{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "bbc5fbce-8c1a-4d8f-92ae-a068106a2a47", "code": "A08AA02", "comments": "ATC|ALIMENTARY TRACT AND METABOLISM|ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS|ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS|Centrally acting antiobesity products|fenfluramine", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=A08AA02&showdescription=yes", "code_system": "WHO-ATC", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "a5a255a8-327c-4b0c-832a-8a93cc5092d7", "code": "QA08AA02", "comments": "VATC|ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS|ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS|Centrally acting antiobesity products|fenfluramine", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QA08AA02&showdescription=yes", "code_system": "WHO-VATC", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "ad15c3d6-9ac7-4254-92c5-770a7134cea0", "code": "458-24-2", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=458-24-2", "code_system": "CAS", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d", "c23e4661-7661-452a-b0a6-fe71b55dc86d" ] }, { "uuid": "51113634-d368-4b51-aadd-dbac07739bc3", "code": "C81418", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C81418", "code_system": "NCI_THESAURUS", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "09241331-2c3b-411a-96ad-6d0acabf0b81", "code": "D005277", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68005277", "code_system": "MESH", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "d1e7a391-db6b-43e7-8276-fb6493f25a93", "code": "SUB07561MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "73c45f67-ede6-48a4-88f6-c96ff1ae1790", "code": "1596", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=1596", "code_system": "INN", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "ae38f513-d6d8-4cf4-a515-e4c866039a5c", "code": "207-276-3", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.006.616", "code_system": "ECHA (EC/EINECS)", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "f18f5c7c-ff3a-4c0b-9d8e-e151a488c984", "code": "1670", "comments": "PART 1308 -- SCHEDULES OF CONTROLLED SUBSTANCES|Sec. 1308.11 Schedule IV.|Fenfluramine", "type": "SUPERSEDED", "url": "http://www.ecfr.gov/cgi-bin/text-idx?rgn=div5&node=21:9.0.1.1.9#se21.9.1308_111", "code_system": "DEA NO.", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "9497f09b-6a18-49e6-b0b6-49678839c277", "code": "4613", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4613", "code_system": "IUPHAR", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "6228e1da-e89c-447b-9064-d23690ee4b9f", "code": "FENFLURAMINE", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Fenfluramine", "code_system": "WIKIPEDIA", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "16338ae9-8b4e-4a31-a0c6-5e845644228b", "code": "4328", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/4328/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "f49e234b-1b5d-4f94-a998-250ede4fc6a7", "code": "m5274", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m5274?q=authorize", "code_system": "MERCK INDEX", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "36255815-1f82-4125-91c2-32fd65a7a4d0", "code": "5220-89-3", "type": "SUPERSEDED", "url": "https://commonchemistry.cas.org/detail?cas_rn=5220-89-3", "code_system": "CAS", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d", "f4798f83-186c-4aa8-b2cb-c374a3f48d2f" ] }, { "uuid": "dcda7c2d-fd86-4e65-8d92-d764f1662a4c", "code": "25990-46-9", "type": "SUPERSEDED", "url": "https://commonchemistry.cas.org/detail?cas_rn=25990-46-9", "code_system": "CAS", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d", "d635fef7-8de8-426b-abea-024941a44792" ] }, { "uuid": "8d618d39-3b09-4213-ba1a-ccb46c233058", "code": "CHEMBL87493", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL87493", "code_system": "ChEMBL", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "04aa3a7f-8d13-4b0e-af0f-78374e0269cb", "code": "3337", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/3337", "code_system": "PUBCHEM", "references": [ "45d69d63-2f19-4f92-8675-eb0ac53a6b1d" ] }, { "uuid": "4135c5b5-8cf9-2668-7711-ecececd08a98", "code": "3080", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3080", "code_system": "HSDB", "references": [ "a6c24a3b-e07e-bcce-a1d3-e5e81469762e" ] }, { "uuid": "fc40cbdc-c214-1221-7afd-d21160d59b08", "code": "DTXSID4023044", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023044", "code_system": "EPA CompTox", "references": [ "1d57d772-f734-447f-9939-c7056f56839e" ] }, { "uuid": "7df8e860-ad9b-1659-03d1-712e8935b9d0", "code": "C29728", "comments": "Pharmacologic Substance[C1909]|Agent Affecting Nervous System[C78272]|Anorexiant", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29728", "code_system": "NCI_THESAURUS", "references": [ "ba69b3ca-6232-fc84-959d-7144733530d0" ] }, { "uuid": "7047a2cd-605d-432f-ae03-6909790fab5b", "code": "2DS058H2CF", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "3d4fa24e-8198-623b-d4d8-c6e618b3594c", "code": "1150", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/1150", "code_system": "DRUG CENTRAL", "references": [ "ba69b3ca-6232-fc84-959d-7144733530d0" ] }, { "uuid": "d8317aaa-7af3-b18b-5a26-97df01d5f5ea", "code": "DB00574", "type": "PRIMARY", "url": "https://go.drugbank.com/drugs/DB00574", "code_system": "DRUG BANK", "references": [ "ba69b3ca-6232-fc84-959d-7144733530d0" ] }, { "uuid": "77376034-9f00-4113-94c9-bf2dad77a746", "code": "5000", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:5000", "code_system": "CHEBI", "references": [ "ba69b3ca-6232-fc84-959d-7144733530d0" ] }, { "uuid": "21150781-ddd0-ce7c-4b66-62b3a74fbe7d", "code": "100000081293", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "b87d174f-fd7c-0429-3166-7902cccfc92e" ] }, { "uuid": "15a190c5-4730-f43a-8c5f-148d6cdd1200", "code": "584217", "comments": "ORPHAN DRUG|Designated/Approved|Treatment of Lennox-Gastaut syndrome", "codeText": "ORPHAN DRUG|Designated/Approved|Treatment of Lennox-Gastaut syndrome", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=584217", "code_system": "FDA ORPHAN DRUG" }, { "uuid": "7f0a8238-1741-45a9-4af3-b575f9d6d205", "code": "2DS058H2CF", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=2DS058H2CF", "code_system": "DAILYMED", "references": [ "aca21878-4366-b122-5abb-410686e0fb29" ] }, { "uuid": "11f57ea5-c1cd-7863-33fb-51d56b5bce20", "code": "21 CFR 216.24", "comments": "PART 216 -- HUMAN DRUG COMPOUNDING|Subpart B--Compounded Drug Products|Sec. 216.24 Drug products withdrawn or removed from the market for reasons of safety or effectiveness.", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=216.24", "code_system": "CFR", "references": [ "b058d7d6-b81a-98f9-4b25-65673c54f311" ] } ], "relationships": [ { "uuid": "d05e70da-647a-43a3-b2ab-4b5a6688d947", "amount": { "uuid": "d65f3d58-68de-4863-afeb-f3761963b91f" }, "type": "ACTIVE MOIETY", "related_substance": { "uuid": "a84e4b41-1e67-4df0-b6bd-607424ed1b03", "refuuid": "76960c91-ffbc-40cd-a862-8a3a858209fd", "name": "FENFLURAMINE", "unii": "2DS058H2CF", "linking_id": "2DS058H2CF", "ref_pname": "FENFLURAMINE", "substance_class": "reference" } }, { "uuid": "8e2b9a48-c8ad-4cae-bd7c-c934cecabfcf", "amount": { "uuid": "010f8936-3090-4d8f-9878-1134485aac8e" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "afa1f392-b432-47aa-8b99-d471fffec5ba", "refuuid": "a4a5294d-3922-4d91-a59b-1fdf9179a96a", "name": "FENFLURAMINE HYDROCHLORIDE", "unii": "3KC089243P", "linking_id": "3KC089243P", "ref_pname": "FENFLURAMINE HYDROCHLORIDE", "substance_class": "reference" } }, { "uuid": "097f5c85-6301-49bb-bd7e-37c887a15312", "amount": { "uuid": "fb3b0a71-cd13-420d-99ba-465a0767857a", "type": "RELATIONSHIP_AMOUNT", "units": "WEIGHT PERCENT", "high_limit": 14, "low_limit": 3 }, "comments": "Percent of dose excreted in urine as metabolite.", "qualification": "URINE", "type": "METABOLITE->PARENT", "interaction_type": "AMOUNT EXCRETED", "references": [ "63120889-6567-451f-b125-ba449ca49c03" ], "related_substance": { "uuid": "fd614d81-f5e8-40c7-a505-6ca7461fe7f4", "refuuid": "1a8941c5-05a3-4922-8ace-2249101efcd9", "name": "Norfenfluramine", "unii": "037A9J3PSW", "linking_id": "037A9J3PSW", "ref_pname": "Norfenfluramine", "substance_class": "reference" } }, { "uuid": "ee9c576e-6e91-4400-adc4-fee8c29eac35", "amount": { "uuid": "f78095c9-e779-4cd6-86be-9995a563a16a", "type": "RELATIONSHIP_AMOUNT", "average": 1, "units": "METABOLITE/PARENT RATIO" }, "comments": "Metabolite to parent drug ratio in non-uraemic human plasma.\nA positive correlation exists between plasma norfenfluramine levels and weight loss in man.", "qualification": "PLASMA; URINE", "type": "METABOLITE->PARENT", "interaction_type": "METABOLITE TO PARENT DRUG RATIO", "references": [ "63120889-6567-451f-b125-ba449ca49c03" ], "related_substance": { "uuid": "de094b2e-7c86-4d34-824d-fcc8376fa65c", "refuuid": "1a8941c5-05a3-4922-8ace-2249101efcd9", "name": "Norfenfluramine", "unii": "037A9J3PSW", "linking_id": "037A9J3PSW", "ref_pname": "Norfenfluramine", "substance_class": "reference" } }, { "uuid": "3bd5b6f2-1bb9-4099-8095-3525150c5c64", "amount": { "uuid": "51f8dd08-9b1d-4360-9100-8115dfcf954f" }, "comments": "Responsible for ", "type": "METABOLITE TOXIC->PARENT", "interaction_type": "MAJOR", "related_substance": { "uuid": "4f556fe4-8e6c-4a5e-85ee-954f75d1b7ad", "refuuid": "1a8941c5-05a3-4922-8ace-2249101efcd9", "name": "Norfenfluramine", "unii": "037A9J3PSW", "linking_id": "037A9J3PSW", "ref_pname": "Norfenfluramine" } }, { "uuid": "7be95912-c5ed-4a00-b433-5a1ffb06901b", "amount": { "uuid": "da85272b-a70f-49d0-ab5d-7533f1c34467" }, "comments": "STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS", "type": "TARGET->AGONIST", "related_substance": { "uuid": "995682a4-11e0-4b64-9403-53a050864adc", "refuuid": "c6fd7267-1e34-44af-a91e-31fc68e4c295", "name": "5-HYDROXYTRYPTAMINE RECEPTOR 2C", "unii": "W4BO00H6K6", "linking_id": "W4BO00H6K6", "ref_pname": "5-HYDROXYTRYPTAMINE RECEPTOR 2C", "substance_class": "reference" } }, { "uuid": "63a5229b-4478-410a-9571-449badac36a4", "amount": { "uuid": "2125e333-33d4-4e00-9a17-a9e76bdda5c4" }, "comments": "5-HT2B receptors, which were subsequently identified as the target for cardiac valvulopathy and pulmonary hypertension. Release of serotonin leads to 5-HT2B signaling.", "type": "OFF-TARGET->AGONIST", "related_substance": { "uuid": "5ffdaf8e-b8bd-4f64-815d-1cf477e5d827", "refuuid": "16a75fdf-b595-4436-b1de-1d9e821d264a", "name": "5-HYDROXYTRYPTAMINE RECEPTOR 2B", "unii": "6E2Z4UWILI", "linking_id": "6E2Z4UWILI", "ref_pname": "5-HYDROXYTRYPTAMINE RECEPTOR 2B", "substance_class": "reference" } }, { "uuid": "e348948e-949d-4d8c-bee3-5be5027b5e8e", "amount": { "uuid": "f40e47b4-cfd7-4e04-9f09-b50952c1d7cc" }, "comments": "STIMULATES SEROTONIN RELEASE.", "type": "TRANSPORTER->SUBSTRATE", "references": [ "8891bbf5-242d-4586-9ec6-fa915fe6604d" ], "related_substance": { "uuid": "5498eb5b-2b57-4c44-8680-4c84e67019b7", "refuuid": "06df8044-d6c0-4403-85ab-26c75e41e405", "name": "SODIUM-DEPENDENT SEROTONIN TRANSPORTER", "unii": "CJZ26L1EGI", "linking_id": "CJZ26L1EGI", "ref_pname": "SODIUM-DEPENDENT SEROTONIN TRANSPORTER", "substance_class": "reference" } }, { "uuid": "8d7d95e1-6caf-455f-9254-8359d9f1fba0", "amount": { "uuid": "a769329f-5b36-4238-9131-1ff98acb57be" }, "type": "IMPURITY->PARENT", "references": [ "18846676-157e-4581-8994-cca450caf12b" ], "related_substance": { "uuid": "c237a555-4e94-4a07-b2e6-b224005bb5d4", "refuuid": "4ab1dc56-a3f7-4f2a-a810-613b8e0b6601", "name": "N-nitroso-fenfluramine", "unii": "5WDC74B71K", "linking_id": "5WDC74B71K", "ref_pname": "N-nitroso-fenfluramine", "substance_class": "reference" } }, { "uuid": "6a52ad5e-38ca-4410-aa01-0a33c07a21d1", "amount": { "uuid": "97e4f783-46fe-4e70-b645-600a6e6aa04f", "average": 3.1, "high": 3.5, "low": 2.7, "units": "MICROMOLAR" }, "qualification": "IC50", "type": "TRANSPORTER->INHIBITOR", "references": [ "0ae666d5-8d66-489a-aba5-ba69d6a93dee" ], "related_substance": { "uuid": "545acfcc-7406-43ee-a85a-d046fa26a3c0", "refuuid": "f9fe89bd-1392-4773-87c1-d7a117b1a22c", "name": "Chromaffin granule amine transporter", "unii": "5PW6T9YK9P", "linking_id": "5PW6T9YK9P", "ref_pname": "Chromaffin granule amine transporter", "substance_class": "reference" } } ], "substance_class": "chemical", "names": [ { "uuid": "17c29d4d-46ab-4498-95d9-bd2f4aff43ec", "name": "2-ETHYLAMINO-1-(3-TRIFLUOROMETHYLPHENYL)PROPANE", "stdName": "2-ETHYLAMINO-1-(3-TRIFLUOROMETHYLPHENYL)PROPANE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "adc13dde-17ec-4edf-ab65-0b2ba8f0f037", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "cf13cf9b-4af3-4595-93f9-e80526564c82", "name": "ACINO", "stdName": "ACINO", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "fdbf46fc-b70e-4c74-b331-89b1a3bc639b" ], "display_name": false }, { "uuid": "67b3f405-3a76-4caf-bec4-967d8e1e49ba", "name": "BENZENEETHANAMINE, N-ETHYL-.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)-", "stdName": "BENZENEETHANAMINE, N-ETHYL-.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)-", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "9cbfd964-672a-44a0-9890-c08d19232f3e" ], "display_name": false }, { "uuid": "38e2335a-173b-4400-864a-879bcbdbec46", "name": "BRABAFEN", "stdName": "BRABAFEN", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "8ccdb068-8dfb-4bac-a72e-1159fdc6d94d", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "cd1fba6e-65de-4d43-ba64-59d44134a844", "name": "FENFLURAMIN", "stdName": "FENFLURAMIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "dc0becb3-0d2b-48a6-9ddc-790078810635", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "7159d204-9322-461e-a86a-c810e5e00b42", "name": "FENFLURAMINE", "stdName": "FENFLURAMINE", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "cbd713f2-1a43-48e1-82ed-da845910bdd0", "0667df41-eee5-43b5-a4a9-69157041c42d", "496bb5e5-fb29-4e7e-9f6a-60b18d65cfba", "edaca99c-384c-4857-b72f-dc5d788ba1ef", "fb86f8c9-774c-467c-8085-39298979243e", "b932e09b-8d16-48e9-98f6-ce9e3dbad7ce", "6ec29c3f-d3e4-4837-864c-1ed984c325e9", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "f97057c5-ea38-4518-acd0-a462922d9f63", "94610af8-5627-4e54-89f5-da5f0da663b4", "933c02a2-b107-4466-820f-48e6d759053a", "9cbfd964-672a-44a0-9890-c08d19232f3e" ], "display_name": true, "domains": [ "drug" ], "name_orgs": [ { "uuid": "5d86c16b-c1e4-43ed-9b81-51e0b61b1c90", "name_org": "INN" } ] }, { "uuid": "f11e6696-5efb-4b4a-8d24-5ce48824fede", "name": "FENFLURAMINE [HSDB]", "stdName": "FENFLURAMINE [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b932e09b-8d16-48e9-98f6-ce9e3dbad7ce", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "2dbfd274-e157-480e-80af-c2bf53dbe5d1", "name": "FENFLURAMINE [MI]", "stdName": "FENFLURAMINE [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "933c02a2-b107-4466-820f-48e6d759053a" ], "display_name": false }, { "uuid": "1fd52095-9dfa-410d-9e20-9ec2e54e0545", "name": "FENFLURAMINE [VANDF]", "stdName": "FENFLURAMINE [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "edaca99c-384c-4857-b72f-dc5d788ba1ef", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "fc1eb9fb-3940-cccb-210d-b01d46273d42", "name": "Fenfluramine [WHO-DD]", "stdName": "FENFLURAMINE [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "c31e3a55-4400-ac1a-9d36-3098874579a3" ], "display_name": false }, { "uuid": "cbd5a2fd-101e-4785-a3b2-610b7bd075e9", "name": "J5.760F", "stdName": "J5.760F", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "dc0becb3-0d2b-48a6-9ddc-790078810635", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "4ccab03b-7667-4e35-b630-8ce5902ac96c", "name": "N-ETHYL-.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE", "stdName": "N-ETHYL-.ALPHA.-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "adc13dde-17ec-4edf-ab65-0b2ba8f0f037", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "5935f6cd-e2a7-4360-bac5-a9ccede67872", "name": "N-ETHYL-.ALPHA.-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE", "stdName": "N-ETHYL-.ALPHA.-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "9cbfd964-672a-44a0-9890-c08d19232f3e" ], "display_name": false }, { "uuid": "7cf67f07-e681-4bb0-bc62-1c1add11f35c", "name": "OBEDREX", "stdName": "OBEDREX", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "fdbf46fc-b70e-4c74-b331-89b1a3bc639b" ], "display_name": false }, { "uuid": "a93f1f00-4896-4bd8-8fd4-aeda8f1b71cc", "name": "PESOS", "stdName": "PESOS", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "fdbf46fc-b70e-4c74-b331-89b1a3bc639b" ], "display_name": false }, { "uuid": "9a0a1530-2ea5-4363-b2bc-bcfb3ef13a44", "name": "PHENFLURAMINE", "stdName": "PHENFLURAMINE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "a9dee2b2-aa81-4569-b5d5-c635b795be4d", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "055e9116-662a-471a-a5a4-424da3da98fc", "name": "PONDERAX", "stdName": "PONDERAX", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "e0b77e65-fec5-4e94-a304-49242d8dcdfc", "5afe5b53-2a65-4cd0-8ce5-c948a5827540" ], "display_name": false }, { "uuid": "1b10146a-a801-4712-8619-30463cf77f89", "name": "PONDERAX PA", "stdName": "PONDERAX PA", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "fdbf46fc-b70e-4c74-b331-89b1a3bc639b" ], "display_name": false }, { "uuid": "c925b4f4-52a2-41d7-a455-1673bc342491", "name": "ROTONDIN", "stdName": "ROTONDIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "fdbf46fc-b70e-4c74-b331-89b1a3bc639b" ], "display_name": false }, { "uuid": "0669d6e1-4d91-453c-9fd0-7f57b912b372", "name": "S-768", "stdName": "S-768", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "adc13dde-17ec-4edf-ab65-0b2ba8f0f037", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "6cb39259-05e4-4f4c-8171-6cdfa85fe6a7", "name": "Z-008", "stdName": "Z-008", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "c7caa783-6ca8-4cb0-b3a6-6d57abbd4a59", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "5e291804-c2a4-4c24-ae34-35e25328da5a", "name": "Z008", "stdName": "Z008", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "8ccdb068-8dfb-4bac-a72e-1159fdc6d94d", "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5" ], "display_name": false }, { "uuid": "f6ef0180-25c2-4540-89be-f0f418d720d9", "name": "ZX-008", "stdName": "ZX-008", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "1d31cead-3764-42a9-0f7c-26893fe847cb" ], "display_name": false }, { "uuid": "d4b5f1b9-d46c-498c-99d8-f48a8ea16538", "name": "ZX008", "stdName": "ZX008", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "1d31cead-3764-42a9-0f7c-26893fe847cb" ], "display_name": false }, { "uuid": "92e49cb6-c4a7-49d5-81bd-904c0db2ef87", "name": "fenfluramine [INN]", "stdName": "FENFLURAMINE [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6ec29c3f-d3e4-4837-864c-1ed984c325e9" ], "display_name": false } ], "references": [ { "uuid": "9cbfd964-672a-44a0-9890-c08d19232f3e", "citation": "USP DICTIONARY 2008", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "f23dec8a-4e82-4fb0-b6d3-469b2de09a8a", "citation": "STN 2007", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "adc13dde-17ec-4edf-ab65-0b2ba8f0f037", "citation": "Merck 14.3", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ee6a323c-c2f0-4c7d-b027-fc7ecaf7f2c5", "citation": "MERCK INDEX", "doc_type": "MERCK INDEX", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "6ec29c3f-d3e4-4837-864c-1ed984c325e9", "citation": "INN Proposed List 14", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL14.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "933c02a2-b107-4466-820f-48e6d759053a", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "5afe5b53-2a65-4cd0-8ce5-c948a5827540", "citation": "KEGG 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e0b77e65-fec5-4e94-a304-49242d8dcdfc", "citation": "D07945", "doc_type": "KEGG", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "b932e09b-8d16-48e9-98f6-ce9e3dbad7ce", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "fb86f8c9-774c-467c-8085-39298979243e", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "edaca99c-384c-4857-b72f-dc5d788ba1ef", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "fdbf46fc-b70e-4c74-b331-89b1a3bc639b", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "a9dee2b2-aa81-4569-b5d5-c635b795be4d", "citation": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657655/pdf/bmjopen-2013-002669.pdf", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657655/pdf/bmjopen-2013-002669.pdf", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "dc0becb3-0d2b-48a6-9ddc-790078810635", "citation": "http://nikkajiweb.jst.go.jp/nikkaji_web/pages/top_e.jsp?CONTENT=syosai&SN=J5.760F", "url": "http://nikkajiweb.jst.go.jp/nikkaji_web/pages/top_e.jsp?CONTENT=syosai&SN=J5.760F", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c7caa783-6ca8-4cb0-b3a6-6d57abbd4a59", "citation": "fda_srs", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "8ccdb068-8dfb-4bac-a72e-1159fdc6d94d", "citation": "http://www.biocentury.com/products/zx008", "url": "http://www.biocentury.com/products/zx008", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "45d69d63-2f19-4f92-8675-eb0ac53a6b1d", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389696000, "tags": [ "NOMEN" ] }, { "uuid": "63120889-6567-451f-b125-ba449ca49c03", "citation": "HANDBOOK OF CLINICAL PHARMACOKINETICS; EDS MILO GIBALDI AND LAURIE PRESCOTT; ADIS HEALTH SCIENCE PRESS; ISBN 0 86792 004 1; 1983", "doc_type": "BOOK", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "fdf69b11-3e16-4fd1-b093-a81a86d700a9", "citation": "SRS import [2DS058H2CF]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=2DS058H2CF", "doc_type": "SRS", "public_domain": true, "document_date": 1493389696000, "tags": [ "NOMEN" ] }, { "uuid": "c6fa4fc9-dd7a-4fec-8aab-c54e4b2d9008", "citation": "USP DICTIONARY 2009", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "0667df41-eee5-43b5-a4a9-69157041c42d", "citation": "FENFLURAMINE [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "cbd713f2-1a43-48e1-82ed-da845910bdd0", "citation": "FENFLURAMINE [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "f97057c5-ea38-4518-acd0-a462922d9f63", "citation": "FENFLURAMINE [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "496bb5e5-fb29-4e7e-9f6a-60b18d65cfba", "citation": "FENFLURAMINE [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "94610af8-5627-4e54-89f5-da5f0da663b4", "citation": "FENFLURAMINE [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "a6c24a3b-e07e-bcce-a1d3-e5e81469762e", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+458-24-2", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1d31cead-3764-42a9-0f7c-26893fe847cb", "citation": "http://www.zogenix.com/c/pipeline/zx008.php", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "1d57d772-f734-447f-9939-c7056f56839e", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=458-24-2", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "b87d174f-fd7c-0429-3166-7902cccfc92e", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "ba69b3ca-6232-fc84-959d-7144733530d0", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "d635fef7-8de8-426b-abea-024941a44792", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "f4798f83-186c-4aa8-b2cb-c374a3f48d2f", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "c23e4661-7661-452a-b0a6-fe71b55dc86d", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "8891bbf5-242d-4586-9ec6-fa915fe6604d", "citation": "Rothman, Richard B., et al. \"Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates: implications for primary pulmonary hypertension.\" Circulation 100.8 (1999): 869-875.", "url": "https://www.ahajournals.org/doi/full/10.1161/01.CIR.100.8.869", "doc_type": "JA", "public_domain": true }, { "uuid": "c31e3a55-4400-ac1a-9d36-3098874579a3", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "aca21878-4366-b122-5abb-410686e0fb29", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "18846676-157e-4581-8994-cca450caf12b", "citation": "Updated Information | Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs). Table 1", "url": "https://www.fda.gov/regulatory-information/search-fda-guidance-documents/updated-information-recommended-acceptable-intake-limits-nitrosamine-drug-substance-related", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "dd0e5177-c21e-4880-9366-dd36da0cc0d8", "citation": "Updated Information | Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs). Table 1", "url": "https://www.fda.gov/regulatory-information/search-fda-guidance-documents/updated-information-recommended-acceptable-intake-limits-nitrosamine-drug-substance-related", "doc_type": "WEB PAGE", "public_domain": true }, { "uuid": "0ae666d5-8d66-489a-aba5-ba69d6a93dee", "citation": "Erickson, Jeffrey D., et al. \"Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.\" Proceedings of the National Academy of Sciences 93.10 (1996): 5166-5171.", "url": "https://www.pnas.org/doi/pdf/10.1073/pnas.93.10.5166", "doc_type": "JA", "public_domain": true }, { "uuid": "b058d7d6-b81a-98f9-4b25-65673c54f311", "citation": "21 CFR 216.24", "doc_type": "CFR", "public_domain": true } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "91aa4b1c-3e10-4d0b-a6d1-c52b02582a8d", "id": "91aa4b1c-3e10-4d0b-a6d1-c52b02582a8d", "molfile": "\n Marvin 01132107332D \n\n 16 16 0 0 0 0 999 V2000\n 8.6847 -3.9290 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.9707 -3.5157 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.2567 -3.9290 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 6.5427 -3.5240 0.0000 C 0 0 0 0 0 0 0 0 0 3 0 0\n 6.5427 -2.6973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.8288 -3.9373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1148 -3.5240 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1106 -2.6973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.3966 -2.2922 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.6868 -2.7056 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.6868 -3.5282 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.4008 -3.9416 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9728 -3.9416 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2589 -3.5365 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9728 -4.7683 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2589 -4.3549 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0 0 0 0\n 2 3 1 0 0 0 0\n 3 4 1 0 0 0 0\n 4 5 1 0 0 0 0\n 4 6 1 0 0 0 0\n 6 7 1 0 0 0 0\n 8 7 1 0 0 0 0\n 7 12 2 0 0 0 0\n 9 8 2 0 0 0 0\n 9 10 1 0 0 0 0\n 10 11 2 0 0 0 0\n 12 11 1 0 0 0 0\n 11 13 1 0 0 0 0\n 14 13 1 0 0 0 0\n 15 13 1 0 0 0 0\n 16 13 1 0 0 0 0\nM END", "smiles": "CCNC(C)Cc1cccc(c1)C(F)(F)F", "formula": "C12H16F3N", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "RACEMIC", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "55619161-4805-4fb7-bf15-df18810e6bb0" }, "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "231.2578", "optical_activity": "( + / - )", "stereo_centers": 1 } ], "definition_level": "COMPLETE", "uuid": "76960c91-ffbc-40cd-a862-8a3a858209fd", "version": "26", "structure": { "id": "d6bf1ece-57a3-480b-b2f6-6ccb42f0205b", "molfile": "\n Marvin 01132111082D \n\n 16 16 0 0 0 0 999 V2000\n 2.9728 -3.9416 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 3.6868 -3.5282 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.4008 -3.9416 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1148 -3.5240 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2589 -3.5365 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 2.9728 -4.7683 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 2.2589 -4.3549 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0\n 5.8288 -3.9373 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.2567 -3.9290 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 3.6868 -2.7056 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 6.5427 -3.5240 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 4.3966 -2.2922 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 5.1106 -2.6973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 7.9707 -3.5157 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 6.5427 -2.6973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 8.6847 -3.9290 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2 1 1 0 0 0 0\n 3 2 1 0 0 0 0\n 4 3 2 0 0 0 0\n 5 1 1 0 0 0 0\n 6 1 1 0 0 0 0\n 7 1 1 0 0 0 0\n 8 4 1 0 0 0 0\n 9 11 1 0 0 0 0\n 10 2 2 0 0 0 0\n 11 8 1 0 0 0 0\n 12 10 1 0 0 0 0\n 13 4 1 0 0 0 0\n 14 9 1 0 0 0 0\n 11 15 1 0 0 0 0\n 16 14 1 0 0 0 0\n 12 13 2 0 0 0 0\nM END", "smiles": "CCNC(C)Cc1cccc(c1)C(F)(F)F", "formula": "C12H16F3N", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "RACEMIC", "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "231.2578", "optical_activity": "( + / - )", "references": [ "fdf69b11-3e16-4fd1-b093-a81a86d700a9", "c6fa4fc9-dd7a-4fec-8aab-c54e4b2d9008", "6ec29c3f-d3e4-4837-864c-1ed984c325e9" ], "stereo_centers": 1 }, "unii": "2DS058H2CF" } ] }