{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "ed0aa85f-13a2-40fe-a2d0-747287a41cb6", "code": "NBK559835", "comments": "LiverTox|CNS|Stimulant|Xanthine", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/NBK559835/", "code_system": "LIVERTOX", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "749baf7e-0000-469f-831b-423d3cb2fff7", "code": "CAFFEINE", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Caffeine", "code_system": "WIKIPEDIA", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "1ee18ba6-fae2-4f0e-982b-050f82e92e22", "code": "21 CFR 340.10", "comments": "PART 340 -- STIMULANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE|Subpart B--Active Ingredient|Sec. 340.10 Stimulant active ingredient.", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=340.10", "code_system": "CFR", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "f82c7be0-bb6a-4e4e-bff6-74307346b460", "code": "21 CFR 340.50", "comments": "PART 340 -- STIMULANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE|Subpart C?Labeling|Sec. 340.50 Labeling of stimulant drug products. (d)", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=340.50", "code_system": "CFR", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "c9f9c0ce-4e6e-4bcd-9f76-d5536f60c6be", "code": "V04CG30", "comments": "ATC|VARIOUS|DIAGNOSTIC AGENTS|OTHER DIAGNOSTIC AGENTS|Tests for gastric secretion|caffeine and sodium benzoate", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=V04CG30&showdescription=yes", "code_system": "WHO-ATC", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "bdc9da97-1b00-45a1-b830-9cf8cbfa15f8", "code": "660", "comments": "EPA PESTICIDE|CONVENTIONAL CHEMICAL", "type": "PRIMARY", "url": "http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:3:0::NO:21,3,31,7,12,25:P3_XCHEMICAL_ID:307", "code_system": "EPA PESTICIDE CODE", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "959e98a0-2f1f-4af8-82fa-babdfbf6e2f9", "code": "200-362-1", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.000.329", "code_system": "ECHA (EC/EINECS)", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "1637efd6-2059-4c2d-9830-444254644106", "code": "407", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=407", "code_system": "IUPHAR", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "299d4c06-cc69-41dc-b9a4-908949127379", "code": "CAFFEINE", "comments": "Description: Silky, colourless crystals or a white, crystalline powder; odourless. Solubility: Soluble in 60 parts of water and in 100 parts of ethanol (~750 g/l) TS; slightly soluble in ether R. Category: Central nervous stimulant. Storage: Caffeine should be kept in a well-closed container. Labelling: The designation on the container of Caffeine should state whether the substance is the monohydrate or is in the anhydrous form. Additional information: Caffeine monohydrate is efflorescent in air. Definition: Caffeine contains not less than 98.5% and not more than 101.0% of C8H10N4O2, calculated with reference to the dried substance.", "type": "PRIMARY", "url": "http://apps.who.int/phint/pdf/b/Jb.6.1.66.pdf", "code_system": "WHO INTERNATIONAL PHARMACOPEIA", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "0a295ae1-c50b-4fa8-b3a9-563b6ae10d28", "code": "1886", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/1886/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "e36abf8e-cb15-41f1-8770-c46a8b787cb5", "code": "m2909", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m2909?q=authorize", "code_system": "MERCK INDEX", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "33d90339-c2a7-434a-bdcb-394d277caecb", "code": "DB00201", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00201", "code_system": "DRUG BANK", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "8d4da1ad-1d93-409a-b45d-ba42ad59999a", "code": "SUB26077", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "d3fc69b4-4e6d-40ed-b82d-7c3c9a4a217b", "code": "SUB13146MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "3d479c56-93dc-4819-a088-a35c3cb849ea", "code": "CHEMBL113", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL113", "code_system": "ChEMBL", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "5f298980-2e02-4b0b-b117-aed40ad2932b", "code": "2519", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/2519", "code_system": "PUBCHEM", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "df1c700a-ee98-4a78-81ae-590e380da569", "code": "N06BC01", "comments": "ATC|NERVOUS SYSTEM|PSYCHOANALEPTICS|PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS|Xanthine derivatives|caffeine", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N06BC01&showdescription=yes", "code_system": "WHO-ATC", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "8c117d11-4b51-4a01-9b6a-fb4fcb7cfe55", "code": "N0000008118", "comments": "Chemical Ingredients [Chemical/Ingredient]|Heterocyclic Compounds [Chemical/Ingredient]|Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]|Purines [Chemical/Ingredient]|Purinones [Chemical/Ingredient]|Xanthines [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000008118", "code_system": "NDF-RT", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "8dbb4ef0-fcb1-4f2a-b12f-579496c22479", "code": "N0000008118", "comments": "Chemical Ingredients [Chemical/Ingredient]|Heterocyclic Compounds [Chemical/Ingredient]|Alkaloids [Chemical/Ingredient]|Xanthines [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000008118", "code_system": "NDF-RT", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "2d1bcb0a-5802-45ce-8b91-d96ea4871252", "code": "N0000175790", "comments": "Established Pharmacologic Class [EPC]|Methylxanthine [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175790", "code_system": "NDF-RT", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "82c33642-3c16-4c9c-87e9-18faa6420b8e", "code": "N0000175739", "comments": "Established Pharmacologic Class [EPC]|Central Nervous System Stimulant [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175739", "code_system": "NDF-RT", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "3fa827ce-2ffd-4254-83a3-cbee2d388395", "code": "QN06BC01", "comments": "VATC|PSYCHOANALEPTICS|PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS|Xanthine derivatives|caffeine", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QN06BC01&showdescription=yes", "code_system": "WHO-VATC", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "0854e5f7-90c1-405e-a672-6ec0bf864df5", "code": "N0000175729", "comments": "Physiological Effects [PE]|Organ System Specific Effects [PE]|Nervous System Activity Alteration [PE]|Central Nervous System Activity Alteration [PE]|Central Nervous System Stimulation [PE]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175729", "code_system": "NDF-RT", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "032d16d0-29b7-4b5b-8d9d-9affa3ba40ac", "code": "QV04CG30", "comments": "VATC|DIAGNOSTIC AGENTS|OTHER DIAGNOSTIC AGENTS|Tests for gastric secretion|caffeine and sodium benzoate", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QV04CG30&showdescription=yes", "code_system": "WHO-VATC", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "dfe1f56c-2d2a-48f2-9ad2-30f56503ac28", "code": "58-08-2", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=58-08-2", "code_system": "CAS", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8", "26fbb050-daf5-4803-a1dc-7b42b7aecac8" ] }, { "uuid": "7de83a78-0a92-49d6-8859-5d653dc3a2a2", "code": "C328", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C328", "code_system": "NCI_THESAURUS", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "07f69e57-dc5b-4629-b948-55fd99f0bb85", "code": "D002110", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68002110", "code_system": "MESH", "references": [ "dfd05a5c-1616-404c-9483-bd2d2fb338d8" ] }, { "uuid": "8527884d-c9f1-cdb2-231b-aa2fdde206ba", "code": "DTXSID0020232", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232", "code_system": "EPA CompTox", "references": [ "8bbdbce1-04e0-b802-76be-3fba36624e30" ] }, { "uuid": "45e8c0af-ed60-74fd-d5da-857d51a43c6b", "code": "35", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/36", "code_system": "HSDB", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "bae92f14-712f-6fec-3acd-90f765e6695f", "code": "367512", "comments": "ORPHAN DRUG|Designated|Treatment of seizure prolongation in patients undergoing electroconvulsive therapy", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=367512", "code_system": "FDA ORPHAN DRUG" }, { "uuid": "833af8c9-43d9-e022-51fb-73562bdf717c", "code": "Caffeine", "comments": "IARC|GROUP 3 ( Not classifiable as to its carcinogenicity to humans)", "type": "PRIMARY", "code_system": "IARC", "references": [ "cc4df23c-e07d-e00b-8178-4e330a53dd65" ] }, { "uuid": "6c40306d-585e-8fc1-7bc5-442ac726614d", "code": "C47795", "comments": "Pharmacologic Substance[C1909]|Agent Affecting Nervous System[C78272]|CNS Stimulant", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47795", "code_system": "NCI_THESAURUS", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "5b5452a9-7efc-7df1-19d5-a6313bebd828", "code": "C54060", "comments": "Food or Food Product[C1949]|Food Component[C1930]|Bioactive Food Component", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C54060", "code_system": "NCI_THESAURUS", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "f123aede-4a29-4f87-80ee-9145deac1280", "code": "3G6A5W338E", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "7d7a8c3a-9937-8cbb-9d30-78b64ff03fd0", "code": "1085003", "type": "PRIMARY", "url": "https://store.usp.org/product/1085003", "code_system": "RS_ITEM_NUM", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "06f312c6-ca1d-7888-8345-c9b40eef3231", "code": "Caffeine", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/n/lactmed/LM582/", "code_system": "LACTMED", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "d0f951c9-b1a5-4f69-93d3-5ab1951d3b21", "code": "31288", "comments": "ORPHAN DRUG|Designated/Approved|Treatment of apnea of prematurity", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=31288", "code_system": "FDA ORPHAN DRUG", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "2d549668-0c44-1806-cdaf-d3a3ecca2bfa", "code": "463", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/463", "code_system": "DRUG CENTRAL", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "8fe828c8-850a-43fb-12e7-ac1bcfc0a517", "code": "367 (Number of products:3156)", "comments": "Dietary Supplement Label Database|Chemical|Caffeine", "type": "PRIMARY", "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=367&item=Caffeine", "code_system": "DSLD", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "874bc148-f8b3-5841-d51c-1d5240f680e7", "code": "27732", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:27732", "code_system": "CHEBI", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "f1c08d87-2b57-d2f3-8c5a-7f670d0f14d3", "code": "100000089693", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "bd820ee2-69e1-c555-217f-c0cd20188712" ] }, { "uuid": "ad3dd0da-0da1-7fb4-5247-220054cf7c68", "code": "5036", "type": "PRIMARY", "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=5036", "code_system": "NSC", "references": [ "73a63248-5378-fffb-1504-b4cb7e523989" ] }, { "uuid": "11cbc3a3-2b81-09ce-7801-ed8af9f9512c", "code": "3G6A5W338E", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=3G6A5W338E", "code_system": "DAILYMED", "references": [ "503ea693-06aa-0708-906c-611abb3c4ce6" ] }, { "uuid": "be709c4a-760a-c51b-4b21-64e346651121", "code": "347", "type": "PRIMARY", "url": "https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=347", "code_system": "GRAS Notification (GRN No.)", "references": [ "84dec17b-36e5-adf0-2973-71718b8c9222" ] }, { "uuid": "305b4e47-3976-48fd-86f5-b28199004206", "code": "1086006", "type": "ALTERNATIVE", "url": "https://store.usp.org/product/1086006", "code_system": "RS_ITEM_NUM", "references": [ "1ace3f55-6fff-c551-084b-2a1c1ada10d8" ] } ], "substance_class": "chemical", "references": [ { "uuid": "62a69e2b-61a4-4653-9ca9-164fe58ca0e1", "citation": "European Pharmacopoeia Online 9.8, Theophylline-Ethylenediamine Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "095910af-920d-b4ac-1c35-bc56f0411f9b", "citation": "European Pharmacopoeia Online 9.8, Theophylline Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "66931e0c-b0fe-e555-c79b-3f66b117d7ec", "citation": "USP42-NF37 - 4284, Theophylline Monograph", "doc_type": "USPNF", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "bd338b3c-857b-41c9-880a-f9211bcd3760", "citation": "USP Dictionary 2008", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "addfdb13-8037-40fd-bfde-9af893de962c", "citation": "USP DICTIONARY 2008", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "07c3efa1-823e-454c-9655-1ddbc735db4d", "citation": "HPUS", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "3eaacc51-e5c3-4d45-80a8-d0940be1adbc", "citation": "HPUS 06/19/2006", "doc_type": "HOMEOPATHIC PHARMACOPOEIA US", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c5bfe759-8a82-42ca-9353-eb3a3f2ab237", "citation": "CHEMID 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "6cfbea5e-9bfe-483c-8c75-84e74de5e90c", "citation": "EP 7.2", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "d974f2ac-f570-4af2-b398-9551f443abc3", "citation": "USP 33", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9eea2254-af95-432c-b251-008fdad6fb56", "citation": "HPUS 2011", "doc_type": "HOMEOPATHIC PHARMACOPOEIA US", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "a4aa18be-b27f-4e86-9347-cf6f6895971a", "citation": "Drugs@FDA 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c1adf665-90b0-44ca-8194-6d08d955b1e5", "citation": "Drugs@FDA 2012", "doc_type": "DRUGS@FDA", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "8ca0255f-658b-4d9c-8bee-824d85db27e2", "citation": "FHFI", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9bc46a5a-460f-43da-84c5-35c732887eb6", "citation": "ORANGE BOOK 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "97b51480-c534-42c9-9b02-5a33a09cd259", "citation": "MARTINDALE 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "684b6411-e9df-4723-a2c0-bc61491fc8dd", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "5d4a75c3-4208-4672-b412-a8c4a2948910", "citation": "PCPC", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "4730d5ba-74f3-43b6-8208-d893159a43c5", "citation": "FCC", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "a78da67b-ef08-46f6-8bd2-d2920cbcd334", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9833eac4-f7ed-4ec0-938b-8938dc1c5733", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "af63fa39-8d00-487b-82d1-6c476c0e5817", "citation": "JAN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "f7cd3787-fed4-4575-ba1b-33e52457d845", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "be88c904-388e-46e4-bf09-6e457d05976d", "citation": "EP", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1e21e521-99be-47c5-a66e-4cd6247a8ca4", "citation": "EP 7.8", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "24591143-4b3f-4e36-b616-cd3839f378d5", "citation": "USP-RS", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "230ef781-2ece-4187-b76a-7632d1c790a9", "citation": "WHO-IP", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "dfd05a5c-1616-404c-9483-bd2d2fb338d8", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389715000, "tags": [ "NOMEN" ] }, { "uuid": "16eaa4b9-bd47-47f6-b7b5-7eb2994df5f1", "citation": "THE INTERNATIONAL PHARMACOPOEIA FIFTH EDITION", "url": "http://apps.who.int/phint/en/p/docf/", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "230bc736-01c5-4fff-83da-1bacf24f4090", "citation": "USP-MC", "url": "https://mc.usp.org/monographs/aminophylline-0-1", "doc_type": "USP-MC", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "9fef6562-f26f-4a65-aab4-96b61010dc88", "citation": "HERBAL MEDICINES 4TH ED", "doc_type": "BOOK", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "849d78c7-4740-4e12-a23c-9b8c307c9d30", "citation": "PEREIRA CARO, G; PROFILES OF PHENOLIC COMPOUNDS AND PURINE ALKALOIDS DURING THE DEVELOPMENT OF SEEDS OFTHEOBROMA CACAOCV. TRINITARIO; JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY; 61(2)427-434, 2013", "url": "http://pubs.acs.org/doi/ipdf/10.1021/jf304397m", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "570114ed-4845-48a3-af84-c53887826123", "citation": "http://www.accessdata.fda.gov/spl/data/3ab46727-2997-4e4e-8b0b-b69b00db9ca5/3ab46727-2997-4e4e-8b0b-b69b00db9ca5.xml", "url": "http://www.accessdata.fda.gov/spl/data/3ab46727-2997-4e4e-8b0b-b69b00db9ca5/3ab46727-2997-4e4e-8b0b-b69b00db9ca5.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "16e9df68-293e-4943-8f36-48deb071ca64", "citation": "https://www.pharmgkb.org/pathway/PA165884757", "url": "https://www.pharmgkb.org/pathway/PA165884757", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c423e0a7-3720-4fdf-8770-50ba3afdc093", "citation": "DRUG METABOLISM HANDBOOK, ED. A.F. NASSER, 2009, PG:371", "doc_type": "BOOK", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "8844f3f7-2f71-4768-81e2-9a43efe31ab5", "citation": "SRS import [3G6A5W338E]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=3G6A5W338E", "doc_type": "SRS", "public_domain": true, "document_date": 1493389715000, "tags": [ "NOMEN" ] }, { "uuid": "9b587fcc-dac5-4ba7-a138-bb1cea49b7e2", "citation": "CAFFEINE [EP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "ce9dec0d-b079-40d3-bca2-f68c93bc42f1", "citation": "CAFFEINE [USP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b2834f85-b0c8-4e1a-8451-63db1df4c99d", "citation": "CAFFEINUM [HPUS]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "927ce17e-491f-48ce-9bb0-4df54eeffdf5", "citation": "CAFFEINE [FHFI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "e928df8a-8bf3-43ea-bf06-a52d626426bb", "citation": "CAFFEINE [ORANGE BOOK]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "19d052b3-b7dd-464a-b067-31f64dd135e8", "citation": "CAFFEINE [MART.]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "76e5bea8-a863-431c-91e5-a7a601031ec0", "citation": "CAFFEINE [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "e57197c0-4960-4adf-8a9e-2f64e06a532e", "citation": "CAFFEINE [INCI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "ebb0c0fe-43e5-49be-8e76-872101d228b8", "citation": "CAFFEINE [FCC]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "113fafc6-3b35-4bc6-9c9a-25680e5ebbdd", "citation": "CAFFEINE [II]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "a2a05f9c-3629-4a35-adee-20f9a7f33584", "citation": "CAFFEINE [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "d092da08-5b58-4aa2-a7ad-7a0345f22a25", "citation": "CAFFEINE [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "a3e5ccd3-91da-4d97-8a9b-f3da062f4f3e", "citation": "ANHYDROUS CAFFEINE [JAN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b05b00b6-1f07-427b-9e6a-e8e10cedbb7a", "citation": "CAFFEINE [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "53c1569c-b0f0-4126-98b5-645a7934e90d", "citation": "DIMENHYDRINATE IMPURITY C [EP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "ee893e0f-7652-465a-99af-3aa5e31d1645", "citation": "CAFFEINE MELTING POINT STANDARD [USP-RS]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "14ee9456-2d37-4a90-a5b5-d5cd24bfd308", "citation": "CAFFEINE [WHO-IP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "99cbe7c2-d8fa-4981-afed-a31a5892011b", "citation": "CAFFEINE ANHYDROUS [WHO-IP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "13892b2d-b8d8-2bc5-211c-654f50874375", "citation": "https://www.clinicalkey.com/pharmacology/monograph/81?sec=monphar", "doc_type": "LEPINDEX", "public_domain": true }, { "uuid": "dc83d0cd-8150-3812-aa36-502251baef0a", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+58-08-2", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "8bbdbce1-04e0-b802-76be-3fba36624e30", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=58-08-2", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e5a747a3-41be-1b7a-10fe-ae307ee23cd3", "citation": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=63841f53-a567-4102-80b5-3565d9b52373", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "96766133-71ad-f65d-0c4d-3a7cefb6635a", "citation": "Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25): 7833–7838.\nPublished online 2015 Jun 8. doi: 10.1073/pnas.142308811", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485143/", "doc_type": "JA", "public_domain": true }, { "uuid": "db36e7c9-6562-742e-aad3-62abe75daea2", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+lactmed:@term+@rel+@rn+58-08-2", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "bd820ee2-69e1-c555-217f-c0cd20188712", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "cc4df23c-e07d-e00b-8178-4e330a53dd65", "citation": "IARC", "doc_type": "IARC", "public_domain": true }, { "uuid": "39938b87-ae0e-1f8b-4ec9-55f20e62f9ca", "citation": "EP", "url": "http://online6.edqm.eu/ep906/mobile/#documentPage", "doc_type": "EP", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "84dec17b-36e5-adf0-2973-71718b8c9222", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "26fbb050-daf5-4803-a1dc-7b42b7aecac8", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f", "citation": "European Pharmacopoeia Online 9.8, Caffeine Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "81112dda-2bb8-46a6-a010-8fa2e49635b3", "citation": "European Pharmacopoeia Online 9.8, Theophylline Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "8f7fafb2-5e89-1bc9-bc94-84eb6419efdf", "citation": "USP42-NF37 - 237, Aminophylline Monograph", "doc_type": "USPNF", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "2ff726f7-96f4-8c1e-9926-c3836add9799", "citation": "European Pharmacopoeia Online 9.8, Pentoxifylline Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7503f783-17ce-5632-ba81-27c184bb25ee", "citation": "European Pharmacopoeia Online 9.8, Theophylline Monohydrate Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "637f7280-046e-4cc0-aed3-d6b0f255a8b2", "citation": "Jacobson, Kenneth A., et al. \"Adenosine A2A receptor antagonists: From caffeine to selective non-xanthines.\" British Journal of Pharmacology (2020).", "url": "https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15103", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1ace3f55-6fff-c551-084b-2a1c1ada10d8", "citation": "USP-RS", "doc_type": "USPNF", "public_domain": true }, { "uuid": "f4774585-911d-4244-add1-7e8456bad8da", "citation": "Clin Pharmacol Ther 1987;42(2):157", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a4736baf-4351-4645-a90f-2c530959f949", "citation": "Clin Pharmacol Ther 1987;42(5):509", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "d99ef65b-af88-47aa-af5c-8c08e9699458", "citation": "Clin Pharmacol Ther 1987;42(2):157", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "6835d53a-5342-02a9-4d99-67986ea27be9", "citation": "EP 10.5", "doc_type": "EP", "public_domain": true }, { "uuid": "63998115-2c57-4b6a-9094-7a25aa019ccc", "citation": "Yu, Fazhi, et al. \"Adenosine A2A Receptor Antagonists for Cancer Immunotherapy: Miniperspective.\" Journal of Medicinal Chemistry 63.21 (2020): 12196-12212.", "url": "https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00237", "doc_type": "JA", "public_domain": true }, { "uuid": "8788538a-1a55-45ef-a944-ce3b20911b58", "citation": "Faudone, Giuseppe, Silvia Arifi, and Daniel Merk. \"The Medicinal Chemistry of Caffeine.\" Journal of Medicinal Chemistry (2021).", "url": "https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00261", "doc_type": "JA", "public_domain": true }, { "uuid": "503ea693-06aa-0708-906c-611abb3c4ce6", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "9fb3af42-ce52-795b-1b28-248d40711cc9", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "73a63248-5378-fffb-1504-b4cb7e523989", "citation": "NCI", "doc_type": "NCI DRUG DICTIONARY", "public_domain": true }, { "uuid": "ddb5bba9-f067-46a9-aa6b-3ddd9b6f884c", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "3f0c2506-5e4c-4ccf-8651-74dad2ff1520", "id": "3f0c2506-5e4c-4ccf-8651-74dad2ff1520", "molfile": "\n Marvin 01132103202D \n\n 14 15 0 0 0 0 999 V2000\n 3.1590 -0.1955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9120 -0.9827 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 3.3905 -1.6464 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9120 -2.3024 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1223 -2.0554 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -2.4644 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -3.2902 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.7049 -2.0554 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.0000 -2.4644 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.7049 -1.2297 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 0.0000 -0.8206 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -0.8206 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1223 -1.2297 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0 0 0 0\n 3 2 1 0 0 0 0\n 2 14 1 0 0 0 0\n 3 4 2 0 0 0 0\n 4 5 1 0 0 0 0\n 6 5 1 0 0 0 0\n 14 5 2 0 0 0 0\n 7 6 1 0 0 0 0\n 8 6 1 0 0 0 0\n 9 8 2 0 0 0 0\n 10 8 1 0 0 0 0\n 11 10 1 0 0 0 0\n 12 10 1 0 0 0 0\n 13 12 2 0 0 0 0\n 12 14 1 0 0 0 0\nM END", "smiles": "Cn1cnc2c1c(=O)n(C)c(=O)n2C", "formula": "C8H10N4O2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ACHIRAL", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "e6ecf480-30ae-435e-afe3-699f19216f0a" }, "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "194.1909", "optical_activity": "NONE", "stereo_centers": 0 } ], "definition_level": "COMPLETE", "uuid": "f9c12f2f-ad99-4f1c-b96b-ac7ec1dc08df", "version": "131", "structure": { "id": "ef060ead-9884-4837-a414-1a9ac8cbf1da", "molfile": "\n Marvin 01132112232D \n\n 14 15 0 0 0 0 999 V2000\n 2.1223 -2.0554 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1223 -1.2297 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -2.4644 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 0.7049 -1.2297 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 0.7049 -2.0554 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -0.8206 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9120 -2.3024 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9120 -0.9827 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 3.3905 -1.6464 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.0000 -2.4644 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4226 -3.2902 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.0000 -0.8206 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.1590 -0.1955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2 1 2 0 0 0 0\n 3 1 1 0 0 0 0\n 4 5 1 0 0 0 0\n 5 3 1 0 0 0 0\n 6 2 1 0 0 0 0\n 7 1 1 0 0 0 0\n 8 2 1 0 0 0 0\n 9 7 2 0 0 0 0\n 10 5 2 0 0 0 0\n 11 6 2 0 0 0 0\n 12 3 1 0 0 0 0\n 13 4 1 0 0 0 0\n 14 8 1 0 0 0 0\n 9 8 1 0 0 0 0\n 6 4 1 0 0 0 0\nM END", "smiles": "Cn1cnc2c1c(=O)n(C)c(=O)n2C", "formula": "C8H10N4O2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ACHIRAL", "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "194.1909", "optical_activity": "NONE", "references": [ "bd338b3c-857b-41c9-880a-f9211bcd3760", "8844f3f7-2f71-4768-81e2-9a43efe31ab5" ], "stereo_centers": 0 }, "unii": "3G6A5W338E", "relationships": [ { "uuid": "a8813bf2-37cf-4319-a401-6b7964ee4132", "amount": { "uuid": "ace7908c-b682-4304-a361-60aad754b65c" }, "comments": "http://apps.who.int/phint/pdf/b/Jb.6.1.66.pdf", "type": "ACTIVE MOIETY", "references": [ "16eaa4b9-bd47-47f6-b7b5-7eb2994df5f1", "62a69e2b-61a4-4653-9ca9-164fe58ca0e1" ], "related_substance": { "uuid": "5efe9c01-02d6-4761-95e6-3fb0ae0a79b5", "refuuid": "f9c12f2f-ad99-4f1c-b96b-ac7ec1dc08df", "name": "CAFFEINE", "unii": "3G6A5W338E", "linking_id": "3G6A5W338E", "ref_pname": "CAFFEINE", "substance_class": "reference" } }, { "uuid": "408ef81a-3b2e-46b0-9a45-517db107bfb2", "amount": { "uuid": "2a48e3ac-e349-4044-adcf-f9c900520381", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "62a69e2b-61a4-4653-9ca9-164fe58ca0e1" ], "related_substance": { "uuid": "2f767554-df61-426e-9eac-e6cfe1046320", "refuuid": "74eb553d-8998-4be3-9979-d8fcd4ef8098", "name": "AMINOPHYLLINE", "unii": "27Y3KJK423", "linking_id": "27Y3KJK423", "ref_pname": "AMINOPHYLLINE", "substance_class": "reference" } }, { "uuid": "d4f3de55-a786-4d1a-ac8e-2d8a6b75c7bd", "amount": { "uuid": "be65d753-dc1c-49a9-82af-bc5b247a2d4d" }, "type": "PARENT->CONSTITUENT ALWAYS PRESENT", "references": [ "9fef6562-f26f-4a65-aab4-96b61010dc88" ], "related_substance": { "uuid": "7f765900-1410-4188-aee9-0ff29552a228", "refuuid": "37e961d8-d4e4-431e-a480-ba81870a29f4", "name": "COLA NUT", "unii": "PQM9SA369U", "linking_id": "PQM9SA369U", "ref_pname": "COLA NUT", "substance_class": "reference" } }, { "uuid": "5910c38b-3ebe-4b10-bea3-4dcb4ec67b09", "amount": { "uuid": "c9d8c74c-4416-490a-80e7-2c651924588a" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "203fc174-19e9-4a9a-a617-1eb095bddd4c", "refuuid": "7ea186d3-1e88-4a65-bd88-f197f94d6eda", "name": "CAFFEINE BENZOATE", "unii": "C2154V12SE", "linking_id": "C2154V12SE", "ref_pname": "CAFFEINE BENZOATE", "substance_class": "reference" } }, { "uuid": "16215880-ed86-4614-ad71-24db1232d19e", "amount": { "uuid": "488b9190-948d-406f-9c73-6fed04036c41" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "6ceeddd3-561a-497b-8e7e-babfe415988e", "refuuid": "964a386b-4195-4f5d-a685-b0d46a20a50e", "name": "CAFFEINE CITRATE", "unii": "U26EO4675Q", "linking_id": "U26EO4675Q", "ref_pname": "CAFFEINE CITRATE", "substance_class": "reference" } }, { "uuid": "964f536f-02c1-4521-a845-e194a161fc07", "amount": { "uuid": "7d80f7bd-8ec8-4355-9301-061440fb496e" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "bfdb2b5b-e630-4da8-b9a2-9b7819360385", "refuuid": "f8660a4c-c3fd-4343-9c26-0c4bf6bb6545", "name": "CAFFEINE MONOHYDRATE", "unii": "9T65I06326", "linking_id": "9T65I06326", "ref_pname": "CAFFEINE MONOHYDRATE", "substance_class": "reference" } }, { "uuid": "f4c13621-866c-42c4-a588-6e904f84c367", "amount": { "uuid": "d248df97-118b-4a80-8156-0c8c30e8fc19" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "70a3f70a-996a-4b0e-93ce-fd98aec98d6a", "refuuid": "9bd77bf2-df85-4418-989a-44ec95b62a4f", "name": "CAFFEINE SALICYLATE", "unii": "U7R78VQQ6O", "linking_id": "U7R78VQQ6O", "ref_pname": "CAFFEINE SALICYLATE", "substance_class": "reference" } }, { "uuid": "81cdc088-2416-4283-ba5f-a5c8c430edcf", "amount": { "uuid": "821aa66f-6178-48df-b465-5f20e24c136a" }, "comments": "Secondary metabolite detected in developing cacao seeds.", "type": "PARENT->CONSTITUENT ALWAYS PRESENT", "references": [ "849d78c7-4740-4e12-a23c-9b8c307c9d30" ], "related_substance": { "uuid": "511ac5ea-c419-42a6-ab33-5975e15773e4", "refuuid": "2c12d667-f6c9-4b7a-9a30-ce616452e284", "name": "COCOA", "unii": "D9108TZ9KG", "linking_id": "D9108TZ9KG", "ref_pname": "COCOA", "substance_class": "reference" } }, { "uuid": "6b4e3b7f-8ad7-43a0-9a55-0629fb1bf702", "amount": { "uuid": "d3668fad-65dd-4919-b1f2-9c211fd30cc4" }, "qualification": "URINE", "type": "METABOLITE->PARENT", "references": [ "f4774585-911d-4244-add1-7e8456bad8da" ], "related_substance": { "uuid": "6a6841a0-3b3d-4a3c-b770-2a1be7cc2207", "refuuid": "adf1b03e-305f-44fd-802e-6d39a5afa357", "name": "1-METHYLXANTHINE", "unii": "7EE8WCA32U", "linking_id": "7EE8WCA32U", "ref_pname": "1-METHYLXANTHINE", "substance_class": "reference" } }, { "uuid": "d89c1f48-3613-4a9e-8086-14360c3f2225", "amount": { "uuid": "9be2c982-2ef9-4253-ad33-7e47f2448009" }, "comments": "Hepatic biotransformation prior to excretion results in about equal amounts of 1-methylxanthine and 1-methyluric acid.", "type": "METABOLITE->PARENT", "references": [ "570114ed-4845-48a3-af84-c53887826123" ], "related_substance": { "uuid": "839811f3-35d8-4640-9ec8-153887acffad", "refuuid": "6bea44c9-4333-409b-81f7-dffc352b6a1b", "name": "1-METHYLURIC ACID", "unii": "2WS4HQ639J", "linking_id": "2WS4HQ639J", "ref_pname": "1-METHYLURIC ACID", "substance_class": "reference" } }, { "uuid": "c6145175-db2e-4c0d-98de-8932ac963152", "amount": { "uuid": "de1c63e6-c8ac-4b2d-b168-6959d1c0e14f", "type": "RELATIONSHIP_AMOUNT", "average": 75, "units": "MOLE PERCENT", "high_limit": 85, "low_limit": 70 }, "comments": "MAIN PRIMARY METABOLITE; METABOLISM OCCURS IN LIVER", "qualification": "PLASMA; URINE", "type": "METABOLITE ACTIVE->PARENT", "interaction_type": "MAJOR", "mediator_substance": { "uuid": "d1efb568-94d3-4ac7-b67e-9caf6900ecd3", "refuuid": "2964cc53-40a9-4b2b-b19c-d61342fadb5a", "name": "CYTOCHROME P450 1A2", "unii": "VK4SQL11C0", "linking_id": "VK4SQL11C0", "ref_pname": "CYTOCHROME P450 1A2", "substance_class": "reference" }, "references": [ "16e9df68-293e-4943-8f36-48deb071ca64" ], "related_substance": { "uuid": "d799effc-336f-4dee-ad6f-c121c8b49e3a", "refuuid": "9305d959-3f47-48ec-b734-afa26a1d97fc", "name": "PARAXANTHINE", "unii": "Q3565Y41V7", "linking_id": "Q3565Y41V7", "ref_pname": "PARAXANTHINE", "substance_class": "reference" } }, { "uuid": "04bb54ac-65e7-41df-ba10-5d4a7e09ce57", "amount": { "uuid": "fda06017-063b-4a1d-8979-4a83307a895a", "type": "RELATIONSHIP_AMOUNT", "average": 7.5, "units": "MOLE PERCENT", "high_limit": 8, "low_limit": 7 }, "qualification": "PLASMA", "type": "METABOLITE ACTIVE->PARENT", "interaction_type": "MINOR", "mediator_substance": { "uuid": "f54c9926-7c0a-4a58-9cd9-9a0b71502642", "refuuid": "2964cc53-40a9-4b2b-b19c-d61342fadb5a", "name": "CYTOCHROME P450 1A2", "unii": "VK4SQL11C0", "linking_id": "VK4SQL11C0", "ref_pname": "CYTOCHROME P450 1A2", "substance_class": "reference" }, "references": [ "16e9df68-293e-4943-8f36-48deb071ca64" ], "related_substance": { "uuid": "da876c62-4101-4040-81f9-9f1187b562b7", "refuuid": "f5c04c2d-acb2-4ae1-8975-75ca33f0ab91", "name": "THEOBROMINE", "unii": "OBD445WZ5P", "linking_id": "OBD445WZ5P", "ref_pname": "THEOBROMINE", "substance_class": "reference" } }, { "uuid": "42bedd4e-8597-45c5-b47a-d825c2171e60", "amount": { "uuid": "0e4881f2-168e-4a43-b098-02a35e2ad272" }, "type": "METABOLIC ENZYME->SUBSTRATE", "references": [ "c423e0a7-3720-4fdf-8770-50ba3afdc093" ], "related_substance": { "uuid": "6e1fe7aa-d2c5-40ec-bf2b-56f2b870f082", "refuuid": "2964cc53-40a9-4b2b-b19c-d61342fadb5a", "name": "CYTOCHROME P450 1A2", "unii": "VK4SQL11C0", "linking_id": "VK4SQL11C0", "ref_pname": "CYTOCHROME P450 1A2", "substance_class": "reference" } }, { "uuid": "2cb59868-03a1-4d45-8d13-a1ac29d07a52", "amount": { "uuid": "16817d49-21fc-4f78-8c0d-d1cb57b509fe" }, "type": "PARENT->METABOLITE ACTIVE", "related_substance": { "uuid": "811f6fc7-4956-4fd9-b808-1c50b94ed6de", "refuuid": "76c4b680-31ca-4f46-95c2-5ba927dc573a", "name": "THEOPHYLLINE ANHYDROUS", "unii": "0I55128JYK", "linking_id": "0I55128JYK", "ref_pname": "THEOPHYLLINE ANHYDROUS" } }, { "uuid": "af64d067-524d-4c95-be0f-88f105918e98", "amount": { "uuid": "fdf2cdc6-fd4a-4f0e-9345-403383c41d76", "average": 23400, "units": "NANOMOLAR" }, "comments": "Nonselective adenosine receptor antagonist. May be responsible for pain relief.", "qualification": "Ki", "type": "TARGET->WEAK INHIBITOR", "references": [ "96766133-71ad-f65d-0c4d-3a7cefb6635a", "63998115-2c57-4b6a-9094-7a25aa019ccc" ], "related_substance": { "uuid": "0d8ab8ca-957d-4ac5-85ab-a203938ce737", "refuuid": "83ef8407-ced8-4588-bbb0-5a500bce6d4e", "name": "ADENOSINE RECEPTOR A2A", "unii": "Y154T023U0", "linking_id": "Y154T023U0", "ref_pname": "ADENOSINE RECEPTOR A2A", "substance_class": "reference" } }, { "uuid": "8e2c1296-46ef-4adb-bbc0-502456295c11", "amount": { "uuid": "d6244afd-296a-495d-a00f-08a9491fc789" }, "type": "METABOLITE->PARENT", "related_substance": { "uuid": "c7354611-6d39-45ae-8c57-5e1ed2806c29", "refuuid": "dd862a69-87a0-4c7a-8da4-4d80eb1f51ee", "name": "1,3,7-TRIMETHYL-5,9-DIHYDRO-4H-PURINE-2,6,8-TRIONE", "unii": "7LK9XP3RST", "linking_id": "7LK9XP3RST", "ref_pname": "1,3,7-TRIMETHYL-5,9-DIHYDRO-4H-PURINE-2,6,8-TRIONE" } }, { "uuid": "9acf981a-267f-44b2-95bd-6f106bdd989a", "amount": { "uuid": "4534ba8a-4e5b-4e5a-9c24-f3b272ce1f49", "average": 36, "high": 36, "low": 10, "units": "%" }, "type": "BINDER->LIGAND", "interaction_type": "BINDING", "references": [ "13892b2d-b8d8-2bc5-211c-654f50874375" ], "related_substance": { "uuid": "94642bb0-9793-4d3d-9e5f-53b20427e21b", "refuuid": "e95d330b-4c2d-44bb-a61b-860afeb4aa30", "name": "PLASMA PROTEIN FRACTION (HUMAN)", "unii": "6D53G0FD0Z", "linking_id": "6D53G0FD0Z", "ref_pname": "PLASMA PROTEIN FRACTION (HUMAN)", "substance_class": "reference" } }, { "uuid": "ddcecbfb-f9bc-4db6-be1f-0632bd7a3447", "amount": { "uuid": "76a25915-36f0-4717-839b-57b8319298c8", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "a62bb373-9ddf-42f3-82eb-0c5e0507f45e", "refuuid": "76c4b680-31ca-4f46-95c2-5ba927dc573a", "name": "THEOPHYLLINE ANHYDROUS", "unii": "0I55128JYK", "linking_id": "0I55128JYK", "ref_pname": "THEOPHYLLINE ANHYDROUS", "substance_class": "reference" } }, { "uuid": "63938d2c-0b1b-4c62-b518-07cc119e7ce2", "amount": { "uuid": "57198a2a-66a5-4333-a1bf-c5c4053c0c00", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "5ea6d6c5-19d0-46ce-b1da-2a3ea376fb62", "refuuid": "9305d959-3f47-48ec-b734-afa26a1d97fc", "name": "PARAXANTHINE", "unii": "Q3565Y41V7", "linking_id": "Q3565Y41V7", "ref_pname": "PARAXANTHINE" } }, { "uuid": "02dc5701-4569-43d6-8314-a384977cf9f7", "amount": { "uuid": "95dd1626-e7d3-40de-9dd1-a086fcd6d5e2", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "ea331107-7d08-456a-a8c4-60a465676624", "refuuid": "4c7120a1-42a5-4c6f-9326-0b05ff4f8e69", "name": "ISOCAFFEINE", "unii": "N4HG7T2QGW", "linking_id": "N4HG7T2QGW", "ref_pname": "ISOCAFFEINE" } }, { "uuid": "c950acb3-8f32-4464-bd7c-3f6e0c3be209", "amount": { "uuid": "dbfa267f-24fe-489e-9d45-00d5e9fc7fe5" }, "type": "PARENT->CONSTITUENT ALWAYS PRESENT", "related_substance": { "uuid": "335eb823-6256-4ca7-b750-a240aca73bfa", "refuuid": "4f90b2cf-b642-497d-8d17-6b29e70198f7", "name": "PAULLINIA CUPANA SEED", "unii": "C21GE7524R", "linking_id": "C21GE7524R", "ref_pname": "PAULLINIA CUPANA SEED" } }, { "uuid": "248a2fd4-e990-423e-85fe-47759fd650f9", "amount": { "uuid": "3d360c0b-dc0a-41b0-b3a4-19bf9a199875", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "63e30a6e-4391-40b5-992f-c73427027b09", "refuuid": "f5c04c2d-acb2-4ae1-8975-75ca33f0ab91", "name": "THEOBROMINE", "unii": "OBD445WZ5P", "linking_id": "OBD445WZ5P", "ref_pname": "THEOBROMINE" } }, { "uuid": "9944ac8c-ef0a-4a17-8874-d0df458ec5aa", "amount": { "uuid": "87170e95-9abf-4625-8678-6246ecf6cc20", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "7fde236b-04e0-4dc5-ba74-5223b3cd4254", "refuuid": "a14cb118-f249-4472-9293-ec1457eb2dfb", "name": "6-AMINO-5-FORMAMIDO-1,3-DIMETHYLURACIL", "unii": "AT170UTH0F", "linking_id": "AT170UTH0F", "ref_pname": "6-AMINO-5-FORMAMIDO-1,3-DIMETHYLURACIL" } }, { "uuid": "8f830268-5000-43db-ae16-dbd955cb40b0", "amount": { "uuid": "d7f85614-2c4d-4566-baff-bee07de068e9", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9d5f5f54-4ec6-583d-2b34-4712fcfd6b0f" ], "related_substance": { "uuid": "26d3762b-e786-452e-8ea8-b12ba3abde47", "refuuid": "825c36b0-28ed-4262-a8cc-24ad249633d3", "name": "CAFFEIDINE", "unii": "VT2A7LG4EQ", "linking_id": "VT2A7LG4EQ", "ref_pname": "CAFFEIDINE" } }, { "uuid": "56cf66ee-7402-42c7-b1ee-53c587d1ef8d", "amount": { "uuid": "03621e09-ae37-4702-b60d-deb93227a6a2", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "095910af-920d-b4ac-1c35-bc56f0411f9b" ], "related_substance": { "uuid": "acdff2bf-9218-4dd8-98ab-52c4bf2dbb25", "refuuid": "76c4b680-31ca-4f46-95c2-5ba927dc573a", "name": "THEOPHYLLINE ANHYDROUS", "unii": "0I55128JYK", "linking_id": "0I55128JYK", "ref_pname": "THEOPHYLLINE ANHYDROUS", "substance_class": "reference" } }, { "uuid": "e0048984-7e36-4fd7-99e1-02b21bfceaf3", "amount": { "uuid": "1c1001fd-4e76-4763-be3d-0757323e8f6e", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "2ff726f7-96f4-8c1e-9926-c3836add9799" ], "related_substance": { "uuid": "bdad7f98-cc40-4d98-8938-3134e0ab342a", "refuuid": "8b111192-4481-4559-b7d5-13bdca3d1a9a", "name": "PENTOXIFYLLINE", "unii": "SD6QCT3TSU", "linking_id": "SD6QCT3TSU", "ref_pname": "PENTOXIFYLLINE", "substance_class": "reference" } }, { "uuid": "4c1acbbc-121e-4765-8654-c5c8323d347f", "amount": { "uuid": "13468e53-0d4e-481e-aa81-608d42b6f59b", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "7503f783-17ce-5632-ba81-27c184bb25ee" ], "related_substance": { "uuid": "82fe06e0-da63-4b1f-81eb-199c8f0f19b5", "refuuid": "6a7f3320-2fc8-47f0-bcd3-c4f73b9ae9d4", "name": "THEOPHYLLINE", "unii": "C137DTR5RG", "linking_id": "C137DTR5RG", "ref_pname": "THEOPHYLLINE", "substance_class": "reference" } }, { "uuid": "fc009144-b6e2-4c15-bec9-11f1260965eb", "amount": { "uuid": "1ed864ab-06ca-4bf2-bbec-0b677bc89267", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "USP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "8f7fafb2-5e89-1bc9-bc94-84eb6419efdf" ], "related_substance": { "uuid": "c67ff79a-9e01-4f87-b525-efb871d0d76d", "refuuid": "74eb553d-8998-4be3-9979-d8fcd4ef8098", "name": "AMINOPHYLLINE", "unii": "27Y3KJK423", "linking_id": "27Y3KJK423", "ref_pname": "AMINOPHYLLINE", "substance_class": "reference" } }, { "uuid": "d3042f10-2890-4c00-8378-460d1d0f90c2", "amount": { "uuid": "b0126c1e-7bbd-47a1-914b-d236d63e7b59", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "USP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "66931e0c-b0fe-e555-c79b-3f66b117d7ec" ], "related_substance": { "uuid": "c2ac9441-fda5-41a0-adcf-8460a41fe02e", "refuuid": "6a7f3320-2fc8-47f0-bcd3-c4f73b9ae9d4", "name": "THEOPHYLLINE", "unii": "C137DTR5RG", "linking_id": "C137DTR5RG", "ref_pname": "THEOPHYLLINE", "substance_class": "reference" } }, { "uuid": "0f7229aa-7456-a857-ed25-02d451992b7e", "amount": { "uuid": "52d0b2ad-fea5-49fb-9344-0265ed45a509" }, "type": "SOLVATE->ANHYDROUS", "references": [ "26fbb050-daf5-4803-a1dc-7b42b7aecac8" ], "related_substance": { "uuid": "bed24108-83ac-4a90-bfb9-89fe818645e2", "refuuid": "f8660a4c-c3fd-4343-9c26-0c4bf6bb6545", "name": "CAFFEINE MONOHYDRATE", "unii": "9T65I06326", "linking_id": "9T65I06326", "ref_pname": "CAFFEINE MONOHYDRATE" } }, { "uuid": "6081d396-820f-42c7-bad8-e211dcad31ff", "amount": { "uuid": "6dbca8d5-1b6f-42b6-8202-c4d5f98c1259" }, "type": "METABOLIC ENZYME->SUBSTRATE", "references": [ "8788538a-1a55-45ef-a944-ce3b20911b58" ], "related_substance": { "uuid": "17f9d1ef-7d70-4204-b7d2-f7f08f0fd3d4", "refuuid": "463ea1a6-dc7e-4a42-b799-8e2852d34a78", "name": "ARYLAMINE N-ACETYLTRANSFERASE 2", "unii": "R17Q1X3RGX", "linking_id": "R17Q1X3RGX", "ref_pname": "ARYLAMINE N-ACETYLTRANSFERASE 2", "substance_class": "reference" } }, { "uuid": "733e4586-3704-4e22-8bc5-3e684d2a8c20", "amount": { "uuid": "71fae33f-fc50-4cca-8e7c-6c6ee75c9b42" }, "type": "METABOLIC ENZYME->SUBSTRATE", "references": [ "8788538a-1a55-45ef-a944-ce3b20911b58" ], "related_substance": { "uuid": "f29e6af0-1aad-4609-bb23-9b14b32223b2", "refuuid": "117e08c3-651b-4717-8a10-8c0a0689b11a", "name": "XANTHINE DEHYDROGENASE/OXIDASE", "unii": "ATA6VBL43H", "linking_id": "ATA6VBL43H", "ref_pname": "XANTHINE DEHYDROGENASE/OXIDASE", "substance_class": "reference" } }, { "uuid": "30af6634-a48c-44e3-8235-b3f9a34a03ca", "amount": { "uuid": "7aa69196-327b-42c6-9b04-8d5d5dd2cd30" }, "qualification": "URINE", "type": "METABOLITE->PARENT", "mediator_substance": { "uuid": "3074764b-053a-4409-8337-c38a6d143ff8", "refuuid": "117e08c3-651b-4717-8a10-8c0a0689b11a", "name": "XANTHINE DEHYDROGENASE/OXIDASE", "unii": "ATA6VBL43H", "linking_id": "ATA6VBL43H", "ref_pname": "XANTHINE DEHYDROGENASE/OXIDASE", "substance_class": "reference" }, "references": [ "d99ef65b-af88-47aa-af5c-8c08e9699458" ], "related_substance": { "uuid": "f7485ca6-87c2-43ba-9a62-45c8bdb2c389", "refuuid": "584170e4-36fa-4625-ac7d-c6f86f2bab5f", "name": "1,7-DIMETHYLURIC ACID", "unii": "Z633Z7KAJU", "linking_id": "Z633Z7KAJU", "ref_pname": "1,7-DIMETHYLURIC ACID" } }, { "uuid": "817590ec-a845-4736-acd9-9915be7b29ec", "amount": { "uuid": "90f3acdd-fa61-4963-9fdd-7dda8d5dc8f5" }, "type": "METABOLIC ENZYME->INDUCER", "references": [ "8788538a-1a55-45ef-a944-ce3b20911b58" ], "related_substance": { "uuid": "5a7ee678-236f-4fad-8414-65abcc299736", "refuuid": "2964cc53-40a9-4b2b-b19c-d61342fadb5a", "name": "CYTOCHROME P450 1A2", "unii": "VK4SQL11C0", "linking_id": "VK4SQL11C0", "ref_pname": "CYTOCHROME P450 1A2", "substance_class": "reference" } }, { "uuid": "72b7147a-2dc4-44b1-8940-f5e0c1f90e4f", "amount": { "uuid": "a3c16712-b3f0-4d7c-991d-b2bf2c5afa6e", "average": 13300, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "TARGET->INHIBITOR", "references": [ "637f7280-046e-4cc0-aed3-d6b0f255a8b2" ], "related_substance": { "uuid": "5e430d25-3c0d-4cc8-9be3-0d4364ed77b7", "refuuid": "c28af090-c320-4c17-acf9-c2d053dffd58", "name": "ADENOSINE RECEPTOR A3", "unii": "ZUL9E7IDX0", "linking_id": "ZUL9E7IDX0", "ref_pname": "ADENOSINE RECEPTOR A3", "substance_class": "reference" } }, { "uuid": "94c2853f-f478-4358-a99a-d18e102fee71", "amount": { "uuid": "2930bd10-e993-4165-8e15-2aaef91043a4", "average": 10400, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "TARGET->INHIBITOR", "references": [ "637f7280-046e-4cc0-aed3-d6b0f255a8b2" ], "related_substance": { "uuid": "8a5bc80b-bab7-4397-8afe-c82be4b85f1b", "refuuid": "fa16d8ec-894f-462d-9781-5d2f93560a44", "name": "ADENOSINE RECEPTOR A2B", "unii": "EX4X9IXA0A", "linking_id": "EX4X9IXA0A", "ref_pname": "ADENOSINE RECEPTOR A2B", "substance_class": "reference" } }, { "uuid": "0c630706-afdc-4a14-98b5-e33bbb0ad148", "amount": { "uuid": "9e11d933-12cc-4541-a467-c9c5de41d5d5", "average": 9560, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "TARGET->INHIBITOR", "references": [ "637f7280-046e-4cc0-aed3-d6b0f255a8b2" ], "related_substance": { "uuid": "508ae9c6-4aef-4b71-acfc-b94403735c3d", "refuuid": "83ef8407-ced8-4588-bbb0-5a500bce6d4e", "name": "ADENOSINE RECEPTOR A2A", "unii": "Y154T023U0", "linking_id": "Y154T023U0", "ref_pname": "ADENOSINE RECEPTOR A2A", "substance_class": "reference" } }, { "uuid": "0ed1ca1c-57a7-43a1-94e5-0e12f04ea6ff", "amount": { "uuid": "74030e23-4523-4914-b01e-c27c3154f208", "average": 10700, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "TARGET->INHIBITOR", "references": [ "637f7280-046e-4cc0-aed3-d6b0f255a8b2" ], "related_substance": { "uuid": "b9a05417-d02d-490d-ac16-889d90c7d698", "refuuid": "ee9c39bd-5774-43c4-8eaa-23b333741b5e", "name": "ADENOSINE RECEPTOR A1", "unii": "9J6QGP7WEA", "linking_id": "9J6QGP7WEA", "ref_pname": "ADENOSINE RECEPTOR A1", "substance_class": "reference" } }, { "uuid": "1ee1940a-4e1d-43e3-950c-1ce8c51d85e9", "amount": { "uuid": "eb19e506-bd65-4239-885c-a915ceb7772b", "average": 20500, "units": "NANOMOLAR" }, "comments": "Nonselective adenosine receptor antagonist", "qualification": "Ki", "type": "TARGET->WEAK INHIBITOR", "references": [ "63998115-2c57-4b6a-9094-7a25aa019ccc" ], "related_substance": { "uuid": "55992159-76a3-4932-aca8-3d0e7476122a", "refuuid": "fa16d8ec-894f-462d-9781-5d2f93560a44", "name": "ADENOSINE RECEPTOR A2B", "unii": "EX4X9IXA0A", "linking_id": "EX4X9IXA0A", "ref_pname": "ADENOSINE RECEPTOR A2B", "substance_class": "reference" } }, { "uuid": "1928d415-20c5-4edb-b262-a0a4d6460a8c", "amount": { "uuid": "77117d05-eb81-44b8-9260-ef3d63500bca" }, "type": "METABOLITE->PARENT", "references": [ "a4736baf-4351-4645-a90f-2c530959f949" ], "related_substance": { "uuid": "7fcfa3c2-8160-4ece-bbcb-a6360582f870", "refuuid": "e0c4ce35-082f-4ac5-ae43-1763ef01f922", "name": "5-ACETYLAMINO-6-AMINO-3-METHYLURACIL", "unii": "R1KU8R8Z0C", "linking_id": "R1KU8R8Z0C", "ref_pname": "5-ACETYLAMINO-6-AMINO-3-METHYLURACIL" } }, { "uuid": "d97d07ec-ef7c-432d-9184-fa3b487926fd", "amount": { "uuid": "82bc83a1-cd9c-4837-a5e0-ad060afb5970" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "2efa9a60-c8f5-4226-a7d1-5880f0d21ef2", "refuuid": "2f4a3d9a-d7f7-49c0-a66a-3f1b6e674ca4", "name": "caffeine sodium iodide", "unii": "7DU9VK8U6A", "linking_id": "7DU9VK8U6A", "ref_pname": "caffeine sodium iodide", "substance_class": "reference" } } ], "names": [ { "uuid": "fc0c2762-0957-45cb-a556-b01a672ab0f1", "name": "1,3,7-Trimethylxanthine", "stdName": "1,3,7-TRIMETHYLXANTHINE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "addfdb13-8037-40fd-bfde-9af893de962c" ], "display_name": false }, { "uuid": "311a4eea-2dfe-4433-83b0-7f3e1617fb0f", "name": "1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-", "stdName": "1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "addfdb13-8037-40fd-bfde-9af893de962c" ], "display_name": false }, { "uuid": "92880776-e099-49b6-ad9b-b43b59b1e603", "name": "ANHYDROUS CAFFEINE", "stdName": "ANHYDROUS CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "a3e5ccd3-91da-4d97-8a9b-f3da062f4f3e", "af63fa39-8d00-487b-82d1-6c476c0e5817" ], "display_name": false }, { "uuid": "e05015bd-82eb-4183-8440-452b193317fd", "name": "ANHYDROUS CAFFEINE [JAN]", "stdName": "ANHYDROUS CAFFEINE [JAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "af63fa39-8d00-487b-82d1-6c476c0e5817" ], "display_name": false }, { "uuid": "f815a0ae-660c-4073-b366-b5dc2650379d", "name": "ANOQUAN COMPONENT CAFFEINE", "stdName": "ANOQUAN COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "3818dc72-181d-4c04-a340-595a44168c82", "name": "CAFERGOT COMPONENT CAFFEINE", "stdName": "CAFERGOT COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "0e840fa1-4195-495a-b43c-908144b116f4", "name": "CAFFEINE", "stdName": "CAFFEINE", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "bd338b3c-857b-41c9-880a-f9211bcd3760", "113fafc6-3b35-4bc6-9c9a-25680e5ebbdd", "e928df8a-8bf3-43ea-bf06-a52d626426bb", "19d052b3-b7dd-464a-b067-31f64dd135e8", "ebb0c0fe-43e5-49be-8e76-872101d228b8", "6cfbea5e-9bfe-483c-8c75-84e74de5e90c", "d092da08-5b58-4aa2-a7ad-7a0345f22a25", "9bc46a5a-460f-43da-84c5-35c732887eb6", "a2a05f9c-3629-4a35-adee-20f9a7f33584", "a78da67b-ef08-46f6-8bd2-d2920cbcd334", "97b51480-c534-42c9-9b02-5a33a09cd259", "e57197c0-4960-4adf-8a9e-2f64e06a532e", "ce9dec0d-b079-40d3-bca2-f68c93bc42f1", "230ef781-2ece-4187-b76a-7632d1c790a9", "9833eac4-f7ed-4ec0-938b-8938dc1c5733", "d974f2ac-f570-4af2-b398-9551f443abc3", "5d4a75c3-4208-4672-b412-a8c4a2948910", "14ee9456-2d37-4a90-a5b5-d5cd24bfd308", "927ce17e-491f-48ce-9bb0-4df54eeffdf5", "9b587fcc-dac5-4ba7-a138-bb1cea49b7e2", "76e5bea8-a863-431c-91e5-a7a601031ec0", "4730d5ba-74f3-43b6-8208-d893159a43c5", "684b6411-e9df-4723-a2c0-bc61491fc8dd", "f7cd3787-fed4-4575-ba1b-33e52457d845", "8ca0255f-658b-4d9c-8bee-824d85db27e2", "b05b00b6-1f07-427b-9e6a-e8e10cedbb7a" ], "display_name": true, "domains": [ "cosmetic" ], "name_orgs": [ { "uuid": "3d43ab27-b98b-49fa-8672-d307fefb3418", "name_org": "INCI" } ] }, { "uuid": "2469b2b8-c304-4726-894d-d85eab0e4418", "name": "CAFFEINE ANHYDROUS [WHO-IP]", "stdName": "CAFFEINE ANHYDROUS [WHO-IP]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "230ef781-2ece-4187-b76a-7632d1c790a9" ], "display_name": false }, { "uuid": "f894749d-3f6d-4e29-b6f1-134aef417812", "name": "CAFFEINE MELTING POINT STANDARD", "stdName": "CAFFEINE MELTING POINT STANDARD", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee893e0f-7652-465a-99af-3aa5e31d1645", "24591143-4b3f-4e36-b616-cd3839f378d5" ], "display_name": false }, { "uuid": "b98983a3-952e-fd17-0e27-5f398a695ec8", "name": "CAFFEINE [EP MONOGRAPH]", "stdName": "CAFFEINE [EP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6835d53a-5342-02a9-4d99-67986ea27be9" ], "display_name": false }, { "uuid": "07bb60f8-8d7a-4bdf-a0fc-5548412ba469", "name": "CAFFEINE [FCC]", "stdName": "CAFFEINE [FCC]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4730d5ba-74f3-43b6-8208-d893159a43c5" ], "display_name": false }, { "uuid": "80bb1dcb-58eb-4eca-9ff8-8c74d0d030cc", "name": "CAFFEINE [FHFI]", "stdName": "CAFFEINE [FHFI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "8ca0255f-658b-4d9c-8bee-824d85db27e2" ], "display_name": false }, { "uuid": "1af7fe1a-d759-4e27-864b-cdd45af66a0c", "name": "CAFFEINE [HSDB]", "stdName": "CAFFEINE [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "a78da67b-ef08-46f6-8bd2-d2920cbcd334" ], "display_name": false }, { "uuid": "a9404172-36e4-93f6-09fa-01020a856a52", "name": "CAFFEINE [IARC]", "stdName": "CAFFEINE [IARC]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "cc4df23c-e07d-e00b-8178-4e330a53dd65" ], "display_name": false }, { "uuid": "043e3689-a910-47dc-a4c9-e5ea9bb94f65", "name": "CAFFEINE [II]", "stdName": "CAFFEINE [II]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "bd338b3c-857b-41c9-880a-f9211bcd3760" ], "display_name": false }, { "uuid": "f97259a6-c9c0-4bf2-a9f5-d50009169c09", "name": "CAFFEINE [MART.]", "stdName": "CAFFEINE [MART.]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "97b51480-c534-42c9-9b02-5a33a09cd259" ], "display_name": false }, { "uuid": "da80c0a2-8284-42b3-ad6b-49ef8fa2fdac", "name": "CAFFEINE [MI]", "stdName": "CAFFEINE [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "684b6411-e9df-4723-a2c0-bc61491fc8dd" ], "display_name": false }, { "uuid": "3aa2e4e3-1fcc-465c-aa53-a5bd295e14fa", "name": "CAFFEINE [ORANGE BOOK]", "stdName": "CAFFEINE [ORANGE BOOK]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "9bc46a5a-460f-43da-84c5-35c732887eb6" ], "display_name": false }, { "uuid": "fecb89d1-e51d-47dd-b8ec-df64c5c48e21", "name": "CAFFEINE [USP MONOGRAPH]", "stdName": "CAFFEINE [USP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "d974f2ac-f570-4af2-b398-9551f443abc3" ], "display_name": false }, { "uuid": "7437dcc3-9542-a3fb-7fd1-ca189ef94e90", "name": "CAFFEINE [USP-RS]", "stdName": "CAFFEINE [USP-RS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1ace3f55-6fff-c551-084b-2a1c1ada10d8" ], "display_name": false }, { "uuid": "9be05320-230c-417d-b3bd-ac759e9019a6", "name": "CAFFEINE [VANDF]", "stdName": "CAFFEINE [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "f7cd3787-fed4-4575-ba1b-33e52457d845" ], "display_name": false }, { "uuid": "d7447e47-dd6b-4602-91a7-ad13f925a578", "name": "CAFFEINE [WHO-IP]", "stdName": "CAFFEINE [WHO-IP]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "230ef781-2ece-4187-b76a-7632d1c790a9" ], "display_name": false }, { "uuid": "c285759e-12a6-4614-b5a1-22aeca0d2575", "name": "CAFFEINUM", "stdName": "CAFFEINUM", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "3eaacc51-e5c3-4d45-80a8-d0940be1adbc", "9eea2254-af95-432c-b251-008fdad6fb56", "b2834f85-b0c8-4e1a-8451-63db1df4c99d", "07c3efa1-823e-454c-9655-1ddbc735db4d" ], "display_name": false }, { "uuid": "45c1f710-0698-4745-a301-aa857832e4c6", "name": "CAFFEINUM [HPUS]", "stdName": "CAFFEINUM [HPUS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "9eea2254-af95-432c-b251-008fdad6fb56", "07c3efa1-823e-454c-9655-1ddbc735db4d" ], "display_name": false }, { "uuid": "8b7d10a4-84f9-46f6-8877-166d1de4951c", "name": "COFFEINUM [WHO-IP LATIN]", "stdName": "COFFEINUM [WHO-IP LATIN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "230ef781-2ece-4187-b76a-7632d1c790a9" ], "display_name": false }, { "uuid": "f0327e1d-f09a-c1d1-f48a-f663367ab286", "name": "Caffeine [WHO-DD]", "stdName": "CAFFEINE [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "9fb3af42-ce52-795b-1b28-248d40711cc9" ], "display_name": false }, { "uuid": "a6833ee2-6524-418c-86b8-cba70f15036b", "name": "DARVON COMPOUND COMPONENT CAFFEINE", "stdName": "DARVON COMPOUND COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "6b5aa023-fb89-4173-878c-437d7d3d61de", "name": "DHC PLUS COMPONENT CAFFEINE", "stdName": "DHC PLUS COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "de7d3c7a-c42b-4f4b-a7b1-72912c8c414c", "name": "DIMENHYDRINATE IMPURITY C", "stdName": "DIMENHYDRINATE IMPURITY C", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "be88c904-388e-46e4-bf09-6e457d05976d", "53c1569c-b0f0-4126-98b5-645a7934e90d" ], "display_name": false }, { "uuid": "4ad6a4ab-1a3d-e53d-624e-0204c3d43391", "name": "DIMENHYDRINATE IMPURITY C [EP IMPURITY]", "stdName": "DIMENHYDRINATE IMPURITY C [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "be88c904-388e-46e4-bf09-6e457d05976d" ], "display_name": false }, { "uuid": "ff4b4658-5d9c-455f-9115-76db8c238460", "name": "DURVITAN", "stdName": "DURVITAN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c" ], "display_name": false }, { "uuid": "80cf8319-cfd9-4dc1-a803-0c1274550e30", "name": "ESGIC COMPONENT CAFFEINE", "stdName": "ESGIC COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "cea6b338-4851-4da2-bc5f-289956ff02db", "name": "EXCEDRIN COMPONENT CAFFEINE", "stdName": "EXCEDRIN COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "02c69624-e40e-4d9c-88e5-7a855c834bfd", "name": "FEMA NO. 2224", "stdName": "FEMA NO. 2224", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "c5bfe759-8a82-42ca-9353-eb3a3f2ab237" ], "display_name": false }, { "uuid": "2f6f6f6e-7553-4d34-b0dc-e719b090f132", "name": "FEMCET COMPONENT CAFFEINE", "stdName": "FEMCET COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "c34588b3-bab5-4ca3-adca-20426669c083", "name": "FIORICET COMPONENT CAFFEINE", "stdName": "FIORICET COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "30c1e5ee-fb8e-432f-809a-eaa8e3f344a2", "name": "FIORINAL COMPONENT CAFFEINE", "stdName": "FIORINAL COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "6662c649-8df2-4c9b-bbb5-d3a8e5be4a73", "name": "GUARANINE", "stdName": "GUARANINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c" ], "display_name": false }, { "uuid": "34ae9bb0-a685-4512-bccc-ef9cd18be441", "name": "INVAGESIC COMPONENT CAFFEINE", "stdName": "INVAGESIC COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "7ca7752d-e5d4-4603-aa79-894a53919010", "name": "INVAGESIC FORTE COMPONENT CAFFEINE", "stdName": "INVAGESIC FORTE COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "f065c352-2eb6-41d9-b99d-23cd7d396b2c", "name": "LANORINAL COMPONENT CAFFEINE", "stdName": "LANORINAL COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "c3cd6f9a-06d3-48c1-a135-ac30e8ca4bb8", "name": "MEDIGESIC PLUS COMPONENT CAFFEINE", "stdName": "MEDIGESIC PLUS COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "c5b119c2-2a33-408d-9838-34c003736713", "name": "METHYLTHEOBROMINE", "stdName": "METHYLTHEOBROMINE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "addfdb13-8037-40fd-bfde-9af893de962c" ], "display_name": false }, { "uuid": "611a39e3-7b70-46ef-ab1c-069199362c9a", "name": "MIGERGOT COMPONENT CAFFEINE", "stdName": "MIGERGOT COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "8333b414-570c-4531-8920-eb0ea6d77a0b", "name": "NORGESIC COMPONENT CAFFEINE", "stdName": "NORGESIC COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "db6828ad-35c2-4622-8108-17c49edbd1d4", "name": "NSC-5036", "stdName": "NSC-5036", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c" ], "display_name": false }, { "uuid": "4c623458-546d-4ff6-aabb-ec7f22d9d0d3", "name": "ORPHENGESIC COMPONENT CAFFEINE", "stdName": "ORPHENGESIC COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "ac643b8b-422f-4a85-8530-cea733427ee2", "name": "ORPHENGESIC FORTE COMPONENT CAFFEINE", "stdName": "ORPHENGESIC FORTE COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "f1a75ed5-0058-1647-7e23-2214c167b100", "name": "PENTOXIFYLLINE IMPURITY F [EP IMPURITY]", "stdName": "PENTOXIFYLLINE IMPURITY F [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "2ff726f7-96f4-8c1e-9926-c3836add9799" ], "display_name": false }, { "uuid": "321679ad-91c3-4b72-98d4-f319016029f6", "name": "SYNALGOS", "stdName": "SYNALGOS", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c" ], "display_name": false }, { "uuid": "414d49a8-e7e9-4057-8a9a-e0bc99a0932b", "name": "SYNALGOS-DC COMPONENT CAFFEINE", "stdName": "SYNALGOS-DC COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "843ebade-b742-4af9-91e0-6ba5e295ec37", "name": "SYNALGOS-DC-A COMPONENT CAFFEINE", "stdName": "SYNALGOS-DC-A COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "5d24df19-50ac-4a47-ab0c-8f3f2cc931ea", "name": "THEINE", "stdName": "THEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "addfdb13-8037-40fd-bfde-9af893de962c" ], "display_name": false }, { "uuid": "1ae19ec2-e07c-755a-77d7-bfba65497a50", "name": "THEOPHYLLINE IMPURITY A [EP IMPURITY]", "stdName": "THEOPHYLLINE IMPURITY A [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1e21e521-99be-47c5-a66e-4cd6247a8ca4" ], "display_name": false }, { "uuid": "fd95f92a-cfb5-f859-5363-4655bf69e4ae", "name": "THEOPHYLLINE MONOHYDRATE IMPURITY A [EP IMPURITY]", "stdName": "THEOPHYLLINE MONOHYDRATE IMPURITY A [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7503f783-17ce-5632-ba81-27c184bb25ee" ], "display_name": false }, { "uuid": "05662abe-978a-2ac0-6d28-c1252549ad7e", "name": "TREZIX COMPONENT CAFFEINE", "stdName": "TREZIX COMPONENT CAFFEINE", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "e5a747a3-41be-1b7a-10fe-ae307ee23cd3" ], "display_name": false }, { "uuid": "73f5ee9d-2e5f-44e9-b6a8-fdda246ffa33", "name": "TRIAD COMPONENT CAFFEINE", "stdName": "TRIAD COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false }, { "uuid": "496e557a-2a06-4e34-ac34-8a3e56f53e53", "name": "VIVARIN", "stdName": "VIVARIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a1b2f9d-5ad5-441f-a0c9-c729c0fb9d1c" ], "display_name": false }, { "uuid": "e371c4ea-990f-4ae7-a839-18aa84f1be42", "name": "WIGRAINE COMPONENT CAFFEINE", "stdName": "WIGRAINE COMPONENT CAFFEINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c1adf665-90b0-44ca-8194-6d08d955b1e5", "a4aa18be-b27f-4e86-9347-cf6f6895971a" ], "display_name": false } ], "properties": [ { "uuid": "af035e74-22e2-4628-8e4c-9642cddbf2cd", "name": "Biological Half-life", "value": { "uuid": "371b94df-6d44-4a96-acba-c994db4582bd", "high": 7, "low": 3, "units": "hours" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "13892b2d-b8d8-2bc5-211c-654f50874375" ] }, { "uuid": "3453766b-f3aa-4a2b-a30f-e72a50380b20", "name": "Volume of Distribution", "value": { "uuid": "093d5435-5d85-4c31-b928-123ca584c738", "average": 0.6, "units": "Liters/Kilogram" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "13892b2d-b8d8-2bc5-211c-654f50874375" ] }, { "uuid": "9cb62de5-ba74-4101-ad12-68e4194be8e8", "name": "ORAL BIOAVAILABILITY", "value": { "uuid": "579dfceb-f7ff-4860-9468-c30a1656f5bd", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 100, "units": "%" }, "defining": false, "property_type": "PHARMACOKINETIC" }, { "uuid": "4cb07f03-8e4a-49c3-b939-31187d96a425", "name": "Cmax", "value": { "uuid": "03d63992-a546-4025-8a48-e6449168b199", "high": 10, "low": 8, "units": "microgram/mL" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "8788538a-1a55-45ef-a944-ce3b20911b58" ] } ], "modifications": { "uuid": "d8deb895-0053-42b5-a034-1ce7ff62764f" } } ] }