{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2026-09-09", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "cc28573b-0224-4a03-9d41-f9274cbdca8d", "code": "500992-11-0", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=500992-11-0", "code_system": "CAS", "references": [ "31202371-f0a3-48b3-a2eb-c831b18af8eb", "2bf26eb5-8163-49e4-8823-a099be14f20e" ] }, { "uuid": "7d737588-ff33-4049-cfa6-90bc098e41c6", "code": "377812", "comments": "ORPHAN DRUG|Designated|Treatment of subarachnoid hemorrhage", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=377812", "code_system": "FDA ORPHAN DRUG" }, { "uuid": "89e48d78-aca6-b73d-0f14-47d2c063141d", "code": "412713", "comments": "ORPHAN DRUG|Designated|Treatment of acute ischemic stroke patients presenting within 3 hours of symptom onset", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=412713", "code_system": "FDA ORPHAN DRUG" }, { "uuid": "4dcdd380-1855-4c53-bb77-b4913d63b383", "code": "10857", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=10857", "code_system": "INN" }, { "uuid": "851404bd-e39f-4d00-9bad-ff15b801548b", "code": "D45TI2TWMA", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "277deae6-9ad7-e8f7-3df7-01330dcfd91c", "code": "C170212", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C170212", "code_system": "NCI_THESAURUS", "references": [ "bc6932c3-ff80-9d93-09c8-b7630e2ae9bf" ] }, { "uuid": "d3668872-725b-9cd9-6839-926378191683", "code": "DB12595", "type": "PRIMARY", "url": "https://go.drugbank.com/drugs/DB12595", "code_system": "DRUG BANK", "references": [ "bc6932c3-ff80-9d93-09c8-b7630e2ae9bf" ] }, { "uuid": "f54a4fd8-ccbb-cc02-6fac-ee0c0e8d682c", "code": "44568939", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/44568939", "code_system": "PUBCHEM", "references": [ "1ef667e8-63dd-0d4d-f108-98c09dd5a666" ] }, { "uuid": "88e16da0-ce5a-902e-c948-36e0e08e88ac", "code": "GH-179", "type": "PRIMARY", "url": "https://searchusan.ama-assn.org/finder/usan/search/GH-179/relevant/1/", "code_system": "USAN", "references": [ "1848d3e2-7339-b658-03c2-b5e8d156d9ce" ] }, { "uuid": "3381e3c8-2eb0-d24e-3f16-cbbf675ee717", "code": "100000174143", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "41de9dd0-4a94-5750-ecce-f7e6c5351e50" ] } ], "substance_class": "protein", "references": [ { "uuid": "bcb7bb67-e3ad-4a66-8f85-57d9dfa4f872", "citation": "USAN COUN 2019", "doc_type": "USANCOUN", "public_domain": true }, { "uuid": "5f79930e-f037-77a1-3533-ca1c96ae5360", "citation": "USAN 2019", "doc_type": "USANCOUN", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "2bf26eb5-8163-49e4-8823-a099be14f20e", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "b1b0d830-f000-4459-800d-5e02cd7ba796", "citation": "FDA_SRS", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "062989fd-6927-4a43-8e16-e512e82ff763", "citation": "http://www.nature.com/aps/journal/v34/n1/pdf/aps2012175a.pdf?WT.ec_id=APS-201301", "url": "http://www.nature.com/aps/journal/v34/n1/pdf/aps2012175a.pdf?WT.ec_id=APS-201301", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "939953ac-5e61-4647-9f2c-b58de628b5bc", "citation": "stn", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "452e1aae-2379-4bfd-937e-385c79b8ad2c", "citation": "STN (SCIFINDER)", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "76e3e223-ac3a-45cb-abfe-3a3405bde2b7", "citation": "orphan drug", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "31202371-f0a3-48b3-a2eb-c831b18af8eb", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493392500000, "tags": [ "NOMEN" ] }, { "uuid": "68d4b5a0-a5cd-48ac-9d2e-9ac97945e46a", "citation": "SRS import [D45TI2TWMA]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=D45TI2TWMA", "doc_type": "SRS", "public_domain": true, "document_date": 1493392500000, "tags": [ "NOMEN" ] }, { "uuid": "75a42ae3-215f-4fcd-91bd-69d434c71011", "citation": "STN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "6b9009d3-92cf-f2af-9ef5-631176313b0a", "citation": "INN Proposed List 119", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL119.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1848d3e2-7339-b658-03c2-b5e8d156d9ce", "citation": "USAD COUN", "doc_type": "USANCOUN", "public_domain": true }, { "uuid": "bc6932c3-ff80-9d93-09c8-b7630e2ae9bf", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "07e9c5d1-e1e1-39bb-eb46-c88ee9327932", "citation": "USAN", "doc_type": "USANCOUN", "public_domain": true }, { "uuid": "1ef667e8-63dd-0d4d-f108-98c09dd5a666", "citation": "PUBCHEM", "doc_type": "PUBCHEM", "public_domain": true }, { "uuid": "1ba8afcc-d55b-8430-367e-42c5a55f5790", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "41de9dd0-4a94-5750-ecce-f7e6c5351e50", "citation": "SMS", "doc_type": "EMA LIST", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "17b9e113-ba4c-4bfa-ad42-29c389ed2cc8", "version": "27", "unii": "D45TI2TWMA", "relationships": [ { "uuid": "a3af20b9-71aa-45aa-804c-0edd695bc64e", "comments": "neurological agent", "type": "ACTIVE MOIETY", "references": [ "6b9009d3-92cf-f2af-9ef5-631176313b0a" ], "related_substance": { "uuid": "d2482e2b-9479-4150-8d50-bcdc0399b696", "refuuid": "17b9e113-ba4c-4bfa-ad42-29c389ed2cc8", "name": "NERINETIDE", "unii": "D45TI2TWMA", "linking_id": "D45TI2TWMA", "ref_pname": "NERINETIDE", "substance_class": "reference" } }, { "uuid": "6658066d-bfed-42d4-8bc9-ce0f63238fd1", "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "69c4ab01-4fbf-408a-8b02-d758cf916c86", "refuuid": "2863d3a9-0b3f-e70f-505e-8185a717a4e8", "name": "NERINETIDE HYDROCHLORIDE", "unii": "PLO8CTF5WR", "linking_id": "PLO8CTF5WR", "ref_pname": "NERINETIDE HYDROCHLORIDE" } }, { "uuid": "94ccc2a4-6adc-485a-be86-f9e4441da896", "type": "SALT/SOLVATE->PARENT", "references": [ "bcb7bb67-e3ad-4a66-8f85-57d9dfa4f872" ], "related_substance": { "uuid": "ea85284e-495c-4b34-bb1a-5185e1a40536", "refuuid": "aa2cd7c3-74a7-404c-91d2-56fa0e0b30a9", "name": "NERINETIDE ACETATE", "unii": "X90D3LLT2N", "linking_id": "X90D3LLT2N", "ref_pname": "NERINETIDE ACETATE" } }, { "uuid": "8d3f1113-b362-4c84-bd1f-7f74cc088b9b", "type": "SUBSTANCE->SUB_ALTERNATE", "related_substance": { "uuid": "102f8257-ae9a-48ef-8341-62f597ba73e9", "refuuid": "74f65fe0-6d71-47b7-acf1-c38cecd35aea", "name": "ALTERNATIVE DEFINITION for [NERINETIDE]", "linking_id": "74f65fe0-6d71-47b7-acf1-c38cecd35aea", "ref_pname": "NO NAME" } } ], "names": [ { "uuid": "71f5538e-6e5d-1009-88f3-2cf6aa8cc95d", "name": "FN-023", "stdName": "FN-023", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "5f79930e-f037-77a1-3533-ca1c96ae5360" ], "display_name": false }, { "uuid": "26b5b947-da51-fb67-f9bf-ef7c2e1eeeae", "name": "FN023", "stdName": "FN023", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "5f79930e-f037-77a1-3533-ca1c96ae5360" ], "display_name": false }, { "uuid": "d6b5eb27-29c1-4eb4-8bca-78f2d4fbab1e", "name": "H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-SER-ASP-VAL-OH", "stdName": "H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-SER-ASP-VAL-OH", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "76e3e223-ac3a-45cb-abfe-3a3405bde2b7", "452e1aae-2379-4bfd-937e-385c79b8ad2c" ], "display_name": false }, { "uuid": "b097135c-6843-51f4-04e2-053707d2f7c3", "name": "L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-VALINE", "stdName": "L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA.-ASPARTYL-L-VALINE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "bcb7bb67-e3ad-4a66-8f85-57d9dfa4f872" ], "display_name": false }, { "uuid": "acc31ec9-4030-4b1d-a3a1-2359b617c615", "name": "L-VALINE, L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA.-ASPARTYL-", "stdName": "L-VALINE, L-TYROSYLGLYCYL-L-ARGINYL-L-LYSYL-L-LYSYL-L-ARGINYL-L-ARGINYL-L-GLUTAMINYL-L-ARGINYL-L-ARGINYL-L-ARGINYL-L-LYSYL-L-LEUCYL-L-SERYL-L-SERYL-L-ISOLEUCYL-L-.ALPHA.-GLUTAMYL-L-SERYL-L-.ALPHA.-ASPARTYL-", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "939953ac-5e61-4647-9f2c-b58de628b5bc", "452e1aae-2379-4bfd-937e-385c79b8ad2c" ], "display_name": false }, { "uuid": "2193aafc-ba61-4afe-be5c-c2f71bec0f85", "name": "NA-1", "stdName": "NA-1", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "062989fd-6927-4a43-8e16-e512e82ff763" ], "display_name": false }, { "uuid": "a80ca404-b775-e9bd-82e2-f918f665ecc7", "name": "NERINETIDE", "stdName": "NERINETIDE", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "6b9009d3-92cf-f2af-9ef5-631176313b0a", "5f79930e-f037-77a1-3533-ca1c96ae5360" ], "display_name": true, "domains": [ "drug" ], "name_orgs": [ { "uuid": "6db5b76c-92cf-40e7-b1f6-3d716603c475", "name_org": "INN" }, { "uuid": "5d55f5f0-8d20-433c-b186-f624305eb7bd", "name_org": "USAN" } ] }, { "uuid": "9d7a4aa2-0fd5-9cf1-b532-66c0bd07917f", "name": "NERINETIDE [USAN]", "stdName": "NERINETIDE [USAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "5f79930e-f037-77a1-3533-ca1c96ae5360" ], "display_name": false, "domains": [ "drug" ], "name_orgs": [ { "uuid": "73b3c0fe-7184-4faa-a1d5-32a72aa77f93", "name_org": "USAN" } ] }, { "uuid": "5a479dbb-d3ca-4477-91cf-669c70c01492", "name": "TAT-NR2B9C", "stdName": "TAT-NR2B9C", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "939953ac-5e61-4647-9f2c-b58de628b5bc", "452e1aae-2379-4bfd-937e-385c79b8ad2c" ], "display_name": false }, { "uuid": "bd317304-26dc-4dd4-89dc-adee520050ed", "name": "TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-SER-ASP-VAL", "stdName": "TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-LYS-LEU-SER-SER-ILE-GLU-SER-ASP-VAL", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "b1b0d830-f000-4459-800d-5e02cd7ba796" ], "display_name": false }, { "uuid": "16ec403b-b56a-2f9b-ad8e-9a80fe8721bc", "name": "nerinetide [INN]", "stdName": "NERINETIDE [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6b9009d3-92cf-f2af-9ef5-631176313b0a" ], "display_name": false } ], "protein": { "uuid": "854d0129-3d89-4f62-b593-7809ef55ce8b", "glycosylation": { "uuid": "d1b972d0-21a7-4a43-a689-6f463fdd5b0b" }, "subunits": [ { "uuid": "b85de9da-b9c1-4e3d-9295-542cde20722d", "sequence": "YGRKKRRQRRRKLSSIESDV", "subunit_index": 1 } ], "references": [ "75a42ae3-215f-4fcd-91bd-69d434c71011", "68d4b5a0-a5cd-48ac-9d2e-9ac97945e46a", "6b9009d3-92cf-f2af-9ef5-631176313b0a" ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "621a4957-774f-4fff-bc54-626c66775c01", "name": "MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)", "type": "amount", "value": { "uuid": "9541120f-085c-4f42-af38-9568acb5c007", "type": "NUMBER AVERAGE", "average": 2519, "units": "Da" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "e6da5f45-bac0-4fbf-a05d-c7e142dfaff4", "name": "Molecular Formula", "value": { "uuid": "1ec212f0-bafb-46f0-98e9-448a78322e2c", "type": "ESTIMATED", "non_numeric_value": "C105H188N42O30" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "4cc478e8-fdf6-4bb0-86c1-5deb6bc86934" } } ] }