{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "f84e8028-95b9-4d28-aa59-b62163c2524a",
          "code": "2732859-77-5",
          "type": "PRIMARY",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=2732859-77-5",
          "code_system": "CAS"
        },
        {
          "uuid": "0225014e-3401-48ec-8a8b-c051f06ee131",
          "code": "F5A38P48PV",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "148a2895-d3de-e010-36ca-5f365567fbaa",
          "code": "300000051401",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "6f99fb49-f1f9-0070-6991-4b84659bdecb"
          ]
        },
        {
          "uuid": "5a98ade0-bdef-3c20-490f-4ef3b6bebc1e",
          "code": "162346700",
          "type": "PRIMARY",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/162346700",
          "code_system": "PUBCHEM",
          "references": [
            "077d64c7-1af0-ce24-9822-80e833a03ae3"
          ]
        }
      ],
      "substance_class": "chemical",
      "references": [
        {
          "uuid": "e003da77-b05f-4061-8c37-783867853221",
          "citation": "stn",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "d50b7c19-d1e3-4295-a173-812ea9ffc4ad",
          "citation": "Lindberg, Mattias F., et al. \"Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate.\" Journal of Medicinal Chemistry (2023).",
          "url": "https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01888",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "077d64c7-1af0-ce24-9822-80e833a03ae3",
          "citation": "PUBCHEM",
          "doc_type": "PUBCHEM",
          "public_domain": true
        },
        {
          "uuid": "6f99fb49-f1f9-0070-6991-4b84659bdecb",
          "citation": "SMS",
          "doc_type": "EMA LIST",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "moieties": [
        {
          "uuid": "9c318cfa-b864-47fb-9751-bf9420d8f1d3",
          "id": "9c318cfa-b864-47fb-9751-bf9420d8f1d3",
          "molfile": "\n  CDK     01242418402D\n\n 25 27  0  0  1  0  0  0  0  0999 V2000\n   22.5624   -6.5414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   28.9189   -7.5801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.4575  -10.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.5453   -7.4691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.9140   -6.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.8093   -7.7851    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   30.3145   -8.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   32.7089   -9.1344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   21.0130   -6.3757    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n   20.3244   -4.9338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.1445  -12.0315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   29.1212  -10.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.4152   -9.8233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   26.3062  -10.6161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   24.8909   -9.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.2281   -7.9790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.6271   -8.7281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.2009   -3.3605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.8321   -4.7853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4306   -9.3172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   24.7498   -8.3236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   31.8093  -10.3382    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n   27.7238   -9.9961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   27.6249   -8.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   20.0948   -7.6347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n  1 16  1  0  0  0  0\n  2 24  2  0  0  0  0\n 12 13  1  0  0  0  0\n 14 15  2  0  0  0  0\n 13 22  1  0  0  0  0\n  3 20  1  0  0  0  0\n  9 25  1  0  0  0  0\n 18 19  1  0  0  0  0\n  4 25  1  0  0  0  0\n 12 23  2  0  0  0  0\n  3 15  1  0  0  0  0\n  2  7  1  0  0  0  0\n 10 19  1  0  0  0  0\n  4  5  1  0  0  0  0\n  9  1  1  6  0  0  0\n 14 23  1  0  0  0  0\n  6  7  1  0  0  0  0\n  6  8  2  0  0  0  0\n  4 17  1  0  0  0  0\n  8 22  1  0  0  0  0\n  7 13  2  0  0  0  0\n 15 21  1  0  0  0  0\n  3 11  2  0  0  0  0\n 16 21  2  0  0  0  0\n 16 20  1  0  0  0  0\n 23 24  1  0  0  0  0\n  9 10  1  0  0  0  0\nM  END",
          "smiles": "CC(C)C[C@H](COC)NC1=N/C(=C\\c2ccc3c(c2)scn3)/C(=O)N1",
          "formula": "C18H22N4O2S",
          "atropisomerism": "No",
          "charge": 0,
          "count": 1,
          "stereochemistry": "ABSOLUTE",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "5ea72e25-b29b-4318-9b90-01bbfaa7b85c"
          },
          "defined_stereo": 1,
          "ez_centers": 1,
          "molecular_weight": "358.4597",
          "optical_activity": "UNSPECIFIED",
          "stereo_centers": 1
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "e303b5b7-7290-43b8-a215-551cb0e0fc12",
      "version": "8",
      "structure": {
        "id": "0193035d-b936-4212-b202-2b5a98332c9c",
        "molfile": "\n   JSDraw201242418402D\n\n 25 27  0  0  1  0              0 V2000\n   22.5624   -6.5414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   28.9189   -7.5801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.4575  -10.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.5453   -7.4691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.9140   -6.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   31.8093   -7.7851    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   30.3145   -8.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   32.7089   -9.1344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   21.0130   -6.3757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   20.3244   -4.9338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.1445  -12.0315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   29.1212  -10.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   30.4152   -9.8233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   26.3062  -10.6161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   24.8909   -9.8752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   23.2281   -7.9790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   17.6271   -8.7281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.2009   -3.3605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   18.8321   -4.7853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   22.4306   -9.3172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   24.7498   -8.3236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   31.8093  -10.3382    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n   27.7238   -9.9961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   27.6249   -8.4433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   20.0948   -7.6347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n  1 16  1  0  0  0  0\n  2 24  2  0  0  0  0\n 12 13  1  0  0  0  0\n 14 15  2  0  0  0  0\n 13 22  1  0  0  0  0\n  3 20  1  0  0  0  0\n  9 25  1  0  0  0  0\n 18 19  1  0  0  0  0\n  4 25  1  0  0  0  0\n 12 23  2  0  0  0  0\n  3 15  1  0  0  0  0\n  2  7  1  0  0  0  0\n 10 19  1  0  0  0  0\n  4  5  1  0  0  0  0\n  9  1  1  6  0  0  0\n 14 23  1  0  0  0  0\n  6  7  1  0  0  0  0\n  6  8  2  0  0  0  0\n  4 17  1  0  0  0  0\n  8 22  1  0  0  0  0\n  7 13  2  0  0  0  0\n 15 21  1  0  0  0  0\n  3 11  2  0  0  0  0\n 16 21  2  0  0  0  0\n 16 20  1  0  0  0  0\n 23 24  1  0  0  0  0\n  9 10  1  0  0  0  0\nM  END",
        "smiles": "CC(C)C[C@H](COC)NC1=N/C(=C\\c2ccc3c(c2)scn3)/C(=O)N1",
        "formula": "C18H22N4O2S",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ABSOLUTE",
        "defined_stereo": 1,
        "ez_centers": 1,
        "molecular_weight": "358.4597",
        "optical_activity": "UNSPECIFIED",
        "references": [
          "d50b7c19-d1e3-4295-a173-812ea9ffc4ad"
        ],
        "stereo_centers": 1
      },
      "unii": "F5A38P48PV",
      "relationships": [
        {
          "uuid": "5393d398-da9a-4014-a69e-c75eb0e0c742",
          "amount": {
            "uuid": "37188dc2-2e56-49b7-811d-6691d3658a57"
          },
          "comments": "Down Syndrome and Alzheimer’s Disease Drug Candidate",
          "type": "ACTIVE MOIETY",
          "references": [
            "d50b7c19-d1e3-4295-a173-812ea9ffc4ad"
          ],
          "related_substance": {
            "uuid": "049baa03-4435-4dab-b9b8-6131d61ee401",
            "refuuid": "e303b5b7-7290-43b8-a215-551cb0e0fc12",
            "name": "5-(6-benzothiazolylmethylene)-3,5-dihydro-2-[[(1S)-1-(methoxymethyl)-3-methylbutyl]amino]-4H-Imidazol-4-one, (5Z)-",
            "unii": "F5A38P48PV",
            "linking_id": "F5A38P48PV",
            "ref_pname": "5-(6-benzothiazolylmethylene)-3,5-dihydro-2-[[(1S)-1-(methoxymethyl)-3-methylbutyl]amino]-4H-Imidazol-4-one, (5Z)-",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "c2afc587-94a9-4823-ab0d-119ae98ee70c",
          "amount": {
            "uuid": "7164421a-5b9b-47fd-bc7e-53dfc8f2c842",
            "average": 0.005,
            "units": "MICROMOLAR"
          },
          "qualification": "IC50",
          "type": "OFF-TARGET->INHIBITOR",
          "related_substance": {
            "uuid": "3d72c9e0-9d02-496f-a9d3-fcfa789f1dd8",
            "refuuid": "4ac2869e-29e4-4fd5-804e-112f1c751bc6",
            "name": "DUAL SPECIFICITY PROTEIN KINASE CLK4",
            "unii": "Z5XK14G4FP",
            "linking_id": "Z5XK14G4FP",
            "ref_pname": "DUAL SPECIFICITY PROTEIN KINASE CLK4",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "2b4b4e99-4d49-4c4b-a850-e6dd31a85433",
          "amount": {
            "uuid": "7344b42b-6bd6-41c1-abea-8a238e92ed1d",
            "average": 2.4,
            "units": "NANOMOLAR"
          },
          "qualification": "IC50",
          "type": "TARGET->INHIBITOR",
          "references": [
            "d50b7c19-d1e3-4295-a173-812ea9ffc4ad"
          ],
          "related_substance": {
            "uuid": "e5963056-9675-4daf-9217-c4eb9537250d",
            "refuuid": "b3055f97-81f8-4b48-9777-f5622aa1054f",
            "name": "DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A",
            "unii": "93EHW9XVKO",
            "linking_id": "93EHW9XVKO",
            "ref_pname": "DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "3ef43262-9c43-45b0-85d3-0075f735465b",
          "amount": {
            "uuid": "b82e7762-133c-426e-98a8-3e193abab51e",
            "average": 0.0118,
            "units": "MICROMOLAR"
          },
          "qualification": "IC50",
          "type": "OFF-TARGET->INHIBITOR",
          "references": [
            "d50b7c19-d1e3-4295-a173-812ea9ffc4ad"
          ],
          "related_substance": {
            "uuid": "abf998ad-63a7-42a9-a9ff-8620f580e7f7",
            "refuuid": "e4a2eaf5-d4fe-43ca-8c67-7b66cfeae0e2",
            "name": "DUAL SPECIFICITY PROTEIN KINASE CLK1",
            "unii": "3LQK5YLN2B",
            "linking_id": "3LQK5YLN2B",
            "ref_pname": "DUAL SPECIFICITY PROTEIN KINASE CLK1",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "403125aa-0ae9-400b-97dc-c820ebb99290",
          "name": "4H-Imidazol-4-one, 5-(6-benzothiazolylmethylene)-3,5-dihydro-2-[[(1S)-1-(methoxymethyl)-3-methylbutyl]amino]-, (5Z)-",
          "stdName": "4H-IMIDAZOL-4-ONE, 5-(6-BENZOTHIAZOLYLMETHYLENE)-3,5-DIHYDRO-2-(((1S)-1-(METHOXYMETHYL)-3-METHYLBUTYL)AMINO)-, (5Z)-",
          "type": "sys",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "e003da77-b05f-4061-8c37-783867853221"
          ],
          "display_name": false
        },
        {
          "uuid": "1a8bb191-101c-4c7f-a3fd-a2690f4392bb",
          "name": "5-(6-benzothiazolylmethylene)-3,5-dihydro-2-[[(1S)-1-(methoxymethyl)-3-methylbutyl]amino]-4H-Imidazol-4-one, (5Z)-",
          "stdName": "5-(6-BENZOTHIAZOLYLMETHYLENE)-3,5-DIHYDRO-2-(((1S)-1-(METHOXYMETHYL)-3-METHYLBUTYL)AMINO)-4H-IMIDAZOL-4-ONE, (5Z)-",
          "type": "sys",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "e003da77-b05f-4061-8c37-783867853221"
          ],
          "display_name": true
        },
        {
          "uuid": "12a9cbc4-4f4d-4379-b8c7-fdb0f2e7be34",
          "name": "Leucettinib-21",
          "stdName": "LEUCETTINIB-21",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "d50b7c19-d1e3-4295-a173-812ea9ffc4ad"
          ],
          "display_name": false
        }
      ],
      "modifications": {
        "uuid": "72eaff53-06bd-4b9a-845a-b61618122df6"
      }
    }
  ]
}