{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "e69b26cf-180c-484a-9b30-18ae87b4a94e", "code": "Q12791", "type": "PRIMARY", "url": "https://www.uniprot.org/uniprot/Q12791", "code_system": "UNIPROT" }, { "uuid": "53e68b83-0068-4230-9ede-c0a408a34d88", "code": "3KF5SO6T4Q", "type": "PRIMARY", "code_system": "FDA UNII" } ], "substance_class": "protein", "references": [ { "uuid": "6a9270d2-cca7-4ff1-b2a4-b01b328e0da6", "citation": "http://www.uniprot.org/uniprot/Q12791", "url": "http://www.uniprot.org/uniprot/Q12791", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1fe8e63c-0b9d-496f-b3fd-7248eb5c6fa3", "citation": "UNIPROT", "doc_type": "UNIPROT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "457f1039-d311-4be4-b61c-d5287df76aed", "citation": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=2307", "url": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=2307", "doc_type": "IUPHAR", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9df117b8-9e82-4c9b-9a8a-268482c58a4f", "citation": "McLeod, J. F., et al. \"GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers.\" British journal of anaesthesia 113.5 (2014): 875-883.", "url": "https://academic.oup.com/bja/article/113/5/875/2919952", "doc_type": "JA", "public_domain": true } ], "definition_type": "PRIMARY", "definition_level": "COMPLETE", "uuid": "0148a59e-4afc-4a76-ba10-77cf92968b34", "version": "10", "unii": "3KF5SO6T4Q", "relationships": [ { "uuid": "1de716ff-6f05-4ee9-979c-949388cf770c", "amount": { "uuid": "1d67ff85-ee75-49c3-a2f7-5032ea8a7798" }, "type": "ACTIVATOR->TARGET", "references": [ "457f1039-d311-4be4-b61c-d5287df76aed" ], "related_substance": { "uuid": "d717df3b-f382-4555-bc13-4d73df2dacac", "refuuid": "25c3df32-9aac-4e7d-b831-4f77653b6ff2", "name": "FLINDOKALNER", "unii": "J57O328W4W", "linking_id": "J57O328W4W", "ref_pname": "FLINDOKALNER" } }, { "uuid": "fcf485d2-d033-46f2-8342-0948a2cb9882", "amount": { "uuid": 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"subunit_index": 2 }, { "uuid": "9fb8c0cd-cca4-4992-9874-d6923ef45cad", "sequence": "MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL", "subunit_index": 3 }, { "uuid": "8a358319-52a6-4f60-ad7d-c9c2eff378e1", "sequence": "MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL", "subunit_index": 4 } ], "references": [ "6a9270d2-cca7-4ff1-b2a4-b01b328e0da6" ], "protein_sub_type": "POTASSIUM CHANNEL", "protein_type": "ION CHANNEL", "sequence_origin": "HUMAN", "sequence_type": "COMPLETE" }, "properties": [ { "uuid": "2c91702b-2346-4e6f-914d-9d43de8731bd", "name": "MOL_WEIGHT", "type": "amount", "value": { "uuid": "4478e7ef-e296-4b34-a294-db26888e0a0b", "units": "DA" }, "defining": false, "property_type": "CHEMICAL" }, { "uuid": "3fd05610-1705-4b8b-ae6e-8242ee64e16b", "name": "Molecular Formula", "value": { "uuid": "3ce86cae-64ce-4e2f-a2d2-ce0078c3920f", "type": "ESTIMATED", "non_numeric_value": "C6118H9533N1652O1843P7S70" }, "defining": false, "property_type": "CHEMICAL" } ], "modifications": { "uuid": "9a06797e-53cb-4aeb-8281-5581a54f0499", "structural_modifications": [ { "uuid": "5476aa9f-9702-4525-9cd4-852e3cbbbb76", "extent": "COMPLETE", "sites": [ { "residue_index": 765, "subunit_index": 1 }, { "residue_index": 778, "subunit_index": 1 }, { "residue_index": 782, "subunit_index": 1 }, { "residue_index": 978, "subunit_index": 1 }, { "residue_index": 982, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "dfbea644-daec-4711-80f5-82e210b1187b", "refuuid": "b6eb2edb-1b4d-46ad-92ad-a43f0f545926", "name": "DEXFOSFOSERINE", "unii": "VI4F0K069V", "linking_id": "VI4F0K069V", "ref_pname": "DEXFOSFOSERINE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" }, { "uuid": "e97ad3f8-ef58-4741-a8ab-293b29fc4897", "extent": "COMPLETE", "sites": [ { "residue_index": 763, "subunit_index": 1 }, { "residue_index": 970, "subunit_index": 1 } ], "molecular_fragment": { "uuid": "15948b7d-5256-408e-b5d2-16fb8a5f8871", "refuuid": "96bbf36a-d049-4313-9712-8608530faef7", "name": "THREONINE PHOSPHATE", "unii": "3L4WX7B1EI", "linking_id": "3L4WX7B1EI", "ref_pname": "THREONINE PHOSPHATE", "substance_class": "reference" }, "structural_modification_type": "AMINO ACID SUBSTITUTION" } ] } } ] }