{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2026-09-09", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "98adaa81-dd4f-411c-a184-6524790d6aab", "code": "N0000175587", "comments": "Established Pharmacologic Class [EPC]|Histamine-1 Receptor Antagonist [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175587", "code_system": "NDF-RT", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "4ca34d93-7abd-455c-929c-437ad7c72871", "code": "R06AX26", "comments": "ATC|RESPIRATORY SYSTEM|ANTIHISTAMINES FOR SYSTEMIC USE|ANTIHISTAMINES FOR SYSTEMIC USE|Other antihistamines for systemic use|fexofenadine", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=R06AX26&showdescription=yes", "code_system": "WHO-ATC", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "23b66a17-ccfd-47e7-aab6-781accdfead8", "code": "N0000000190", "comments": "Cellular or Molecular Interactions [MoA]|Receptor Interactions [MoA]|G-Protein-linked Receptor Interactions [MoA]|Histamine Receptor Interactions [MoA]|Histamine Receptor Antagonists [MoA]|Histamine H1 Receptor Antagonists [MoA]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000000190", "code_system": "NDF-RT", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "3b43e4c6-c866-4ea4-af45-3dbbd43555cb", "code": "83799-24-0", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=83799-24-0", "code_system": "CAS", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a", "88041754-d081-4d8e-8bcc-ae84b09a08e1" ] }, { "uuid": "c533a50c-462d-4190-a44e-5db3399de148", "code": "C61764", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61764", "code_system": "NCI_THESAURUS", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "65a67de0-54b8-46fd-a616-304ce912b7bd", "code": "C093230", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/67093230", "code_system": "MESH", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "e710f9de-80de-41ce-b73b-50f9e2b2fe1d", "code": "NBK548571", "comments": "LiverTox|Respiratory|Allergy symptoms|Antihistamine", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/NBK548571/", "code_system": "LIVERTOX", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "76851b95-c09c-4bfc-bebd-46bdef109cc3", "code": "FEXOFENADINE", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Fexofenadine", "code_system": "WIKIPEDIA", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "c0b80818-0f55-4487-9ba3-308060b53e5e", "code": "SUB13883MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "e55d91ad-8fc2-4e6d-b57e-961b150af392", "code": "7469", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=7469", "code_system": "INN", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "7eae5631-7f88-49f9-a0e2-0c97bc95fdbf", "code": "4819", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4819", "code_system": "IUPHAR", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "856d5aab-e9d6-4f44-93e1-f165e0647b5e", "code": "87636", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/87636/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "97dfdc57-3bc3-48d8-9c7d-3f666a30bead", "code": "m5367", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m5367?q=authorize", "code_system": "MERCK INDEX", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "a2133e08-6e0e-401c-b42e-6dd643c56f27", "code": "QR06AX26", "comments": "VATC|ANTIHISTAMINES FOR SYSTEMIC USE|ANTIHISTAMINES FOR SYSTEMIC USE|Other antihistamines for systemic use|fexofenadine", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QR06AX26&showdescription=yes", "code_system": "WHO-VATC", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "6ee85bfa-6bea-45e6-b8c3-d81cd42e38d5", "code": "CHEMBL914", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL914", "code_system": "ChEMBL", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "8a8f8bed-03bd-4239-8a4e-0f3b3e7de137", "code": "3348", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/3348", "code_system": "PUBCHEM", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "e2934b6a-0e25-45bb-bc5b-f017cd9180dc", "code": "DB00950", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00950", "code_system": "DRUG BANK", "references": [ "7d0cd229-daf7-4611-a99f-721e2002022a" ] }, { "uuid": "706588c0-5d07-dd88-a5a7-a58f36644417", "code": "7486", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7486", "code_system": "HSDB", "references": [ "36f11653-2292-74a0-4c8f-a91aa54d4f96" ] }, { "uuid": "f744107d-16a1-ffc5-0b93-aafd6d191c9e", "code": "C29578", "comments": "Pharmacologic Substance[C1909]|Immunotherapeutic Agent[C308]|Histamine-1 Receptor Antagonist", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29578", "code_system": "NCI_THESAURUS", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "9091b076-1531-4c58-a2ce-b2f84503dde3", "code": "E6582LOH6V", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "419ab82a-1d8b-849d-5380-f12bf05a3b8a", "code": "Fexofenadine", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/n/lactmed/LM111/", "code_system": "LACTMED", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "124ebd7e-acdd-f7c7-7071-5885e34b41f7", "code": "1170", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/1170", "code_system": "DRUG CENTRAL", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "e06827fc-6938-fbd1-def8-807cae067612", "code": "5050", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:5050", "code_system": "CHEBI", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "af22ec14-b7fe-f563-e62c-43b212f3acda", "code": "1270363", "type": "PRIMARY", "url": "https://store.usp.org/product/1270363", "code_system": "RS_ITEM_NUM", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] }, { "uuid": "d98edd6b-1eb0-4c90-c359-8050569b4340", "code": "100000078495", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "999da0f4-5a41-0898-a50a-d6fb3e02a7c7" ] }, { "uuid": "f27b594c-7aae-feac-b238-523df9c792f6", "code": "E6582LOH6V", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=E6582LOH6V", "code_system": "DAILYMED", "references": [ "9211a95b-4a23-ae9a-a87a-9381a8b27744" ] }, { "uuid": "cc647e91-ce71-ed75-1acd-d6152c176cc4", "code": "DTXSID00861411", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID00861411", "code_system": "EPA CompTox", "references": [ "3d61dc5c-0abf-67f5-9c64-e9430f22bd13" ] } ], "substance_class": "chemical", "references": [ { "uuid": "50ebe780-5db9-450b-9633-11ee7715c9dc", "citation": "DMF 18948", "doc_type": "DMF", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "66e90fca-9655-425d-a83f-0654694f9722", "citation": "ACD 9.0(DMF 18948)", "doc_type": "DMF", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "af71a853-8064-48ab-b3db-23fd83936da7", "citation": "USP Dictionary 2009", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "ad2e9971-d526-4ef2-a27e-de8b0871c27e", "citation": "USP DICTIONARY 2009", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "2f7f5047-49b9-4643-8951-93205bb2ecb4", "citation": "INN Proposed List 77", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL77.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ef11d3f4-ce0f-47c8-b9af-3b9cbbd92159", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "bcc5612c-42bb-4c29-8330-ecd81884c275", "citation": "KEGG 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "902670f2-6fb7-43c2-a60f-5b1e857561b3", "citation": "D07958", "doc_type": "KEGG", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "59bef135-a6a9-431a-b01d-902aabf2c0f3", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "46a8966c-8a8a-4398-a8c6-27cb229b8ca1", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ac97fbc8-c705-483f-b515-9d39004dc9c0", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7d0cd229-daf7-4611-a99f-721e2002022a", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389954000, "tags": [ "NOMEN" ] }, { "uuid": "660f0000-595e-4cd3-9a4e-f853a7aca158", "citation": "https://en.wikipedia.org/wiki/Fexofenadine", "url": "https://en.wikipedia.org/wiki/Fexofenadine", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "2e1134a5-ff21-4ad9-bd3d-aec7d2b384eb", "citation": "SRS import [E6582LOH6V]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=E6582LOH6V", "doc_type": "SRS", "public_domain": true, "document_date": 1493389954000, "tags": [ "NOMEN" ] }, { "uuid": "ef793c3a-36d9-4a3c-ac4f-2f243247380a", "citation": "USP Dictionary 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "58a68ede-ee0b-4cc5-9ee9-ecb5c0e59482", "citation": "FEXOFENADINE [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "8669b46c-bcec-49df-8ec0-55f3a2cc582b", "citation": "FEXOFENADINE [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "1e7712f0-81e8-4ba9-9d98-61a193436ca7", "citation": "FEXOFENADINE [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "0dbef759-9df9-4dba-b98e-41ef80b5a877", "citation": "FEXOFENADINE [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "a6849a26-0130-42f3-a979-2d28a611d3e9", "citation": "FEXOFENADINE [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "5d513560-03c8-e235-cf7d-40ef70dcc26d", "citation": "Pharmacol Rev 65:578–640, April 2013", "url": "http://dx.doi.org/10.1124/pr.111.005439", "doc_type": "JA", "public_domain": true }, { "uuid": "36f11653-2292-74a0-4c8f-a91aa54d4f96", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+83799-24-0", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7a8fc9bb-c8b7-0627-0138-8a1efb204615", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+lactmed:@term+@rel+@rn+83799-24-0", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e940b6a1-be03-d4ae-453b-98cca8f8437e", "citation": "Molimard, M., B. Diquet, and M. Strolin Benedetti. \"Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.\" Fundamental & clinical pharmacology 18.4 (2004): 399-411.", "url": "http://web.a.ebscohost.com/ehost/pdfviewer/pdfviewer?vid=1&sid=8ac40531-5c5b-45c8-b0b5-730ed448a1ac%40sessionmgr4008", "doc_type": "JA", "public_domain": true }, { "uuid": "e09ae9c4-eb9f-b1e0-aeff-d3fcd01ceeb2", "citation": "Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999;27:866–71.", "url": "http://dmd.aspetjournals.org/content/27/8/866.long", "doc_type": "JA", "public_domain": true }, { "uuid": "0f609721-7b0e-bb4a-4136-d3f0b822c002", "citation": "FEXOFENADINE", "doc_type": "MICROMEDEX", "public_domain": true }, { "uuid": "3d61dc5c-0abf-67f5-9c64-e9430f22bd13", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "88041754-d081-4d8e-8bcc-ae84b09a08e1", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "744ab6b4-869a-4b2c-9d81-a9590c3223a6", "citation": "Peng Li, Guang-Ji Wang, Thomas A. Robertson and Michael S. Roberts, “ Liver Transporters in Hepatic Drug Disposition: An Update”, Current Drug Metabolism (2009) 10: 482.", "url": "https://www.ncbi.nlm.nih.gov/pubmed/19689245", "doc_type": "JA", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "635fd3cf-302d-e2e4-a4d4-d2e5dc55e511", "citation": "USP-RS", "doc_type": "USPNF", "public_domain": true }, { "uuid": "f9cd6166-a834-4715-b593-eb0721149728", "citation": "J Chromatogr 1991 Sep 18;570(1):139-48", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9211a95b-4a23-ae9a-a87a-9381a8b27744", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "b05fc449-20d5-706f-dea7-e8b3233edfc0", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "999da0f4-5a41-0898-a50a-d6fb3e02a7c7", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "681d6d0d-edfa-4fde-a190-ab2af1d6b4d6", "citation": "https://www.uniprot.org/uniprotkb/B8K1W2/entry#ptm_processing", "url": "https://www.uniprot.org/uniprotkb/B8K1W2/entry#ptm_processing", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "714e6b17-0e09-4836-b4ff-87cf6f10e9f5", "citation": "https://www.uniprot.org/uniprotkb/B8K1W2/entry#ptm_processing", "url": "https://www.uniprot.org/uniprotkb/B8K1W2/entry#ptm_processing", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "110f70be-9041-4fa4-a99a-6f2e44d28b47", "citation": "Pharmacol Rev 65:578–640, April 2013", "url": "http://dx.doi.org/10.1124/pr.111.005439", "doc_type": "JA", "public_domain": true }, { "uuid": "cd6ceeae-eb78-4d15-895c-a9702150cce6", "citation": "J Chromatogr 1991 Sep 18;570(1):139-48", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "a76df8af-fa0e-4b88-bf07-10e90f416aed", "id": "a76df8af-fa0e-4b88-bf07-10e90f416aed", "molfile": "\n Marvin 01132108422D \n\n 37 40 0 0 0 0 999 V2000\n 2.6256 -3.8596 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0356 -3.1390 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.7644 -3.5159 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2984 -2.7498 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5778 -3.1681 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2445 -1.9091 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 3.4207 -2.4060 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.2283 -2.4060 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.6423 -1.6814 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.2283 -0.9525 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.4207 -0.9525 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0066 -1.6814 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.6423 -0.2567 0.0000 C 0 0 0 0 0 0 0 0 0 3 0 0\n 5.4831 -0.2567 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 4.2283 0.4679 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.4207 0.4679 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0066 1.1885 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1659 1.1885 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.7642 0.4679 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.9194 0.4679 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.5135 1.1885 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.9194 1.8760 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.7311 1.8760 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3064 1.1885 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1430 1.1885 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3064 0.3520 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.4017 -0.0745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.4017 -0.8779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3064 -1.2921 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0187 -0.8779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0187 -0.0745 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3064 2.0044 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0187 2.4185 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0187 3.2592 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3064 3.6360 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.4017 3.2592 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.4017 2.4185 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0 0 0 0\n 3 2 1 0 0 0 0\n 4 2 1 0 0 0 0\n 2 7 1 0 0 0 0\n 5 4 1 0 0 0 0\n 6 4 2 0 0 0 0\n 8 7 1 0 0 0 0\n 7 12 2 0 0 0 0\n 8 9 2 0 0 0 0\n 9 10 1 0 0 0 0\n 11 10 2 0 0 0 0\n 10 13 1 0 0 0 0\n 12 11 1 0 0 0 0\n 14 13 1 0 0 0 0\n 13 15 1 0 0 0 0\n 15 16 1 0 0 0 0\n 16 17 1 0 0 0 0\n 17 18 1 0 0 0 0\n 18 19 1 0 0 0 0\n 18 23 1 0 0 0 0\n 19 20 1 0 0 0 0\n 20 21 1 0 0 0 0\n 22 21 1 0 0 0 0\n 21 24 1 0 0 0 0\n 23 22 1 0 0 0 0\n 25 24 1 0 0 0 0\n 26 24 1 0 0 0 0\n 32 24 1 0 0 0 0\n 27 26 1 0 0 0 0\n 31 26 2 0 0 0 0\n 28 27 2 0 0 0 0\n 28 29 1 0 0 0 0\n 29 30 2 0 0 0 0\n 30 31 1 0 0 0 0\n 33 32 1 0 0 0 0\n 37 32 2 0 0 0 0\n 34 33 2 0 0 0 0\n 35 34 1 0 0 0 0\n 35 36 2 0 0 0 0\n 36 37 1 0 0 0 0\nM END", "smiles": "CC(C)(c1ccc(cc1)C(CCCN2CCC(CC2)C(c3ccccc3)(c4ccccc4)O)O)C(=O)O", "formula": "C32H39NO4", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "RACEMIC", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "6df9709d-86f9-4e84-adfe-49f5c24fc3ea" }, "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "501.6576", "optical_activity": "( + / - )", "stereo_centers": 1 } ], "definition_level": "COMPLETE", "uuid": "09db577e-ecf0-4d71-a102-935bda550214", "version": "41", "structure": { "id": "513e7c4b-ff94-41d9-ad6f-83c741d59a6c", "molfile": "\n JSDraw203192412422D\n\n 37 40 0 0 0 0 0 V2000\n 16.6487 -6.1589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.9283 -14.2903 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.5431 -13.5590 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.2941 -6.1589 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 23.6519 -12.9130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.1893 -6.1589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.1694 -10.1818 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.1891 -14.3450 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 16.6487 -4.6258 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.6487 -7.7307 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.8738 -11.5514 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.1694 -12.9130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.9473 -11.5514 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.6519 -10.1818 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.9520 -7.5129 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 18.9520 -4.8671 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.4772 -4.8671 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 20.5393 -7.5129 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.0767 -6.1589 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 25.9473 -8.8744 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 21.4418 -11.9793 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 22.8738 -6.1589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 27.5272 -8.8744 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 22.1579 -15.6443 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 24.2977 -14.9985 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.6519 -7.5129 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.1694 -7.5129 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.9792 -8.5321 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.3103 -3.8477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.3103 -8.5321 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.9792 -3.8477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.3103 -2.2680 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.9792 -10.0417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 15.3103 -10.0417 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 17.9792 -2.2680 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.6487 -10.8199 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 16.6487 -1.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2 5 1 0 0 0 0\n 3 2 1 0 0 0 0\n 4 17 1 0 0 0 0\n 5 11 1 0 0 0 0\n 6 1 1 0 0 0 0\n 7 20 1 0 0 0 0\n 8 3 2 0 0 0 0\n 9 1 1 0 0 0 0\n 10 1 1 0 0 0 0\n 11 14 2 0 0 0 0\n 12 13 1 0 0 0 0\n 13 7 2 0 0 0 0\n 14 7 1 0 0 0 0\n 15 6 1 0 0 0 0\n 16 6 1 0 0 0 0\n 17 16 1 0 0 0 0\n 18 15 1 0 0 0 0\n 19 1 1 0 0 0 0\n 20 27 1 0 0 0 0\n 21 3 1 0 0 0 0\n 22 4 1 0 0 0 0\n 23 20 1 0 0 0 0\n 24 2 1 0 0 0 0\n 25 2 1 0 0 0 0\n 26 22 1 0 0 0 0\n 27 26 1 0 0 0 0\n 28 10 1 0 0 0 0\n 29 9 2 0 0 0 0\n 30 10 2 0 0 0 0\n 31 9 1 0 0 0 0\n 32 29 1 0 0 0 0\n 33 28 2 0 0 0 0\n 34 30 1 0 0 0 0\n 35 31 2 0 0 0 0\n 36 34 2 0 0 0 0\n 37 32 2 0 0 0 0\n 4 18 1 0 0 0 0\n 33 36 1 0 0 0 0\n 37 35 1 0 0 0 0\n 12 5 2 0 0 0 0\nM END", "smiles": "CC(C)(c1ccc(cc1)C(CCCN2CCC(CC2)C(c3ccccc3)(c4ccccc4)O)O)C(=O)O", "formula": "C32H39NO4", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "RACEMIC", "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "501.6576", "optical_activity": "( + / - )", "references": [ "ef793c3a-36d9-4a3c-ac4f-2f243247380a", "2e1134a5-ff21-4ad9-bd3d-aec7d2b384eb", "2f7f5047-49b9-4643-8951-93205bb2ecb4" ], "stereo_centers": 1 }, "unii": "E6582LOH6V", "relationships": [ { "uuid": "0e0297b1-c0cd-4a24-ba62-f3d2fce18234", "amount": { "uuid": "5f7d4f5e-eb52-4d67-bdc9-3964e768c6b6" }, "type": "ACTIVE MOIETY", "related_substance": { "uuid": "fe823f8c-dcd9-4e44-8d30-0e34c6b3a1b3", "refuuid": "09db577e-ecf0-4d71-a102-935bda550214", "name": "FEXOFENADINE", "unii": "E6582LOH6V", "linking_id": "E6582LOH6V", "ref_pname": "FEXOFENADINE", "substance_class": "reference" } }, { "uuid": "3ecac860-5c93-4427-9b38-4ff055061f16", "amount": { "uuid": "86722831-28a4-45e8-a68b-9d221c8ec9ae" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "80eb00ff-7417-44c5-bac1-3db7daee6abd", "refuuid": "60850564-82a1-4913-ae06-3deadb071a8d", "name": "FEXOFENADINE HYDROCHLORIDE", "unii": "2S068B75ZU", "linking_id": "2S068B75ZU", "ref_pname": "FEXOFENADINE HYDROCHLORIDE", "substance_class": "reference" } }, { "uuid": "bb291282-f430-4c60-b92e-06a10277620e", "amount": { "uuid": "c31c7297-4057-45e7-a5f6-37d4c6a75906" }, "type": "PARENT->METABOLITE ACTIVE", "interaction_type": "MAJOR", "references": [ "110f70be-9041-4fa4-a99a-6f2e44d28b47", "cd6ceeae-eb78-4d15-895c-a9702150cce6" ], "related_substance": { "uuid": "2a90d512-8eae-4036-8586-b09bdf37cb34", "refuuid": "cbba806d-6033-46e3-8629-180a084d86e5", "name": "TERFENADINE", "unii": "7BA5G9Y06Q", "linking_id": "7BA5G9Y06Q", "ref_pname": "TERFENADINE", "substance_class": "reference" } }, { "uuid": "b283e04a-d54d-42c6-b828-41ccfccd365e", "type": "TARGET->INHIBITOR", "references": [ "660f0000-595e-4cd3-9a4e-f853a7aca158" ], "related_substance": { "uuid": "ea3405c4-6d96-4a63-88b9-51bed6b129e5", "refuuid": "23559f52-21c8-4b43-92f1-981b36cdfe1d", "name": "HISTAMINE H1 RECEPTOR", "unii": "28XBT591QG", "linking_id": "28XBT591QG", "ref_pname": "HISTAMINE H1 RECEPTOR", "substance_class": "reference" } }, { "uuid": "fd3d4392-55a5-4415-b83e-e981240959ff", "amount": { "uuid": "5932da0e-2fe1-4ea1-9038-4a803d17ab87", "average": 65, "units": "%" }, "type": "BINDER->LIGAND", "references": [ "5d513560-03c8-e235-cf7d-40ef70dcc26d" ], "related_substance": { "uuid": "8448286f-530b-43e4-8da8-147370c3fc07", "refuuid": "e95d330b-4c2d-44bb-a61b-860afeb4aa30", "name": "PLASMA PROTEIN FRACTION (HUMAN)", "unii": "6D53G0FD0Z", "linking_id": "6D53G0FD0Z", "ref_pname": "PLASMA PROTEIN FRACTION (HUMAN)", "substance_class": "reference" } }, { "uuid": "5b60fad0-cd15-4f92-89cf-7272d1f104ad", "amount": { "uuid": "650397bd-67cc-4e66-84b6-3e386dca8723", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 80, "units": "%" }, "qualification": "FECAL", "type": "EXCRETED UNCHANGED", "references": [ "e940b6a1-be03-d4ae-453b-98cca8f8437e" ], "related_substance": { "uuid": "42f5e090-2dff-4c7c-bd25-776c6fd33d07", "refuuid": "09db577e-ecf0-4d71-a102-935bda550214", "name": "FEXOFENADINE", "unii": "E6582LOH6V", "linking_id": "E6582LOH6V", "ref_pname": "FEXOFENADINE", "substance_class": "reference" } }, { "uuid": "7446a0fd-2858-4bcd-bb72-12ed902e961e", "amount": { "uuid": "bf9a5e4b-1289-4ad4-8675-0465137f93cc", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 11, "units": "%" }, "qualification": "URINE", "type": "EXCRETED UNCHANGED", "references": [ "e940b6a1-be03-d4ae-453b-98cca8f8437e" ], "related_substance": { "uuid": "a3963576-8960-48b7-9309-38c6008414e7", "refuuid": "09db577e-ecf0-4d71-a102-935bda550214", "name": "FEXOFENADINE", "unii": "E6582LOH6V", "linking_id": "E6582LOH6V", "ref_pname": "FEXOFENADINE", "substance_class": "reference" } }, { "uuid": "583b7b05-c740-4b2c-a028-947756ac1cd2", "type": "TRANSPORTER->SUBSTRATE", "references": [ "e09ae9c4-eb9f-b1e0-aeff-d3fcd01ceeb2" ], "related_substance": { "uuid": "d02a60da-1272-4f7e-99e8-fbf509e4a6b8", "refuuid": "7d2225e6-e467-47fb-b130-4ce9ed30684e", "name": "OATP1B1", "unii": "AIN96D6SGL", "linking_id": "AIN96D6SGL", "ref_pname": "OATP1B1", "substance_class": "reference" } }, { "uuid": "76db23f9-f810-42dd-b6f9-08d2f8c845e1", "type": "TRANSPORTER->SUBSTRATE", "references": [ "e09ae9c4-eb9f-b1e0-aeff-d3fcd01ceeb2" ], "related_substance": { "uuid": "72c83ebf-b098-4883-9d56-f6b685ec600a", "refuuid": "367a46c3-9b21-43b0-826b-b265b7dcea8e", "name": "OATP-B", "unii": "G49RZO51ZC", "linking_id": "G49RZO51ZC", "ref_pname": "OATP-B", "substance_class": "reference" } }, { "uuid": "8066a1ff-9446-487b-8946-a767b185d59a", "type": "TRANSPORTER->SUBSTRATE", "references": [ "744ab6b4-869a-4b2c-9d81-a9590c3223a6" ], "related_substance": { "uuid": "fff28f72-4b5a-4f00-82d9-4af6a83257a4", "refuuid": "42747e01-2eff-4042-97e4-3c464a97f1d7", "name": "SOLUTE CARRIER FAMILY 21 MEMBER 3", "unii": "570V991KGQ", "linking_id": "570V991KGQ", "ref_pname": "SOLUTE CARRIER FAMILY 21 MEMBER 3" } } ], "names": [ { "uuid": "80fc6a18-903f-444b-a05a-50892b618881", "name": "(±)-P-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)PIPERIDINO)BUTYL)-.ALPHA.-METHYLHYDRATROPIC ACID", "stdName": "(+/-)-P-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)PIPERIDINO)BUTYL)-.ALPHA.-METHYLHYDRATROPIC ACID", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ad2e9971-d526-4ef2-a27e-de8b0871c27e" ], "display_name": false }, { "uuid": "aaccf1d4-5625-42ee-ae95-84246b098b0b", "name": "4-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL)BUTYL)-ALPHA,ALPHA-DIMETHYLBENZENEACETIC ACID", "stdName": "4-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL)BUTYL)-ALPHA,ALPHA-DIMETHYLBENZENEACETIC ACID", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "f9cd6166-a834-4715-b593-eb0721149728" ], "display_name": false }, { "uuid": "b0bf9c47-3c76-4229-9bbb-60439d7cd92e", "name": "BENZENEACETIC ACID, 4-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL)BUTYL)-.ALPHA.,.ALPHA.-DIMETHYL-, (±)-", "stdName": "BENZENEACETIC ACID, 4-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL)BUTYL)-.ALPHA.,.ALPHA.-DIMETHYL-, (+/-)-", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ad2e9971-d526-4ef2-a27e-de8b0871c27e" ], "display_name": false }, { "uuid": "d2be2989-81e3-4c75-8542-9d863aef6705", "name": "FEXOFENADINE", "stdName": "FEXOFENADINE", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "58a68ede-ee0b-4cc5-9ee9-ecb5c0e59482", "8669b46c-bcec-49df-8ec0-55f3a2cc582b", "ef11d3f4-ce0f-47c8-b9af-3b9cbbd92159", "2f7f5047-49b9-4643-8951-93205bb2ecb4", "59bef135-a6a9-431a-b01d-902aabf2c0f3", "1e7712f0-81e8-4ba9-9d98-61a193436ca7", "ac97fbc8-c705-483f-b515-9d39004dc9c0", "af71a853-8064-48ab-b3db-23fd83936da7", "46a8966c-8a8a-4398-a8c6-27cb229b8ca1", "0dbef759-9df9-4dba-b98e-41ef80b5a877", "a6849a26-0130-42f3-a979-2d28a611d3e9" ], "display_name": true, "domains": [ "drug" ], "name_orgs": [ { "uuid": "af27f235-9cc5-45ca-908d-3d973f5f0dc5", "name_org": "INN" } ] }, { "uuid": "de9ba92a-8551-4d96-8ad5-f30d64365ab8", "name": "FEXOFENADINE [HSDB]", "stdName": "FEXOFENADINE [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "59bef135-a6a9-431a-b01d-902aabf2c0f3" ], "display_name": false }, { "uuid": "86fcfce1-03bd-4778-aa69-d2992bc1cd4e", "name": "FEXOFENADINE [MI]", "stdName": "FEXOFENADINE [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ef11d3f4-ce0f-47c8-b9af-3b9cbbd92159" ], "display_name": false }, { "uuid": "166a8ea8-dfe7-623d-58ea-e64794e28aa2", "name": "FEXOFENADINE [USP-RS]", "stdName": "FEXOFENADINE [USP-RS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "635fd3cf-302d-e2e4-a4d4-d2e5dc55e511" ], "display_name": false }, { "uuid": "4b6a430d-7eac-40ec-a911-f1e020d9d6d2", "name": "FEXOFENADINE [VANDF]", "stdName": "FEXOFENADINE [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ac97fbc8-c705-483f-b515-9d39004dc9c0" ], "display_name": false }, { "uuid": "33b32655-cdce-7e39-9f28-77ee0dff9501", "name": "Fexofenadine [WHO-DD]", "stdName": "FEXOFENADINE [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b05fc449-20d5-706f-dea7-e8b3233edfc0" ], "display_name": false }, { "uuid": "f12ec26b-3ec3-431e-9568-9cb5a3c0d16c", "name": "TELFAST", "stdName": "TELFAST", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "bcc5612c-42bb-4c29-8330-ecd81884c275", "902670f2-6fb7-43c2-a60f-5b1e857561b3" ], "display_name": false }, { "uuid": "7df615aa-f9e3-4695-ade3-79b41a96ab97", "name": "fexofenadine [INN]", "stdName": "FEXOFENADINE [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "2f7f5047-49b9-4643-8951-93205bb2ecb4" ], "display_name": false } ], "properties": [ { "uuid": "9eccb746-1165-4c56-831d-7a87c3ae8355", "name": "Tmax", "value": { "uuid": "41b84144-734d-441c-b398-42359bace0fe", "average": 2.6, "units": "hours" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "2a4c9d9b-fff0-44b7-8bf3-bb31357881e7", "name": "PROTEIN BINDING", "value": { "uuid": "5d21cf1d-417f-4187-8933-3d8d9b2d9de7", "high": 70, "low": 60, "units": "%" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "7afdfc3e-a17e-458a-9904-4c98b59acba4", "name": "Route of Elimination", "value": { "uuid": "d9d54f7a-189c-42cf-9030-679e3e99b163", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 80, "units": "%", "non_numeric_value": "FECAL, UNCHANGED" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "8b272f7d-193c-47b4-949c-1f04ed2efa4b", "name": "Route of Elimination", "value": { "uuid": "36ed4c6f-77b5-4c27-8203-b086c82ac11e", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 11, "units": "%", "non_numeric_value": "RENAL, UNCHANGED" }, "defining": false, "property_type": "PHARMACOKINETIC" }, { "uuid": "c967aabe-7d5a-4cf3-ac19-bb612761faf8", "name": "Biological Half-life", "value": { "uuid": "cd1eca59-471f-4027-9701-711871b4965a", "average": 14.4, "units": "hours" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "2560ec3f-ccce-46cb-add2-7816f25d76a2", "name": "Biological Half-life", "value": { "uuid": "dc7f8cf0-ff02-43bc-b99d-6f2dc8c7cf06", "average": 22.9, "units": "hours", "non_numeric_value": "MILD TO MODERATE RENAL IMPAIRMENT (CrCL 41 mL/min TO 80 mL/min)" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "7f70d4db-8577-40bc-bc98-54ddb171fa14", "name": "Biological Half-life", "value": { "uuid": "57e45fb7-3f6d-404f-b000-990dbc6000b3", "average": 24.8, "units": "hours", "non_numeric_value": "SEVERE RENAL IMPAIRMENT (CrCL 11 mL/min TO 40 mL/min)" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] }, { "uuid": "4dac766f-2951-40dd-ab0d-588137e3c43d", "name": "Biological Half-life", "value": { "uuid": "b4bdb584-146a-4c28-8e15-9697c301efe3", "average": 18.9, "units": "hours", "non_numeric_value": "ON DIALYSIS (CrCL LESS THAN OR EQUAL TO 10 mL/min)" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "0f609721-7b0e-bb4a-4136-d3f0b822c002" ] } ] } ] }