{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-09-09",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "4dcaec4f-8097-4ea0-83a2-9e94a3e1130d",
          "code": "64224-21-1",
          "type": "PRIMARY",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=64224-21-1",
          "code_system": "CAS",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb",
            "f479e4f2-92aa-4c60-bfc3-b10cce066669"
          ]
        },
        {
          "uuid": "bae43e9e-fc3e-43cf-8550-bb714b63f84d",
          "code": "C1177",
          "type": "PRIMARY",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1177",
          "code_system": "NCI_THESAURUS",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "31cd62ef-f788-4d04-9624-cc23d4ade4e6",
          "code": "C026209",
          "type": "PRIMARY",
          "url": "http://www.ncbi.nlm.nih.gov/mesh/67026209",
          "code_system": "MESH",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "75efb536-b47e-40cb-9061-680580aecfd5",
          "code": "OLTIPRAZ",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/Oltipraz",
          "code_system": "WIKIPEDIA",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "a2f2aed9-1830-4f7c-a1ea-0ef4ac7295da",
          "code": "SUB09437MIG",
          "type": "PRIMARY",
          "code_system": "EVMPD",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "66d1c832-efc0-4a92-a39b-f40cd39fc214",
          "code": "4730",
          "type": "PRIMARY",
          "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=4730",
          "code_system": "INN",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "e73ca175-1518-40b0-9637-895b99ffc7c7",
          "code": "264-736-6",
          "type": "PRIMARY",
          "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.058.833",
          "code_system": "ECHA (EC/EINECS)",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "9e2e28fd-10cd-45f2-802d-f137217691d5",
          "code": "CHEMBL178459",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL178459",
          "code_system": "ChEMBL",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "d2d92f46-bc0a-464c-8cce-d495a0d4a123",
          "code": "47318",
          "type": "PRIMARY",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/47318",
          "code_system": "PUBCHEM",
          "references": [
            "cb614f91-9418-4ca5-b824-5bf0aae378cb"
          ]
        },
        {
          "uuid": "707d66e5-17cc-0931-0b89-9bb89edc9d09",
          "code": "DTXSID7021079",
          "type": "PRIMARY",
          "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021079",
          "code_system": "EPA CompTox",
          "references": [
            "f320a604-72cf-0b6c-a095-25ec1f374435"
          ]
        },
        {
          "uuid": "8f918b0b-f6e1-1dde-f1b5-e6f3c433f5bf",
          "code": "C1742",
          "comments": "Pharmacologic Substance[C1909]|Antineoplastic Agent[C274]|Angiogenesis Inhibitor",
          "codeText": "Pharmacologic Substance[C1909]|Antineoplastic Agent[C274]|Angiogenesis Inhibitor",
          "type": "CONCEPT",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1742",
          "code_system": "NCI_THESAURUS",
          "references": [
            "619aa8dd-fa4c-db4e-a27e-04ebb76a187b"
          ]
        },
        {
          "uuid": "ceecb456-8925-680e-a2de-204e4682a001",
          "code": "C54630",
          "comments": "Pharmacologic Substance[C1909]|Chemopreventive Agent[C1892]|Phase II Enzymes Inducer",
          "type": "CONCEPT",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C54630",
          "code_system": "NCI_THESAURUS",
          "references": [
            "619aa8dd-fa4c-db4e-a27e-04ebb76a187b"
          ]
        },
        {
          "uuid": "953ef285-8ce0-5192-db66-fc47140f641f",
          "code": "C54629",
          "comments": "Pharmacologic Substance[C1909]|Chemopreventive Agent[C1892]|Phase I Enzymes Inhibitor",
          "type": "CONCEPT",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C54629",
          "code_system": "NCI_THESAURUS",
          "references": [
            "619aa8dd-fa4c-db4e-a27e-04ebb76a187b"
          ]
        },
        {
          "uuid": "76041b1a-3721-4170-b382-eb49997bd5e6",
          "code": "6N510JUL1Y",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "1909bab9-dd56-8c47-643e-495e6335d23c",
          "code": "DB12539",
          "type": "PRIMARY",
          "url": "https://go.drugbank.com/drugs/DB12539",
          "code_system": "DRUG BANK",
          "references": [
            "619aa8dd-fa4c-db4e-a27e-04ebb76a187b"
          ]
        },
        {
          "uuid": "1043ec3c-5aa1-68b3-eadc-9a657d2ce4d6",
          "code": "77319",
          "type": "PRIMARY",
          "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:77319",
          "code_system": "CHEBI",
          "references": [
            "619aa8dd-fa4c-db4e-a27e-04ebb76a187b"
          ]
        },
        {
          "uuid": "5afbbb4f-b834-5a9f-3473-6a6c4b3bd696",
          "code": "100000083317",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "5ce9cff7-390d-e07c-0010-064fa913cb69"
          ]
        },
        {
          "uuid": "ed3abea1-540d-2c39-ead2-7f44ee552316",
          "code": "347901",
          "type": "PRIMARY",
          "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=347901",
          "code_system": "NSC",
          "references": [
            "5b3bdfb0-65cc-cf18-34cc-d9ac4f3a6935"
          ]
        }
      ],
      "relationships": [
        {
          "uuid": "77844db5-ae7c-48ce-b0bf-dad706142a96",
          "type": "ACTIVE MOIETY",
          "related_substance": {
            "uuid": "e409c79e-9861-40c3-b6bf-cc70aac91b9e",
            "refuuid": "c6b7a6c6-e3c4-4ff0-915e-d92a4d0e0f5c",
            "name": "OLTIPRAZ",
            "unii": "6N510JUL1Y",
            "linking_id": "6N510JUL1Y",
            "ref_pname": "OLTIPRAZ",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "ab5ed100-0b29-4746-9c53-4e226bd7b950",
          "type": "METABOLITE->PARENT",
          "references": [
            "5e86d829-c7df-435b-b1d6-bd0ab7a840d8"
          ],
          "related_substance": {
            "uuid": "391c64f6-78ca-4ff3-88e0-8cc210d2a72b",
            "refuuid": "28500578-8e88-49f1-8988-a41a09d7d59b",
            "name": "RP-36642",
            "unii": "TE5V0VLV9R",
            "linking_id": "TE5V0VLV9R",
            "ref_pname": "RP-36642"
          }
        }
      ],
      "substance_class": "chemical",
      "names": [
        {
          "uuid": "2045e52d-44a8-4d1e-8ed5-7c03f066cbde",
          "name": "4-METHYL-5-(PYRAZINYL)-3H-1,2-DITHIOLE-3-THIONE",
          "stdName": "4-METHYL-5-(PYRAZINYL)-3H-1,2-DITHIOLE-3-THIONE",
          "type": "sys",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f6824f01-7d0b-41fc-92ae-f7b99f24ad64"
          ],
          "display_name": false
        },
        {
          "uuid": "5c524d40-e775-47bd-a761-7511a59dbd59",
          "name": "NSC-347901",
          "stdName": "NSC-347901",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "3b7b06ba-8fc0-461a-819b-4931cb75e010"
          ],
          "display_name": false
        },
        {
          "uuid": "695e9519-39d0-4330-8986-35a7df087a42",
          "name": "OLTIPRAZ",
          "stdName": "OLTIPRAZ",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f6824f01-7d0b-41fc-92ae-f7b99f24ad64",
            "8da4c194-02d7-4be7-a7b0-9e75eabfe908",
            "446564ab-57ac-4cbf-80c0-8259b4e09a03",
            "d8fd082a-ea7d-49c0-a848-8f42e77d16c6",
            "d1ea132a-f63f-49f9-bb00-755c5a4443e1"
          ],
          "display_name": true,
          "domains": [
            "drug"
          ],
          "name_orgs": [
            {
              "uuid": "d9bfd062-2e30-43ef-bfbf-fca839939ba6",
              "name_org": "INN"
            }
          ]
        },
        {
          "uuid": "44b46ebd-8129-fd99-3089-f9e171bb9940",
          "name": "Oltipraz [WHO-DD]",
          "stdName": "OLTIPRAZ [WHO-DD]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "fd5540fe-9184-068f-d8a8-310901b70959"
          ],
          "display_name": false
        },
        {
          "uuid": "0bd9d66a-ee0b-4664-81fd-205df2c813c4",
          "name": "oltipraz [INN]",
          "stdName": "OLTIPRAZ [INN]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "d8fd082a-ea7d-49c0-a848-8f42e77d16c6"
          ],
          "display_name": false
        }
      ],
      "references": [
        {
          "uuid": "f6824f01-7d0b-41fc-92ae-f7b99f24ad64",
          "citation": "USP DICTIONARY 2008",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "d8fd082a-ea7d-49c0-a848-8f42e77d16c6",
          "citation": "INN Proposed List 43",
          "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL43.pdf",
          "doc_type": "INN_LIST",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "d1ea132a-f63f-49f9-bb00-755c5a4443e1",
          "citation": "WHO-DD",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "3b7b06ba-8fc0-461a-819b-4931cb75e010",
          "citation": "CHEMID",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "cb614f91-9418-4ca5-b824-5bf0aae378cb",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390463000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "b8430eba-f4b6-4322-ad95-45df4ce9b868",
          "citation": "SRS import [6N510JUL1Y]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=6N510JUL1Y",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493390463000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "8da4c194-02d7-4be7-a7b0-9e75eabfe908",
          "citation": "OLTIPRAZ [INN]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "446564ab-57ac-4cbf-80c0-8259b4e09a03",
          "citation": "OLTIPRAZ [WHO-DD]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "f320a604-72cf-0b6c-a095-25ec1f374435",
          "citation": "WEBSITE",
          "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=64224-21-1",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "5ce9cff7-390d-e07c-0010-064fa913cb69",
          "citation": "EU-SRS",
          "doc_type": "EMA LIST",
          "public_domain": true
        },
        {
          "uuid": "619aa8dd-fa4c-db4e-a27e-04ebb76a187b",
          "doc_type": "SYSTEM",
          "public_domain": true
        },
        {
          "uuid": "f479e4f2-92aa-4c60-bfc3-b10cce066669",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "5e86d829-c7df-435b-b1d6-bd0ab7a840d8",
          "citation": "Ko, Myong Suk, et al. \"DIFFERENTIAL EFFECTS OF THE OXIDIZED METABOLITES OF OLTIPRAZ ON THE ACTIVATION OF C/EBPβ AND NRF2 FOR GSTA2 GENE INDUCTION.\" Drug Metabolism and Disposition (2006).",
          "url": "http://dmd.aspetjournals.org/content/dmd/34/8/1353.full.pdf",
          "doc_type": "JA",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "5b3bdfb0-65cc-cf18-34cc-d9ac4f3a6935",
          "citation": "NCI",
          "doc_type": "NCI DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "fd5540fe-9184-068f-d8a8-310901b70959",
          "citation": "WHO-DD",
          "doc_type": "WHO DRUG DICTIONARY",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "moieties": [
        {
          "uuid": "1b465cd5-45cf-4d4b-b15f-56240d255d8d",
          "id": "1b465cd5-45cf-4d4b-b15f-56240d255d8d",
          "molfile": "\n  Marvin  01132101362D          \n\n 13 14  0  0  0  0            999 V2000\n    1.6837   -2.1496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.4468   -1.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.9231   -0.6951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.4391   -0.0335    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    0.6668   -0.2935    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    0.6642   -1.1121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.0000   -1.5859    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    2.7521   -0.7028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.1537   -1.4236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.9801   -1.4236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    4.3971   -0.7286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.0006    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.1820    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n  1  2  1  0  0  0  0\n  2  3  2  0  0  0  0\n  6  2  1  0  0  0  0\n  4  3  1  0  0  0  0\n  8  3  1  0  0  0  0\n  5  4  1  0  0  0  0\n  5  6  1  0  0  0  0\n  7  6  2  0  0  0  0\n  9  8  1  0  0  0  0\n 13  8  2  0  0  0  0\n 10  9  2  0  0  0  0\n 11 10  1  0  0  0  0\n 11 12  2  0  0  0  0\n 12 13  1  0  0  0  0\nM  END",
          "smiles": "Cc1c(-c2cnccn2)ssc1=S",
          "formula": "C8H6N2S3",
          "atropisomerism": "No",
          "charge": 0,
          "count": 1,
          "stereochemistry": "ACHIRAL",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "92d60ccc-1814-4578-abb4-158c3acdd964"
          },
          "defined_stereo": 0,
          "ez_centers": 0,
          "molecular_weight": "226.3452",
          "optical_activity": "NONE",
          "stereo_centers": 0
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "c6b7a6c6-e3c4-4ff0-915e-d92a4d0e0f5c",
      "version": "17",
      "structure": {
        "id": "aee90764-211d-440d-ac0c-f8a888d746b7",
        "molfile": "\n  Marvin  01132109042D          \n\n 13 14  0  0  0  0            999 V2000\n    1.9231   -0.6951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.4468   -1.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.4391   -0.0335    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    0.6642   -1.1121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.6668   -0.2935    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    2.7521   -0.7028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.0000   -1.5859    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0\n    3.1820    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    3.9801   -1.4236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    1.6837   -2.1496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.1537   -1.4236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.0006    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.3971   -0.7286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n  2  1  2  0  0  0  0\n  3  1  1  0  0  0  0\n  4  2  1  0  0  0  0\n  5  3  1  0  0  0  0\n  6  1  1  0  0  0  0\n  7  4  2  0  0  0  0\n  8  6  1  0  0  0  0\n  9 11  1  0  0  0  0\n 10  2  1  0  0  0  0\n 11  6  2  0  0  0  0\n 12  8  2  0  0  0  0\n 13  9  2  0  0  0  0\n  5  4  1  0  0  0  0\n 13 12  1  0  0  0  0\nM  END",
        "smiles": "Cc1c(-c2cnccn2)ssc1=S",
        "formula": "C8H6N2S3",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ACHIRAL",
        "defined_stereo": 0,
        "ez_centers": 0,
        "molecular_weight": "226.3452",
        "optical_activity": "NONE",
        "references": [
          "f6824f01-7d0b-41fc-92ae-f7b99f24ad64",
          "b8430eba-f4b6-4322-ad95-45df4ce9b868",
          "d8fd082a-ea7d-49c0-a848-8f42e77d16c6"
        ],
        "stereo_centers": 0
      },
      "unii": "6N510JUL1Y"
    }
  ]
}