{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "ecbf9f77-d1a1-4f0d-afb1-a93e97a32266", "code": "65P5WPF3BJ", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "structurallyDiverse", "references": [ { "uuid": "3b618bc5-3bd5-49d1-9f45-1ce2b9559667", "citation": "Bush, Karen, and Malcolm GP Page. \"What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles.\" Journal of pharmacokinetics and pharmacodynamics 44.2 (2017): 113-132.", "url": "https://link.springer.com/article/10.1007/s10928-017-9506-4", "doc_type": "JA", "public_domain": true }, { "uuid": "979cba80-30db-4ca1-9012-abb6ff74930b", "citation": "https://www.nuzyra.com/hcp/antimicrobial-activity", "url": "https://www.nuzyra.com/hcp/antimicrobial-activity", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c60e238d-bfe0-44f5-8bb4-300981b1b45d", "citation": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444182/pdf/e00120-17.pdf", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444182/pdf/e00120-17.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ad4b32b3-e277-476c-bcb2-0b897554ff2b", "citation": "https://www.destinypharma.com/platform/xf-73-exeporfinium-chloride/", "url": "https://www.destinypharma.com/platform/xf-73-exeporfinium-chloride/", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c45d80d9-12a9-4a3c-8fd5-06074037102c", "citation": "Sohng, Jae Kyung, et al. \"Production, isolation and biological activity of nargenicin from Nocardia sp. CS682.\" Archives of pharmacal research 31.10 (2008): 1339-1345.", "url": "https://link.springer.com/article/10.1007/s12272-001-2115-0", "doc_type": "JA", "public_domain": true }, { "uuid": "35f9d0c1-4bb2-2d93-36e3-579b8bbe64c6", "citation": "https://www.cdc.gov/mrsa/index.html", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "7f19cb5c-2e9c-07c6-4901-7ce440e7b5fe", "citation": "Catalog of Life 2009", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "7069b3ec-ff65-7ce3-1f98-9f89da10a378", "citation": "SRS import [O478WX4004]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=O478WX4004", "doc_type": "SRS", "public_domain": true, "document_date": 1493391218000, "tags": [ "NOMEN" ] }, { "uuid": "21cb828e-660d-fcc7-8141-611ad21435d3", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050717s009lbl.pdf", "doc_type": "FDA APPROVED DRUG LABEL", "public_domain": true }, { "uuid": "67e2016b-bcf3-433b-9e50-717fc9d209a2", "citation": "https://www.nabriva.com/Portals/_default/Skins/ProfessionalUs/pdfs/Poster_1218_ID%20Week%202017_Lefamulin%20S%20aureus%20pneumonia_FINAL.pdf", "doc_type": "MEETING ABSTRACT", "public_domain": true }, { "uuid": "7214d6d0-9931-4687-843c-caa892b4518f", "citation": "Brown, Nicholas M., et al. \"Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK.\" JAC-antimicrobial resistance 3.1 (2021): dlaa114.", "url": "https://watermark.silverchair.com/dlaa114.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtowggLWBgkqhkiG9w0BBwagggLHMIICwwIBADCCArwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMy6SFp7OTfoyaCiQyAgEQgIICjRQf07JTcBWr7NHuIFvhgaJft_dU2egqDlUQjFDUqXgAu-85TjBQK6gfBPpsFNz6EMEvcC0TdWvgOFM1utksoO6M15rJNgooC5jG8aaSzEQ2UzMDheXM-tzbK4auiadtYF3ApEXkSgbSZlMRbliDCQ6DKHt8i1WuSbqkQCCnvhXM0n3oSF8o43uDmM6SiQWuc6JQf-lwkxLYnrf-wQtg2kpBXcH8FjZk5RgX78QpYP2QCWIX4kNd047wI0j1u8PRsyXk0t09djorTnLJuUGR3BQCE2TharAEeNjV-kX9dAydVFuLcTlXt-iejRMp_6mNz0lxwOMkA03Y20OtGqs9FktspOiHRmDGlePSpXENdOaX-pT1H7VpZKvg6gKDvb1iiOZiX6gnTvK1rw0sQx2vrMB60nGxLc_AdXDiS0po2_Nabuehd8C6Yi1Y4jPlFMFqTrJ_6W6qLE7piUDSvyCCBWEa9qoOdBpSP1nb2jqH2iej8VrqO24m5U0tTQvA3CDly_65k2bv33hRUeYi6KxNNZv-sR8pni-_jFu1q5ZLB-A4AYVOTRuY24yiZfhThMEbbApC2UCowxX0WQhrbbcCcbZGyelaiGdhBXp_drwj4scNG0VIpu4yGgoV1zYKOzz0lt9q-ZHWjFCuzjOmZDTO2QylHCeUWjkDbJsr39GG_ilQgQqhno9w7Wy8-b-IlhU4ITjVhJ_68BtPHhFG8YTP-PaGfGgpd0ihl9StK6MU8-Q5bgouPWWHugpzUsbbHWiMfyKhHS23AMarvJcJ0AqyRmp_oJHQhofjSCt_iRT1rDbgby2FO-Gk2jySXx3OWCCb7csiqAWOXDqi8OFfLA404jZpGk-vsReoaAOkFuR3", "doc_type": "JA", "public_domain": true }, { "uuid": "6b311c8b-a158-421b-9a0d-c9c25710eb0f", "citation": "Jame, Wissal, Bilgen Basgut, and Abdikarim Abdi. \"Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis.\" PloS one 16.11 (2021): e0260539.", "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260539", "doc_type": "JA", "public_domain": true }, { "uuid": "d96be458-4fd3-41a8-90cf-09d33ae5d7d1", "citation": "Abate, Getahun, Grace Wang, and Jared Frisby. \"Ceftaroline: Systematic Review of Clinical Uses and Emerging Drug Resistance.\" Annals of Pharmacotherapy (2022): 10600280221082326.", "url": "https://journals.sagepub.com/doi/pdf/10.1177/10600280221082326?casa_token=m8ueSdpEUggAAAAA:M6hrrcAZAt_O_Y2YLrxSSqdy_x4F7tZFxz39LZqVlW17lK9xBBNBl75fxdhnK_AdbroFoUtCW4OA5w", "doc_type": "JA", "public_domain": true }, { "uuid": "9ee7f40f-9cd9-4f24-9a40-f65efae34167", "citation": "Feng, Jingjuan, et al. \"Comparative Efficacy and Safety of Vancomycin, Linezolid, Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven Complicated Skin and Soft Tissue Infections: An Updated Network Meta-Analysis.\" Infectious diseases and therapy 10.3 (2021): 1531-1547.", "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260539", "doc_type": "JA", "public_domain": true }, { "uuid": "9d41d869-cf57-4175-8573-7b78470a83e7", "citation": "Cellics Therapeutics Announces the Publication of Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity in Nano Letters", "url": "https://www.globenewswire.com/news-release/2020/06/17/2049506/0/en/Cellics-Therapeutics-Announces-the-Publication-of-Cellular-Nanosponges-Inhibit-SARS-CoV-2-Infectivity-in-Nano-Letters.html", "doc_type": "WEBSITE", "public_domain": true }, { "uuid": "31cff434-6a0e-4bbe-9cdb-ccd7b68dcf63", "citation": "Hoy SM. Contezolid: First Approval. Drugs. 2021 Sep;81(13):1587-1591. doi: 10.1007/s40265-021-01576-0. Erratum in: Drugs. 2021 Nov;81(16):1945. PMID: 34365606; PMCID: PMC8536612.", "url": "https://pubmed.ncbi.nlm.nih.gov/34365606/", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "0151ad96-1da7-4268-92e3-64d5cfa6252d", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "2b7b2fd5-0161-4671-9378-e797e31beddf", "citation": "https://journals.asm.org/doi/10.1128/AAC.05048-14", "url": "https://journals.asm.org/doi/10.1128/AAC.05048-14", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "5dea7b70-88b0-4ed5-af65-2456d0558c26", "citation": "https://www.sciencedirect.com/topics/medicine-and-dentistry/iclaprim#:~:text=In%20addition%2C%20iclaprim%20has%20demonstrated,and%20atypical%20bacteria%20%5B310%2C311%5D.", "url": "https://www.sciencedirect.com/topics/medicine-and-dentistry/iclaprim#:~:text=In%20addition%2C%20iclaprim%20has%20demonstrated,and%20atypical%20bacteria%20%5B310%2C311%5D.", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "feeb0bf2-05c5-4a40-95a4-5561ba119291", "citation": "https://www.japi.org/s2646464/garenoxacin#:~:text=of%20resistance%20development.-,Spectrum,and%201%20for%20MSSA%2C%20Strep.", "url": "https://www.japi.org/s2646464/garenoxacin#:~:text=of%20resistance%20development.-,Spectrum,and%201%20for%20MSSA%2C%20Strep.", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e417764e-7be3-492c-bfac-ed140e7ff40d", "citation": "Greer ND. Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics. Proc (Bayl Univ Med Cent). 2006 Apr;19(2):155-61. doi: 10.1080/08998280.2006.11928154. PMID: 16609746; PMCID: PMC1426172.", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426172/#:~:text=Tigecycline%20has%20been%20shown%20to,and%20Staphylococcus%20aureus%20(4).", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "750f8c1e-6e50-4168-a400-8f6547674057", "citation": "https://journals.asm.org/doi/10.1128/AAC.42.3.721", "url": "https://journals.asm.org/doi/10.1128/AAC.42.3.721", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "8c877218-f062-4ce0-a25b-71c2086cc8dc", "citation": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915564/pdf/antibiotics-10-00170.pdf", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915564/pdf/antibiotics-10-00170.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "70354ddf-a8bf-4356-86cc-b03700799dda", "citation": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981229/pdf/0267-10.pdf", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981229/pdf/0267-10.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "f3d2c33c-1c8f-4e97-8577-6465d33354f5", "citation": "https://pubs.acs.org/doi/10.1021/acs.joc.7b02318", "url": "https://pubs.acs.org/doi/10.1021/acs.joc.7b02318", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "3ce0248d-1f3c-4b07-aeb1-30ef399c9139", "citation": "https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/radezolid", "url": "https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/radezolid", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "39d79722-6f38-4c7d-b343-7e8803d62c3f", "citation": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488728/pdf/10.1177_8755122519834615.pdf", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488728/pdf/10.1177_8755122519834615.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "4b13a9bb-ca40-4715-aa1a-01b24bb6e1a7", "citation": "https://drugs.ncats.io/drug/312V80FR4J", "url": "https://drugs.ncats.io/drug/312V80FR4J", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ba5855f5-3a26-4464-b0b3-aae6d30d28c2", "citation": "https://drugs.ncats.io/drug/OZV2QPB39M", "url": "https://drugs.ncats.io/drug/OZV2QPB39M", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "139d0ed7-eb66-4b9e-9b39-05b43c06133e", "citation": "https://www.intechopen.com/chapters/68429", "url": "https://www.intechopen.com/chapters/68429", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "df0934ae-4266-407b-a77b-0682be2e5b70", "citation": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067199/pdf/0936-10.pdf", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067199/pdf/0936-10.pdf", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1c65acc4-3c2a-4b13-aa50-af7f57b6c310", "citation": "Martinelli, Nicolò, et al. \"The benefits of antimicrobial photodynamic therapy with RLP068 in the management of diabetic foot ulcers.\" Drugs in context 8 (2019).", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048156/", "doc_type": "JA", "public_domain": true }, { "uuid": "02f681a2-f48c-454f-952f-fcac8f6a9e27", "citation": "Ramoplanin: A Lipoglycodepsipeptide Antibiotic", "url": "Farver, Debra K., Dennis D. Hedge, and Steven C. Lee. \"Ramoplanin: a lipoglycodepsipeptide antibiotic.\" Annals of Pharmacotherapy 39.5 (2005): 863-868.", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "c1e28b44-c741-a8ba-cad6-cb4fe44c9eab", "version": "40", "unii": "65P5WPF3BJ", "relationships": [ { "uuid": "07af9c3e-4a21-4bd8-93b2-b0435123c926", "amount": { "uuid": "bbb6ac32-b62c-479c-90c1-d1d03cdee801" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "67e2016b-bcf3-433b-9e50-717fc9d209a2" ], "related_substance": { "uuid": "00b06901-9584-45d8-8cee-817b7f31148d", "refuuid": "3340dfae-3832-4067-9cf8-4f7cdbb3628f", "name": "LEFAMULIN", "unii": "21904A5386", "linking_id": "21904A5386", "ref_pname": "LEFAMULIN" } }, { "uuid": "9fd151c7-4e4e-41ce-b0f0-ec42e0bd5c19", "amount": { "uuid": "1cede7a7-7306-4cf9-88dc-334097d02fb2" }, "type": "INHIBITOR->TARGET ORGANISM", "related_substance": { "uuid": "cf49f464-ed06-4d80-ac46-5f5264677531", "refuuid": "0d39720e-a2ad-4ee2-a7be-c40f73413203", "name": "Levonadifloxacin", "unii": "8WHH66L098", "linking_id": "8WHH66L098", "ref_pname": "Levonadifloxacin", "substance_class": "reference" } }, { "uuid": "4fb01cd4-7b73-41f8-a3f7-351b4ba8be78", "amount": { "uuid": "5ce2582d-557e-4350-bf1d-357162c62e04" }, "type": "INHIBITOR->TARGET ORGANISM", "related_substance": { "uuid": "74bb92aa-33d0-47fb-a883-49fcac36d9f5", "refuuid": "b4270dee-01c3-4c0d-825c-020f63b3343f", "name": "ACORAFLOXACIN", "unii": "070SV15RJA", "linking_id": "070SV15RJA", "ref_pname": "ACORAFLOXACIN", "substance_class": "reference" } }, { "uuid": "cacb61a6-0531-49bb-a2df-fc611062fc9c", "amount": { "uuid": "93d352e3-1cfa-4042-b184-cf5e1c50c592" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "c60e238d-bfe0-44f5-8bb4-300981b1b45d" ], "related_substance": { "uuid": "a080e928-e43b-4447-a339-41098c7b0307", "refuuid": "30236abd-853d-4c81-8871-ffa4a4c09b8f", "name": "LASCUFLOXACIN", "unii": "55MOB566V7", "linking_id": "55MOB566V7", "ref_pname": "LASCUFLOXACIN", "substance_class": "reference" } }, { "uuid": "a9eda30d-ce66-4083-89ea-2c3da872bdbd", "amount": { "uuid": "5387958f-328a-45dc-af78-a8cf0313a1e8" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "4990675f-98c5-46da-8a1e-2101d784df39", "refuuid": "df5ebd55-c29f-4487-a1fa-faf3cd4a0730", "name": "DOXYCYCLINE", "unii": "N12000U13O", "linking_id": "N12000U13O", "ref_pname": "DOXYCYCLINE", "substance_class": "reference" } }, { "uuid": "aac71ffb-23a6-456e-8b6c-ccd07733551a", "amount": { "uuid": "7b87b635-8f83-4741-91e9-e6dd86f11e25" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "95d58d6e-c537-483c-9b00-3e606a3da632", "refuuid": "7bfba404-14d2-4ac6-89e6-b062ec66a8c1", "name": "DAPTOMYCIN", "unii": "NWQ5N31VKK", "linking_id": "NWQ5N31VKK", "ref_pname": "DAPTOMYCIN", "substance_class": "reference" } }, { "uuid": "107ec989-b125-44e2-9c7b-416c05e4aef9", "amount": { "uuid": "52296f33-4919-45c3-a964-824ae18e2f1f" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "f2ff00e4-d1a1-4f9b-b695-138f3004877c", "refuuid": "56a5959c-6a5f-4bb1-bd3a-f2d296887091", "name": "CLINDAMYCIN", "unii": "3U02EL437C", "linking_id": "3U02EL437C", "ref_pname": "CLINDAMYCIN", "substance_class": "reference" } }, { "uuid": "91886d8d-39c1-4651-b23a-3bf6b2946b68", "amount": { "uuid": "da77fa3d-5f80-4c43-9299-9185b6d111cb" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "37a7026c-05f5-4c53-8e09-e1f0e38ce6fe", "refuuid": "a4f83e40-c9db-4096-ab66-7d0c2493a304", "name": "LINEZOLID", "unii": "ISQ9I6J12J", "linking_id": "ISQ9I6J12J", "ref_pname": "LINEZOLID", "substance_class": "reference" } }, { "uuid": "7b007713-d6bf-4570-bd8f-8b05b9c3c641", "amount": { "uuid": "369eb0ff-f39f-4432-acef-0e6f202b2e71" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "ac9ec61b-4854-4454-b1b3-893f9159d98b", "refuuid": "c0145b5f-0f77-4810-9917-f89115347e45", "name": "Vancomycin", "unii": "6Q205EH1VU", "linking_id": "6Q205EH1VU", "ref_pname": "Vancomycin", "substance_class": "reference" } }, { "uuid": "c991a67d-c16f-4f1c-b3ea-6f354a2d27ee", "amount": { "uuid": "8075339c-69e7-4256-9335-5c8eb53d43d6" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "d896890c-418f-4cd3-8bf8-a3a29013e1b5", "refuuid": "0bc73c08-4702-4f9b-be5a-712b4fabab26", "name": "CHLORAMPHENICOL", "unii": "66974FR9Q1", "linking_id": "66974FR9Q1", "ref_pname": "CHLORAMPHENICOL", "substance_class": "reference" } }, { "uuid": "01d14f82-8bce-4349-b27a-0e190a228b8a", "amount": { "uuid": "05861908-5a42-40da-abe6-574ec8dee701" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "55ec2c35-8f9e-4a12-a385-d80e1279cab1", "refuuid": "19f91581-bb45-49bf-84eb-eb256e20eb7e", "name": "GENTAMICIN", "unii": "T6Z9V48IKG", "linking_id": "T6Z9V48IKG", "ref_pname": "GENTAMICIN", "substance_class": "reference" } }, { "uuid": "bf62f0d3-cf15-4698-ba2c-1410f6860071", "amount": { "uuid": "02859dce-be24-4b24-85e3-663bc3f5e94f" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "3ce0248d-1f3c-4b07-aeb1-30ef399c9139" ], "related_substance": { "uuid": "7465b819-2691-47d6-bf85-a0657b17fdde", "refuuid": "2949024d-ae68-4098-ae2b-204ab430df36", "name": "RADEZOLID", "unii": "53PC6LO35W", "linking_id": "53PC6LO35W", "ref_pname": "RADEZOLID", "substance_class": "reference" } }, { "uuid": "1a655991-f25e-4e88-b13b-749a2d043750", "amount": { "uuid": "3e6aa386-67f9-4a37-8441-24af2dc4cba0" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "f3d2c33c-1c8f-4e97-8577-6465d33354f5" ], "related_substance": { "uuid": "0e3de68c-03cb-4810-9c53-c4abccf2d824", "refuuid": "1afb2399-7b80-474e-9889-3e5c33ab5577", "name": "LOTILIBCIN", "unii": "XT4808181K", "linking_id": "XT4808181K", "ref_pname": "LOTILIBCIN", "substance_class": "reference" } }, { "uuid": "53b8a3fa-9d03-485b-9a14-b6ed89e8f38b", "amount": { "uuid": "a0a5290b-a5e5-4565-a0ac-2054b89da121" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "39d79722-6f38-4c7d-b343-7e8803d62c3f" ], "related_substance": { "uuid": "f2f58714-1eca-4796-bfde-bf0d5693a1bb", "refuuid": "d078c9f3-bcac-409e-849c-65d5455300cc", "name": "DELAFLOXACIN", "unii": "6315412YVF", "linking_id": "6315412YVF", "ref_pname": "DELAFLOXACIN", "substance_class": "reference" } }, { "uuid": "aead9a86-8314-48d9-b6be-aa81e108e0c5", "amount": { "uuid": "c1861ee8-133f-48ee-a065-4a6977460875" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "ad4b32b3-e277-476c-bcb2-0b897554ff2b" ], "related_substance": { "uuid": "3977779c-470f-43c7-85a6-0e25afd9897a", "refuuid": "c8ba2ca6-1019-4538-b219-38f906d1f9e0", "name": "EXEPORFINIUM", "unii": "R41ECT47G6", "linking_id": "R41ECT47G6", "ref_pname": "EXEPORFINIUM", "substance_class": "reference" } }, { "uuid": "bf572b32-a0f4-4c4a-abb7-5b8c0852be40", "amount": { "uuid": "00be67d3-7dcc-49fe-a1a8-37d3370e0c84" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "979cba80-30db-4ca1-9012-abb6ff74930b" ], "related_substance": { "uuid": "67138667-4215-4e52-acad-cf3a3f81e8d2", "refuuid": "e830b957-4b9e-4100-b413-5791e6689dfb", "name": "OMADACYCLINE", "unii": "090IP5RV8F", "linking_id": "090IP5RV8F", "ref_pname": "OMADACYCLINE", "substance_class": "reference" } }, { "uuid": "639158a5-8ba0-4ecf-ab3b-c6f45b9a9fb4", "amount": { "uuid": "5b9d9b97-433c-4d73-8d24-f077b0aa5226" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "3b618bc5-3bd5-49d1-9f45-1ce2b9559667" ], "related_substance": { "uuid": "24cca818-5575-48a6-8a53-9f88e229b3f0", "refuuid": "1c91bc6f-90d7-47da-8d30-2f393cd228a9", "name": "Gepotidacin", "unii": "DVF0PR037D", "linking_id": "DVF0PR037D", "ref_pname": "Gepotidacin", "substance_class": "reference" } }, { "uuid": "c48e19f8-c68d-40c9-9a2d-d0493c837430", "amount": { "uuid": "7089a5c5-ef3f-439c-9a5b-71d4d0cd1808" }, "type": "INHIBITOR->TARGET ORGANISM", "related_substance": { "uuid": "4fd05d9a-7103-4c79-9f49-7ab263f272d1", "refuuid": "457c6e3e-6e3f-4b97-8dbc-75937df85299", "name": "BRILACIDIN", "unii": "I1679X069H", "linking_id": "I1679X069H", "ref_pname": "BRILACIDIN", "substance_class": "reference" } }, { "uuid": "ed565f40-8737-4159-adb8-a4608d6f9191", "amount": { "uuid": "98247158-1e37-4df4-a6a6-e1c6a2eba166" }, "comments": "Efficacy and safety profiles of both dalbavancin and oritavancin were the same as vancomycin in the treatment of gram-positive bacterial infections in different clinical settings,", "type": "INHIBITOR->TARGET ORGANISM", "references": [ "6b311c8b-a158-421b-9a0d-c9c25710eb0f" ], "related_substance": { "uuid": "582f8818-45aa-4fe3-98d6-c228c0fea267", "refuuid": "ed686d5d-4854-4e16-a9da-74057b051125", "name": "DALBAVANCIN", "unii": "808UI9MS5K", "linking_id": "808UI9MS5K", "ref_pname": "DALBAVANCIN", "substance_class": "reference" } }, { "uuid": "065d1bfa-415a-46fd-9203-60ca7c69a4c6", "amount": { "uuid": "4b8f5f37-3766-4cb7-b8f5-af1318451ff4" }, "comments": "Efficacy and safety profiles of both dalbavancin and oritavancin were the same as vancomycin in the treatment of gram-positive bacterial infections in different clinical settings,", "type": "INHIBITOR->TARGET ORGANISM", "references": [ "6b311c8b-a158-421b-9a0d-c9c25710eb0f" ], "related_substance": { "uuid": "0f4ed510-93a8-4757-ae66-4461ab22b2bd", "refuuid": "20253039-7930-461e-9d56-ff0f4324509b", "name": "ORITAVANCIN", "unii": "PUG62FRZ2E", "linking_id": "PUG62FRZ2E", "ref_pname": "ORITAVANCIN", "substance_class": "reference" } }, { "uuid": "7671f0ad-7b19-4ea3-9e42-49cbd12de0fd", "amount": { "uuid": "943db25c-23d4-4b79-99cc-36184730ae1d" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "6b311c8b-a158-421b-9a0d-c9c25710eb0f" ], "related_substance": { "uuid": "366e1c79-db25-404d-b940-fa43d9a641b8", "refuuid": "d258bfc4-a022-4374-aece-705581dd523a", "name": "TELAVANCIN", "unii": "XK134822Z0", "linking_id": "XK134822Z0", "ref_pname": "TELAVANCIN", "substance_class": "reference" } }, { "uuid": "e6703bd3-3081-45ef-b57c-7191d34a4e33", "amount": { "uuid": "7320e9b4-3cac-41fe-b4b9-e00d2231600b" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "d96be458-4fd3-41a8-90cf-09d33ae5d7d1" ], "related_substance": { "uuid": "2f55866d-97a8-4fe5-a1de-18d9f2d9f883", "refuuid": "820e0c35-a48c-4fc0-9451-e8a2d6d97add", "name": "CEFTAROLINE", "unii": "H36Z0FHR8K", "linking_id": "H36Z0FHR8K", "ref_pname": "CEFTAROLINE", "substance_class": "reference" } }, { "uuid": "fcd9f7ee-0229-4841-85ef-93b2ce7378b3", "amount": { "uuid": "136f458a-aac9-43ca-9d87-70e899fcfb23" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "c45d80d9-12a9-4a3c-8fd5-06074037102c" ], "related_substance": { "uuid": "29c0bde4-60e2-4bde-9839-abc7e42aacb3", "refuuid": "b4f4e72c-5804-492f-a276-332ffef80e0b", "name": "TRIMETHOPRIM", "unii": "AN164J8Y0X", "linking_id": "AN164J8Y0X", "ref_pname": "TRIMETHOPRIM", "substance_class": "reference" } }, { "uuid": "2a5923f4-1e7e-4a3f-998a-d6e55a38751a", "amount": { "uuid": "64f5a4fe-5252-4ecc-a32d-e30fab77995f" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "7214d6d0-9931-4687-843c-caa892b4518f" ], "related_substance": { "uuid": "351e7e35-cd0e-4bb7-b429-e999248ce978", "refuuid": "0430384b-a445-4afb-9a34-beb393b2549c", "name": "SULFAMETHOXAZOLE", "unii": "JE42381TNV", "linking_id": "JE42381TNV", "ref_pname": "SULFAMETHOXAZOLE", "substance_class": "reference" } }, { "uuid": "36d2232a-444c-4d4e-82b0-9bd004f968b3", "amount": { "uuid": "c730a29d-d805-422b-bb0a-365972b51144" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "c45d80d9-12a9-4a3c-8fd5-06074037102c" ], "related_substance": { "uuid": "74b01376-6a17-47f4-bc9f-5b52eb2bd7d5", "refuuid": "ad28b49c-61c6-4c37-a9e2-410b920fa46a", "name": "Rifamycin", "unii": "DU69T8ZZPA", "linking_id": "DU69T8ZZPA", "ref_pname": "Rifamycin", "substance_class": "reference" } }, { "uuid": "8df54d22-70e1-4dd5-989b-e7ad86d9242d", "amount": { "uuid": "1bffbb43-a92d-4755-915c-21cf959b6e4d" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "9ee7f40f-9cd9-4f24-9a40-f65efae34167" ], "related_substance": { "uuid": "9c7970d3-73d4-4719-a5c9-e9a021d0fa33", "refuuid": "7fc33112-c1d9-4b17-8121-d2530195026d", "name": "TEDIZOLID", "unii": "97HLQ82NGL", "linking_id": "97HLQ82NGL", "ref_pname": "TEDIZOLID", "substance_class": "reference" } }, { "uuid": "5023eadf-e5df-4c9e-9254-6e7dfa26f133", "amount": { "uuid": "22681605-69c7-423a-9113-7df338a1040b" }, "type": "INHIBITOR->TARGET ORGANISM", "interaction_type": "PRECLINICAL", "references": [ "9d41d869-cf57-4175-8573-7b78470a83e7", "c45d80d9-12a9-4a3c-8fd5-06074037102c" ], "related_substance": { "uuid": "d8124b81-8b2e-48fb-9be6-eb056ed70ce1", "refuuid": "ddb6d23e-d075-40a8-bf5e-dcd19f073696", "name": "NARGENICIN", "unii": "XP2QP458K4", "linking_id": "XP2QP458K4", "ref_pname": "NARGENICIN", "substance_class": "reference" } }, { "uuid": "1bfe7cd1-8a5b-409a-8b08-5a82bef97265", "amount": { "uuid": "a91a1891-fca9-4eae-8488-0e0334acebbd" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "31cff434-6a0e-4bbe-9cdb-ccd7b68dcf63" ], "related_substance": { "uuid": "93a4dd9b-a016-4ebb-aaa9-b8c52fdebee4", "refuuid": "0590aa20-f9ba-42a5-8e65-2a3bb8b62860", "name": "CONTEZOLID", "unii": "B669M62ELP", "linking_id": "B669M62ELP", "ref_pname": "CONTEZOLID", "substance_class": "reference" } }, { "uuid": "bc762e7d-b69c-4625-97bd-ad78283ba1ce", "amount": { "uuid": "e40c4bdb-8c48-4bcf-b8b3-82911b7d3b97" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "0151ad96-1da7-4268-92e3-64d5cfa6252d" ], "related_substance": { "uuid": "7d5ef288-d2dd-4e22-acf6-2da3c2232347", "refuuid": "eb6822b6-0ce7-47b3-96f1-520fc9abab72", "name": "VOXVOGANAN", "unii": "HO813QDF65", "linking_id": "HO813QDF65", "ref_pname": "VOXVOGANAN", "substance_class": "reference" } }, { "uuid": "05d26650-a72d-45a0-8fe7-a33e5e6bb181", "amount": { "uuid": "7e902db2-b037-4648-8a60-645184732eeb" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "02f681a2-f48c-454f-952f-fcac8f6a9e27" ], "related_substance": { "uuid": "57db1745-a46f-4c14-90ff-762ca205b356", "refuuid": "46e942c6-6ae6-4a60-9c8e-84b253e583b5", "name": "RAMOPLANIN", "unii": "0WX9996O2G", "linking_id": "0WX9996O2G", "ref_pname": "RAMOPLANIN", "substance_class": "reference" } }, { "uuid": "2d3021a1-a9b8-417e-9a45-f0fd36779752", "amount": { "uuid": "70475f46-0fce-4f99-81a0-0acb33c28555" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "139d0ed7-eb66-4b9e-9b39-05b43c06133e" ], "related_substance": { "uuid": "46665d8a-7b6d-43fa-96ea-98da71301d56", "refuuid": "54d05af1-a05c-42fd-83f1-cf519b7f4326", "name": "NEMONOXACIN", "unii": "P94L0PVO94", "linking_id": "P94L0PVO94", "ref_pname": "NEMONOXACIN", "substance_class": "reference" } }, { "uuid": "1d219f85-37a1-4372-b57f-e3dbcf7800a0", "amount": { "uuid": "e66f775f-cae7-419f-b6bc-9b1f5aedeba9" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "750f8c1e-6e50-4168-a400-8f6547674057" ], "related_substance": { "uuid": "3f4adc49-536d-4f4c-9442-710793778605", "refuuid": "b14c71b0-2550-4656-9b83-85b01c0d9e08", "name": "EPEREZOLID", "unii": "C460ZSU1OW", "linking_id": "C460ZSU1OW", "ref_pname": "EPEREZOLID", "substance_class": "reference" } }, { "uuid": "839160d7-4f97-44f5-96ea-b34a514b8024", "amount": { "uuid": "1239bb2e-b09e-471d-9e59-afb046ab42fb" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "8c877218-f062-4ce0-a25b-71c2086cc8dc" ], "related_substance": { "uuid": "31b097b3-59bf-4c80-8570-3b11cf9c3e45", "refuuid": "806f66d8-d4e9-4b34-a156-19fafd3442f6", "name": "CEFTOBIPROLE", "unii": "5T97333YZK", "linking_id": "5T97333YZK", "ref_pname": "CEFTOBIPROLE", "substance_class": "reference" } }, { "uuid": "573bb802-91f1-4834-8dee-dcea7fc1d86d", "amount": { "uuid": "d93c22f3-5bf9-446c-8bc0-285ce0fc3342" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "df0934ae-4266-407b-a77b-0682be2e5b70" ], "related_substance": { "uuid": "57c56e42-3117-48ed-9b2f-49409a88e615", "refuuid": "c4c0b098-f2ea-44ac-ad93-a2f082425eb7", "name": "RAZUPENEM", "unii": "26020H3Q1L", "linking_id": "26020H3Q1L", "ref_pname": "RAZUPENEM", "substance_class": "reference" } }, { "uuid": "da6e4a8d-c27c-4e18-9417-f93ecb4c78df", "amount": { "uuid": "3886830d-6bab-4b79-b56e-bbbab7772261" }, "type": "INHIBITOR->TARGET ORGANISM", "related_substance": { "uuid": "045f4684-b2f1-4d5e-95a2-2b0a64985681", "refuuid": "707a01e4-50e0-41ce-bb7c-8ae532ad3454", "name": "EVERNIMICIN", "unii": "5X287491KH", "linking_id": "5X287491KH", "ref_pname": "EVERNIMICIN", "substance_class": "reference" } }, { "uuid": "1c26bba9-af16-44c5-a44c-e0c1d60bb3b1", "amount": { "uuid": "20b134d3-b176-491d-b681-3061815a27f0" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "ba5855f5-3a26-4464-b0b3-aae6d30d28c2" ], "related_substance": { "uuid": "c2d3effc-557b-4557-8c15-fcfbd8ce33ab", "refuuid": "b209ef27-af00-4d41-9817-72e3f2b8195c", "name": "FLOPRISTIN", "unii": "OZV2QPB39M", "linking_id": "OZV2QPB39M", "ref_pname": "FLOPRISTIN", "substance_class": "reference" } }, { "uuid": "4710217d-9cb6-4350-bada-703eaaf34e32", "amount": { "uuid": "525eed92-15de-426a-b648-e8d19560443b" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "feeb0bf2-05c5-4a40-95a4-5561ba119291" ], "related_substance": { "uuid": "e030c75e-ef24-4f99-9c59-0722f70f567e", "refuuid": "f28633c6-136f-4059-a1de-ac938abcd015", "name": "GARENOXACIN", "unii": "V72H9867WB", "linking_id": "V72H9867WB", "ref_pname": "GARENOXACIN", "substance_class": "reference" } }, { "uuid": "9ee119db-f49a-4144-aa2c-09ddcc51d38f", "amount": { "uuid": "e4c3664c-35ec-482c-9aa7-bb6f143d4441" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "5dea7b70-88b0-4ed5-af65-2456d0558c26" ], "related_substance": { "uuid": "e2545636-8e9b-4edb-9bf0-d47a9165e4a2", "refuuid": "d08c9c57-a973-477f-925f-ee4504f61a3a", "name": "ICLAPRIM", "unii": "42445HUU0O", "linking_id": "42445HUU0O", "ref_pname": "ICLAPRIM", "substance_class": "reference" } }, { "uuid": "19fe1676-c6df-4553-871a-d71d6b3ffbc5", "amount": { "uuid": "b04a949e-724a-441d-b18f-27e2c35c885e" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "2b7b2fd5-0161-4671-9378-e797e31beddf" ], "related_substance": { "uuid": "95918c71-bddd-4918-9bfc-0e88d096dd2d", "refuuid": "0369cab3-3bd1-46e2-bab6-5ad2067c25b5", "name": "OLANEXIDINE", "unii": "92C2328G7P", "linking_id": "92C2328G7P", "ref_pname": "OLANEXIDINE", "substance_class": "reference" } }, { "uuid": "936a602a-f697-4768-a471-77de68115ec0", "amount": { "uuid": "08190c7c-ed30-4173-929a-2f35e09dd245" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "e417764e-7be3-492c-bfac-ed140e7ff40d" ], "related_substance": { "uuid": "4e0d0e3f-2ece-4f76-b756-02c5f95b3c9c", "refuuid": "54b01884-3d7c-497a-8cdf-4e3a3948d58a", "name": "TIGECYCLINE", "unii": "70JE2N95KR", "linking_id": "70JE2N95KR", "ref_pname": "TIGECYCLINE", "substance_class": "reference" } }, { "uuid": "e83f50cf-d02b-4c67-ab95-c3e5e40428db", "amount": { "uuid": "8df7569e-55e5-46e6-830c-24b04e2828df" }, "type": "INHIBITOR->TARGET ORGANISM", "references": [ "70354ddf-a8bf-4356-86cc-b03700799dda" ], "related_substance": { "uuid": "c68b1f44-8309-42b2-99ee-88c377ba17e6", "refuuid": "64f4b027-0de1-45c5-8c7b-c70c7b6429c9", "name": "TOMOPENEM", "unii": "1654W9611T", "linking_id": "1654W9611T", "ref_pname": "TOMOPENEM", "substance_class": "reference" } }, { "uuid": "c70bf6a4-4497-4c0a-ac49-0e7e1ff51d56", "amount": { "uuid": "9e4dfa0d-e06f-4eda-b449-e51d6ee6e0d2", "high": 4, "low": 1, "units": "microgram/mL" }, "qualification": "MIC", "type": "INHIBITOR->TARGET ORGANISM", "related_substance": { "uuid": "27294c39-8d72-4650-ae0f-805a5f306b53", "refuuid": "04d537ee-d07c-4b94-bcd1-713d25650175", "name": "Rx-01_423", "unii": "BB3RZX8UR5", "linking_id": "BB3RZX8UR5", "ref_pname": "Rx-01_423", "substance_class": "reference" } }, { "uuid": "873c7666-1c8d-4007-82f3-40abed33cb4c", "amount": { "uuid": "9994d2b3-c3c9-4986-b0ab-379bc20deb87" }, "comments": "With photodynamic therapy.", "type": "INHIBITOR->TARGET ORGANISM", "references": [ "1c65acc4-3c2a-4b13-aa50-af7f57b6c310" ], "related_substance": { "uuid": "2c27257a-528a-4421-b147-497382aaeb9f", "refuuid": "694f2751-2e7b-4cc8-b30a-54cb0ba9eabf", "name": "RLP-068", "unii": "CC9GT34DD3", "linking_id": "CC9GT34DD3", "ref_pname": "RLP-068", "substance_class": "reference" } } ], "names": [ { "uuid": "7536ed5d-47fd-a82c-fef9-a3095859f5dc", "name": "METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS", "stdName": "METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "35f9d0c1-4bb2-2d93-36e3-579b8bbe64c6" ], "display_name": true }, { "uuid": "6ffc2bba-8366-f5ec-359a-f5036dd44453", "name": "MRSA", "stdName": "MRSA", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "35f9d0c1-4bb2-2d93-36e3-579b8bbe64c6" ], "display_name": false }, { "uuid": "e7e37c4f-6a8f-7ce6-7e19-08e55179aee4", "name": "STAPHYLOCOCCUS AUREUS METHICILLIN RESISTANT", "stdName": "STAPHYLOCOCCUS AUREUS METHICILLIN RESISTANT", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "21cb828e-660d-fcc7-8141-611ad21435d3" ], "display_name": false } ], "properties": [ { "uuid": "2de60d82-81e8-0982-99d1-5a438a98271b", "name": "MIC", "value": { "uuid": "07be666c-adea-eb8b-70bf-6b5bbbde810c", "high": 4, "low": 0.5, "units": "microgram/mL" }, "defining": false, "parameters": [ { "uuid": "127667d5-1669-4156-955a-368df8598e2c", "name": "AGENT: FOSFOMYCIN", "references": [] } ], "property_type": "BIOLOGICAL", "references": [ "21cb828e-660d-fcc7-8141-611ad21435d3" ] } ], "structurally_diverse": { "uuid": "f836cb88-3668-6ccd-d92f-2629f6f4831f", "infra_specific_name": "METHICILLIN RESISTANCE", "infra_specific_type": "STRAIN", "organism_author": "ROSENBACH, 1884", "organism_family": "Staphylococcaceae", "organism_genus": "Staphylococcus", "organism_species": "aureus", "part": [ "whole" ], "references": [ "35f9d0c1-4bb2-2d93-36e3-579b8bbe64c6", "7069b3ec-ff65-7ce3-1f98-9f89da10a378", "7f19cb5c-2e9c-07c6-4901-7ce440e7b5fe" ], "source_material_class": "ORGANISM", "source_material_state": "LIVE", "source_material_type": "BACTERIUM" }, "modifications": { "uuid": "7b7536f0-ab6e-b555-f12a-40f3b539bee2" } } ] }