{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "71798adf-6259-414a-8012-5612010d5c18", "code": "Q9UM73", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/Q9UM73", "code_system": "UNIPROT", "references": [ "efa2da1d-8176-40a0-8a0d-a0de107b3146" ] }, { "uuid": "3983e5a6-f941-471a-bcdc-8e784f52caae", "code": "ANAPLASTIC LYMPHOMA KINASE", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Anaplastic_lymphoma_kinase", "code_system": "WIKIPEDIA", "references": [ "efa2da1d-8176-40a0-8a0d-a0de107b3146" ] }, { "uuid": "0a133650-1f7f-4641-86bf-d83d3f4c556f", "code": "4M56WLI1MN", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "0160b9a3-3a16-4fa9-af9e-9b5467e61ba1", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "7b950fd9-48fe-44f4-b82b-30632615a5f4", "citation": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "0bf8e0c3-03b4-48de-83e9-410ad3f82a94", "citation": "fda_srs", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "4999295a-70e4-4308-b4d1-a2e67d54fd15", "citation": "http://www.uniprot.org/uniprot/Q9UM73", "url": "http://www.uniprot.org/uniprot/Q9UM73", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "efa2da1d-8176-40a0-8a0d-a0de107b3146", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493393995000, "tags": [ "NOMEN" ] }, { "uuid": "ad9ee010-375b-4db7-ba9b-b0880c890547", "citation": "CURRENT OPINION IN PHARMACOLOGY 2015, 23:39?44", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9dc7030c-f788-47ed-bee2-3b2e674756e5", "citation": "CURRENT OPINION IN PHARMACOLOGY 2015, 23:39?49", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "d96093a0-b5ec-49fb-a361-6bd4648bf25e", "citation": "CURRENT OPINION IN PHARMACOLOGY 2015, 23:39?47", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ae885984-7b4e-46b1-83be-b00a281188de", "citation": "CURRENT OPINION IN PHARMACOLOGY 2015, 23:39?50", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "af9a2b11-758b-4864-b68a-fae409e22aa6", "citation": "CURRENT OPINION IN PHARMACOLOGY 2015, 23:39?51", "url": "http://www.sciencedirect.com/science/article/pii/S1471489215000545#", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "4e7e66fd-0f64-414d-8e09-26008652fd89", "citation": "SRS import [4M56WLI1MN]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=4M56WLI1MN", "doc_type": "SRS", "public_domain": true, "document_date": 1493393995000, "tags": [ "NOMEN" ] }, { "uuid": "420e65ce-70f2-43e0-a099-c13f4b2506f5", "citation": "https://cco.amegroups.com/article/view/22320/26073", "url": "https://cco.amegroups.com/article/view/22320/26073", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "46cab5b9-8a24-49b6-960f-5c9846f97a05", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/208434Orig1s000ClinPharmR.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "07191f49-6cc8-43ee-aaf2-e0a404845e0a", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "db51836a-4b05-434e-8759-6f0cae8af0cd", "citation": "https://memoinoncology.com/elcc-2022/oncogene-driven-lung-cancer-egfr-metex14-ros1-ret/", "url": "https://memoinoncology.com/elcc-2022/oncogene-driven-lung-cancer-egfr-metex14-ros1-ret/", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ad2df3dd-023b-4c90-bf3c-d3e308eb8a56", "citation": "https://www.medchemexpress.com/unecritinib.html", "url": "https://www.medchemexpress.com/unecritinib.html", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "925d6dc1-1dde-458a-a67d-aa5c75fc1004", "citation": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=11874", "url": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=11874", "doc_type": "IUPHAR", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "13072f62-69fd-49cf-afca-7d9335e0e9c2", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "c7c05335-c2a4-4556-a4d5-6e66163a2f0f", "citation": "List 132", "url": "https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl132.pdf", "doc_type": "INN", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "6dd4877d-b101-4c25-968a-64e0884773cd", "version": "17", "unii": "4M56WLI1MN", "relationships": [ { "uuid": "89f7c6ff-fde3-45a9-912a-04e09d4e32f5", "amount": { "uuid": "7191e485-86d8-4660-bf04-71659bb9e634", "type": "RELATIONSHIP_AMOUNT", "average": 0.024, "units": "MICROMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "ad9ee010-375b-4db7-ba9b-b0880c890547" ], "related_substance": { "uuid": "77834be1-636f-4fac-a576-77cb60b05815", "refuuid": "f6f83e6a-308c-4d00-9bc9-229e373e8c55", "name": "Crizotinib", "unii": "53AH36668S", "linking_id": "53AH36668S", "ref_pname": "Crizotinib", "substance_class": "reference" } }, { "uuid": "23c89b71-cf7e-4cbd-8117-839c69bf431b", "amount": { "uuid": "c5a04c8d-a7e0-4ace-af1a-c8ceaa2a4826", "type": "RELATIONSHIP_AMOUNT", "units": "NANOMOLAR", "high_limit": 0.4 }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "9dc7030c-f788-47ed-bee2-3b2e674756e5" ], "related_substance": { "uuid": "fd0af455-4e21-47ef-a52f-20216ad1226f", "refuuid": "27e07bb1-fe89-4b23-8721-c39edb45f304", "name": "X-376", "unii": "7DR7JMB8BH", "linking_id": "7DR7JMB8BH", "ref_pname": "X-376", "substance_class": "reference" } }, { "uuid": "9ca6e91f-e53a-402e-8fd5-f7780c79a325", "amount": { "uuid": "72e70cc6-7b00-44a3-8aa1-209ef790cc0c", "type": "RELATIONSHIP_AMOUNT", "average": 0.2, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "d96093a0-b5ec-49fb-a361-6bd4648bf25e" ], "related_substance": { "uuid": "66fc3e52-52f8-4e47-a04a-fcbd253f65b8", "refuuid": "3ded3ebd-5f5a-403b-a612-f554a8bd2115", "name": "CERITINIB", "unii": "K418KG2GET", "linking_id": "K418KG2GET", "ref_pname": "CERITINIB", "substance_class": "reference" } }, { "uuid": "5717bcb7-1e54-4bd5-a67f-6a2d109153c0", "amount": { "uuid": "e6e0b401-8228-46f1-ad6b-0b35491ac0e1", "type": "RELATIONSHIP_AMOUNT", "average": 0.62, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "d96093a0-b5ec-49fb-a361-6bd4648bf25e" ], "related_substance": { "uuid": "256bc055-130e-4cff-8040-341f602440b8", "refuuid": "e6975804-a97e-4786-bd13-2237c35784db", "name": "BRIGATINIB", "unii": "HYW8DB273J", "linking_id": "HYW8DB273J", "ref_pname": "BRIGATINIB", "substance_class": "reference" } }, { "uuid": "587293fd-ebd1-4d76-8a3d-878de7a4859f", "amount": { "uuid": "4d6413ea-1948-4c8e-8cc2-e9e44aae7a18", "type": "RELATIONSHIP_AMOUNT", "average": 3.5, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "ae885984-7b4e-46b1-83be-b00a281188de" ], "related_substance": { "uuid": "2cf6c80e-f1d9-4b2b-be5a-6d45eb726f1a", "refuuid": "e3249d66-6c7c-4092-a5b4-8fa6d9af9b51", "name": "ASP-3026", "unii": "HP4L6MXF10", "linking_id": "HP4L6MXF10", "ref_pname": "ASP-3026", "substance_class": "reference" } }, { "uuid": "ea75c017-1ebc-4bd5-b172-436e695bce41", "amount": { "uuid": "eb991562-0c60-4154-910b-00d42dd42f01", "type": "RELATIONSHIP_AMOUNT", "average": 1.9, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "ae885984-7b4e-46b1-83be-b00a281188de" ], "related_substance": { "uuid": "a3e29331-ff95-46d7-a75c-a9ac3a8010e6", "refuuid": "7bceb40d-c97b-4bc5-8d61-3e42ef686bbc", "name": "ALECTINIB", "unii": "LIJ4CT1Z3Y", "linking_id": "LIJ4CT1Z3Y", "ref_pname": "ALECTINIB", "substance_class": "reference" } }, { "uuid": "d30d301d-f94c-43f0-9ff0-17121507876c", "amount": { "uuid": "15c83a35-4538-4805-9dea-901b90c20ae7", "type": "RELATIONSHIP_AMOUNT", "average": 12, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "af9a2b11-758b-4864-b68a-fae409e22aa6" ], "related_substance": { "uuid": "c0a11e09-74dc-4f75-bc10-d6ae30f9690e", "refuuid": "5e05f025-6d16-4447-90de-5ae649f8eaff", "name": "ENTRECTINIB", "unii": "L5ORF0AN1I", "linking_id": "L5ORF0AN1I", "ref_pname": "ENTRECTINIB", "substance_class": "reference" } }, { "uuid": "ee86733a-b4fa-4a9a-8fe0-42c334c2309d", "amount": { "uuid": "7fce6229-3bbe-47f8-abc5-d86e57853e84", "type": "RELATIONSHIP_AMOUNT", "units": "NANOMOLAR", "high_limit": 0.07 }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "ae885984-7b4e-46b1-83be-b00a281188de" ], "related_substance": { "uuid": "067172d3-5c97-4ef7-be8d-4fa24e485e03", "refuuid": "fdc924ca-d8e6-4987-9c64-cc865c2e5ec7", "name": "LORLATINIB", "unii": "OSP71S83EU", "linking_id": "OSP71S83EU", "ref_pname": "LORLATINIB", "substance_class": "reference" } }, { "uuid": "91634a20-c176-46bf-a4c9-760514976aac", "amount": { "uuid": "044024a1-89ba-4020-9725-fda29108677a", "type": "RELATIONSHIP_AMOUNT", "average": 0.7, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "interaction_type": "INHIBITOR ", "references": [ "ae885984-7b4e-46b1-83be-b00a281188de" ], "related_substance": { "uuid": "32edc73c-d16c-4a74-b4e8-df7358f86eda", "refuuid": "73150d2e-1e80-4793-b055-710b9e81496d", "name": "BELIZATINIB", "unii": "Z8A6022P3J", "linking_id": "Z8A6022P3J", "ref_pname": "BELIZATINIB", "substance_class": "reference" } }, { "uuid": "467c41f0-fc41-4257-b3a1-3cd19b9ba8dc", "amount": { "uuid": "abffa84a-02ba-4a52-a555-61cd197c2ebc", "average": 24, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "0d8e2933-efbb-4f3a-ab81-d4064feeed65", "refuuid": "2ba2db33-43c2-4278-a71d-803c5ff96c85", "name": "CEP-11981", "unii": "J8AY0Z4CBP", "linking_id": "J8AY0Z4CBP", "ref_pname": "CEP-11981" } }, { "uuid": "f7da3c04-71ce-48fd-8a2a-1bb70e779cce", "amount": { "uuid": "a4d8a036-c403-4e02-a3f5-f54de3beb5be", "average": 5.38, "high": 8.85, "low": 1.91, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "07191f49-6cc8-43ee-aaf2-e0a404845e0a" ], "related_substance": { "uuid": "808ec9f5-a7b5-4104-808d-8fc41347077a", "refuuid": "1820996f-580c-41e7-a93f-2190625cf092", "name": "IRUPLINALKIB", "unii": "Z5F65W1YAZ", "linking_id": "Z5F65W1YAZ", "ref_pname": "IRUPLINALKIB" } }, { "uuid": "485d3688-b2b5-4709-9e96-fb004918ef13", "amount": { "uuid": "1d7ffc71-0c4c-4fee-93b1-538e6b1a6a03", "average": 1.2, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "46cab5b9-8a24-49b6-960f-5c9846f97a05" ], "related_substance": { "uuid": "0a9b902d-6a60-4fbb-8189-9faccc8a8854", "refuuid": "93cfa186-cb92-412e-963b-7b1c28a5dad8", "name": "5H-BENZO(B)CARBAZOLE-3-CARBONITRILE, 9-ETHYL-6,11-DIHYDRO-8-(4-((2-HYDROXYETHYL)AMINO)-1-PIPERIDINYL)-6,6-DIMETHYL-11-OXO-", "unii": "6L7WLR552I", "linking_id": "6L7WLR552I", "ref_pname": "5H-BENZO(B)CARBAZOLE-3-CARBONITRILE, 9-ETHYL-6,11-DIHYDRO-8-(4-((2-HYDROXYETHYL)AMINO)-1-PIPERIDINYL)-6,6-DIMETHYL-11-OXO-" } }, { "uuid": "8e8bc91f-4adf-42b0-aa1d-bbd00f1801ae", "amount": { "uuid": "78f11b7a-2347-4816-b85d-e2b89ba31237" }, "type": "INHIBITOR->TARGET", "references": [ "420e65ce-70f2-43e0-a099-c13f4b2506f5" ], "related_substance": { "uuid": "baab8dc8-9e6a-42ba-ae03-dd9f52f1155f", "refuuid": "e3449c58-3b7f-47e2-aed0-601aa007c2b0", "name": "ENSARTINIB", "unii": "SMA5ZS5B22", "linking_id": "SMA5ZS5B22", "ref_pname": "ENSARTINIB", "substance_class": "reference" } }, { "uuid": "e74cb7dd-dd1e-480a-a225-2b526de2f97b", "amount": { "uuid": "a73735fa-911b-4084-84c6-6491024e99f1" }, "type": "INHIBITOR->TARGET", "interaction_type": "IN-VITRO, IN-VIVO", "related_substance": { "uuid": "30025c94-0bc4-4a47-858f-155de550d7f0", "refuuid": "74f3d8ce-331a-4cdb-ac82-6049793b6b97", "name": "Zotizalkib", "unii": "5BKJ4Z6RBU", "linking_id": "5BKJ4Z6RBU", "ref_pname": "Zotizalkib" } }, { "uuid": "58555280-7098-44f9-99c7-c233c6bb6e03", "amount": { "uuid": "e6267138-627c-41e5-8db9-3ca9cad1fed8" }, "type": "INHIBITOR->TARGET", "references": [ "925d6dc1-1dde-458a-a67d-aa5c75fc1004" ], "related_substance": { "uuid": "debd915c-194b-4605-808b-4e529c200a75", "refuuid": "11f62f0f-c712-4157-8840-8f90ecd8d41e", "name": "ENVONALKIB", "unii": "QB7KTQ7VW9", "linking_id": "QB7KTQ7VW9", "ref_pname": "ENVONALKIB", "substance_class": "reference" } }, { "uuid": "e0392e33-e80b-4799-8ebe-119e01c071ed", "amount": { "uuid": "9dc21d86-ff9d-44ad-8467-cdfa5ce30755" }, "type": "INHIBITOR->TARGET", "references": [ "db51836a-4b05-434e-8759-6f0cae8af0cd", "ad2df3dd-023b-4c90-bf3c-d3e308eb8a56" ], "related_substance": { "uuid": "358d1870-95d3-43fc-8000-1ff7d556a592", "refuuid": "36251a6b-dc09-4449-8bf3-a41252570bce", "name": "Unecritinib", "unii": "4T3Z98RR86", "linking_id": "4T3Z98RR86", "ref_pname": "Unecritinib", "substance_class": "reference" } }, { "uuid": "eb7fb6ee-4d8e-4d05-894f-d074cbe2692b", "amount": { "uuid": "07d6d622-c282-4eaa-8679-ad60018e5688" }, "type": "INHIBITOR->TARGET", "references": [ "c7c05335-c2a4-4556-a4d5-6e66163a2f0f" ], "related_substance": { "uuid": "246c3e0e-6d78-44f7-801e-df2c64ddae17", "refuuid": "e0acfdb5-37b3-4aa9-9209-c430a2bd1a14", "name": "Dirozalkib", "unii": "2FH56C28YT", "linking_id": "2FH56C28YT", "ref_pname": "Dirozalkib", "substance_class": "reference" } } ], "names": [ { "uuid": "8ad381f0-3177-41d1-9830-7cf593a6978a", "name": "ALK", "stdName": "ALK", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0bf8e0c3-03b4-48de-83e9-410ad3f82a94" ], "display_name": false }, { "uuid": "2b2b22be-c123-43b5-bd48-5a5d0db64338", "name": "ALK TYROSINE KINASE RECEPTOR", "stdName": "ALK TYROSINE KINASE RECEPTOR", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "4999295a-70e4-4308-b4d1-a2e67d54fd15" ], "display_name": false }, { "uuid": "ac822d12-b3f5-4b9e-9473-17f64c855d4e", "name": "ANAPLASTIC LYMPHOMA KINASE", "stdName": "ANAPLASTIC LYMPHOMA KINASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7b950fd9-48fe-44f4-b82b-30632615a5f4" ], "display_name": true }, { "uuid": "bde9e4f8-a77e-4a65-850f-7ab4c4d5207f", "name": "CD-246", "stdName": "CD-246", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "4999295a-70e4-4308-b4d1-a2e67d54fd15" ], "display_name": false }, { "uuid": "917703d2-65c5-4fd6-82e6-24f19da483b4", "name": "CD246", "stdName": "CD246", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "4999295a-70e4-4308-b4d1-a2e67d54fd15" ], "display_name": false } ], "protein": { "uuid": "d474d4af-b625-47b1-9896-40f309cf3d69", "glycosylation": { "uuid": "c905a419-bd1c-4369-b63a-8007291abd9a", "glycosylation_type": "HUMAN", "n_glycosylation_sites": [ { "residue_index": 151, "subunit_index": 1 }, { "residue_index": 226, "subunit_index": 1 }, { "residue_index": 267, "subunit_index": 1 }, { "residue_index": 306, "subunit_index": 1 }, { "residue_index": 393, "subunit_index": 1 }, { "residue_index": 406, "subunit_index": 1 }, { "residue_index": 427, "subunit_index": 1 }, { "residue_index": 545, "subunit_index": 1 }, { "residue_index": 553, "subunit_index": 1 }, { "residue_index": 609, "subunit_index": 1 }, { "residue_index": 691, "subunit_index": 1 }, { "residue_index": 790, "subunit_index": 1 }, { "residue_index": 845, "subunit_index": 1 }, { "residue_index": 846, "subunit_index": 1 }, { "residue_index": 868, "subunit_index": 1 }, { "residue_index": 968, "subunit_index": 1 } ] }, "subunits": [ { "uuid": "9cd22dfb-68c2-4c87-9948-0cf5a7775155", "sequence": "VGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP", "subunit_index": 1 } ], "references": [ "4999295a-70e4-4308-b4d1-a2e67d54fd15", "4e7e66fd-0f64-414d-8e09-26008652fd89" ], "protein_sub_type": "", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "b51bc739-08eb-4dfa-9ebc-fa96063499d8", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "0dd665ca-420b-4fdd-8b12-6fb3eaea5937", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "9ff589d3-3983-4138-a984-6af87119bd78", "structural_modifications": [ { "uuid": "55d29ba1-23ad-4517-93b3-9c604356c352", "extent": "COMPLETE", "sites": [ { "residue_index": 1060, "subunit_index": 1 }, { "residue_index": 1074, "subunit_index": 1 }, { "residue_index": 1078, "subunit_index": 1 }, { "residue_index": 1113, "subunit_index": 1 }, { "residue_index": 1260, "subunit_index": 1 }, { "residue_index": 1489, "subunit_index": 1 }, { "residue_index": 1586, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "d9e2afca-17d8-4fdf-9995-90308cbe9ba6", "refuuid": "6534bbf5-6eb4-4a29-aba8-46e6ed9c50bd", "name": "TYROSINE O-PHOSPHATE", "unii": "2R86C98KDX", "linking_id": "2R86C98KDX", "ref_pname": "TYROSINE O-PHOSPHATE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" } ] } } ] }