{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "2afb8d63-a952-4d8b-a4bf-f733cf29e960", "code": "N02AX02", "comments": "ATC|NERVOUS SYSTEM|ANALGESICS|OPIOIDS|Other opioids|tramadol", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N02AX02&showdescription=yes", "code_system": "WHO-ATC", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "7b84abbf-ab6c-4c1a-a810-4a894304121b", "code": "N0000175690", "comments": "Established Pharmacologic Class [EPC]|Opioid Agonist [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175690", "code_system": "NDF-RT", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "4ce1faf5-cffe-485c-9a63-30943c8822e7", "code": "N0000175684", "comments": "Cellular or Molecular Interactions [MoA]|Receptor Interactions [MoA]|G-Protein-linked Receptor Interactions [MoA]|Opioid Receptor Interactions [MoA]|Opioid Agonists [MoA]|Full Opioid Agonists [MoA]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175684", "code_system": "NDF-RT", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "e612f7e5-ca86-468d-8458-739a9cb32d36", "code": "QN02AX52", "comments": "VATC|ANALGESICS|OPIOIDS|Other opioids|tramadol, combinations", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QN02AX52&showdescription=yes", "code_system": "WHO-VATC", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "00fd5858-c584-4934-ae04-f24237dd5503", "code": "QN02AX02", "comments": "VATC|ANALGESICS|OPIOIDS|Other opioids|tramadol", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QN02AX02&showdescription=yes", "code_system": "WHO-VATC", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "ea1374b9-444e-4e8d-9df9-ecffe0bef3de", "code": "27203-92-5", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=27203-92-5", "code_system": "CAS", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e", "95f6c118-a44d-4e94-9372-be385f1569c8" ] }, { "uuid": "d977eee5-d95c-4211-97f2-ebc8c3d2469a", "code": "NBK548235", "comments": "LiverTox|Analgesic|Moderate pain|Opiate", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/NBK548235/", "code_system": "LIVERTOX", "references": [ "edc1fe1b-b8df-dbed-560e-13333f0a6f53" ] }, { "uuid": "8e868a0d-8422-4282-9d7c-2a1d89c78caf", "code": "D014147", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68014147", "code_system": "MESH", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "1b4c61d6-9bc7-4bf4-871f-b4785f75a50b", "code": "TRAMADOL", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Tramadol", "code_system": "WIKIPEDIA", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "62beab79-38ea-4b1e-88dc-ee4c9f5a08c7", "code": "N02AX52", "comments": "ATC|NERVOUS SYSTEM|ANALGESICS|OPIOIDS|Other opioids|tramadol, combinations", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N02AX52&showdescription=yes", "code_system": "WHO-ATC", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "97568367-6d5d-4dfb-8b45-8aa127bd4d5d", "code": "SUB11210MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "8bfd447e-7e9a-4954-899f-6bc24f2c0458", "code": "2722", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=2722", "code_system": "INN", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "208d2dbb-72bd-4138-905d-d09386e91861", "code": "248-319-6", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.043.912", "code_system": "ECHA (EC/EINECS)", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "4c5d6bb1-3144-443d-85fc-2d28330808a4", "code": "9278", "comments": "PART 1308 -- SCHEDULES OF CONTROLLED SUBSTANCES|Sec. 1308.11 Schedule IV.|Narcotic Drugs", "type": "PRIMARY", "url": "http://www.ecfr.gov/cgi-bin/text-idx?rgn=div5&node=21:9.0.1.1.9#se21.9.1308_111", "code_system": "DEA NO.", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "8bc88c12-6f7d-492d-b4c4-b37a515b40ed", "code": "8286", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8286", "code_system": "IUPHAR", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "2b25527a-e9d6-482d-81e6-23af2a00fbf2", "code": "C29507", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29507", "code_system": "NCI_THESAURUS", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "b1882cb7-c295-4505-adee-493cade62811", "code": "10689", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/10689/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "cedac05d-8473-42fd-b95f-91e2fae2152c", "code": "m10996", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m10996?q=authorize", "code_system": "MERCK INDEX", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "65743705-0d95-4b02-a960-03789f4c979a", "code": "DB00193", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00193", "code_system": "DRUG BANK", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "04d99a4b-4902-41ba-855d-df8d917ae436", "code": "CHEMBL1237044", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1237044", "code_system": "ChEMBL", "references": [ "035eacce-5513-4490-9e5a-46ab2c2a8b1e" ] }, { "uuid": "68a4d325-31ea-2e4e-3dda-3d2bb88b9a3e", "code": "7047", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7047", "code_system": "HSDB", "references": [ "76141b2a-98a9-c92e-6c92-3a45309a54f7" ] }, { "uuid": "f601d5a9-42a9-6e59-9bcc-f0afcf1d334e", "code": "DTXSID90858931", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID90858931", "code_system": "EPA CompTox", "references": [ "b1029028-e2a5-530b-4635-1da0f0b48daa" ] }, { "uuid": "824bfce0-a810-07c0-a456-2e1262354f8f", "code": "Tramadol", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/n/lactmed/LM391/", "code_system": "LACTMED", "references": [ "edc1fe1b-b8df-dbed-560e-13333f0a6f53" ] }, { "uuid": "54926a68-e657-c389-9319-89978f75575e", "code": "N02AJ14", "comments": "ATC|NERVOUS SYSTEM|ANALGESICS|OPIOIDS|Opioids in combination with non-opioid analgesics|tramadol and dexketoprofen", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N02AJ14&showdescription=yes", "code_system": "WHO-ATC" }, { "uuid": "7443820b-b971-4b32-b3f5-d50443548da6", "code": "2914-77-4", "type": "NON-SPECIFIC STEREOCHEMISTRY", "url": "https://commonchemistry.cas.org/detail?cas_rn=2914-77-4", "code_system": "CAS", "references": [ "98492a80-1fc1-4fe6-92b0-3ccf45c4ee05", "68b56527-f928-4e46-b2d1-4c787d95ac15" ] }, { "uuid": "89631571-0b3c-ce89-3bdd-a11b21671c4a", "code": "N02AJ15", "comments": "ATC|NERVOUS SYSTEM|ANALGESICS|OPIOIDS|Opioids in combination with non-opioid analgesics|tramadol and other non-opioid analgesics", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N02AJ15&showdescription=yes", "code_system": "WHO-ATC" }, { "uuid": "2b423e0b-8a78-c73e-3077-ff215ecabdd3", "code": "N02AJ13", "comments": "ATC|NERVOUS SYSTEM|ANALGESICS|OPIOIDS|Opioids in combination with non-opioid analgesics|tramadol and paracetamol", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=N02AJ13&showdescription=yes", "code_system": "WHO-ATC" }, { "uuid": "bc690a17-2f6d-0184-5fe6-101157bc3175", "code": "C241", "comments": "Pharmacologic Substance[C1909]|Agent Affecting Nervous System[C78272]|Analgesic Agent", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C241", "code_system": "NCI_THESAURUS", "references": [ "edc1fe1b-b8df-dbed-560e-13333f0a6f53" ] }, { "uuid": "e9910bee-6bdf-4935-a7a0-d8cfb9794e40", "code": "39J1LGJ30J", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "da583060-2655-1a4f-d0f9-12f358c49a0b", "code": "220-831-4", "type": "ALTERNATIVE", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.018.939", "code_system": "ECHA (EC/EINECS)", "references": [ "cfd973ee-8c37-cbd0-d3c8-7c05b079f51c" ] }, { "uuid": "a507205b-cd26-98a8-9426-7a9746286b03", "code": "2711", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/2711", "code_system": "DRUG CENTRAL", "references": [ "edc1fe1b-b8df-dbed-560e-13333f0a6f53" ] }, { "uuid": "ae80270f-4a06-ecc4-ef03-2562e282d96c", "code": "9648", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:9648", "code_system": "CHEBI", "references": [ "edc1fe1b-b8df-dbed-560e-13333f0a6f53" ] }, { "uuid": "c8bb278c-9908-8ab1-9ebe-82c4d90eb210", "code": "39J1LGJ30J", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=39J1LGJ30J", "code_system": "DAILYMED", "references": [ "117ec9b8-db25-3a95-7a08-4f89f8fb4667" ] }, { "uuid": "17520411-da32-d1d2-c21f-381a65b14ebf", "code": "100000077198", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "256675f1-9d77-315c-0831-b37374a77b97" ] } ], "substance_class": "chemical", "references": [ { "uuid": "7ce575f2-c1ae-4882-aaa7-f510281e16c3", "citation": "Huttunen, Kristiina M., Hannu Raunio, and Jarkko Rautio. \"Prodrugs—from serendipity to rational design.\" Pharmacological reviews 63.3 (2011): 750-771.", "url": "http://pharmrev.aspetjournals.org/content/pharmrev/63/3/750.full.pdf", "doc_type": "JA", "public_domain": true }, { "uuid": "98492a80-1fc1-4fe6-92b0-3ccf45c4ee05", "citation": "USP Dictionary", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "18ebcf30-2015-404c-b2dd-915e43bde5de", "citation": "USP DICTIONARY 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ac654f5e-2e72-4794-b5fa-06d6ad0be035", "citation": "INN Proposed List 22", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL22.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7f0e0c9f-43af-486b-b5a0-5e567ceaaa04", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "01a5c860-d5ee-48ed-8c2c-2074835c1284", "citation": "KEGG 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "45e7f61a-19fe-4b9f-98f9-cb9bdccdb4f0", "citation": "D08623", "doc_type": "KEGG", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "af0dd73b-108b-4a06-866f-9c7aba734b90", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "559ee164-e6f6-4ea1-8b76-bb6f4348b137", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "a849fef0-748a-4b31-aafe-c1158c9953f0", "citation": "http://www.biocentury.com/products/ets6103", "url": "http://www.biocentury.com/products/ets6103", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "035eacce-5513-4490-9e5a-46ab2c2a8b1e", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389952000, "tags": [ "NOMEN" ] }, { "uuid": "bb70947c-5da5-4b4b-94c4-d962e12ac0dc", "citation": "PHARMACOLOGY 2011;87:274?285", "url": "http://www.karger.com/Article/Pdf/326085", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "5576db1c-be6a-46d2-b410-e9f22efb84fb", "citation": "SRS import [39J1LGJ30J]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=39J1LGJ30J", "doc_type": "SRS", "public_domain": true, "document_date": 1493389952000, "tags": [ "NOMEN" ] }, { "uuid": "e0f9d972-63dc-41ba-8d45-7b425a9578b4", "citation": "USP Dictionary; INN 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "457a2cc0-db52-4709-8eeb-acf917e660c8", "citation": "TRAMADOL [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "adc69688-14b6-4e10-95a0-15f4cf5170b3", "citation": "TRAMADOL [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "8ea82b14-50c5-4d54-bc8c-b7ea96eed5f3", "citation": "TRAMADOL [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "a9795c93-fe22-4e12-b381-24fb8f092268", "citation": "TRAMADOL [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b6926a09-632c-f755-c3f4-01ba273da792", "citation": "Naunyn-Schmiedeberg’s Arch Pharmacol (2000) 362: 116–121", "url": "https://ewsd.wiv-isp.be/Publications%20on%20new%20psychoactive%20substances/ODT/Gillen2000_tramadol-human-opioid-receptor.pdf", "doc_type": "JA", "public_domain": true }, { "uuid": "76141b2a-98a9-c92e-6c92-3a45309a54f7", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+27203-92-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "b1029028-e2a5-530b-4635-1da0f0b48daa", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=27203-92-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "3bd33f87-d865-4c38-f793-0a2f5e740657", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+lactmed:@term+@rel+@rn+27203-92-5", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "256675f1-9d77-315c-0831-b37374a77b97", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "eb36693e-b68f-aeb7-c540-525cbba5a27a", "citation": "TRAMADOL", "doc_type": "MICROMEDEX", "public_domain": true }, { "uuid": "edc1fe1b-b8df-dbed-560e-13333f0a6f53", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "87ea7c6c-2a6b-479c-8b31-2c69543941f8", "citation": "Lintz, W., et al. \"Biotransformation of tramadol in man and animal (author's transl).\" Arzneimittel-Forschung 31.11 (1981): 1932-1943.", "url": "https://europepmc.org/abstract/med/7198474", "doc_type": "JA", "public_domain": true }, { "uuid": "b870015b-82dc-ae33-da57-ce4031e02b78", "citation": "Lintz, W., et al. \"Biotransformation of tramadol in man and animal (author's transl).\" Arzneimittel-Forschung 31.11 (1981): 1932-1943.", "url": "https://europepmc.org/abstract/med/7198474", "doc_type": "JA", "public_domain": true }, { "uuid": "68b56527-f928-4e46-b2d1-4c787d95ac15", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "95f6c118-a44d-4e94-9372-be385f1569c8", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "964a605d-a67b-b2dd-b4f8-a226cbd88e1c", "citation": "Grond, Stefan, and Armin Sablotzki. \"Clinical pharmacology of tramadol.\" Clinical pharmacokinetics 43.13 (2004): 879-923.", "url": "https://link.springer.com/article/10.2165/00003088-200443130-00004", "doc_type": "JA", "public_domain": true }, { "uuid": "1f3e810b-6dad-4574-825b-a107405cb964", "citation": "Subrahmanyam, Vangala, et al. \"Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.\" Drug Metabolism and Disposition 29.8 (2001): 1146-1155.", "url": "http://dmd.aspetjournals.org/content/29/8/1146", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "c69a34df-3aa7-442b-a796-b0eb106a0c28", "citation": "DMF-33396", "url": "https://www.nflis.deadiversion.usdoj.gov/DesktopModules/DrugList/NFLISDrugListDateSorted.pdf", "doc_type": "DMF", "public_domain": true }, { "uuid": "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9", "citation": "Subrahmanyam, Vangala, et al. \"Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.\" Drug Metabolism and Disposition 29.8 (2001): 1146-1155.", "url": "http://dmd.aspetjournals.org/content/29/8/1146", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "91868321-836e-487a-a41b-be6c0c587499", "citation": "Subrahmanyam, Vangala, et al. \"Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.\" Drug Metabolism and Disposition 29.8 (2001): 1146-1155.", "url": "http://dmd.aspetjournals.org/content/29/8/1146", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "0155bca9-e4f4-5140-7d01-6f77de44c864", "citation": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022370s000lbl.pdf", "doc_type": "NDA PUBLIC REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "cfd973ee-8c37-cbd0-d3c8-7c05b079f51c", "citation": "EC", "doc_type": "ECHA (EC/EINECS)", "public_domain": true }, { "uuid": "0e4a829d-e509-23c9-335c-b517185986c9", "citation": "JAN", "doc_type": "JAN", "public_domain": true }, { "uuid": "7e7f0d55-09c4-48e3-be3d-25e808402430", "citation": "Huttunen, Kristiina M., Hannu Raunio, and Jarkko Rautio. \"Prodrugs—from serendipity to rational design.\" Pharmacological reviews 63.3 (2011): 750-771.", "url": "http://pharmrev.aspetjournals.org/content/pharmrev/63/3/750.full.pdf", "doc_type": "JA", "public_domain": true }, { "uuid": "7f4d2df7-82c7-4077-a6bc-d3dcb37b4a6e", "citation": "J Chromatogr 1993 Feb 26;612(2):223-30", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "bbf3fc35-f215-4c44-9b25-3a5ae6fd00f7", "citation": "J Pharm Biomed Anal 2007 Sep 3;44(5):1168-73", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ed61117d-d6e0-49e0-abc7-2733b2781805", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "39e60dab-c645-149a-1e7b-35ce67c8fcb2", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "117ec9b8-db25-3a95-7a08-4f89f8fb4667", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "1ad4f00f-f6b8-77dc-7bdc-261a09d43718", "citation": "PUBCHEM", "doc_type": "PUBCHEM", "public_domain": true } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "f038895b-ffcd-48b4-986c-08aec6a16c78", "id": "f038895b-ffcd-48b4-986c-08aec6a16c78", "molfile": "\n Marvin 01132112282D \n\n 19 20 0 0 0 0 999 V2000\n -1.0594 -5.7025 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n -1.8023 -5.3180 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.5347 -5.7182 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n -3.0945 -6.4323 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -3.2959 -5.3415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0594 -6.5344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3374 -6.9503 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3610 -6.4716 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -5.6633 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3662 -5.2552 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n -0.8868 -4.6353 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3740 -4.3214 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0725 -3.9055 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0594 -3.0815 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3505 -2.6734 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -3.0893 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.0673 -2.6891 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.0699 -1.8651 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -3.9212 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 6 0 0 0\n 1 6 1 0 0 0 0\n 1 10 1 0 0 0 0\n 3 2 1 0 0 0 0\n 4 3 1 0 0 0 0\n 5 3 1 0 0 0 0\n 7 6 1 0 0 0 0\n 7 8 1 0 0 0 0\n 8 9 1 0 0 0 0\n 10 9 1 0 0 0 0\n 10 11 1 6 0 0 0\n 10 12 1 0 0 0 0\n 13 12 1 0 0 0 0\n 19 12 2 0 0 0 0\n 14 13 2 0 0 0 0\n 15 14 1 0 0 0 0\n 15 16 2 0 0 0 0\n 17 16 1 0 0 0 0\n 16 19 1 0 0 0 0\n 18 17 1 0 0 0 0\nM END", "smiles": "CN(C)C[C@H]1CCCC[C@@]1(c2cccc(c2)OC)O", "formula": "C16H25NO2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ABSOLUTE", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "2bca90be-8cc0-4f95-833a-b8c5924a17ff" }, "defined_stereo": 2, "ez_centers": 0, "molecular_weight": "263.3758", "optical_activity": "UNSPECIFIED", "stereo_centers": 2 } ], "definition_level": "COMPLETE", "uuid": "2966d491-86e8-429b-85e9-cd22e4f13278", "version": "59", "structure": { "id": "47723d28-94b2-46b4-9abf-b659c81b5a1b", "molfile": "\n Marvin 01132103452D \n\n 19 20 0 0 0 0 999 V2000\n -0.3662 -5.2552 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n -1.0594 -5.7025 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n -0.3740 -4.3214 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.8023 -5.3180 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -3.9212 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.5347 -5.7182 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n -0.8868 -4.6353 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -3.0893 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3401 -5.6633 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0725 -3.9055 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0594 -6.5344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.0673 -2.6891 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -1.0594 -3.0815 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3505 -2.6734 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -3.0945 -6.4323 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -3.2959 -5.3415 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.0699 -1.8651 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.3610 -6.4716 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.3374 -6.9503 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2 1 1 0 0 0 0\n 1 3 1 1 0 0 0\n 2 4 1 6 0 0 0\n 5 3 2 0 0 0 0\n 6 4 1 0 0 0 0\n 1 7 1 6 0 0 0\n 8 5 1 0 0 0 0\n 9 1 1 0 0 0 0\n 10 3 1 0 0 0 0\n 11 2 1 0 0 0 0\n 12 8 1 0 0 0 0\n 13 10 2 0 0 0 0\n 14 13 1 0 0 0 0\n 15 6 1 0 0 0 0\n 16 6 1 0 0 0 0\n 17 12 1 0 0 0 0\n 18 9 1 0 0 0 0\n 19 18 1 0 0 0 0\n 19 11 1 0 0 0 0\n 14 8 2 0 0 0 0\nM END", "smiles": "CN(C)C[C@H]1CCCC[C@@]1(c2cccc(c2)OC)O", "formula": "C16H25NO2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "RACEMIC", "defined_stereo": 2, "ez_centers": 0, "molecular_weight": "263.3758", "optical_activity": "( + / - )", "references": [ "5576db1c-be6a-46d2-b410-e9f22efb84fb", "e0f9d972-63dc-41ba-8d45-7b425a9578b4", "ac654f5e-2e72-4794-b5fa-06d6ad0be035" ], "stereo_centers": 2 }, "unii": "39J1LGJ30J", "relationships": [ { "uuid": "5219a322-f56a-4c46-a047-78696c5b2cd6", "amount": { "uuid": "0b5b995d-e8d6-4c0c-953c-bbaf19c01a1a" }, "type": "ACTIVE MOIETY", "related_substance": { "uuid": "f8755fac-36dc-4e59-b3e6-0c67447d6350", "refuuid": "2966d491-86e8-429b-85e9-cd22e4f13278", "name": "TRAMADOL", "unii": "39J1LGJ30J", "linking_id": "39J1LGJ30J", "ref_pname": "TRAMADOL", "substance_class": "reference" } }, { "uuid": "e2f24481-cb86-406f-9baf-7473531c251c", "amount": { "uuid": "2f6eef1e-f46e-4252-85b6-09d1b8cb9428" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "4ff0c42b-35a1-4343-a85f-3a1989a2889f", "refuuid": "2c0a9c46-b752-432d-adea-44270c01be5a", "name": "TRAMADOL HYDROCHLORIDE", "unii": "9N7R477WCK", "linking_id": "9N7R477WCK", "ref_pname": "TRAMADOL HYDROCHLORIDE", "substance_class": "reference" } }, { "uuid": "865521ff-fc4d-4948-a482-e3f5293dace3", "amount": { "uuid": "311941bd-dc88-4b1c-8fc2-fa2f4664aa93" }, "type": "METABOLITE ACTIVE->PRODRUG", "interaction_type": "MAJOR", "mediator_substance": { "uuid": "fd62721e-6386-4707-b4c9-697acf021ebb", "refuuid": "cc92795c-ba54-4e71-a72b-1af36b57df6b", "name": "CYTOCHROME P450 2D6", "unii": "8E4LAA4357", "linking_id": "8E4LAA4357", "ref_pname": "CYTOCHROME P450 2D6", "substance_class": "reference" }, "references": [ "7e7f0d55-09c4-48e3-be3d-25e808402430", "7f4d2df7-82c7-4077-a6bc-d3dcb37b4a6e" ], "related_substance": { "uuid": "eb62e28e-240b-4388-a787-908cc4acc33d", "refuuid": "67b9e91e-e92f-45b6-8ae0-090ed09aff24", "name": "DESMETRAMADOL", "unii": "2WA8F50C3F", "linking_id": "2WA8F50C3F", "ref_pname": "DESMETRAMADOL", "substance_class": "reference" } }, { "uuid": "9051ff87-78c1-450a-8ba7-6beffccfd550", "amount": { "uuid": "917013a2-0fc9-44db-866c-83d6b6afa0f2" }, "type": "METABOLIC ENZYME->SUBSTRATE", "references": [ "bb70947c-5da5-4b4b-94c4-d962e12ac0dc" ], "related_substance": { "uuid": "8e1dee42-0988-44af-afea-4199a35fb6ba", "refuuid": "cc92795c-ba54-4e71-a72b-1af36b57df6b", "name": "CYTOCHROME P450 2D6", "unii": "8E4LAA4357", "linking_id": "8E4LAA4357", "ref_pname": "CYTOCHROME P450 2D6", "substance_class": "reference" } }, { "uuid": "7ba97dd1-b214-48ef-ba02-dbc80ac9fca3", "amount": { "uuid": "e2d32aa7-4405-47dc-b661-612d564b4c48" }, "type": "METABOLITE ACTIVE->PRODRUG", "mediator_substance": { "uuid": "121cf656-ae5e-4f8c-bff1-8b597219fed6", "refuuid": "4275827d-e329-4907-95b5-7d690692872a", "name": "CYTOCHROME P450 3A4", "unii": "PUO0521HZV", "linking_id": "PUO0521HZV", "ref_pname": "CYTOCHROME P450 3A4", "substance_class": "reference" }, "references": [ "bbf3fc35-f215-4c44-9b25-3a5ae6fd00f7" ], "related_substance": { "uuid": "ee1998e8-091f-45a7-be62-e70c8dbc48be", "refuuid": "96960b3a-4d80-4684-ae0e-6b02e42cadca", "name": "O,N-DIDESMETHYLTRAMADOL", "unii": "F6F6QC876T", "linking_id": "F6F6QC876T", "ref_pname": "O,N-DIDESMETHYLTRAMADOL", "substance_class": "reference" } }, { "uuid": "5d403271-f160-4f8d-820b-da52564969cc", "amount": { "uuid": "0179f9bd-74fc-42f6-b7f1-fb65e1e2b3f9", "average": 2400, "units": "NANOMOLAR", "non_numeric_value": "NALOXONE COMPETITOR" }, "comments": "(+)-isomer", "qualification": "Ki", "type": "TARGET->AGONIST", "interaction_type": "COMPETITIVE INHIBITOR", "references": [ "b6926a09-632c-f755-c3f4-01ba273da792" ], "related_substance": { "uuid": "2d9430fc-9e98-4016-9f6d-1cac073b755c", "refuuid": "39262e4f-d963-4b83-9b34-52fd55036f0e", "name": "MU-TYPE OPIOID RECEPTOR", "unii": "1PE72K8X46", "linking_id": "1PE72K8X46", "ref_pname": "MU-TYPE OPIOID RECEPTOR", "substance_class": "reference" } }, { "uuid": "54070214-da72-40d3-849b-be4f4e353ace", "amount": { "uuid": "10181d7b-5c3e-4fa4-9da9-c7b489215056" }, "type": "METABOLITE->PARENT", "interaction_type": "MAJOR", "mediator_substance": { "uuid": "bd2aeffd-4659-48f9-8046-ea1d2152da11", "refuuid": "83e3f07e-be5b-48ac-be08-0c68c20e8bf0", "name": "CYTOCHROME P450 2B6", "unii": "0UY97CSG1T", "linking_id": "0UY97CSG1T", "ref_pname": "CYTOCHROME P450 2B6", "substance_class": "reference" }, "references": [ "87ea7c6c-2a6b-479c-8b31-2c69543941f8", "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "ffbf6f37-df43-403f-b52a-7caf56f389c5", "refuuid": "2e3974d1-fd31-4f55-b5a0-c65730ad27fb", "name": "N-DESMETHYLTRAMADOL", "unii": "8M7YSN2KII", "linking_id": "8M7YSN2KII", "ref_pname": "N-DESMETHYLTRAMADOL" } }, { "uuid": "e21e3cf8-3a07-4409-85d6-551d35a09003", "amount": { "uuid": "d3c16601-73c9-4866-b69f-ebd7d97a9bf4" }, "comments": "Agonist of the μ. opioid receptor and inhibits serotonin reuptake.", "type": "ENANTIOMER->RACEMATE", "references": [ "964a605d-a67b-b2dd-b4f8-a226cbd88e1c" ], "related_substance": { "uuid": "bb37e831-db52-4172-ac34-eb65b0a1071d", "refuuid": "c0ea25ba-3b0a-4a7c-83b8-2c3743b619c9", "name": "TRAMADOL, (+)-", "unii": "0NG5TTM63P", "linking_id": "0NG5TTM63P", "ref_pname": "TRAMADOL, (+)-", "substance_class": "reference" } }, { "uuid": "0b48ecf7-3b7c-4190-a81c-3c519956b7d7", "amount": { "uuid": "d825824e-ad18-40c6-9643-9e3544f65e62" }, "type": "ENANTIOMER->RACEMATE", "references": [ "964a605d-a67b-b2dd-b4f8-a226cbd88e1c" ], "related_substance": { "uuid": "1bdb3f29-ba83-442f-8a1d-c81ec5c3bf89", "refuuid": "64148c70-b89e-48dd-8f9e-084bc0f7e2ed", "name": "TRAMADOL, (-)-", "unii": "26J30IC20Q", "linking_id": "26J30IC20Q", "ref_pname": "TRAMADOL, (-)-", "substance_class": "reference" } }, { "uuid": "9711584f-5cf4-4a6b-97a4-1b5a3cd09ab9", "amount": { "uuid": "b5ee8613-29b7-4230-b797-72a32def66a9" }, "comments": "(+)-Tramadol inhibits serotonin reuptake", "type": "TARGET->INHIBITOR", "references": [ "964a605d-a67b-b2dd-b4f8-a226cbd88e1c" ], "related_substance": { "uuid": "fc1eb77d-ee85-403c-b79b-77a6057faf71", "refuuid": "06df8044-d6c0-4403-85ab-26c75e41e405", "name": "SODIUM-DEPENDENT SEROTONIN TRANSPORTER", "unii": "CJZ26L1EGI", "linking_id": "CJZ26L1EGI", "ref_pname": "SODIUM-DEPENDENT SEROTONIN TRANSPORTER", "substance_class": "reference" } }, { "uuid": "09ad0dba-bfd2-4c87-b1e8-58f9fc37435e", "amount": { "uuid": "5933f79f-a012-4ca6-b055-b65920ccc813" }, "comments": "(−)-tramadol inhibits norepinephrine reuptake", "type": "TARGET->INHIBITOR", "references": [ "964a605d-a67b-b2dd-b4f8-a226cbd88e1c" ], "related_substance": { "uuid": "3b3a2b68-70e7-4b44-bd21-63b131159670", "refuuid": "0984671c-0dd0-410d-b763-0a7c9195929d", "name": "SODIUM-DEPENDENT NORADRENALINE TRANSPORTER", "unii": "HN86OLH1NW", "linking_id": "HN86OLH1NW", "ref_pname": "SODIUM-DEPENDENT NORADRENALINE TRANSPORTER", "substance_class": "reference" } }, { "uuid": "1b19182a-9555-4566-9abf-6ba03f89634e", "amount": { "uuid": "b00eb88f-8a4d-418d-a21d-99c09d2afc27" }, "type": "METABOLITE ACTIVE->PRODRUG", "mediator_substance": { "uuid": "e355ca9e-421e-47b4-bc6f-57d299e2e7f4", "refuuid": "4275827d-e329-4907-95b5-7d690692872a", "name": "CYTOCHROME P450 3A4", "unii": "PUO0521HZV", "linking_id": "PUO0521HZV", "ref_pname": "CYTOCHROME P450 3A4", "substance_class": "reference" }, "references": [ "964a605d-a67b-b2dd-b4f8-a226cbd88e1c" ], "related_substance": { "uuid": "9ea884c9-a191-463f-8f62-66dee509c35b", "refuuid": "67b9e91e-e92f-45b6-8ae0-090ed09aff24", "name": "DESMETRAMADOL", "unii": "2WA8F50C3F", "linking_id": "2WA8F50C3F", "ref_pname": "DESMETRAMADOL", "substance_class": "reference" } }, { "uuid": "27e048b4-2040-480f-b527-17c6c9b14dc7", "amount": { "uuid": "96332423-c083-496c-a10b-8c5776c222e6" }, "type": "SALT/SOLVATE->PARENT", "references": [ "c69a34df-3aa7-442b-a796-b0eb106a0c28" ], "related_substance": { "uuid": "94dd3e66-5d61-43ba-a632-a6bdbd882f05", "refuuid": "1c9b37fa-e406-49dc-ab0a-0efd38f3a0ed", "name": "CELECOXIB TRAMADOL HYDROBROMIDE CO-CRYSTAL", "unii": "EFC42N2AU4", "linking_id": "EFC42N2AU4", "ref_pname": "CELECOXIB TRAMADOL HYDROBROMIDE CO-CRYSTAL" } }, { "uuid": "55bdb5ef-eb62-4693-9f5d-dd004af8da06", "amount": { "uuid": "369b0922-40be-4791-9750-e3a35c872322" }, "type": "METABOLITE->PARENT", "interaction_type": "MINOR", "references": [ "91868321-836e-487a-a41b-be6c0c587499" ], "related_substance": { "uuid": "9513c319-772b-4d98-bad0-4898cf8024db", "refuuid": "2b8ed037-fb2d-4caf-9626-ddc5f3ad9137", "name": "CYCLOHEXANOL, 2-(AMINOMETHYL)-1-(3-METHOXYPHENYL)-, CIS-", "unii": "XDX4ZNH4WE", "linking_id": "XDX4ZNH4WE", "ref_pname": "CYCLOHEXANOL, 2-(AMINOMETHYL)-1-(3-METHOXYPHENYL)-, CIS-" } }, { "uuid": "260872c8-4428-422a-9741-fbc845adedd0", "amount": { "uuid": "e04582cc-871a-44bc-a4c9-84984fadbd1b" }, "type": "METABOLITE->PARENT", "interaction_type": "MINOR", "references": [ "1f3e810b-6dad-4574-825b-a107405cb964" ], "related_substance": { "uuid": "4704db09-a162-4d78-936e-d0a4d715c356", "refuuid": "0a284d07-2c8c-46fb-8406-0c00eb383a4d", "name": "N,N,O-TRIDEMETHYLTRAMADOL", "unii": "SRZ6938M82", "linking_id": "SRZ6938M82", "ref_pname": "N,N,O-TRIDEMETHYLTRAMADOL" } }, { "uuid": "b06a82e5-d3d3-488e-950b-d82d230b5705", "amount": { "uuid": "0111dd78-f18e-4943-b19a-5280abfbb25c" }, "type": "METABOLIC ENZYME->SUBSTRATE", "interaction_type": "MAJOR", "references": [ "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "7466076d-8282-4575-a3e9-094618c47fe8", "refuuid": "83e3f07e-be5b-48ac-be08-0c68c20e8bf0", "name": "CYTOCHROME P450 2B6", "unii": "0UY97CSG1T", "linking_id": "0UY97CSG1T", "ref_pname": "CYTOCHROME P450 2B6", "substance_class": "reference" } }, { "uuid": "73e481ad-b345-47ca-99d3-28d79a07624b", "amount": { "uuid": "eccdc9fb-04b5-4805-ba71-fa53b54caeef" }, "type": "METABOLIC ENZYME->SUBSTRATE", "interaction_type": "MAJOR", "references": [ "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "0403472b-2e49-4f55-87d1-07cd6419bbbd", "refuuid": "4275827d-e329-4907-95b5-7d690692872a", "name": "CYTOCHROME P450 3A4", "unii": "PUO0521HZV", "linking_id": "PUO0521HZV", "ref_pname": "CYTOCHROME P450 3A4", "substance_class": "reference" } }, { "uuid": "419500a3-1991-490e-b73f-d20342691b48", "amount": { "uuid": "bfd2add2-0af9-48ac-8b57-ab49793e3122" }, "type": "METABOLIC ENZYME->SUBSTRATE", "interaction_type": "MINOR", "references": [ "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "75b41856-247d-40b5-8ba3-a7da4db9e02d", "refuuid": "2964cc53-40a9-4b2b-b19c-d61342fadb5a", "name": "CYTOCHROME P450 1A2", "unii": "VK4SQL11C0", "linking_id": "VK4SQL11C0", "ref_pname": "CYTOCHROME P450 1A2", "substance_class": "reference" } }, { "uuid": "ed4e6c3f-b7f6-43b9-b657-062295d274d7", "amount": { "uuid": "f66eaaf8-f1e0-45eb-96a8-471000fbfb5e" }, "type": "METABOLIC ENZYME->SUBSTRATE", "interaction_type": "MAJOR", "references": [ "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "754be27b-7e7d-4baf-b17c-912df93504d1", "refuuid": "50fbc0e6-a35d-4d72-849b-84bfc9d44cd5", "name": "CYTOCHROME P450 2C9", "unii": "L9DP834D1P", "linking_id": "L9DP834D1P", "ref_pname": "CYTOCHROME P450 2C9", "substance_class": "reference" } }, { "uuid": "9c7a788e-4ea8-4ef0-84ed-d40081631f93", "amount": { "uuid": "3b00229a-8a07-4d9f-a7f6-5da7c447c3a2" }, "type": "METABOLIC ENZYME->SUBSTRATE", "interaction_type": "MINOR", "references": [ "b20fb70e-8b33-2a97-4a60-6da7bcbd5ad9" ], "related_substance": { "uuid": "e49b98c4-f0c9-40aa-ac31-4e5ab37e1d3c", "refuuid": "4f746c19-0e0a-447a-beda-d28b91d6f23e", "name": "CYTOCHROME P450 2C19", "unii": "081I12ZA58", "linking_id": "081I12ZA58", "ref_pname": "CYTOCHROME P450 2C19", "substance_class": "reference" } }, { "uuid": "779ce8ff-e391-4237-a673-0dd1bc12b61d", "amount": { "uuid": "1f758987-0b6f-4483-b21e-b98d2953bfe3", "average": 30, "units": "%" }, "qualification": "URINE", "type": "EXCRETED UNCHANGED", "interaction_type": "AMOUNT EXCRETED", "references": [ "0155bca9-e4f4-5140-7d01-6f77de44c864" ], "related_substance": { "uuid": "1ff55929-77c5-40ca-90e3-0f80d9f91322", "refuuid": "2966d491-86e8-429b-85e9-cd22e4f13278", "name": "TRAMADOL", "unii": "39J1LGJ30J", "linking_id": "39J1LGJ30J", "ref_pname": "TRAMADOL", "substance_class": "reference" } }, { "uuid": "bd4a58b0-9cb0-4706-a748-930da50b7adf", "amount": { "uuid": "1956a60a-6bf2-4dee-b8cf-74a797eb77b2" }, "type": "SALT/SOLVATE->PARENT", "references": [ "ed61117d-d6e0-49e0-abc7-2733b2781805" ], "related_substance": { "uuid": "cecdb1c4-dbfb-40c0-bc1b-2645ef456c20", "refuuid": "f5f863d0-10fa-4f5c-8061-92433cd5f436", "name": "CELECOXIB TRAMADOL HYDROCHLORIDE CO-CRYSTAL", "unii": "80FJ28572U", "linking_id": "80FJ28572U", "ref_pname": "CELECOXIB TRAMADOL HYDROCHLORIDE CO-CRYSTAL" } } ], "names": [ { "uuid": "3e1b6c24-67e2-4dc1-ba88-4316b0b15aa2", "name": "(±)-CIS-2-((DIMETHYLAMINO)METHYL)-1-(M-METHOXYPHENYL)CYCLOHEXANOL", "stdName": "(+/-)-CIS-2-((DIMETHYLAMINO)METHYL)-1-(M-METHOXYPHENYL)CYCLOHEXANOL", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "18ebcf30-2015-404c-b2dd-915e43bde5de" ], "display_name": false }, { "uuid": "31ecd344-d6b0-4ea9-86f5-71959abc78bd", "name": "(±)-TRAMADOL", "stdName": "(+/-)-TRAMADOL", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "68b56527-f928-4e46-b2d1-4c787d95ac15" ], "display_name": false }, { "uuid": "94eb5820-7ddc-4fb2-9f63-1b6452f7ca48", "name": "AMANDA", "stdName": "AMANDA", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "45e7f61a-19fe-4b9f-98f9-cb9bdccdb4f0", "01a5c860-d5ee-48ed-8c2c-2074835c1284" ], "display_name": false }, { "uuid": "7da4e911-f42f-4321-af79-ab49f5dec8f4", "name": "CG-315E", "stdName": "CG-315E", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "68b56527-f928-4e46-b2d1-4c787d95ac15" ], "display_name": false }, { "uuid": "18351e52-5016-4a15-bff3-7e68ff8dc110", "name": "E-265", "stdName": "E-265", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "68b56527-f928-4e46-b2d1-4c787d95ac15" ], "display_name": false }, { "uuid": "b4362efc-98d2-4d20-9778-ffa44cff5a4a", "name": "E265", "stdName": "E265", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "68b56527-f928-4e46-b2d1-4c787d95ac15" ], "display_name": false }, { "uuid": "c0078c4d-dc46-4de7-8426-550e5ca1e354", "name": "ETS-6103", "stdName": "ETS-6103", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "a849fef0-748a-4b31-aafe-c1158c9953f0" ], "display_name": false }, { "uuid": "2394d40f-c4a5-4471-a87a-05a1df857b04", "name": "ETS6103", "stdName": "ETS6103", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "a849fef0-748a-4b31-aafe-c1158c9953f0" ], "display_name": false }, { "uuid": "0cb24f07-0446-4205-9955-91833e4c1285", "name": "TRAMADOL", "stdName": "TRAMADOL", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "ac654f5e-2e72-4794-b5fa-06d6ad0be035", "7f0e0c9f-43af-486b-b5a0-5e567ceaaa04", "adc69688-14b6-4e10-95a0-15f4cf5170b3", "a9795c93-fe22-4e12-b381-24fb8f092268", "8ea82b14-50c5-4d54-bc8c-b7ea96eed5f3", "559ee164-e6f6-4ea1-8b76-bb6f4348b137", "457a2cc0-db52-4709-8eeb-acf917e660c8", "98492a80-1fc1-4fe6-92b0-3ccf45c4ee05", "af0dd73b-108b-4a06-866f-9c7aba734b90" ], "display_name": true, "domains": [ "drug" ], "name_orgs": [ { "uuid": "cfe36f1b-c3f9-49eb-a374-bc565c749249", "name_org": "INN" } ] }, { "uuid": "e0267eb9-94f6-11a2-ab98-0bea8d913cbc", "name": "TRAMADOL [JAN]", "stdName": "TRAMADOL [JAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0e4a829d-e509-23c9-335c-b517185986c9" ], "display_name": false }, { "uuid": "50dc21b1-e982-4fd3-be61-830f02581734", "name": "TRAMADOL [MI]", "stdName": "TRAMADOL [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7f0e0c9f-43af-486b-b5a0-5e567ceaaa04" ], "display_name": false }, { "uuid": "fdd17bc4-a374-4e98-b308-372caee506c0", "name": "TRAMADOL [VANDF]", "stdName": "TRAMADOL [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "559ee164-e6f6-4ea1-8b76-bb6f4348b137" ], "display_name": false }, { "uuid": "acbd8a5f-e562-87f5-f97d-86a2ccb3ff8b", "name": "Tramadol [WHO-DD]", "stdName": "TRAMADOL [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "39e60dab-c645-149a-1e7b-35ce67c8fcb2" ], "display_name": false }, { "uuid": "d61403ea-f06d-4098-86b9-1546c394e84b", "name": "U-26255A", "stdName": "U-26255A", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "68b56527-f928-4e46-b2d1-4c787d95ac15" ], "display_name": false }, { "uuid": "f81a0c3e-1cca-4fc8-8fca-e13d5e0d18ed", "name": "tramadol [INN]", "stdName": "TRAMADOL [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ac654f5e-2e72-4794-b5fa-06d6ad0be035" ], "display_name": false } ], "properties": [ { "uuid": "459e5ff8-af23-4cd6-8572-310fdc9e8128", "name": "PROTEIN BINDING", "value": { "uuid": "950319be-680a-4b4e-ac7f-b80e347d6316", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 20, "units": "%" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "007692a6-6dfc-4146-bc8b-6da0275e3f95", "name": "Route of Elimination", "value": { "uuid": "f5cd009d-a343-409c-b89e-bdf629b7c540", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 60, "units": "%", "non_numeric_value": "AS METABOLITE, RENAL" }, "defining": false, "parameters": [ { "uuid": "52751b32-d029-439b-9741-708bd51d4660", "name": "EXCRETED UNCHANGED, RENAL", "type": "PHARMACOKINETIC", "value": { "uuid": "4d68578e-0d6e-47cb-80ff-d488b1ee711c", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 30, "units": "%", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "053e4ef9-88a2-4520-a477-3013c30869e0", "name": "MAXIMUM TOLERATED DOSE", "value": { "uuid": "387ca8fc-88a0-4d9e-baa7-b1827fea34e2", "average": 300, "units": "mg/day", "non_numeric_value": "ORAL EXTENDED-RELEASE TABLET" }, "defining": false, "parameters": [ { "uuid": "491666a5-564c-4b4f-bd63-606b37c5e51f", "name": "IMMEDIATE-RELEASE TABLET", "value": { "uuid": "d1401a20-73fb-4afb-ab77-8cfaf0323188", "average": 400, "units": "mg/day", "references": [] }, "references": [] } ], "property_type": "TOXICITY", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "8b67b049-9935-4d32-a0da-62ed906308b2", "name": "Tmax", "value": { "uuid": "894ae974-b926-4db8-99ae-71ea03790461", "high": 2.3, "low": 1, "units": "hours", "non_numeric_value": "ORAL, IMMEDIATE-RELEASE TABLET" }, "defining": false, "parameters": [ { "uuid": "d51bf3a7-96d4-4076-ab8a-66781b28ff6f", "name": "ORAL, IMMEDIATE-RELEASE TABLET (GERIATRICS)", "type": "PHARMACOKINETIC", "value": { "uuid": "41769ecb-c1fe-47f6-b5a3-6f74dd4f0031", "average": 2.1, "units": "hours", "references": [] }, "references": [] }, { "uuid": "db5c87fa-1f15-40b0-a402-0ffe5f05efc3", "name": "ORAL, IMMEDIATE-RELEASE TABLET (HEPATIC IMPAIRMENT)", "type": "PHARMACOKINETIC", "value": { "uuid": "a98fe2da-0e38-4d9b-ba8e-042a6557f499", "average": 1.9, "units": "hours", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "027aca0b-c523-4210-9029-7926a8b9258c", "name": "ORAL BIOAVAILABILITY", "value": { "uuid": "efa18987-27d8-447c-84fb-be92ea0edfe0", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 75, "units": "%", "non_numeric_value": "IMMEDIATE-RELEASE TABLET" }, "defining": false, "parameters": [ { "uuid": "093fb07b-a362-4b62-8e84-9fdf092c1d31", "name": "EXTENDED-RELEASE TABLET", "type": "PHARMACOKINETIC", "value": { "uuid": "14426297-9561-4efb-a641-f6f4818d36cd", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "high": 95, "low": 85, "units": "%", "references": [], "non_numeric_value": "RELATIVE TO IMMEDIATE-RELEASE TABLET" }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "283029df-8553-4116-9922-24401907f708", "name": "Tmax", "value": { "uuid": "628bb4c2-b80d-4089-ad3d-556d2532f266", "high": 12, "low": 4, "units": "hours", "non_numeric_value": "ORAL, EXTENDED-RELEASE TABLET" }, "defining": false, "parameters": [ { "uuid": "f968e270-f93e-4c44-82df-3e693715c399", "name": "EFFECT OF FOOD", "type": "PHARMACOKINETIC", "value": { "uuid": "0a6e1a85-3265-4d92-bd15-b430bb3af27e", "references": [], "non_numeric_value": "INCREASED 3 HOURS" }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "409deeab-cd2f-41d5-81d3-d75d2ef972d8", "name": "Volume of Distribution", "value": { "uuid": "6dbf6a3d-fd72-4fb0-a7e6-f986ba74d27a", "average": 2.9, "units": "Liters/Kilogram", "non_numeric_value": "FEMALE" }, "defining": false, "parameters": [ { "uuid": "27856da0-6e99-43a0-9b6a-d67ed4c15f53", "name": "MALE", "type": "PHARMACOKINETIC", "value": { "uuid": "1535529d-2388-472e-9dca-96ae177ddc2e", "average": 2.6, "units": "Liters/Kilogram", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "0e72aa6b-05bc-46ed-9f48-20109d2edf07", "name": "Route of Elimination", "value": { "uuid": "9d548ebb-1d81-4bd9-9cec-e84b50bce501", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 60, "units": "%", "non_numeric_value": "AS METABOLITE" }, "defining": false, "parameters": [ { "uuid": "1dfc6d7b-2390-4f56-a4e5-0c7d5bc14633", "name": "PERCENT EXCRETED UNCHANGED", "type": "PHARMACOKINETIC", "value": { "uuid": "ebc0e3e7-7731-499d-b199-2a67374cb223", "type": "MOLE PERCENT OF AMOUNT EXCRETED", "average": 30, "units": "%", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] }, { "uuid": "8dae5824-8a4f-48b6-a5f8-7c411928098e", "name": "Biological Half-life", "value": { "uuid": "effd4dbf-1505-4cbb-838f-62eb17a9e5bc", "high": 6.7, "low": 5.6, "units": "hours", "non_numeric_value": "IMMEDIATE-RELEASE, ADULTS" }, "defining": false, "parameters": [ { "uuid": "a270a763-c37c-49a8-90dd-b93098f9c6c2", "name": "EXTENDED-RELEASE", "type": "PHARMACOKINETIC", "value": { "uuid": "6fc6d347-e3d6-4f9b-b314-91bffb068852", "high": 10, "low": 6.5, "units": "hours", "references": [] }, "references": [] }, { "uuid": "0963c9f0-9503-439a-a6eb-c983bd955da9", "name": "IMMEDIATE-RELEASE (GERIATRIC 75 YEARS AND OLDER)", "type": "PHARMACOKINETIC", "value": { "uuid": "b1fc8dba-b51a-4b43-9def-930333fdd2fe", "average": 7, "units": "hours", "references": [] }, "references": [] }, { "uuid": "54b8c9ae-08c4-4044-88f7-ffb44c7caafe", "name": "IMMEDIATE-RELEASE (HEPATIC IMPAIRMENT)", "type": "PHARMACOKINETIC", "value": { "uuid": "46fbf786-c462-4034-881a-990819c30dbf", "average": 13, "units": "hours", "references": [] }, "references": [] }, { "uuid": "56e054be-d9c0-42d7-914b-f08f9a052211", "name": "IV, RENAL IMPAIRMENT (CrCL LESS THAN 30 mL/min)", "type": "PHARMACOKINETIC", "value": { "uuid": "071a5d4e-b821-48bd-9062-ea529d46c781", "high": 11, "low": 10.6, "units": "hours", "references": [] }, "references": [] }, { "uuid": "1d1d6ec7-e48e-48d0-a74d-a90352ff90ad", "name": "O-DESMETHYL-TRAMADOL (M1), IMMEDIATE-RELEASE", "type": "PHARMACOKINETIC", "value": { "uuid": "ffbfabc6-bda6-4d9a-815c-b9bde470d419", "high": 7, "low": 6.7, "references": [], "non_numeric_value": "IMMEDIATE-RELEASE" }, "references": [] }, { "uuid": "89c7508f-fafd-4185-b8f1-81714c97fe15", "name": "O-DESMETHYL-TRAMADOL (M1), EXTENDED-RELEASE", "type": "PHARMACOKINETIC", "value": { "uuid": "69dd1fd0-bbc1-429d-a83b-adc5d63d25a3", "high": 11, "low": 7.5, "units": "hours", "references": [] }, "references": [] }, { "uuid": "f121a504-65c2-43c1-a00a-17a7a292be0b", "name": "O-DESMETHYL-TRAMADOL (M1), IMMEDIATE-RELEASE (HEPATIC IMPAIRMENT)", "type": "PHARMACOKINETIC", "value": { "uuid": "97fbcf38-ef34-4854-913b-80f4637ca691", "high": 19, "low": 18.5, "units": "hours", "references": [] }, "references": [] }, { "uuid": "fce046e5-747a-4c17-b37c-c192af1d5f95", "name": "O-DESMETHYL-TRAMADOL (M1), IV, RENAL IMPAIRMENT (CrCL LESS THAN 30 mL/min)", "type": "PHARMACOKINETIC", "value": { "uuid": "3f68146e-a621-4862-9e48-5ebfc030fd6b", "high": 16.9, "low": 11.5, "units": "hours", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "eb36693e-b68f-aeb7-c540-525cbba5a27a" ] } ], "modifications": { "uuid": "d6d8ab1b-3a48-4a35-b360-88f7c4d86932" } } ] }