{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "1daa4e7e-4588-4b6b-b69b-efb2fc6f1aad",
          "code": "880633",
          "type": "PRIMARY",
          "url": "https://www.uniprot.org/taxonomy/880633",
          "code_system": "UNIPROT"
        },
        {
          "uuid": "ae7fccdc-5908-4a71-8b47-6870a264ab0a",
          "code": "880633",
          "type": "PRIMARY",
          "url": "https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=880633",
          "code_system": "NCBI TAXONOMY"
        },
        {
          "uuid": "cdc3bebd-b3e7-4217-b6b4-51f299366101",
          "code": "7GG6L4M8NF",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "43412aee-ed99-f602-b47e-f666a0d17787",
          "code": "300000055830",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "15ca67cc-07bd-0493-0312-c4ad83622cba"
          ]
        }
      ],
      "relationships": [
        {
          "uuid": "a3c1644d-1545-457b-a2c4-ad535e84678c",
          "amount": {
            "uuid": "0e3530ae-1459-47da-b08b-884f9f66e3d7"
          },
          "type": "PARENT ORGANISM->INFRASPECIFIC",
          "references": [
            "e7d2fc51-a385-480e-9d1b-9cb2b24870c9"
          ],
          "related_substance": {
            "uuid": "518c9882-22e6-40b0-88f3-d525f3966a80",
            "refuuid": "b6df3825-d3f6-42be-9766-b814f7bd25e5",
            "name": "LACTOBACILLUS HELVETICUS",
            "unii": "Q08Z44662J",
            "linking_id": "Q08Z44662J",
            "ref_pname": "LACTOBACILLUS HELVETICUS",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "a7a67efa-5ffe-45a1-9f35-bd3881686145",
          "amount": {
            "uuid": "25c5e27f-12be-4c4e-bef6-deb5b9586ab6"
          },
          "comments": "Psychobiotic reported to have positive effects in relieving depression.  ",
          "type": "PROBIOTIC",
          "references": [
            "e7d2fc51-a385-480e-9d1b-9cb2b24870c9"
          ],
          "related_substance": {
            "uuid": "bc1168c5-6625-446f-80bb-d3473b4d5df8",
            "refuuid": "59693594-8ac2-46cb-ad0f-15f7d300fdca",
            "name": "Lactobacillus helveticus R0052",
            "unii": "7GG6L4M8NF",
            "linking_id": "7GG6L4M8NF",
            "ref_pname": "Lactobacillus helveticus R0052",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "4fdd6dcd-abab-44e1-b9b4-afe70e970018",
          "amount": {
            "uuid": "a9672774-490c-4dea-a8e1-5a04e32651e5"
          },
          "type": "ACTIVE MOIETY",
          "references": [
            "e7d2fc51-a385-480e-9d1b-9cb2b24870c9"
          ],
          "related_substance": {
            "uuid": "78aa6c43-9770-472a-8f1d-27a2ab37e457",
            "refuuid": "59693594-8ac2-46cb-ad0f-15f7d300fdca",
            "name": "Lactobacillus helveticus R0052",
            "unii": "7GG6L4M8NF",
            "linking_id": "7GG6L4M8NF",
            "ref_pname": "Lactobacillus helveticus R0052",
            "substance_class": "reference"
          }
        }
      ],
      "substance_class": "structurallyDiverse",
      "names": [
        {
          "uuid": "39db73bb-42ad-407c-92f2-9484a1afd0e8",
          "name": "CEREBIOME component Lactobacillus helveticus R0052",
          "stdName": "CEREBIOME COMPONENT LACTOBACILLUS HELVETICUS R0052",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "b982c924-11c9-c46d-4a66-41e409bb2e5a"
          ],
          "display_name": false
        },
        {
          "uuid": "b372e1ef-a46f-4d5c-9c12-552756d13ede",
          "name": "L. helveticus R0052",
          "stdName": "L. HELVETICUS R0052",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "e7d2fc51-a385-480e-9d1b-9cb2b24870c9"
          ],
          "display_name": false
        },
        {
          "uuid": "a03624f0-1e33-df6f-a43e-831d95d7a7eb",
          "name": "LACTOBACILLUS HELVETICUS ROSELL-52 (R0052)",
          "stdName": "LACTOBACILLUS HELVETICUS ROSELL-52 (R0052)",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "2273575e-d366-156b-bfb7-483375740003"
          ],
          "display_name": false
        },
        {
          "uuid": "52adb7d5-e160-7663-a899-9dc7eee709f0",
          "name": "LACTOBACILLUS HELVETICUS STR. R0052",
          "stdName": "LACTOBACILLUS HELVETICUS STR. R0052",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "7affb874-9e9b-7bdf-1828-caf1f3cd7b1f"
          ],
          "display_name": false
        },
        {
          "uuid": "6262e2d0-684e-7f30-0be3-39eba185ba56",
          "name": "LH-R0052",
          "stdName": "LH-R0052",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "d34525ff-03e5-8ee2-2144-f8279609eaa4"
          ],
          "display_name": false
        },
        {
          "uuid": "715e6473-76a1-88f2-e6d5-9f5c0959e143",
          "name": "Lactobacillus helveticus R0052",
          "stdName": "LACTOBACILLUS HELVETICUS R0052",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "e6ee76e9-6250-f43c-de10-5d9ac611295b",
            "32d3974f-1305-0804-dad9-23ed788cf101"
          ],
          "display_name": true
        }
      ],
      "references": [
        {
          "uuid": "b982c924-11c9-c46d-4a66-41e409bb2e5a",
          "citation": "CLINICAL TRIALS",
          "url": "https://clinicaltrials.gov/ct2/show/NCT00796393",
          "doc_type": "CLINICAL_TRIALS.GOV",
          "public_domain": true
        },
        {
          "uuid": "2273575e-d366-156b-bfb7-483375740003",
          "citation": "FDA.GOV",
          "url": "https://www.fda.gov/media/122558/download",
          "doc_type": "WEB PAGE",
          "public_domain": true
        },
        {
          "uuid": "30ed28c8-e757-55f6-4b9a-38e6bd4f63f6",
          "citation": "PLOS",
          "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169847",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "0d382f82-3523-9551-157b-a5a7557719d0",
          "citation": "CLINICAL TRIALS",
          "url": "https://clinicaltrials.gov/ct2/show/NCT01709825",
          "doc_type": "CLINICAL_TRIALS.GOV",
          "public_domain": true
        },
        {
          "uuid": "8858c815-eee9-00f0-925f-432d31b8bba2",
          "citation": "CLINICAL TRIALS",
          "url": "https://clinicaltrials.gov/ct2/show/NCT02334644",
          "doc_type": "CLINICAL_TRIALS.GOV",
          "public_domain": true
        },
        {
          "uuid": "78765bc0-fe36-f760-7f60-3b85a78dc04b",
          "citation": "CLINICAL TRIALS",
          "url": "https://clinicaltrials.gov/ct2/show/NCT02215304",
          "doc_type": "CLINICAL_TRIALS.GOV",
          "public_domain": true
        },
        {
          "uuid": "7affb874-9e9b-7bdf-1828-caf1f3cd7b1f",
          "citation": "UNIPROT",
          "url": "https://www.uniprot.org/taxonomy/880633",
          "doc_type": "UNIPROT",
          "public_domain": true
        },
        {
          "uuid": "32d3974f-1305-0804-dad9-23ed788cf101",
          "citation": "CLINICAL TRIALS",
          "url": "https://clinicaltrials.gov/ct2/show/NCT02545634",
          "doc_type": "CLINICAL_TRIALS.GOV",
          "public_domain": true
        },
        {
          "uuid": "e6ee76e9-6250-f43c-de10-5d9ac611295b",
          "citation": "JOURNAL ARTICLES",
          "url": "https://www.ncbi.nlm.nih.gov/pubmed/20974015",
          "doc_type": "NCBI",
          "public_domain": true
        },
        {
          "uuid": "d34525ff-03e5-8ee2-2144-f8279609eaa4",
          "citation": "JOURNAL ARTICLE",
          "url": "https://www.ncbi.nlm.nih.gov/pubmed/28099447",
          "doc_type": "NCBI",
          "public_domain": true
        },
        {
          "uuid": "e7d2fc51-a385-480e-9d1b-9cb2b24870c9",
          "citation": "Messaoudi, Michaël, et al. \"Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers.\" Gut microbes 2.4 (2011): 256-261.",
          "url": "https://www.tandfonline.com/doi/abs/10.4161/gmic.2.4.16108",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "15ca67cc-07bd-0493-0312-c4ad83622cba",
          "citation": "SMS",
          "doc_type": "EMA LIST",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "59693594-8ac2-46cb-ad0f-15f7d300fdca",
      "version": "12",
      "structurally_diverse": {
        "uuid": "f6c0f438-07f8-4160-a375-8aac2d88f258",
        "infra_specific_name": "R0052",
        "infra_specific_type": "STRAIN",
        "organism_author": "(ORLA-JENSEN, 1919) BERGEY ET AL., 1925",
        "organism_family": "Lactobacillaceae",
        "organism_genus": "Lactobacillus",
        "organism_species": "helveticus",
        "part": [
          "whole"
        ],
        "references": [
          "e6ee76e9-6250-f43c-de10-5d9ac611295b",
          "d34525ff-03e5-8ee2-2144-f8279609eaa4"
        ],
        "source_material_class": "ORGANISM",
        "source_material_state": "LIVE",
        "source_material_type": "BACTERIUM"
      },
      "modifications": {
        "uuid": "b050da6f-db4c-415f-babf-d65c03f9c661"
      },
      "unii": "7GG6L4M8NF"
    }
  ]
}