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          "molfile": "\n  Marvin  01132105332D          \n\n 20 23  0  0  1  0            999 V2000\n    5.6310   -1.1972    0.0000 C   0  0  1  0  0  0  0  0  0  2  0  0\n    5.8914   -0.4084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1211   -1.8608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.6310   -2.5194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8499   -2.2693    0.0000 C   0  0  1  0  0  0  0  0  0  2  0  0\n    4.1428   -2.6828    0.0000 C   0  0  2  0  0  0  0  0  0  1  0  0\n    4.1428   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.4256   -3.9233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.7262   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.0089   -3.9233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.2891   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    0.5820   -3.9233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    1.2891   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.0089   -2.2693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.7262   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.4256   -2.2693    0.0000 C   0  0  1  0  0  0  0  0  0  2  0  0\n    3.4256   -1.4473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.1428   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8499   -1.4473    0.0000 C   0  0  2  0  0  0  0  0  0  2  0  0\n    4.8499   -0.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n  1  2  1  1  0  0  0\n  1  3  1  0  0  0  0\n 19  1  1  0  0  0  0\n  3  4  1  0  0  0  0\n  5  4  1  1  0  0  0\n  6  5  1  0  0  0  0\n  5 19  1  0  0  0  0\n  6  7  1  6  0  0  0\n  6 16  1  0  0  0  0\n  8  7  1  0  0  0  0\n  8  9  1  0  0  0  0\n 10  9  1  0  0  0  0\n  9 15  2  0  0  0  0\n 11 10  2  0  0  0  0\n 12 11  1  0  0  0  0\n 11 13  1  0  0  0  0\n 13 14  2  0  0  0  0\n 14 15  1  0  0  0  0\n 16 15  1  0  0  0  0\n 16 17  1  1  0  0  0\n 17 18  1  0  0  0  0\n 19 18  1  0  0  0  0\n 19 20  1  1  0  0  0\nM  END",
          "smiles": "C[C@@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]2CC[C@@H]1O)O",
          "formula": "C18H24O2",
          "atropisomerism": "No",
          "charge": 0,
          "count": 1,
          "stereochemistry": "ABSOLUTE",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "233e6f6c-9488-4067-a3ab-06db19b5d9e6"
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          "ez_centers": 0,
          "molecular_weight": "272.3826",
          "optical_activity": "UNSPECIFIED",
          "stereo_centers": 5
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "dbe30db9-e2f7-42a1-897d-344c3d8f9272",
      "version": "133",
      "structure": {
        "id": "7230eb19-175f-4b70-b51c-b72c4bdd9d3b",
        "molfile": "\n  Marvin  01132105552D          \n\n 23 26  0  0  1  0            999 V2000\n    4.8499   -1.4473    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n    4.8499   -2.2693    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n    4.1428   -2.6828    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n    3.4256   -2.2693    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n    2.7262   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.7262   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.1428   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    3.4256   -1.4473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.1428   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.6310   -2.5194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.0089   -2.2693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.6310   -1.1972    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0\n    3.4256   -3.9233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    2.0089   -3.9233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1211   -1.8608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.2891   -3.5098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    1.2891   -2.6828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8499   -0.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.8914   -0.4084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    0.5820   -3.9233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    3.4332   -2.9508    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8499   -2.9967    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n    4.1378   -1.8634    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n  2  1  1  0  0  0  0\n  3  2  1  0  0  0  0\n  4  8  1  0  0  0  0\n  5  4  1  0  0  0  0\n  6  5  2  0  0  0  0\n  7  1  1  0  0  0  0\n  8  7  1  0  0  0  0\n  9  3  1  0  0  0  0\n 10  2  1  0  0  0  0\n 11  5  1  0  0  0  0\n 12  1  1  0  0  0  0\n 13  9  1  0  0  0  0\n 14  6  1  0  0  0  0\n 15 12  1  0  0  0  0\n 16 17  1  0  0  0  0\n 17 11  2  0  0  0  0\n  1 18  1  1  0  0  0\n 12 19  1  1  0  0  0\n 20 16  1  0  0  0  0\n  4 21  1  6  0  0  0\n  2 22  1  6  0  0  0\n  3 23  1  1  0  0  0\n 15 10  1  0  0  0  0\n  4  3  1  0  0  0  0\n 13  6  1  0  0  0  0\n 16 14  2  0  0  0  0\nM  END",
        "smiles": "C[C@@]12CC[C@]3([H])c4ccc(cc4CC[C@@]3([H])[C@]2([H])CC[C@@H]1O)O",
        "formula": "C18H24O2",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ABSOLUTE",
        "defined_stereo": 5,
        "ez_centers": 0,
        "molecular_weight": "272.3826",
        "optical_activity": "( + )",
        "references": [
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          "55e939e9-80d5-41a0-ab7a-ed26ccda3660",
          "bc3b458e-ad13-4037-b4be-bd153b905ab4"
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          "type": "ACTIVE MOIETY",
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            "name": "ESTRADIOL",
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            "units": "PERCENT PEAK AREA",
            "high_limit": 0.1
          },
          "qualification": "EP",
          "type": "PARENT->IMPURITY",
          "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)",
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            "f607410a-af6c-4ee7-b4b6-016befa9d432",
            "f4a075cc-d581-40cd-9f0c-fc48b34844c2"
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            "refuuid": "5ad05fae-0e42-4ab4-8276-17f02baaeb05",
            "name": "ETHINYL ESTRADIOL",
            "unii": "423D2T571U",
            "linking_id": "423D2T571U",
            "ref_pname": "ETHINYL ESTRADIOL",
            "substance_class": "reference"
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        {
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            "units": "WEIGHT PERCENT",
            "high_limit": 103,
            "low_limit": 97
          },
          "qualification": "USP",
          "type": "BASIS OF STRENGTH->SUBSTANCE",
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            "name": "ESTRADIOL HEMIHYDRATE",
            "unii": "CXY7B3Q98Z",
            "linking_id": "CXY7B3Q98Z",
            "ref_pname": "ESTRADIOL HEMIHYDRATE"
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        },
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            "high": 0.36,
            "low": 0.22,
            "units": "MICROMOLAR"
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          "type": "METABOLIC ENZYME->INHIBITOR",
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            "name": "ALDEHYDE OXIDASE",
            "unii": "LR0F81F33L",
            "linking_id": "LR0F81F33L",
            "ref_pname": "ALDEHYDE OXIDASE",
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        },
        {
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          "type": "PARENT->METABOLITE",
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            "linking_id": "653Z31ON80",
            "ref_pname": "MAP/MICROTUBULE AFFINITY-REGULATING KINASE 4",
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            "refuuid": "331a7728-ee30-474a-babf-aa6db2994cf7",
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            "unii": "35LT29625A",
            "linking_id": "35LT29625A",
            "ref_pname": "ESTRAMUSTINE",
            "substance_class": "reference"
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        },
        {
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            "units": "%"
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            "unii": "2DI9HA706A",
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            "units": "%"
          },
          "comments": "E2 is then extensively metabolized to estrone (E1) (15%), estrone sulfate (E1S) (65%), and other compounds.",
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            "name": "ESTRONE SULFATE",
            "unii": "QTL48N278K",
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            "ref_pname": "ESTRONE SULFATE",
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        },
        {
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            "units": "%"
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            "unii": "ZIF514RVZR",
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        {
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          "qualification": "IC50",
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            "name": "ESTROGEN RECEPTOR",
            "unii": "SIDP85PFD6",
            "linking_id": "SIDP85PFD6",
            "ref_pname": "ESTROGEN RECEPTOR",
            "substance_class": "reference"
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        },
        {
          "uuid": "e724e245-0bc2-46b4-bca3-c94ed7315f79",
          "amount": {
            "uuid": "5699a1e8-0476-4831-824c-22b4d0c761a7"
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            "refuuid": "9a8e9ce2-8b2e-4158-ab74-63b0f694a0f2",
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        },
        {
          "uuid": "2b00c353-2a9f-496d-8534-f9586e901043",
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            "name": "ESTRADIOL VALERATE",
            "unii": "OKG364O896",
            "linking_id": "OKG364O896",
            "ref_pname": "ESTRADIOL VALERATE"
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        },
        {
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