{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "ade83a03-d07a-415f-a326-5cd381f0e6d2", "code": "4726", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4726", "code_system": "IUPHAR", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "e23cd72d-7ac9-4d6d-be2c-81245bf6ebda", "code": "DIGOXIN", "comments": "Description: Colourless crystals or a white or almost white, crystalline powder; odourless.Solubility: Practically insoluble in water and ether R; freely soluble in pyridine R; slightly soluble in ethanol (~750 g/l) TS.Category: Cardiotonic.Storage: Digoxin should be kept in a well-closed container, protected from light.Additional information: CAUTION: Digoxin is extremely poisonous and should be handled with care.Requirements : Definition. Digoxin contains not less than 95.0% and not more than 103.0% of C41H64O14, calculated with reference to the driedsubstance.", "type": "PRIMARY", "url": "http://apps.who.int/phint/pdf/b/Jb.6.1.141.pdf", "code_system": "WHO INTERNATIONAL PHARMACOPEIA", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "ac495b02-8713-4ff3-b1e4-7c88450f68af", "code": "C28990", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28990", "code_system": "NCI_THESAURUS", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "3cb7b14c-9ca0-4e0c-bfda-ec3383caa1a6", "code": "3407", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/3407/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "1509bfbe-c6f8-4823-a730-385b43c5ad25", "code": "m4456", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m4456?q=authorize", "code_system": "MERCK INDEX", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "9069d103-83d7-419f-aa42-23e6ab47bba3", "code": "DB00390", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00390", "code_system": "DRUG BANK", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "8f9d3bfe-12ef-4aa0-afee-8da6b922a67a", "code": "21 CFR 862.3320", "comments": "PART 862 -- CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES|Subpart D--Clinical Toxicology Test Systems|Sec. 862.3320 Digoxin test system.", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=862.3320", "code_system": "CFR", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "46802903-d435-40ab-bfbf-90caf2c927ce", "code": "CHEMBL1751", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1751", "code_system": "ChEMBL", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "026c6e25-7cd9-43ec-9c0a-f3fc6ecb7b2e", "code": "244-068-1", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.040.047", "code_system": "ECHA (EC/EINECS)", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "e1173988-53f4-41ba-ad31-5ec35469bebd", "code": "2724385", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/2724385", "code_system": "PUBCHEM", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "81511d38-272d-429c-9232-bbac26d6aa24", "code": "N0000008157", "comments": "Chemical Ingredients [Chemical/Ingredient]|Carbohydrates [Chemical/Ingredient]|Glycosides [Chemical/Ingredient]|Cardiac Glycosides [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000008157", "code_system": "NDF-RT", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "6cd91b59-e4c8-403f-8fbe-262b29dbdacd", "code": "N0000008157", "comments": "Chemical Ingredients [Chemical/Ingredient]|Polycyclic Compounds [Chemical/Ingredient]|Steroids [Chemical/Ingredient]|Cardanolides [Chemical/Ingredient]|Cardiac Glycosides [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000008157", "code_system": "NDF-RT", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "f3675b4e-242f-4577-b39a-d9939d110d27", "code": "C01AA05", "comments": "ATC|CARDIOVASCULAR SYSTEM|CARDIAC THERAPY|CARDIAC GLYCOSIDES|Digitalis glycosides|digoxin", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C01AA05&showdescription=yes", "code_system": "WHO-ATC", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "0f090f2f-ad0e-4771-a882-8ac9048888ea", "code": "N0000175568", "comments": "Established Pharmacologic Class [EPC]|Cardiac Glycoside [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175568", "code_system": "NDF-RT", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "1c25f657-ba4e-452c-adcb-c7e254fff8f3", "code": "QC01AA05", "comments": "VATC|CARDIAC THERAPY|CARDIAC GLYCOSIDES|Digitalis glycosides|digoxin", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC01AA05&showdescription=yes", "code_system": "WHO-VATC", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "2ee8c362-644f-4df4-90f8-8ef0c1ab2dbc", "code": "20830-75-5", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=20830-75-5", "code_system": "CAS", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827", "dc1716ee-e7aa-40be-b22e-b4dbe5957b48" ] }, { "uuid": "cb743160-60c5-4750-9b16-f68e15847184", "code": "D004077", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68004077", "code_system": "MESH", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "5bb80a62-e36b-44cb-bc7a-19a171c0c6c0", "code": "307", "comments": "LiverTox|Cardiac|Heart failure|Cardiac glycoside", "type": "PRIMARY", "url": "https://livertox.nlm.nih.gov/Digoxin.htm", "code_system": "LIVERTOX", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "6074ce3f-7465-4c99-a4c5-02720f3f25d0", "code": "DIGOXIN", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Digoxin", "code_system": "WIKIPEDIA", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "406e74fd-6c41-4480-8ed7-2877f0c2f533", "code": "12.2", "comments": "WHO ESSENTIAL MEDICINES LIST|Cardiovascular medicines|Antiarrhythmic medicines", "type": "PRIMARY", "url": "http://prais.paho.org/medicine/217/?section=92#type534", "code_system": "WHO-ESSENTIAL MEDICINES LIST", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "c258edd7-bd19-4887-a029-6febc30a140b", "code": "12.4", "comments": "WHO ESSENTIAL MEDICINES LIST|Cardiovascular medicines|Medicines used in heart failure", "type": "PRIMARY", "url": "http://prais.paho.org/medicine/217/?section=94#type534", "code_system": "WHO-ESSENTIAL MEDICINES LIST", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "3a769ef9-618e-4a2e-8e3a-23f12c0e5889", "code": "SUB07135MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "54c62282-a5b0-4eb9-b61d-97e7938d0a61", "code": "389", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=389", "code_system": "INN", "references": [ "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827" ] }, { "uuid": "0a1c62c0-4b3a-965f-9395-94485b72682f", "code": "214", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/214", "code_system": "HSDB", "references": [ "7c2253e1-a47b-8a4e-95d0-4f1865c880d5" ] }, { "uuid": "15a5292e-97b9-6d08-f46d-34a235822d56", "code": "DTXSID5022934", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID5022934", "code_system": "EPA CompTox", "references": [ "1a93606c-810f-ec7f-a4cf-17f3804eba8e" ] }, { "uuid": "e03153e3-19ac-1e8d-75b4-3110ad6e3427", "code": "C78322", "comments": "Pharmacologic Substance[C1909]|Agent Affecting Cardiovascular System[C78274]|Cardiotonic Agent", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C78322", "code_system": "NCI_THESAURUS", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "4a9a78a9-e2b7-e621-2cf7-c40cd6644823", "code": "C823", "comments": "Drug or Chemical by Structure[C1913]|Organic Chemical[C718]|Glycoside Compound[C45653]|Saponin", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C823", "code_system": "NCI_THESAURUS", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "c7bea184-b49d-4c77-82f9-8277b9dd83c4", "code": "73K4184T59", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "d6f4ba58-d8cb-1611-4315-4bf535e72f42", "code": "1200000", "type": "PRIMARY", "url": "https://store.usp.org/product/1200000", "code_system": "RS_ITEM_NUM", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "808f0113-402d-0add-4479-b3d4d5367af7", "code": "Digoxin", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/n/lactmed/LM93/", "code_system": "LACTMED", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "8b6d24ac-d046-1609-6712-830c5eef2ae8", "code": "882", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/882", "code_system": "DRUG CENTRAL", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "3d78ac26-9a68-6237-5421-78184decfb6a", "code": "145795", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:145795", "code_system": "CHEBI", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "b858c39d-19e6-be22-e700-bc8019fb9dda", "code": "4551", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:4551", "code_system": "CHEBI", "references": [ "4e7a6136-289f-f438-fa2b-52826f5e352e" ] }, { "uuid": "65fd1553-a40b-4a61-4471-3ce46d6fa0c8", "code": "95100", "type": "PRIMARY", "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=95100", "code_system": "NSC", "references": [ "598159d3-841d-6fb4-460b-616ff9e80c7b" ] }, { "uuid": "30a2e3a1-9ef1-36f1-bd4d-20c17f9a0968", "code": "100000091378", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "50cd498c-a044-429f-3a1e-ca1a9f34be00" ] }, { "uuid": "d9d5b839-a858-548d-3a12-8c011d812e9c", "code": "73K4184T59", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=73K4184T59", "code_system": "DAILYMED", "references": [ "c59dbfe8-2526-5d36-ac40-9568d64bb21e" ] } ], "substance_class": "chemical", "references": [ { "uuid": "4cc8f1bc-03c1-437f-b3d7-b3bbf0d5ad5c", "citation": "USP Dictionary 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "ba71b0c6-16e3-44a5-818c-f21e40ba9a6b", "citation": "USP DICTIONARY 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7fb9ad29-6134-4b6b-a84b-a236c05f0ec3", "citation": "INN Proposed List 4", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL04.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "4fab4d4f-47d7-4492-bf22-006672b0b11f", "citation": "EP 7.2", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "08834ecb-1f69-459a-824b-550546a1b5c2", "citation": "USP 33", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9cf659da-0614-4d0e-9e54-a403ffcc3a8d", "citation": "ORANGE BOOK 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "852ee355-d072-4d0f-9a2b-548b7e930276", "citation": "MARTINDALE 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "75f8e71b-37b9-4db9-97a9-d9d07489816f", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "45de3b0e-734d-4774-80e0-55b94d091b02", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "03d972cb-2173-437a-a4ce-86632fa3be3c", "citation": "USP/NF", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "21007b2d-262a-4f64-9c68-66570a2f6316", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "178f6c68-4161-40c9-a817-af805f5bff72", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "92e318c5-8768-46d9-bc53-b710a5bc5586", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "fd31175d-bac4-4485-9b1b-ee6076f48ad4", "citation": "WHO-IP", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1f1b2b83-cb92-4ea0-8f68-a0bba4a30827", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389680000, "tags": [ "NOMEN" ] }, { "uuid": "69800e8b-848f-4e9d-99ee-074a75918297", "citation": "ARCH INTERN MED. 1978;138(7):1074-1076", "url": "http://archinte.jamanetwork.com/article.aspx?articleid=588156", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7b8f2867-2912-40f2-909f-adc9f460dd79", "citation": "http://www.accessdata.fda.gov/spl/data/dc9c799a-3c8e-4860-891c-fc3fff243a85/dc9c799a-3c8e-4860-891c-fc3fff243a85.xml", "url": "http://www.accessdata.fda.gov/spl/data/dc9c799a-3c8e-4860-891c-fc3fff243a85/dc9c799a-3c8e-4860-891c-fc3fff243a85.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "600ae085-ca05-4463-b0db-1b0c2c6b47ad", "citation": "SRS import [73K4184T59]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=73K4184T59", "doc_type": "SRS", "public_domain": true, "document_date": 1493389680000, "tags": [ "NOMEN" ] }, { "uuid": "c023ef86-fab6-4b2b-befc-deb6dbf1cba0", "citation": "DIGOXIN [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "d3337ba3-4e3b-45fb-944c-9e9aa1dd78e5", "citation": "DIGOXIN [EP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "8b69cd84-f314-4acc-abcc-c4eac0a8eb51", "citation": "DIGOXIN [USP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "2c9a98b6-9dd7-4996-9007-372aefddd841", "citation": "DIGOXIN [ORANGE BOOK]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "70710fc0-b1a1-415a-b69c-8ae0a6ab9e7c", "citation": "DIGOXIN [MART.]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "0feb15b9-ae51-4ff6-ab81-3b5176ee194c", "citation": "DIGOXIN [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "26c2ed0a-fdcd-44c3-ad08-ab54497121f6", "citation": "DIGOXIN [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "0c502ee3-1a37-47e5-bffe-8656960ae466", "citation": "DIGOXIN [USP-RS]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "d40d40aa-661a-4293-bc58-219a66e8b432", "citation": "DIGOXIN [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b0c7368e-419e-4e7e-9568-e1b5aabd2e4e", "citation": "DIGOXIN [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "6d269b3d-5d56-47f8-8599-ae60c443ffb3", "citation": "DIGOXIN [WHO-IP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "90746984-7f08-b471-32b0-3172f0d5c8c5", "citation": "JAN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7c2253e1-a47b-8a4e-95d0-4f1865c880d5", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+20830-75-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1a93606c-810f-ec7f-a4cf-17f3804eba8e", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=20830-75-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "438b3690-535d-28dd-0eb2-a3118841fd11", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+lactmed:@term+@rel+@rn+20830-75-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "50cd498c-a044-429f-3a1e-ca1a9f34be00", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "dddda21a-3f87-f985-9ed2-c8a1b5c4bb03", "citation": "IARC", "doc_type": "IARC", "public_domain": true }, { "uuid": "4e7a6136-289f-f438-fa2b-52826f5e352e", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "dc1716ee-e7aa-40be-b22e-b4dbe5957b48", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "5db79fd9-972c-f0d4-7d74-56848a65a3f9", "citation": "USP 10/2020", "doc_type": "USPNF", "public_domain": true }, { "uuid": "f0c25dcb-d2e9-4d44-821a-8d29753dc9c3", "citation": "stn", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "793c7c95-4af7-4219-b842-7563ac3b8894", "citation": "stn", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9271c401-c86a-4bdf-8718-5a7b77f9dfce", "citation": "Josephs, Ralf Dieter, et al. \"Simultaneous determination of various cardiac glycosides by liquid chromatography–hybrid mass spectrometry for the purity assessment of the therapeutic monitored drug digoxin.\" Journal of Chromatography A 1217.27 (2010): 4535-4543.", "url": "https://www.sciencedirect.com/science/article/pii/S0021967310005637", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "6b745e13-bbc7-e09a-123d-688b1d75d5c9", "citation": "EP 10.5", "doc_type": "EP", "public_domain": true }, { "uuid": "598159d3-841d-6fb4-460b-616ff9e80c7b", "citation": "NCI", "doc_type": "NCI DRUG DICTIONARY", "public_domain": true }, { "uuid": "c59dbfe8-2526-5d36-ac40-9568d64bb21e", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "48b51ed4-8ba1-ce58-91c0-b0cba1f14e9a", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "7a000e1a-1f84-41b9-9615-09d32a176e90", "citation": "Kikuchi, Ryota, Sonia M. de Morais, and J. Cory Kalvass. \"In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class.\" Drug Metabolism and Disposition 41.12 (2013): 2012-2017.", "url": "https://dmd.aspetjournals.org/content/dmd/41/12/2012.full.pdf", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "32d9c95f-b1b4-4284-a556-90cf067330c9", "id": "32d9c95f-b1b4-4284-a556-90cf067330c9", "molfile": "\n Marvin 01132102432D \n\n 55 62 0 0 1 0 999 V2000\n 9.6042 -0.4378 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 10.0861 -1.0894 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 9.6042 -1.7342 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.7998 -1.4967 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 8.7964 -2.3111 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 8.0703 -1.9072 0.0000 C 0 0 2 0 0 0 0 0 0 1 0 0\n 8.0703 -2.7183 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.3439 -3.1256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 6.6347 -2.7183 0.0000 C 0 0 2 0 0 0 0 0 0 1 0 0\n 5.9186 -3.1256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1856 -2.7183 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 5.1856 -1.9072 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.9186 -1.4967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 6.6347 -1.9072 0.0000 C 0 0 1 0 0 0 0 0 0 2 0 0\n 6.6381 -1.0962 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.3439 -1.4967 0.0000 C 0 0 1 0 0 0 0 0 0 2 0 0\n 7.3439 -0.6787 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.0703 -0.2681 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 8.0703 0.5464 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 8.7998 -0.6787 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 8.7964 0.1357 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.4831 -3.1561 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 3.7603 -3.5668 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 3.7603 -4.3779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0408 -4.7885 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 3.0408 -5.5997 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.3146 -4.3779 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 1.5882 -4.7783 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8621 -4.3711 0.0000 C 0 0 1 0 0 0 0 0 0 2 0 0\n 0.1425 -4.7783 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5870 -4.3711 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n -1.3134 -4.7816 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5870 -3.5499 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n -1.3100 -3.1392 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0294 -3.5498 0.0000 C 0 0 1 0 0 0 0 0 0 2 0 0\n -2.0294 -4.3608 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7556 -4.7715 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n -2.7556 -5.5860 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -3.4819 -4.3608 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n -4.2081 -4.7647 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -3.4819 -3.5498 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n -4.2048 -3.1392 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7556 -3.1392 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1323 -3.1459 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 0.1323 -2.3348 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8621 -3.5567 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.3146 -3.5668 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 1.5917 -3.1595 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0408 -3.1561 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 10.0453 0.2579 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 10.8836 0.2613 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 11.2162 0.9095 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 11.9730 1.2489 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 10.4525 1.3981 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 9.6652 0.8586 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0 0 0 0\n 20 1 1 0 0 0 0\n 1 50 1 1 0 0 0\n 2 3 1 0 0 0 0\n 4 3 1 0 0 0 0\n 4 5 1 1 0 0 0\n 6 4 1 0 0 0 0\n 4 20 1 0 0 0 0\n 6 7 1 6 0 0 0\n 16 6 1 0 0 0 0\n 8 7 1 0 0 0 0\n 9 8 1 0 0 0 0\n 9 10 1 6 0 0 0\n 9 14 1 0 0 0 0\n 11 10 1 0 0 0 0\n 11 12 1 0 0 0 0\n 11 22 1 1 0 0 0\n 12 13 1 0 0 0 0\n 14 13 1 0 0 0 0\n 14 15 1 1 0 0 0\n 14 16 1 0 0 0 0\n 16 17 1 1 0 0 0\n 18 17 1 0 0 0 0\n 18 19 1 1 0 0 0\n 20 18 1 0 0 0 0\n 20 21 1 1 0 0 0\n 23 22 1 1 0 0 0\n 24 23 1 0 0 0 0\n 49 23 1 0 0 0 0\n 25 24 1 0 0 0 0\n 25 26 1 6 0 0 0\n 25 27 1 0 0 0 0\n 27 28 1 6 0 0 0\n 27 47 1 0 0 0 0\n 29 28 1 1 0 0 0\n 30 29 1 0 0 0 0\n 46 29 1 0 0 0 0\n 31 30 1 0 0 0 0\n 31 32 1 6 0 0 0\n 33 31 1 0 0 0 0\n 33 34 1 6 0 0 0\n 33 44 1 0 0 0 0\n 35 34 1 1 0 0 0\n 36 35 1 0 0 0 0\n 43 35 1 0 0 0 0\n 37 36 1 0 0 0 0\n 37 38 1 6 0 0 0\n 37 39 1 0 0 0 0\n 39 40 1 6 0 0 0\n 39 41 1 0 0 0 0\n 41 42 1 1 0 0 0\n 41 43 1 0 0 0 0\n 44 45 1 1 0 0 0\n 44 46 1 0 0 0 0\n 47 48 1 1 0 0 0\n 47 49 1 0 0 0 0\n 51 50 2 0 0 0 0\n 55 50 1 0 0 0 0\n 52 51 1 0 0 0 0\n 53 52 2 0 0 0 0\n 54 52 1 0 0 0 0\n 54 55 1 0 0 0 0\nM END", "smiles": "C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@H]([C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)O)C4)O)O", "formula": "C41H64O14", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ABSOLUTE", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "078d27a6-15b0-410b-afff-af58789e0be0" }, "defined_stereo": 21, "ez_centers": 0, "molecular_weight": "780.94", "optical_activity": "UNSPECIFIED", "stereo_centers": 21 } ], "definition_level": "COMPLETE", "uuid": "45095b8b-e37d-43fb-b4a1-59deac2175d0", "version": "52", "structure": { "id": "b839ad86-5515-4a64-8656-deca34f7f2c4", "molfile": "\n Marvin 01132109322D \n\n 61 68 0 0 1 0 999 V2000\n 8.7998 -1.4967 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 8.7998 -0.6787 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 6.6347 -1.9072 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 7.3439 -1.4967 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 8.0703 -1.9072 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 9.6042 -0.4378 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 8.0703 -0.2681 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 10.0453 0.2579 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5870 -3.5499 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 2.3146 -4.3779 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 6.6347 -2.7183 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 5.9186 -1.4967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0294 -3.5498 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 0.8621 -4.3711 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 7.3439 -0.6787 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.7603 -3.5668 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 0.8621 -3.5567 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7556 -3.1392 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0408 -3.1561 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1425 -4.7783 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.7603 -4.3779 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0294 -4.3608 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 10.8836 0.2613 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0408 -4.7885 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n -0.5870 -4.3711 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n -3.4819 -4.3608 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 9.6042 -1.7342 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.3146 -3.5668 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 0.1323 -3.1459 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n -2.7556 -4.7715 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 11.2162 0.9095 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -3.4819 -3.5498 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n -1.3100 -3.1392 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5882 -4.7783 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1856 -1.9072 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 10.4525 1.3981 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 10.0861 -1.0894 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.0703 -2.7183 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1856 -2.7183 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 5.9186 -3.1256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 9.6652 0.8586 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.4831 -3.1561 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 7.3439 -3.1256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.7964 -2.3111 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 11.9730 1.2489 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 8.7964 0.1357 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.0703 0.5464 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -4.2081 -4.7647 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 3.0408 -5.5997 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -1.3134 -4.7816 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7556 -5.5860 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 6.6381 -1.0962 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1323 -2.3348 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5917 -3.1595 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -4.2048 -3.1392 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8621 -5.1856 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n -1.3066 -3.9570 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 4.4865 -3.9707 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 7.3439 -2.3111 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 8.0703 -1.0962 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 6.6347 -3.5330 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 2 1 1 0 0 0 0\n 3 4 1 0 0 0 0\n 4 5 1 0 0 0 0\n 5 1 1 0 0 0 0\n 6 2 1 0 0 0 0\n 7 2 1 0 0 0 0\n 6 8 1 1 0 0 0\n 9 25 1 0 0 0 0\n 10 24 1 0 0 0 0\n 11 43 1 0 0 0 0\n 12 3 1 0 0 0 0\n 13 33 1 0 0 0 0\n 14 34 1 0 0 0 0\n 15 4 1 0 0 0 0\n 16 42 1 0 0 0 0\n 17 14 1 0 0 0 0\n 18 13 1 0 0 0 0\n 19 16 1 0 0 0 0\n 20 14 1 0 0 0 0\n 21 16 1 0 0 0 0\n 22 13 1 0 0 0 0\n 23 8 2 0 0 0 0\n 24 21 1 0 0 0 0\n 25 20 1 0 0 0 0\n 26 30 1 0 0 0 0\n 27 1 1 0 0 0 0\n 28 19 1 0 0 0 0\n 29 17 1 0 0 0 0\n 30 22 1 0 0 0 0\n 31 23 1 0 0 0 0\n 32 18 1 0 0 0 0\n 9 33 1 6 0 0 0\n 10 34 1 6 0 0 0\n 35 12 1 0 0 0 0\n 36 41 1 0 0 0 0\n 37 27 1 0 0 0 0\n 38 5 1 0 0 0 0\n 39 40 1 0 0 0 0\n 40 11 1 0 0 0 0\n 41 8 1 0 0 0 0\n 39 42 1 1 0 0 0\n 43 38 1 0 0 0 0\n 1 44 1 1 0 0 0\n 45 31 2 0 0 0 0\n 2 46 1 1 0 0 0\n 7 47 1 1 0 0 0\n 26 48 1 6 0 0 0\n 24 49 1 6 0 0 0\n 25 50 1 6 0 0 0\n 30 51 1 6 0 0 0\n 3 52 1 1 0 0 0\n 29 53 1 1 0 0 0\n 28 54 1 1 0 0 0\n 32 55 1 1 0 0 0\n 14 56 1 6 0 0 0\n 13 57 1 6 0 0 0\n 16 58 1 6 0 0 0\n 4 59 1 6 0 0 0\n 5 60 1 1 0 0 0\n 11 61 1 1 0 0 0\n 37 6 1 0 0 0 0\n 7 15 1 0 0 0 0\n 11 3 1 0 0 0 0\n 36 31 1 0 0 0 0\n 39 35 1 0 0 0 0\n 28 10 1 0 0 0 0\n 9 29 1 0 0 0 0\n 26 32 1 0 0 0 0\nM END", "smiles": "C[C@@H]1[C@H]([C@H](C[C@@]([H])(O1)O[C@@H]2[C@@H](C)O[C@]([H])(C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@]([H])(C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@]([H])(CC[C@]6([H])[C@]5([H])C[C@H]([C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)O)C4)O)O", "formula": "C41H64O14", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ABSOLUTE", "defined_stereo": 21, "ez_centers": 0, "molecular_weight": "780.94", "optical_activity": "UNSPECIFIED", "references": [ "4cc8f1bc-03c1-437f-b3d7-b3bbf0d5ad5c", "600ae085-ca05-4463-b0db-1b0c2c6b47ad", "7fb9ad29-6134-4b6b-a84b-a236c05f0ec3" ], "stereo_centers": 21 }, "unii": "73K4184T59", "relationships": [ { "uuid": "a041425c-522c-4570-9228-ccd63f2c90ef", "amount": { "uuid": "86965788-2875-4907-90e1-5f1369fcef84" }, "type": "TRANSPORTER->SUBSTRATE", "related_substance": { "uuid": "15b1bf6e-20ee-41d2-81b4-d5374fb5ea43", "refuuid": "a996cecc-ab9e-45b6-8ea7-beebcabd3c8e", "name": "MDR-3", "unii": "GL0S96GM0A", "linking_id": "GL0S96GM0A", "ref_pname": "MDR-3", "substance_class": "reference" } }, { "uuid": "852e2a19-565a-4b57-8e8a-a46102fe9d11", "amount": { "uuid": "6c5bc84a-4b8b-42c8-9ef4-e3b990c9c281", "type": "WEIGHT PERCENT", "units": "%", "high_limit": 0.7, "non_numeric_value": "peak area" }, "qualification": "EP", "type": "ACTIVE MOIETY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "related_substance": { "uuid": "03cb25de-6e8f-49ba-bd54-bf64779ea313", "refuuid": "45095b8b-e37d-43fb-b4a1-59deac2175d0", "name": "Digoxin", "unii": "73K4184T59", "linking_id": "73K4184T59", "ref_pname": "Digoxin", "substance_class": "reference" } }, { "uuid": "f31d614f-bbe3-42d8-b477-cc1ccddeb846", "amount": { "uuid": "a26a1b05-b2e9-479c-892e-cbfe2d7faad9", "average": 35 }, "comments": "in vitro ER in the MDCK-MDR1 cell line from National Institutes of Health", "qualification": "EFFLUX RATIO", "type": "TRANSPORTER->SUBSTRATE", "references": [ "7a000e1a-1f84-41b9-9615-09d32a176e90" ], "related_substance": { "uuid": "38e0f12a-66a4-405d-9186-84f96045eae1", "refuuid": "3921aa0b-fd6d-40ec-9c07-d83e5c6f124a", "name": "MULTIDRUG RESISTANCE PROTEIN 1", "unii": "22ES734693", "linking_id": "22ES734693", "ref_pname": "MULTIDRUG RESISTANCE PROTEIN 1", "substance_class": "reference" } }, { "uuid": "5318385e-0f56-4293-aef5-5f82f48d76bd", "amount": { "uuid": "e3ce4c7a-c9da-4a8f-bb63-8b3c83339f6c" }, "qualification": "PLASMA", "type": "METABOLITE->PARENT", "interaction_type": "MAJOR", "related_substance": { "uuid": "d59d9019-5244-4ec0-8f02-671e21f91c6b", "refuuid": "d79c76bb-177a-4efa-892b-532a5439e57b", "name": "DIHYDRODIGOXIN", "unii": "42R45Q8ZZ2", "linking_id": "42R45Q8ZZ2", "ref_pname": "DIHYDRODIGOXIN", "substance_class": "reference" } }, { "uuid": "aca18562-a095-4a2b-8af1-cb747941ba48", "amount": { "uuid": "e4cf6c81-78ea-40fc-9b8f-1215bc85de34" }, "type": "METABOLITE->PARENT", "references": [ "7b8f2867-2912-40f2-909f-adc9f460dd79" ], "related_substance": { "uuid": "8e9c1451-4b2f-4abc-a7a6-555122cc3c86", "refuuid": "e6b606a7-630b-464f-878d-76ea78fffc69", "name": "DIGOXIGENIN", "unii": "NQ1SX9LNAU", "linking_id": "NQ1SX9LNAU", "ref_pname": "DIGOXIGENIN", "substance_class": "reference" } }, { "uuid": "910c9348-b223-4d05-8cf4-07e5a9571d81", "type": "METABOLITE->PARENT", "related_substance": { "uuid": "10e56797-d60a-4e7b-b1b9-6caa8cfe7b14", "refuuid": "dee144a0-6e8d-4d29-a08a-b050cbfc9b82", "name": "3-OXODIGOXIGENIN", "unii": "DVS6F48Y72", "linking_id": "DVS6F48Y72", "ref_pname": "3-OXODIGOXIGENIN", "substance_class": "reference" } }, { "uuid": "33afc1c2-aa0e-48a8-97f7-41f2670fc743", "type": "METABOLITE->PARENT", "related_substance": { "uuid": "048bb8a3-c0bb-4d18-b3fc-7d9f83c21810", "refuuid": "9020fb6c-04e3-43af-8dc8-92499c375c25", "name": "DIGOXIGENIN 3-O-SULFATE", "unii": "ZA62C2LB6X", "linking_id": "ZA62C2LB6X", "ref_pname": "DIGOXIGENIN 3-O-SULFATE", "substance_class": "reference" } }, { "uuid": "d47fd5e7-7701-409b-bfb2-fe64ac8bc7ba", "type": "METABOLITE->PARENT", "related_substance": { "uuid": "ebca3fc7-8835-41ca-b0cd-447670f70b85", "refuuid": "8661f62d-bab6-4147-8d16-967195fc8096", "name": "DIGOXIGENIN-3-GLUCURONIDE", "unii": "BE4K93LS8A", "linking_id": "BE4K93LS8A", "ref_pname": "DIGOXIGENIN-3-GLUCURONIDE", "substance_class": "reference" } }, { "uuid": "415504f4-b132-4aba-bffc-4e0ec383ab34", "type": "IMPURITY->PARENT", "related_substance": { "uuid": "dfcbbc0f-d4f2-4076-b606-6c308dee03e1", "refuuid": "20a4fca4-f750-468d-bdbc-b57320a5a910", "name": "LANATOSIDE C", "unii": "5RR3JFZ771", "linking_id": "5RR3JFZ771", "ref_pname": "LANATOSIDE C" } }, { "uuid": "912f17b2-f202-4626-9e4e-c580279de88e", "amount": { "uuid": "a8ee92c5-a9a3-49aa-8617-e2783f798338", "type": "WEIGHT PERCENT", "units": "%", "high_limit": 0.7, "non_numeric_value": "peak area" }, "type": "IMPURITY->PARENT", "related_substance": { "uuid": "179d89e9-ed35-4307-bdc4-d861b650ea18", "refuuid": "226f3eea-2abe-48bf-8c98-2aaa36b62541", "name": "GITOXIN", "unii": "VOR2TD6SO4", "linking_id": "VOR2TD6SO4", "ref_pname": "GITOXIN" } }, { "uuid": "e93c497f-7c38-4022-acf9-64b8d3bbe6bd", "type": "IMPURITY->PARENT", "related_substance": { "uuid": "eae952fe-602e-4260-9a55-801c80bbe307", "refuuid": "736dc98d-8b96-4f76-a341-cc300947860f", "name": "DIGINATIN", "unii": "41E2842504", "linking_id": "41E2842504", "ref_pname": "DIGINATIN" } }, { "uuid": "f26c7f92-f979-4632-8f0b-2de8b6abc784", "type": "IMPURITY->PARENT", "related_substance": { "uuid": "7ad3db86-2ad2-4270-9c0f-5506fcc94025", "refuuid": "a293e5de-1668-4ce4-8ed6-24352986f521", "name": "Digitoxin", "unii": "E90NZP2L9U", "linking_id": "E90NZP2L9U", "ref_pname": "Digitoxin" } }, { "uuid": "51ab9d0d-bae4-48f4-ab92-ec5eeb75832f", "type": "IMPURITY->PARENT", "related_substance": { "uuid": "22434c30-9836-45c5-a36c-973c5a9890e4", "refuuid": "6504a7db-7bde-48de-a1b4-c36091c2fa57", "name": ".BETA.-ACETYLDIGOXIN", "unii": "P7K44M64CW", "linking_id": "P7K44M64CW", "ref_pname": ".BETA.-ACETYLDIGOXIN" } }, { "uuid": "27ccc4c3-90ed-4152-992b-843f6c9377fb", "type": "IMPURITY->PARENT", "related_substance": { "uuid": "47d45536-9f52-4c4d-a5bb-241e8fe03fcc", "refuuid": "fe4c04d9-1e40-4ea8-bc1d-b25d8a44ea71", "name": "3.BETA.-(2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYLOXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE", "unii": "TP62PJG6J3", "linking_id": "TP62PJG6J3", "ref_pname": "3.BETA.-(2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYLOXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE" } }, { "uuid": "25fd424b-6432-49c8-a2ce-2cf64a2793eb", "amount": { "uuid": "d35ccfe7-74e1-4c33-9bf5-a1225459e0fa", "type": "WEIGHT PERCENT", "units": "%", "high_limit": 0.7, "non_numeric_value": "peak area" }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "related_substance": { "uuid": "0caa72c0-b60f-4e18-b385-94d5f6016a12", "refuuid": "e6b606a7-630b-464f-878d-76ea78fffc69", "name": "DIGOXIGENIN", "unii": "NQ1SX9LNAU", "linking_id": "NQ1SX9LNAU", "ref_pname": "DIGOXIGENIN" } }, { "uuid": "0933e406-6807-4471-a630-755f26eda71e", "amount": { "uuid": "8a07b9fe-b3b1-4f5f-8a1f-c449668cf0f6" }, "type": "IMPURITY->PARENT", "references": [ "793c7c95-4af7-4219-b842-7563ac3b8894", "9271c401-c86a-4bdf-8718-5a7b77f9dfce" ], "related_substance": { "uuid": "71868050-3091-4a82-ade5-6d69045fb3fe", "refuuid": "a4a07a66-be3d-49b0-bf34-5b31d809b975", "name": "DIGOXOSIDE", "unii": "5EJ5Y5DB53", "linking_id": "5EJ5Y5DB53", "ref_pname": "DIGOXOSIDE" } }, { "uuid": "797c79b5-81b9-49e9-86dd-410171a0fad5", "amount": { "uuid": "24f2bee2-c125-404c-a3bb-b550686f10bc" }, "type": "IMPURITY->PARENT", "references": [ "f0c25dcb-d2e9-4d44-821a-8d29753dc9c3" ], "related_substance": { "uuid": "2de4f299-087c-4f42-bee3-f4451008a14f", "refuuid": "0b5d4719-a9f7-44ed-aa90-01ee9affcb79", "name": "BISDIGOXIGENIN", "unii": "PPY8HS8NF3", "linking_id": "PPY8HS8NF3", "ref_pname": "BISDIGOXIGENIN" } } ], "names": [ { "uuid": "71ed23bc-d5e1-46ee-b47d-737e13df2f43", "name": "3.BETA.-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE", "stdName": "3.BETA.-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12.BETA.,14-DIHYDROXY-5.BETA.-CARD-20(22)-ENOLIDE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4cc8f1bc-03c1-437f-b3d7-b3bbf0d5ad5c" ], "display_name": false }, { "uuid": "d1c535a9-f685-4065-a972-50feb3731d49", "name": "CARD-20(22)-ENOLIDE, 3-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12,14-DIHYDROXY-,(3.BETA.,5.BETA.,12.BETA.)-", "stdName": "CARD-20(22)-ENOLIDE, 3-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-12,14-DIHYDROXY-,(3.BETA.,5.BETA.,12.BETA.)-", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4cc8f1bc-03c1-437f-b3d7-b3bbf0d5ad5c" ], "display_name": false }, { "uuid": "59ee1865-0046-65c7-18a8-1a848316e14e", "name": "DIGOXIN [EP MONOGRAPH]", "stdName": "DIGOXIN [EP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6b745e13-bbc7-e09a-123d-688b1d75d5c9" ], "display_name": false }, { "uuid": "5aa5f375-953c-4e31-b6a9-2f29719bca30", "name": "DIGOXIN [HSDB]", "stdName": "DIGOXIN [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "45de3b0e-734d-4774-80e0-55b94d091b02" ], "display_name": false }, { "uuid": "1017b4d0-84a5-98ec-f6a9-6d8a8fdf7611", "name": "DIGOXIN [IARC]", "stdName": "DIGOXIN [IARC]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "dddda21a-3f87-f985-9ed2-c8a1b5c4bb03" ], "display_name": false }, { "uuid": "b3c5d770-a8fb-4579-8a44-7596e61d8f8f", "name": "DIGOXIN [JAN]", "stdName": "DIGOXIN [JAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "90746984-7f08-b471-32b0-3172f0d5c8c5" ], "display_name": false }, { "uuid": "ae1bf366-0762-44a3-a19f-fbf7763a1a3b", "name": "DIGOXIN [MART.]", "stdName": "DIGOXIN [MART.]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "852ee355-d072-4d0f-9a2b-548b7e930276" ], "display_name": false }, { "uuid": "2963f203-6eef-4803-a5ae-afa714887107", "name": "DIGOXIN [MI]", "stdName": "DIGOXIN [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "75f8e71b-37b9-4db9-97a9-d9d07489816f" ], "display_name": false }, { "uuid": "f3f54f87-38c9-4073-8e64-575e2815bfa6", "name": "DIGOXIN [ORANGE BOOK]", "stdName": "DIGOXIN [ORANGE BOOK]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "9cf659da-0614-4d0e-9e54-a403ffcc3a8d" ], "display_name": false }, { "uuid": "bb5f5338-9807-0019-47f2-19fb8616f89b", "name": "DIGOXIN [USP MONOGRAPH]", "stdName": "DIGOXIN [USP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "5db79fd9-972c-f0d4-7d74-56848a65a3f9" ], "display_name": false }, { "uuid": "a4316236-b8a9-4f9d-8313-bd70af50aa8c", "name": "DIGOXIN [USP-RS]", "stdName": "DIGOXIN [USP-RS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "03d972cb-2173-437a-a4ce-86632fa3be3c" ], "display_name": false }, { "uuid": "566ccf61-2740-4150-8dbe-76caddce7ae6", "name": "DIGOXIN [VANDF]", "stdName": "DIGOXIN [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "178f6c68-4161-40c9-a817-af805f5bff72" ], "display_name": false }, { "uuid": "2670fca5-3e0d-485f-a916-f6798d353a0e", "name": "DIGOXIN [WHO-IP]", "stdName": "DIGOXIN [WHO-IP]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "fd31175d-bac4-4485-9b1b-ee6076f48ad4" ], "display_name": false }, { "uuid": "7766b852-333b-4410-8bcd-bb1364fd1d42", "name": "DIGOXINUM [WHO-IP LATIN]", "stdName": "DIGOXINUM [WHO-IP LATIN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "fd31175d-bac4-4485-9b1b-ee6076f48ad4" ], "display_name": false }, { "uuid": "08ddd179-5ecf-49fc-b15f-c162ec5fb4d0", "name": "DYNAMOS", "stdName": "DYNAMOS", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "fb6e0a40-be7e-4d3f-a3d3-b0dc7a3beaec", "name": "Digoxin", "stdName": "DIGOXIN", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "8b69cd84-f314-4acc-abcc-c4eac0a8eb51", "fd31175d-bac4-4485-9b1b-ee6076f48ad4", "26c2ed0a-fdcd-44c3-ad08-ab54497121f6", "21007b2d-262a-4f64-9c68-66570a2f6316", "70710fc0-b1a1-415a-b69c-8ae0a6ab9e7c", "178f6c68-4161-40c9-a817-af805f5bff72", "4fab4d4f-47d7-4492-bf22-006672b0b11f", "9cf659da-0614-4d0e-9e54-a403ffcc3a8d", "0feb15b9-ae51-4ff6-ab81-3b5176ee194c", "45de3b0e-734d-4774-80e0-55b94d091b02", "75f8e71b-37b9-4db9-97a9-d9d07489816f", "4cc8f1bc-03c1-437f-b3d7-b3bbf0d5ad5c", "c023ef86-fab6-4b2b-befc-deb6dbf1cba0", "7fb9ad29-6134-4b6b-a84b-a236c05f0ec3", "852ee355-d072-4d0f-9a2b-548b7e930276", "b0c7368e-419e-4e7e-9568-e1b5aabd2e4e", "0c502ee3-1a37-47e5-bffe-8656960ae466", "2c9a98b6-9dd7-4996-9007-372aefddd841", "d3337ba3-4e3b-45fb-944c-9e9aa1dd78e5", "03d972cb-2173-437a-a4ce-86632fa3be3c", "6d269b3d-5d56-47f8-8599-ae60c443ffb3", "d40d40aa-661a-4293-bc58-219a66e8b432", "08834ecb-1f69-459a-824b-550546a1b5c2" ], "display_name": true, "domains": [ "drug" ], "name_orgs": [ { "uuid": "8bcf8370-8daa-4b33-a1e9-fef69dbb5952", "name_org": "INN" } ] }, { "uuid": "3c4ec782-0786-698b-3fde-1ccc3a8368da", "name": "Digoxin [WHO-DD]", "stdName": "DIGOXIN [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "48b51ed4-8ba1-ce58-91c0-b0cba1f14e9a" ], "display_name": false }, { "uuid": "fd9b9480-eb34-4bdd-afed-487d131b8121", "name": "FARGOXIN", "stdName": "FARGOXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "2172c64c-f435-4090-900a-b7b1a1c92dcf", "name": "LANOCARDIN", "stdName": "LANOCARDIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "f47bfda8-6014-41eb-8848-c7231c2f7b67", "name": "LANOXIN", "stdName": "LANOXIN", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "ba71b0c6-16e3-44a5-818c-f21e40ba9a6b" ], "display_name": false }, { "uuid": "55acac61-c6f8-4752-9cd1-a92bb8e00a47", "name": "MAPLUXIN", "stdName": "MAPLUXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "874c2a52-9b28-46bf-989c-5f89ab2eb4af", "name": "NATIGOXIN", "stdName": "NATIGOXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "d21a2096-c59d-40bb-baf6-d85700e5f6d6", "name": "NSC-95100", "stdName": "NSC-95100", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "f910c48f-0110-4155-a583-a16bf3332659", "name": "ROUGOXIN", "stdName": "ROUGOXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "1b6e9e90-5552-450e-aac7-faa824dfa69d", "name": "STILLACOR-", "stdName": "STILLACOR-", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "3f155518-8c08-4348-8123-eca9bb758805", "name": "TOLOXIN", "stdName": "TOLOXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "bbb832b5-a5e3-4415-8e6f-9f343c5d1cb7", "name": "VANOXIN", "stdName": "VANOXIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "92e318c5-8768-46d9-bc53-b710a5bc5586" ], "display_name": false }, { "uuid": "980d6654-1bf8-4e6d-8e64-64dd65f707b5", "name": "digoxin [INN]", "stdName": "DIGOXIN [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7fb9ad29-6134-4b6b-a84b-a236c05f0ec3" ], "display_name": false } ], "modifications": { "uuid": "24ddc291-fef6-4c71-981f-e79aacca5d86" } } ] }