{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "2ae74807-c69c-4035-b103-616ac69fe03e",
          "code": "SUB129548",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "0977ebc8-05b7-84aa-4849-ee12055206c2"
          ]
        },
        {
          "uuid": "bddc7915-19ea-8e3e-98c0-8358132116fb",
          "code": "429",
          "type": "PRIMARY",
          "url": "https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=429",
          "code_system": "GRAS Notification (GRN No.)",
          "references": [
            "9db9a3aa-4f5f-5dd6-8cfa-46c4b7ccce38"
          ]
        },
        {
          "uuid": "4981e1a0-d9cf-4b41-82c9-04f3952b85ea",
          "code": "C89593O648",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "relationships": [
        {
          "uuid": "c5bd1bf4-6719-4826-8462-fcd0e033019e",
          "amount": {
            "uuid": "381e9638-6a71-417d-a61c-4cdd343461cf"
          },
          "type": "PARENT ORGANISM->INFRASPECIFIC",
          "references": [
            "fb19c777-450f-4d81-958d-dc54ef357c87"
          ],
          "related_substance": {
            "uuid": "4f55ff2b-4fe6-4030-b209-7f96a6b42112",
            "refuuid": "9115c0cd-6590-40cd-8d43-aee4dfa808ed",
            "name": "Lacticaseibacillus casei",
            "unii": "SA940P2U00",
            "linking_id": "SA940P2U00",
            "ref_pname": "Lacticaseibacillus casei",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "51dd3e06-539b-45cf-af71-8a09a91e7dfd",
          "amount": {
            "uuid": "1d88ef24-7420-4e4d-9720-2cebced39f70"
          },
          "type": "ACTIVE MOIETY",
          "references": [
            "78d6fea2-305c-4f18-938f-347261aa32a4"
          ],
          "related_substance": {
            "uuid": "cb7a0f48-2594-4ebd-8fea-f5975e5408b9",
            "refuuid": "6cf12bab-7195-44db-8772-956cc39c9f9a",
            "name": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
            "unii": "C89593O648",
            "linking_id": "C89593O648",
            "ref_pname": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "112b1384-a906-4e55-8026-b77ff4da8d01",
          "amount": {
            "uuid": "7256de1b-31ee-44ec-bb1d-7a54a6113142"
          },
          "type": "PROBIOTIC",
          "references": [
            "78d6fea2-305c-4f18-938f-347261aa32a4"
          ],
          "related_substance": {
            "uuid": "f842c8f5-db1c-4635-8b8e-994234600bc0",
            "refuuid": "6cf12bab-7195-44db-8772-956cc39c9f9a",
            "name": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
            "unii": "C89593O648",
            "linking_id": "C89593O648",
            "ref_pname": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
            "substance_class": "reference"
          }
        }
      ],
      "substance_class": "structurallyDiverse",
      "names": [
        {
          "uuid": "cdc15630-dc27-4dd1-b51b-834989f03d16",
          "name": "L. CASEI STRAIN SHIROTA",
          "stdName": "L. CASEI STRAIN SHIROTA",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fb19c777-450f-4d81-958d-dc54ef357c87",
            "8f7eaf20-c84d-47cc-85a0-4b7ce764fdde"
          ],
          "display_name": false
        },
        {
          "uuid": "866e4b63-2ca1-49b5-9139-da2e5b74b8d7",
          "name": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
          "stdName": "LACTICASEIBACILLUS CASEI STRAIN SHIROTA",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "392421a0-f3d2-4b3e-a652-dbdc98a39883"
          ],
          "display_name": true
        },
        {
          "uuid": "391dc96e-a73d-4fb3-a342-a5a9221e40aa",
          "name": "LACTOBACILLUS CASEI SHIROTA",
          "stdName": "LACTOBACILLUS CASEI SHIROTA",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fb19c777-450f-4d81-958d-dc54ef357c87",
            "8f7eaf20-c84d-47cc-85a0-4b7ce764fdde"
          ],
          "display_name": false
        },
        {
          "uuid": "619c62d5-48ab-443b-be2c-fe040e413f33",
          "name": "LACTOBACILLUS CASEI STRAIN SHIROTA",
          "stdName": "LACTOBACILLUS CASEI STRAIN SHIROTA",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "7b9f1dce-1790-4d02-8610-c6e6eea80e22"
          ],
          "display_name": false
        }
      ],
      "references": [
        {
          "uuid": "7b9f1dce-1790-4d02-8610-c6e6eea80e22",
          "citation": "https://en.wikipedia.org/wiki/Yakult",
          "url": "https://en.wikipedia.org/wiki/Yakult",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "fb19c777-450f-4d81-958d-dc54ef357c87",
          "citation": "https://en.wikipedia.org/wiki/Lactobacillus_casei",
          "url": "https://en.wikipedia.org/wiki/Lactobacillus_casei",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "8f7eaf20-c84d-47cc-85a0-4b7ce764fdde",
          "citation": "WEB PAGE",
          "doc_type": "WEB PAGE",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "0977ebc8-05b7-84aa-4849-ee12055206c2",
          "citation": "EVMPD",
          "doc_type": "EVMPD",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "392421a0-f3d2-4b3e-a652-dbdc98a39883",
          "citation": "https://isappscience.org/new-names-for-important-probiotic-lactobacillus-species/",
          "url": "https://isappscience.org/new-names-for-important-probiotic-lactobacillus-species/",
          "doc_type": "WEB PAGE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "9db9a3aa-4f5f-5dd6-8cfa-46c4b7ccce38",
          "doc_type": "SYSTEM",
          "public_domain": true
        },
        {
          "uuid": "78d6fea2-305c-4f18-938f-347261aa32a4",
          "citation": "Zhang, Xiaomei, et al. \"Effects of fermented milk containing Lacticaseibacillus paracasei strain shirota on constipation in patients with depression: A randomized, double-blind, placebo-controlled trial.\" Nutrients 13.7 (2021): 2238.",
          "url": "https://www.mdpi.com/2072-6643/13/7/2238",
          "doc_type": "JA",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "6cf12bab-7195-44db-8772-956cc39c9f9a",
      "version": "7",
      "structurally_diverse": {
        "uuid": "eda4f313-c73d-4080-a9d8-a8d3fd3e650b",
        "infra_specific_name": "SHIROTA",
        "infra_specific_type": "STRAIN",
        "organism_author": "NONE",
        "organism_family": "Lactobacillaceae",
        "organism_genus": "Lacticaseibacillus",
        "organism_species": "casei",
        "part": [
          "whole"
        ],
        "references": [
          "fb19c777-450f-4d81-958d-dc54ef357c87",
          "392421a0-f3d2-4b3e-a652-dbdc98a39883"
        ],
        "source_material_class": "ORGANISM",
        "source_material_state": "LIVE",
        "source_material_type": "BACTERIUM"
      },
      "modifications": {
        "uuid": "09a74c64-349b-4a08-a27c-1827f4e233e9"
      },
      "unii": "C89593O648"
    }
  ]
}