{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-09-09",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "cef508cd-edc1-48ee-bd18-d66a573da3ba",
          "code": "492990-36-0",
          "type": "GENERIC (FAMILY)",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=492990-36-0",
          "code_system": "CAS"
        },
        {
          "uuid": "3a0dc9d9-743c-4028-883e-16baa2a05955",
          "code": "8YD927SYG7",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "08fbbc04-65fb-42e8-8abb-561f5b22d3a7",
          "citation": "UNIPROT",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "366b2308-fc1e-4d1d-8c71-f3612757fb34",
          "citation": "UNIPROT",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "151c1748-8963-4612-8c27-0fa94a7f12a2",
          "citation": "PCPC-DB",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "1ae8f3c6-638e-40ee-930b-af985d29909a",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493392801000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "e81f8f54-6190-420e-be5d-7c6a09658fb7",
          "citation": "SRS import [8YD927SYG7]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=8YD927SYG7",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493392801000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "747cb1c4-829d-42f9-99c4-c4fc9ee9a977",
          "citation": "SH-POLYPEPTIDE-70 [INCI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "932cb7c8-bc14-4208-a6bc-121b382a8580",
          "citation": "INN Proposed List 109",
          "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL109.pdf",
          "doc_type": "INN_LIST",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "cff1f9d3-605e-4bb5-97c5-d6bc794b9f57",
          "citation": "Jiang, Jian-kang, et al. \"Discovery of 3-(4-sulfamoylnaphthyl) pyrazolo [1, 5-a] pyrimidines as potent and selective ALK2 inhibitors.\" Bioorganic & medicinal chemistry letters 28.20 (2018): 3356-3362.",
          "url": "https://www.sciencedirect.com/science/article/pii/S0960894X18307376",
          "doc_type": "JA",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "4699b043-6ab6-4ae6-88bb-a66fb944ad86",
      "version": "7",
      "unii": "8YD927SYG7",
      "relationships": [
        {
          "uuid": "de7ced56-ef01-4926-afed-719dab14123b",
          "comments": "Binds to 2 different types of serine-threonine kinase receptors known as BMPR1 and BMPR2.",
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "3c72e63b-2841-4f79-a2d3-8e649024188e",
            "refuuid": "91cd8c38-f1de-4eb3-834b-9c84520bc79d",
            "name": "HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4",
            "unii": "08RQ4CQ601",
            "linking_id": "08RQ4CQ601",
            "ref_pname": "HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4"
          }
        },
        {
          "uuid": "85b8a879-b5f4-4430-a861-591678f7062c",
          "amount": {
            "uuid": "d23ca1ef-9651-486e-b4d1-55eaffa65e52"
          },
          "type": "AGONIST->TARGET",
          "references": [
            "932cb7c8-bc14-4208-a6bc-121b382a8580"
          ],
          "related_substance": {
            "uuid": "bbee6bdd-f83a-462e-a07f-2f7fcdf38607",
            "refuuid": "0f54bcf2-a74f-4ce2-9cab-1136953503fa",
            "name": "NEBOTERMIN",
            "unii": "2X44YP3489",
            "linking_id": "2X44YP3489",
            "ref_pname": "NEBOTERMIN",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "866f987c-b61b-400d-8a56-54104bc24826",
          "amount": {
            "uuid": "a24a6e92-bb84-4918-bcf0-d5f71e5bd83d"
          },
          "type": "AGONIST->TARGET",
          "related_substance": {
            "uuid": "87cc59ea-8037-47fe-939a-94e3586b36a7",
            "refuuid": "45f18927-416a-4314-850d-5ebcdca84f09",
            "name": "DIBOTERMIN ALFA",
            "unii": "T472P45MG6",
            "linking_id": "T472P45MG6",
            "ref_pname": "DIBOTERMIN ALFA",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "619211f0-5c54-4a32-84af-0abbe4e090f5",
          "amount": {
            "uuid": "385db597-c723-4a09-95e9-f2f3d9fdd752",
            "average": 19,
            "units": "NANOMOLAR"
          },
          "qualification": "IC50",
          "type": "INHIBITOR->TARGET",
          "references": [
            "cff1f9d3-605e-4bb5-97c5-d6bc794b9f57"
          ],
          "related_substance": {
            "uuid": "a724e64c-956e-406a-86ca-94ff0d6dc494",
            "refuuid": "38875910-1825-40ff-ac09-ec5b09edc68e",
            "name": "LDN-193189",
            "unii": "W69H5YQU9O",
            "linking_id": "W69H5YQU9O",
            "ref_pname": "LDN-193189",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "58a84777-a9b3-418e-9ecd-d602c68d08fd",
          "name": "ACTIVIN RECEPTOR-LIKE KINASE 3",
          "stdName": "ACTIVIN RECEPTOR-LIKE KINASE 3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        },
        {
          "uuid": "a61e1033-46f7-492c-9ad0-615acddc8cb6",
          "name": "ALK-3",
          "stdName": "ALK-3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        },
        {
          "uuid": "7c4e0b87-74d9-79c5-6c96-ee2556ca2d31",
          "name": "ALK3",
          "stdName": "ALK3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34"
          ],
          "display_name": false
        },
        {
          "uuid": "0841cd5c-0ecd-4a38-b7ea-1169ceb16aad",
          "name": "BMPR-1A",
          "stdName": "BMPR-1A",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "151c1748-8963-4612-8c27-0fa94a7f12a2",
            "366b2308-fc1e-4d1d-8c71-f3612757fb34"
          ],
          "display_name": false
        },
        {
          "uuid": "7a782604-4e38-4647-8e9c-d0f4aa5f775a",
          "name": "BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A",
          "stdName": "BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": true
        },
        {
          "uuid": "62f1468e-c85d-46e2-8570-a90ce5644382",
          "name": "BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A (HUMAN)",
          "stdName": "BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A (HUMAN)",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        },
        {
          "uuid": "ffc501c5-51c7-49a6-bd95-35f251aa37aa",
          "name": "EC 2.7.11.30",
          "stdName": "EC 2.7.11.30",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        },
        {
          "uuid": "6f6dca7b-976b-494d-b06e-28f93dce7b11",
          "name": "JENHANCER 1",
          "stdName": "JENHANCER 1",
          "type": "bn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "151c1748-8963-4612-8c27-0fa94a7f12a2",
            "366b2308-fc1e-4d1d-8c71-f3612757fb34"
          ],
          "display_name": false
        },
        {
          "uuid": "2298093b-79fa-4b4d-a761-1d45e37470ce",
          "name": "SERINE/THREONINE-PROTEIN KINASE RECEPTOR R5",
          "stdName": "SERINE/THREONINE-PROTEIN KINASE RECEPTOR R5",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        },
        {
          "uuid": "11723b13-93af-4677-b1d3-c1acbce31615",
          "name": "SH-POLYPEPTIDE-70",
          "stdName": "SH-POLYPEPTIDE-70",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": true,
          "references": [
            "151c1748-8963-4612-8c27-0fa94a7f12a2",
            "747cb1c4-829d-42f9-99c4-c4fc9ee9a977",
            "366b2308-fc1e-4d1d-8c71-f3612757fb34"
          ],
          "display_name": false,
          "domains": [
            "cosmetic"
          ],
          "name_orgs": [
            {
              "uuid": "3369730f-ab76-430b-92f9-d7b476f74e58",
              "name_org": "INCI"
            }
          ]
        },
        {
          "uuid": "a6cf8d1e-4b5f-46c9-8b81-6f995d94bf80",
          "name": "SKR5",
          "stdName": "SKR5",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "366b2308-fc1e-4d1d-8c71-f3612757fb34",
            "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "953de598-d76a-49e3-81f6-311833a08165",
        "glycosylation": {
          "uuid": "fe76a43c-43b9-47e4-a088-bed6988341d6",
          "n_glycosylation_sites": [
            {
              "residue_index": 50,
              "subunit_index": 1
            }
          ]
        },
        "subunits": [
          {
            "uuid": "acdd3903-1718-455d-b2a2-b4531806ca3c",
            "sequence": "QNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI",
            "subunit_index": 1
          }
        ],
        "references": [
          "e81f8f54-6190-420e-be5d-7c6a09658fb7",
          "08fbbc04-65fb-42e8-8abb-561f5b22d3a7"
        ],
        "disulfide_links": [
          {
            "sites": [
              {
                "residue_index": 38,
                "subunit_index": 1
              },
              {
                "residue_index": 59,
                "subunit_index": 1
              }
            ]
          },
          {
            "sites": [
              {
                "residue_index": 40,
                "subunit_index": 1
              },
              {
                "residue_index": 44,
                "subunit_index": 1
              }
            ]
          },
          {
            "sites": [
              {
                "residue_index": 53,
                "subunit_index": 1
              },
              {
                "residue_index": 77,
                "subunit_index": 1
              }
            ]
          },
          {
            "sites": [
              {
                "residue_index": 87,
                "subunit_index": 1
              },
              {
                "residue_index": 101,
                "subunit_index": 1
              }
            ]
          },
          {
            "sites": [
              {
                "residue_index": 102,
                "subunit_index": 1
              },
              {
                "residue_index": 107,
                "subunit_index": 1
              }
            ]
          }
        ],
        "protein_sub_type": "",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "f56073f2-a75c-4e56-884b-e296f164dd74",
          "name": "MOL_WEIGHT:NUMBER(CALCULATED)",
          "type": "amount",
          "value": {
            "uuid": "ff85b971-576c-4063-910f-795986cf0a6a",
            "type": "ESTIMATED",
            "average": 57500,
            "units": "Da"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "fb7dd219-97ed-4a0e-8bc0-f540531a2a95",
          "name": "Molecular Formula",
          "value": {
            "uuid": "abbec7a1-9747-4b92-bc99-a7027f4f7021",
            "type": "ESTIMATED",
            "non_numeric_value": "C2536H3986N693O754S38"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "4d398f1c-3283-40f0-983c-9eb51428174f"
      }
    }
  ]
}