7e62-562f-4b41-8dfe-7308ce49ac70", "refuuid": "82bdb684-c993-4600-aae0-0ff45a663b9f", "name": "C4-TYPE ZINC FINGER", "unii": "C56TF4V7OP", "linking_id": "C56TF4V7OP", "ref_pname": "C4-TYPE ZINC FINGER", "substance_class": "reference" }, "structural_modification_type": "AMINO_ACID_SUBSTITUTION" }, { "uuid": "9346aa16-754d-45d8-a053-db5e227ec6b0", "sites": [ { "residue_index": 457, "subunit_index": 1 }, { "residue_index": 463, "subunit_index": 1 }, { "residue_index": 473, "subunit_index": 1 }, { "residue_index": 476, "subunit_index": 1 } ], "location_type": "SITE_SPECIFIC", "molecular_fragment": { "uuid": "5133af2d-aaa8-4238-8d6d-21fcb567c489", "refuuid": "82bdb684-c993-4600-aae0-0ff45a663b9f", "name": "C4-TYPE ZINC FINGER", "unii": "C56TF4V7OP", "linking_id": "C56TF4V7OP", "ref_pname": "C4-TYPE ZINC FINGER", "substance_class": "reference" }, "structural_modification_type": "AMINO_ACID_SUBSTITUTION" } ] } } ] }