{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "2d33ad8f-99c4-4af1-a5df-c7d2b45188af",
          "code": "P00439",
          "type": "PRIMARY",
          "url": "http://www.uniprot.org/uniprot/P00439",
          "code_system": "UNIPROT",
          "references": [
            "942f95fb-c22b-4646-9986-dd41b430c0d4"
          ]
        },
        {
          "uuid": "79df5cc1-20a2-4aa2-8f2f-de9eb882cc5d",
          "code": "559J4TS483",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "93b1cabe-c07c-4e06-a6f8-0fb7c456ef28",
          "code": "Phenylalanine_hydroxylase",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/Phenylalanine_hydroxylase",
          "code_system": "WIKIPEDIA"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "26d70875-5448-4cd2-8aa3-30f6b75ecfc9",
          "citation": "http://www.uniprot.org/uniprot/P00439",
          "url": "http://www.uniprot.org/uniprot/P00439",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "23139d8f-6c76-4bad-b6ed-4e7fe0ac65d9",
          "citation": "UNIPROT",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "942f95fb-c22b-4646-9986-dd41b430c0d4",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493393611000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "35c34981-9804-4a42-903d-6af569bbbb03",
          "citation": "INN 125",
          "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl125.pdf?sfvrsn=af269747_5&download=true",
          "doc_type": "INN",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "f7c23758-4e7d-4c86-ae71-98e78b6e05fe",
          "citation": "https://en.wikipedia.org/wiki/Phenylalanine_hydroxylase",
          "url": "https://en.wikipedia.org/wiki/Phenylalanine_hydroxylase",
          "doc_type": "WIKI",
          "public_domain": true
        },
        {
          "uuid": "03b3edb7-636a-4a63-937d-63f29deff3ec",
          "citation": "https://en.wikipedia.org/wiki/Phenylalanine_hydroxylase",
          "url": "https://en.wikipedia.org/wiki/Phenylalanine_hydroxylase",
          "doc_type": "WIKI",
          "public_domain": true
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "0ac2f92c-5bf9-4334-93f1-b45b5111d8d0",
      "version": "14",
      "unii": "559J4TS483",
      "relationships": [
        {
          "uuid": "47d056cb-8717-48c5-ac65-c14cbe41d43e",
          "amount": {
            "uuid": "ec118d2b-4a63-4a97-a843-cc8cec93f49a"
          },
          "type": "ENZYME REPLACEMENT->TARGET",
          "references": [
            "35c34981-9804-4a42-903d-6af569bbbb03"
          ],
          "related_substance": {
            "uuid": "f938daab-52b8-40d2-b31d-7c7566b9fe7b",
            "refuuid": "fd0a613f-aa51-a687-1fcc-a96a156bf354",
            "name": "DOMOFENOGENE ZALFAPARVOVEC",
            "unii": "PN77BRS6J9",
            "linking_id": "PN77BRS6J9",
            "ref_pname": "DOMOFENOGENE ZALFAPARVOVEC"
          }
        },
        {
          "uuid": "91183ef5-a85e-4f8a-b666-f6653f678780",
          "amount": {
            "uuid": "623abc70-4dcb-4f1e-b004-41afec0768e6"
          },
          "type": "VECTOR->EXPRESSED PROTEIN",
          "related_substance": {
            "uuid": "c3ed8e0b-d254-4ba7-9bfe-fc81657802ff",
            "refuuid": "a1d7e839-2709-4f32-8ceb-3778be75e8a9",
            "name": "BEVUFENOGENE NOFEPARVOVEC",
            "unii": "W6GL3Z8KWT",
            "linking_id": "W6GL3Z8KWT",
            "ref_pname": "BEVUFENOGENE NOFEPARVOVEC"
          }
        },
        {
          "uuid": "8db5b296-1c47-4b33-9d66-9ef8348d1bb1",
          "amount": {
            "uuid": "ef7ad802-f6b1-4c3e-bc47-3371c59a5ffc"
          },
          "type": "SUBSTRATE->METABOLIC ENZYME",
          "references": [
            "f7c23758-4e7d-4c86-ae71-98e78b6e05fe"
          ],
          "related_substance": {
            "uuid": "5a6e131e-3e35-4908-aee4-08f01f55e30b",
            "refuuid": "6a922272-bbed-4f3a-9987-8d0552c8828d",
            "name": "Phenylalanine",
            "unii": "47E5O17Y3R",
            "linking_id": "47E5O17Y3R",
            "ref_pname": "Phenylalanine",
            "substance_class": "reference"
          }
        }
      ],
      "names": [
        {
          "uuid": "6811ddb4-2487-4b87-9e58-46d735db37b4",
          "name": "PHE",
          "stdName": "PHE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "26d70875-5448-4cd2-8aa3-30f6b75ecfc9",
            "23139d8f-6c76-4bad-b6ed-4e7fe0ac65d9"
          ],
          "display_name": false
        },
        {
          "uuid": "fc2cbb42-da09-48af-9a03-ba8495a5a954",
          "name": "PHE-4-MONOOXYGENASE",
          "stdName": "PHE-4-MONOOXYGENASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "26d70875-5448-4cd2-8aa3-30f6b75ecfc9",
            "23139d8f-6c76-4bad-b6ed-4e7fe0ac65d9"
          ],
          "display_name": false
        },
        {
          "uuid": "5d7e4934-0f20-4164-abb9-f01bd0cdbb87",
          "name": "PHENYLALANINE-4-HYDROXYLASE",
          "stdName": "PHENYLALANINE-4-HYDROXYLASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "26d70875-5448-4cd2-8aa3-30f6b75ecfc9",
            "23139d8f-6c76-4bad-b6ed-4e7fe0ac65d9"
          ],
          "display_name": true
        },
        {
          "uuid": "72ef1c32-c6cf-465b-b345-b815cd6d7bb3",
          "name": "Phenylalanine hydroxylase",
          "stdName": "PHENYLALANINE HYDROXYLASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "03b3edb7-636a-4a63-937d-63f29deff3ec"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "a8e2d2a5-86b6-4e47-ada1-af92bd8be0c1",
        "glycosylation": {
          "uuid": "abd5a463-0b80-4861-9742-331f1cb56905"
        },
        "subunits": [
          {
            "uuid": "04f11cbe-fd58-4575-9af5-7d5031140d65",
            "sequence": "MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK",
            "subunit_index": 1
          },
          {
            "uuid": "ac714a3d-ed72-4e1a-888e-e65154751aa4",
            "sequence": "MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK",
            "subunit_index": 2
          },
          {
            "uuid": "9ace5722-4217-498e-aa2d-47d486ca8915",
            "sequence": "MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK",
            "subunit_index": 3
          },
          {
            "uuid": "b7b90086-c9cb-4d02-9bfa-5956261254af",
            "sequence": "MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKTHACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINSEIGILCSALQKIK",
            "subunit_index": 4
          }
        ],
        "references": [
          "26d70875-5448-4cd2-8aa3-30f6b75ecfc9"
        ],
        "protein_sub_type": "",
        "protein_type": "ENZYME",
        "sequence_origin": "HUMAN",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "54e68118-927e-4c48-8ab1-d10316842091",
          "name": "MOL_WEIGHT",
          "type": "amount",
          "value": {
            "uuid": "2d54202f-4a39-4b5b-a3ea-da41ab93a7fb",
            "units": "DA"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "100ca3bf-a436-4b70-affc-70f713ececaf",
          "name": "Molecular Formula",
          "value": {
            "uuid": "01e66ec8-e7d6-423f-8dbd-7e54eb96497a",
            "type": "ESTIMATED",
            "non_numeric_value": "C9400H14439N2476O2736PS48"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "b1d624e5-04d9-4683-903f-35349ebf0375",
        "structural_modifications": [
          {
            "uuid": "4b66985b-8fb2-410c-a20f-bb3327c2b965",
            "extent": "COMPLETE",
            "sites": [
              {
                "residue_index": 16,
                "subunit_index": 1
              }
            ],
            "molecular_fragment": {
              "uuid": "199e24e4-6c34-4f40-a430-26e60a28d507",
              "refuuid": "b6eb2edb-1b4d-46ad-92ad-a43f0f545926",
              "name": "DEXFOSFOSERINE",
              "unii": "VI4F0K069V",
              "linking_id": "VI4F0K069V",
              "ref_pname": "DEXFOSFOSERINE",
              "substance_class": "reference"
            },
            "structural_modification_type": "AMINO_ACID_SUBSTITUTION"
          }
        ]
      }
    }
  ]
}