{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "5ea3a14f-7940-4992-ae24-4d507bce994b",
          "code": "7631-86-9",
          "type": "PRIMARY",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=7631-86-9",
          "code_system": "CAS",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8",
            "5057f052-e6e9-40b6-be98-c0319ba859df"
          ]
        },
        {
          "uuid": "de46da56-7b19-47fd-9085-8211a79b82ff",
          "code": "C29853",
          "type": "PRIMARY",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29853",
          "code_system": "NCI_THESAURUS",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "9b2b15e1-a7cf-4eb1-b3a2-f745e869f2ab",
          "code": "21 CFR 172.230",
          "comments": "PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION|Subpart C--Coatings, Films and Related Substances|Sec. 172.230 Microcapsules for flavoring substances",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=172.230",
          "code_system": "CFR",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "c2c3e63d-4706-4e89-ba7a-e498f0b4eece",
          "code": "21 CFR 172.480",
          "comments": "PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION|Subpart E--Anticaking Agents|Sec. 172.480 Silicon dioxide.",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=172.480",
          "code_system": "CFR",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "e164997a-18b3-4adb-a46e-32ffae90fc95",
          "code": "FCN NO. 155",
          "comments": "FCN|COATING|PET PACKAGING",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=fcslisting&id=155",
          "code_system": "Food Contact Sustance Notif, (FCN No.)",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "37550084-60f8-435e-888c-fe401af0aaf0",
          "code": "D012824",
          "type": "PRIMARY",
          "url": "http://www.ncbi.nlm.nih.gov/mesh/68012824",
          "code_system": "MESH",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "349e9b77-afe2-4bca-9b0b-6ba3448ac561",
          "code": "D012822",
          "type": "PRIMARY",
          "url": "http://www.ncbi.nlm.nih.gov/mesh/68012822",
          "code_system": "MESH",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "41edf778-1819-4953-99a1-c965ddac0fab",
          "code": "63231-67-4",
          "type": "ALTERNATIVE",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=63231-67-4",
          "code_system": "CAS",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8",
            "3b0fa1b5-2854-4b3f-bc90-7bfbee07c1e1"
          ]
        },
        {
          "uuid": "a9f96c79-13d7-4fe0-9d2d-8ca2a60da5b4",
          "code": "FCN NO. 401",
          "comments": "FCN|BARRIER COATING|PET PACKAGING",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=fcslisting&id=401",
          "code_system": "Food Contact Sustance Notif, (FCN No.)",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "b28075f0-a828-4802-8ad2-4423ef6025e0",
          "code": "FCN NO. 329",
          "comments": "FCN|BARRIER COATING|PET PACKAGING",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=fcslisting&id=329",
          "code_system": "Food Contact Sustance Notif, (FCN No.)",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "2aacda00-7ad4-478b-9427-fae0aba8df56",
          "code": "SILICON DIOXIDE",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/Silicon_dioxide",
          "code_system": "WIKIPEDIA",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "3e576abb-fa3d-4576-ad6d-4d9bad9b85f0",
          "code": "21 CFR 176.170",
          "comments": "PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS|Subpart B--Substances for Use Only as Components of Paper and Paperboard|Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=176.170",
          "code_system": "CFR",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "9186cc41-ba87-46c7-9639-45d904290b4e",
          "code": "14808-60-7",
          "type": "ALTERNATIVE",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=14808-60-7",
          "code_system": "CAS",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8",
            "0e8923a0-7f9c-463a-8969-60bf7941af61"
          ]
        },
        {
          "uuid": "3941e7fa-6960-40f6-8a98-6dd163b39580",
          "code": "21 CFR 178.3297",
          "comments": "PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS|Subpart D--Certain Adjuvants and Production Aids|Sec. 178.3297 Colorants for polymers.",
          "type": "PRIMARY",
          "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=178.3297",
          "code_system": "CFR",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "92a92328-7889-441a-bade-13d66f9d29a0",
          "code": "72602",
          "comments": "EPA PESTICIDE|CONVENTIONAL CHEMICAL",
          "type": "PRIMARY",
          "url": "http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:3:0::NO:21,3,31,7,12,25:P3_XCHEMICAL_ID:3764",
          "code_system": "EPA PESTICIDE CODE",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "8ad23e87-899d-4144-a156-fcaf8b79d750",
          "code": "72605",
          "comments": "EPA PESTICIDE|CONVENTIONAL CHEMICAL",
          "type": "PRIMARY",
          "url": "http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:3:0::NO:21,3,31,7,12,25:P3_XCHEMICAL_ID:3768",
          "code_system": "EPA PESTICIDE CODE",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "5680c224-a8a2-4faa-b71c-63b30698f3fe",
          "code": "INS-551",
          "comments": "Codex Alimentarius|Functional Classification|Anticaking agent|Antifoaming agent|Carrier",
          "type": "PRIMARY",
          "url": "http://www.fao.org/gsfaonline/additives/details.html?id=284",
          "code_system": "CODEX ALIMENTARIUS (GSFA)",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "932a2b4c-b24e-4cb7-b3bd-21f846c194d4",
          "code": "INS-551",
          "comments": "JECFA|Functional Classification|ANTICAKING AGENT",
          "type": "PRIMARY",
          "url": "http://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemINS=551",
          "code_system": "JECFA EVALUATION",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "6837ed6b-44d8-4d0d-956d-c4d835f1ff92",
          "code": "231-545-4",
          "type": "PRIMARY",
          "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.028.678",
          "code_system": "ECHA (EC/EINECS)",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "25ac27fa-53dd-4ba2-8aa4-9a4d3f8bfbe3",
          "code": "1311243",
          "type": "ALTERNATIVE",
          "url": "https://rxnav.nlm.nih.gov/REST/rxcui/1311243/allProperties.xml?prop=all",
          "code_system": "RXCUI",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "eb5b98be-cc32-4ab1-9927-f046b4a584ef",
          "code": "9771",
          "type": "PRIMARY",
          "url": "https://rxnav.nlm.nih.gov/REST/rxcui/9771/allProperties.xml?prop=all",
          "code_system": "RXCUI",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "99f03e50-3eeb-4d0f-88ea-7c0ebdfb2e6a",
          "code": "m9902",
          "comments": "Merck Index",
          "type": "PRIMARY",
          "url": "https://merckindex.rsc.org/monographs/m9902?q=authorize",
          "code_system": "MERCK INDEX",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "e696dad0-0101-4cd6-b7c0-91a578e896ed",
          "code": "SUB171092",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "a5641f10-ba6c-43e5-8b53-4f1ff78f1e03",
          "code": "SUB171236",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "c1cee14f-858b-4e07-9f96-32ae39f8dfdd",
          "code": "SUB20041",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "0b206eeb-8730-4092-96da-68b1ea372bb9",
          "code": "SUB15238MIG",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "803d883d-fbd8-40c7-9b7b-9e7e89c0d94c",
          "code": "SUB15239MIG",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "ef459a24-2129-4e06-804a-003d89857037",
          "code": "CHEMBL2108563",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2108563",
          "code_system": "ChEMBL",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "3d930e44-c105-4520-b6db-0caa8e0274d4",
          "code": "SUB47557",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8"
          ]
        },
        {
          "uuid": "132a35ad-e80f-9598-f4c6-5fcf08a3779e",
          "code": "24261",
          "type": "PRIMARY",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/24261",
          "code_system": "PUBCHEM",
          "references": [
            "ed26cb84-d333-e257-8688-79f68232f707"
          ]
        },
        {
          "uuid": "8351a31e-add4-8933-c1ff-66f8f9ad0df0",
          "code": "DTXSID1029677",
          "type": "PRIMARY",
          "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677",
          "code_system": "EPA CompTox",
          "references": [
            "261adbf3-3ce4-58a0-dca4-6c8d0af9cf73"
          ]
        },
        {
          "uuid": "9965a539-9a7d-62c7-69c0-fcd96ef3dfe4",
          "code": "209 (Number of products:67)",
          "comments": "Dietary Supplement Label Database|Mineral|silica",
          "type": "PRIMARY",
          "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=209&item=silica",
          "code_system": "DSLD",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "daafdff6-47f9-402d-e014-c44ec21efe46",
          "code": "4284",
          "type": "PRIMARY",
          "url": "https://drugcentral.org/drugcard/4284",
          "code_system": "DRUG CENTRAL",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "6f9cb67e-3937-1aaa-92ae-789945e69204",
          "code": "DB14138",
          "type": "PRIMARY",
          "url": "https://go.drugbank.com/drugs/DB14138",
          "code_system": "DRUG BANK",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "b7048750-b9bd-4646-8093-c5072f817489",
          "code": "ETJ7Z6XBU4",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "3ce9f139-5912-8bf9-092c-55b9304d33a9",
          "code": "2042 (Number of products:1)",
          "comments": "Dietary Supplement Label Database|Chemical|Silicic Acid",
          "type": "PRIMARY",
          "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=2042&item=Silicic Acid",
          "code_system": "DSLD",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "c02f3e00-a6e8-a33a-1563-006dfbb0e5aa",
          "code": "30563",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:30563",
          "code_system": "CHEBI",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "5105f4f6-d1bb-8466-9e32-a184f93e7405",
          "code": "29241",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:29241",
          "code_system": "CHEBI",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "0abe3f42-85b3-b3c3-33c4-a4f7b95dc4c0",
          "code": "26675",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:26675",
          "code_system": "CHEBI",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        },
        {
          "uuid": "07288838-4de9-12e2-2c4c-8b9f58271954",
          "code": "ETJ7Z6XBU4",
          "type": "PRIMARY",
          "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=ETJ7Z6XBU4",
          "code_system": "DAILYMED",
          "references": [
            "e893f9b4-75d1-f6c2-c5e0-a5545b12626e"
          ]
        },
        {
          "uuid": "1c8d6332-7ccd-aa7c-4f2c-d587736b342e",
          "code": "100000091508",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "34705114-9af8-2d50-2c0f-bc1096c80694"
          ]
        },
        {
          "uuid": "e5786d76-acb8-c218-f9a3-e6659f2391b8",
          "code": "silica gel",
          "type": "PRIMARY",
          "url": "https://pesticidecompendium.bcpc.org/silica gel.html",
          "code_system": "ALANWOOD",
          "references": [
            "912d0318-ebd0-46b4-7387-b85a6627e337"
          ]
        },
        {
          "uuid": "f6de726f-b6ce-9dbc-4b1c-228573c38322",
          "code": "298",
          "type": "PRIMARY",
          "url": "https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=298",
          "code_system": "GRAS Notification (GRN No.)",
          "references": [
            "e88287c7-4cd7-2159-6f6a-972beea18581"
          ]
        }
      ],
      "relationships": [
        {
          "uuid": "0d3166d2-5509-4905-8096-25021a208617",
          "amount": {
            "uuid": "5ae6c94f-55dc-40b3-9ce9-d8cb39a0a351"
          },
          "type": "ACTIVE MOIETY",
          "related_substance": {
            "uuid": "7271c4f7-deaa-4c56-ab3f-63d70a34c555",
            "refuuid": "a2cc7bb4-0675-466d-841d-3f6d48d629bf",
            "name": "SILICON DIOXIDE",
            "unii": "ETJ7Z6XBU4",
            "linking_id": "ETJ7Z6XBU4",
            "ref_pname": "SILICON DIOXIDE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "96337b4f-d2aa-48e8-82e1-6beb8cb127a5",
          "amount": {
            "uuid": "bdd5cdaf-4378-4c94-a968-b2b1404389e8"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "4a4d9e6d-8189-491a-8775-8dd4bd670a40",
            "refuuid": "b16a2b75-43f8-4ebf-a483-fadc3cc02197",
            "name": "AGATE",
            "linking_id": "b16a2b75-43f8-4ebf-a483-fadc3cc02197",
            "ref_pname": "AGATE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "04c5f180-0957-4c9c-9ec8-eeba5bd96550",
          "amount": {
            "uuid": "9cf9593a-dfe1-45e0-b9b9-3a3747fbebe3"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "4de35530-c545-461e-9580-9c71e07c0ee4",
            "refuuid": "e0a95064-f616-4566-be78-18761bd09c23",
            "name": "QUARTZ",
            "linking_id": "e0a95064-f616-4566-be78-18761bd09c23",
            "ref_pname": "QUARTZ",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "d8a07712-0872-48d9-b339-6ebd1c208c6d",
          "amount": {
            "uuid": "576b4715-5497-4438-bf7c-b6240be92c07"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "fd5db473-2c7e-4e58-b874-9a4427fe68a1",
            "refuuid": "408c92fc-57d9-4fde-b541-9954398c2fb0",
            "name": "TRIDYMITE",
            "linking_id": "408c92fc-57d9-4fde-b541-9954398c2fb0",
            "ref_pname": "TRIDYMITE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "24cdae78-2a4a-45cc-9cdf-3a1a321d6162",
          "amount": {
            "uuid": "f20f91bb-d79d-4232-9a8b-6c2d59fa86c3"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "9a75eae2-de57-4b79-821a-55d8c5ff9981",
            "refuuid": "0b3ebd14-24ea-4fb0-a7a1-7e6f17eb043a",
            "name": "SILICEA",
            "linking_id": "0b3ebd14-24ea-4fb0-a7a1-7e6f17eb043a",
            "ref_pname": "SILICEA",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "13df6f0f-330e-4bf7-aeeb-68843c3f1fa6",
          "amount": {
            "uuid": "6bc53e78-bb69-4b5c-81fc-d6f2a6e56065"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "ba76276c-b16a-47a2-be45-ed49d348e726",
            "refuuid": "1b77ae85-ca03-4d15-8b1a-f8eba57b898d",
            "name": "QUSO F-22",
            "linking_id": "1b77ae85-ca03-4d15-8b1a-f8eba57b898d",
            "ref_pname": "QUSO F-22",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "649232b2-fcdb-4d75-95e0-4920d1289a24",
          "amount": {
            "uuid": "32ad305d-591a-4d60-8290-65cadc85f7ce"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "97e727d4-3498-4b94-9594-6714e3382751",
            "refuuid": "0e3aaadb-fa04-4bdb-b9cf-0590b36a26c4",
            "name": "SILICA, DENTAL",
            "linking_id": "0e3aaadb-fa04-4bdb-b9cf-0590b36a26c4",
            "ref_pname": "SILICA, DENTAL",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "9fd6b059-370a-4ba9-b9c7-d285ca1c27fa",
          "amount": {
            "uuid": "237cb3cf-504a-4ec8-9479-fab4d4f70fdb"
          },
          "type": "SUB_CONCEPT->SUBSTANCE",
          "related_substance": {
            "uuid": "c02f773b-8985-45da-94a7-ed9d28015ded",
            "refuuid": "30c81518-2980-47ec-996b-b5b19c734638",
            "name": "SILICON DIOXIDE, COLLOIDAL",
            "linking_id": "30c81518-2980-47ec-996b-b5b19c734638",
            "ref_pname": "SILICON DIOXIDE, COLLOIDAL",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "6ddc6ddd-c217-4eef-a59b-4d9781c7c074",
          "amount": {
            "uuid": "764febb1-9b59-40ab-a55e-dc199c6e9a50",
            "type": "WEIGHT PERCENT",
            "units": "%",
            "high_limit": 5
          },
          "type": "PARENT->IMPURITY",
          "references": [
            "23ba4731-f9db-4fc4-96fb-73359e24dedf"
          ],
          "related_substance": {
            "uuid": "97bad839-545e-417a-93a9-6c51372228b8",
            "refuuid": "259cc39b-37b7-4811-b356-532459df89cc",
            "name": "D&C Black No. 3",
            "unii": "8X7LUT95FD",
            "linking_id": "8X7LUT95FD",
            "ref_pname": "D&C Black No. 3",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "7ca7926a-da84-118e-9b29-6435e7de8e41",
          "amount": {
            "uuid": "95f048c9-6ead-4a7c-9b32-da76b228f2df"
          },
          "type": "SOLVATE->ANHYDROUS",
          "references": [
            "5057f052-e6e9-40b6-be98-c0319ba859df"
          ],
          "related_substance": {
            "uuid": "1229e5f6-ee66-4e2d-b56d-c14581e977a2",
            "refuuid": "9a409ba1-7562-4738-a95e-7cb772b0273e",
            "name": "HYDRATED SILICA",
            "unii": "Y6O7T4G8P9",
            "linking_id": "Y6O7T4G8P9",
            "ref_pname": "HYDRATED SILICA"
          }
        }
      ],
      "substance_class": "chemical",
      "names": [
        {
          "uuid": "daaee8ea-d025-4f25-89cd-8873fef670c7",
          "name": "E-551",
          "stdName": "E-551",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fcfe4cd1-cec3-456b-81e5-290fd54e5831"
          ],
          "display_name": false
        },
        {
          "uuid": "e6e3ccde-6b02-45a6-95e5-ca1c0ef9a563",
          "name": "INS NO.551",
          "stdName": "INS NO.551",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fcfe4cd1-cec3-456b-81e5-290fd54e5831"
          ],
          "display_name": false
        },
        {
          "uuid": "fa963a1e-e434-41f2-94c7-e30e40a747ac",
          "name": "INS-551",
          "stdName": "INS-551",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fcfe4cd1-cec3-456b-81e5-290fd54e5831"
          ],
          "display_name": false
        },
        {
          "uuid": "5d2bc8db-a680-4758-9181-a555a9975ac1",
          "name": "SAND",
          "stdName": "SAND",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": true,
          "references": [
            "19a9e580-c649-4c88-9329-8878ef231555",
            "023963a5-4c8e-4e86-b45c-03c130197eae",
            "dfb3231d-3e92-4a54-b4ed-62e73b037c50"
          ],
          "display_name": false,
          "domains": [
            "cosmetic"
          ],
          "name_orgs": [
            {
              "uuid": "a195d918-08cb-4b20-8906-6290a7eca85e",
              "name_org": "INCI"
            }
          ]
        },
        {
          "uuid": "fee12e4f-00b0-40df-929d-a41b0e08bc13",
          "name": "SILICA AEROGEL",
          "stdName": "SILICA AEROGEL",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "353974cf-cdff-424f-ab47-e5ca224508e3"
          ],
          "display_name": false
        },
        {
          "uuid": "b6fbacbe-f880-4098-9b86-1a90d865ec05",
          "name": "SILICA GEL",
          "stdName": "SILICA GEL",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "747ac5ee-7733-4632-a025-18f13273b345",
            "cab8da6e-8fca-4e7d-a1a7-4bb70ddab54b",
            "f1bc4d0b-f0a9-4ee9-a231-de971f7bded1",
            "34e2e105-772d-4dfa-b150-f1ceaffd0e74",
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "8da0cfc9-4d2f-47e6-9821-1455719534e7",
          "name": "SILICA GEL [VANDF]",
          "stdName": "SILICA GEL [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "94aa1dca-6fa3-48f1-31f8-f4932c6030d0",
          "name": "SILICA, AMORPHOUS [IARC]",
          "stdName": "SILICA, AMORPHOUS [IARC]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "3bd22e01-8c40-d002-476c-84a82525fbcd"
          ],
          "display_name": false
        },
        {
          "uuid": "0fb35ff1-52c0-4172-bc64-f874cc0811fe",
          "name": "SILICATE [VANDF]",
          "stdName": "SILICATE [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "0dd622a0-197c-403a-87e3-0f47313d7874",
          "name": "SILICON DIOXIDE",
          "stdName": "SILICON DIOXIDE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "526ad402-10f6-41aa-aba9-fc62e64759c8",
            "a5704c70-f456-4482-8595-dec21398c8d1",
            "34e2e105-772d-4dfa-b150-f1ceaffd0e74",
            "0a1d583e-6188-42ed-8952-f7b942cbd188",
            "4e3e02f8-483c-4ab9-ad5b-bedfaaf2ed43",
            "a0269c2f-e65e-4b44-99c1-a56a7aeb05c9",
            "d2e298ef-35ba-45a2-859f-44ade477e39e",
            "05f4a89a-9777-4551-a808-18445586a738",
            "d015b77b-d274-40a4-b535-bf473b82ed37"
          ],
          "display_name": true
        },
        {
          "uuid": "df762101-0e52-426c-8740-f8a603dc8857",
          "name": "SILICON DIOXIDE [FCC]",
          "stdName": "SILICON DIOXIDE [FCC]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "a5704c70-f456-4482-8595-dec21398c8d1"
          ],
          "display_name": false
        },
        {
          "uuid": "bed4627c-e6c0-49b4-98dd-80d1997fb00e",
          "name": "SILICON DIOXIDE [II]",
          "stdName": "SILICON DIOXIDE [II]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "526ad402-10f6-41aa-aba9-fc62e64759c8"
          ],
          "display_name": false
        },
        {
          "uuid": "aa5caf44-a942-4277-a396-295b70118093",
          "name": "SILICON DIOXIDE [VANDF]",
          "stdName": "SILICON DIOXIDE [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "444a48c8-615c-4410-8a2c-bd2ed720f938",
          "name": "SILICON DIOXIDE, AMORPHOUS",
          "stdName": "SILICON DIOXIDE, AMORPHOUS",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fcfe4cd1-cec3-456b-81e5-290fd54e5831"
          ],
          "display_name": false
        },
        {
          "uuid": "a01da14d-8d91-4e55-a92d-5199408b5d60",
          "name": "SILICONE DIOXIDE [VANDF]",
          "stdName": "SILICONE DIOXIDE [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "d015abfc-55d3-4f34-8393-65a07136564f",
          "name": "SIMETHICONE COMPONENT SILICON DIOXIDE",
          "stdName": "SIMETHICONE COMPONENT SILICON DIOXIDE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "cb399131-6a85-47fb-941a-aeec5f370e2b"
          ],
          "display_name": false
        },
        {
          "uuid": "7d14dba4-2751-467d-82e0-5256af5275f0",
          "name": "SYLOID 244 [VANDF]",
          "stdName": "SYLOID 244 [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "1796d1a3-e7ec-43e0-afab-b8c1cad993e3",
          "name": "SYLOID SILICA GEL [VANDF]",
          "stdName": "SYLOID SILICA GEL [VANDF]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "05f4a89a-9777-4551-a808-18445586a738"
          ],
          "display_name": false
        },
        {
          "uuid": "d6d907c2-ed0e-482f-8d6b-f06ee494746f",
          "name": "Silica",
          "stdName": "SILICA",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": true,
          "references": [
            "747ac5ee-7733-4632-a025-18f13273b345",
            "19a9e580-c649-4c88-9329-8878ef231555",
            "ea7af022-54b3-4fa5-9555-c667428508d5"
          ],
          "display_name": false,
          "domains": [
            "cosmetic"
          ],
          "name_orgs": [
            {
              "uuid": "277fb4fb-298b-4c73-86ed-27cf7989542e",
              "name_org": "INCI"
            }
          ]
        },
        {
          "uuid": "ec6fbe82-1b5b-95fc-8cb1-6c5ddd206b8d",
          "name": "Silica gel [WHO-DD]",
          "stdName": "SILICA GEL [WHO-DD]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "ff136f0c-6204-c3ac-38cd-5ad418932712"
          ],
          "display_name": false
        },
        {
          "uuid": "0731158e-0eda-0794-48dc-56ffda7ebb78",
          "name": "Silicon dioxide [WHO-DD]",
          "stdName": "SILICON DIOXIDE [WHO-DD]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "ff136f0c-6204-c3ac-38cd-5ad418932712"
          ],
          "display_name": false
        }
      ],
      "references": [
        {
          "uuid": "747ac5ee-7733-4632-a025-18f13273b345",
          "citation": "USP DICTIONARY 2009",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "526ad402-10f6-41aa-aba9-fc62e64759c8",
          "citation": "USP 29",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "023963a5-4c8e-4e86-b45c-03c130197eae",
          "citation": "Merck Index 14.3",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "353974cf-cdff-424f-ab47-e5ca224508e3",
          "citation": "WIKIPEDIA",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "cb399131-6a85-47fb-941a-aeec5f370e2b",
          "citation": "USP/NF",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "19a9e580-c649-4c88-9329-8878ef231555",
          "citation": "PCPC",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "a5704c70-f456-4482-8595-dec21398c8d1",
          "citation": "FCC",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "34e2e105-772d-4dfa-b150-f1ceaffd0e74",
          "citation": "WHO-DD",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "05f4a89a-9777-4551-a808-18445586a738",
          "citation": "NDF-RT",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "fcfe4cd1-cec3-456b-81e5-290fd54e5831",
          "citation": "http://www.codexalimentarius.net/gsfaonline/additives/details.html?id=284",
          "url": "http://www.codexalimentarius.net/gsfaonline/additives/details.html?id=284",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "98e8d64c-9dd1-45d2-8d5b-68cda9d1d6e8",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390688000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "1928b85a-9729-4dc7-aa78-5c480a323eb5",
          "citation": "SRS import [ETJ7Z6XBU4]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=ETJ7Z6XBU4",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390688000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "dfb3231d-3e92-4a54-b4ed-62e73b037c50",
          "citation": "SAND [INCI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "ea7af022-54b3-4fa5-9555-c667428508d5",
          "citation": "SILICA [INCI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "d015b77b-d274-40a4-b535-bf473b82ed37",
          "citation": "SILICON DIOXIDE [FCC]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "0a1d583e-6188-42ed-8952-f7b942cbd188",
          "citation": "SILICON DIOXIDE [II]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "cab8da6e-8fca-4e7d-a1a7-4bb70ddab54b",
          "citation": "SILICA GEL [WHO-DD]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "4e3e02f8-483c-4ab9-ad5b-bedfaaf2ed43",
          "citation": "SILICON DIOXIDE [WHO-DD]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "7c087cad-a4f0-430d-809e-304c0f46b0f2",
          "citation": "SYLOID 244 [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "c898c882-96ed-4afd-b0e8-66556bdd722c",
          "citation": "SYLOID SILICA GEL [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "f1bc4d0b-f0a9-4ee9-a231-de971f7bded1",
          "citation": "SILICA GEL [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "fa251bfa-1f42-4b6c-9ac4-bc43dfb77e9f",
          "citation": "SILICATE [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "d2e298ef-35ba-45a2-859f-44ade477e39e",
          "citation": "SILICON DIOXIDE [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "16647ea4-91e2-498c-a23d-0c74a47fdec0",
          "citation": "SILICONE DIOXIDE [VANDF]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "a0269c2f-e65e-4b44-99c1-a56a7aeb05c9",
          "citation": "SILICON DIOXIDE [DASH]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "4ba29e63-6a26-9b89-b0b8-5f267441ba79",
          "citation": "WEBSITE",
          "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=63231-67-4",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "3bd22e01-8c40-d002-476c-84a82525fbcd",
          "citation": "IARC",
          "doc_type": "IARC",
          "public_domain": true
        },
        {
          "uuid": "4880d397-b799-7626-ef3a-c19cc1f13c7e",
          "citation": "HPUS",
          "doc_type": "HOMEOPATHIC PHARMACOPOEIA US",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE",
            "NOMEN"
          ]
        },
        {
          "uuid": "ed26cb84-d333-e257-8688-79f68232f707",
          "citation": "PUBCHEM",
          "doc_type": "PUBCHEM",
          "public_domain": true
        },
        {
          "uuid": "5057f052-e6e9-40b6-be98-c0319ba859df",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "3b0fa1b5-2854-4b3f-bc90-7bfbee07c1e1",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "0e8923a0-7f9c-463a-8969-60bf7941af61",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "912d0318-ebd0-46b4-7387-b85a6627e337",
          "citation": "AW",
          "doc_type": "ALANWOOD",
          "public_domain": true
        },
        {
          "uuid": "e88287c7-4cd7-2159-6f6a-972beea18581",
          "doc_type": "SYSTEM",
          "public_domain": true
        },
        {
          "uuid": "ff136f0c-6204-c3ac-38cd-5ad418932712",
          "citation": "WHO-DD",
          "doc_type": "WHO DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "e893f9b4-75d1-f6c2-c5e0-a5545b12626e",
          "citation": "DailyMed",
          "doc_type": "DAILYMED",
          "public_domain": true
        },
        {
          "uuid": "23ba4731-f9db-4fc4-96fb-73359e24dedf",
          "citation": "CFR - Code of Federal Regulations Title 21",
          "url": "https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=74.2053",
          "doc_type": "CFR",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "6eb08037-b94b-413a-a9ce-3e373a911edf",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "34705114-9af8-2d50-2c0f-bc1096c80694",
          "citation": "EU-SRS",
          "doc_type": "EMA LIST",
          "public_domain": true
        },
        {
          "uuid": "261adbf3-3ce4-58a0-dca4-6c8d0af9cf73",
          "citation": "EPA",
          "doc_type": "EPA",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "moieties": [
        {
          "uuid": "7defb03c-e672-4e75-9bc5-1116f0da2c36",
          "id": "7defb03c-e672-4e75-9bc5-1116f0da2c36",
          "molfile": "\n  Marvin  01132106322D          \n\n  3  2  0  0  0  0            999 V2000\n    5.9358   -4.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    6.7540   -4.9464    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0\n    7.5858   -4.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n  2  1  2  0  0  0  0\n  2  3  2  0  0  0  0\nM  END",
          "smiles": "O=[Si]=O",
          "formula": "O2Si",
          "atropisomerism": "No",
          "charge": 0,
          "count": 1,
          "stereochemistry": "ACHIRAL",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "2f488143-98a0-44ea-8f60-fc088d5d4ce1"
          },
          "defined_stereo": 0,
          "ez_centers": 0,
          "molecular_weight": "60.0842",
          "optical_activity": "NONE",
          "stereo_centers": 0
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "a2cc7bb4-0675-466d-841d-3f6d48d629bf",
      "version": "37",
      "structure": {
        "id": "0fecd9dc-c059-4ab1-871a-7047b6f14a6a",
        "molfile": "\n  Marvin  01132101032D          \n\n  3  2  0  0  0  0            999 V2000\n    6.7540   -4.9464    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0\n    5.9358   -4.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5858   -4.9464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n  1  2  2  0  0  0  0\n  1  3  2  0  0  0  0\nM  END",
        "smiles": "O=[Si]=O",
        "formula": "O2Si",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ACHIRAL",
        "defined_stereo": 0,
        "ez_centers": 0,
        "molecular_weight": "60.0842",
        "optical_activity": "NONE",
        "references": [
          "526ad402-10f6-41aa-aba9-fc62e64759c8",
          "1928b85a-9729-4dc7-aa78-5c480a323eb5"
        ],
        "stereo_centers": 0
      },
      "unii": "ETJ7Z6XBU4"
    }
  ]
}