{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2025-09-19",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "96912440-63f2-42ba-a48a-27b8e7ead951",
          "code": "13497",
          "type": "PRIMARY",
          "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=13497",
          "code_system": "INN",
          "references": [
            "5f39b256-d4f5-4416-8195-ca4fa7bb79da"
          ]
        },
        {
          "uuid": "446a5f51-971a-482b-96d2-b710286a6ad8",
          "code": "C28952",
          "type": "PRIMARY",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28952",
          "code_system": "NCI_THESAURUS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb"
          ]
        },
        {
          "uuid": "556b6474-ec4f-45ba-804e-6f678940f5da",
          "code": "C009438",
          "type": "PRIMARY",
          "url": "http://www.ncbi.nlm.nih.gov/mesh/67009438",
          "code_system": "MESH",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb"
          ]
        },
        {
          "uuid": "cd4e66eb-9967-4673-b9a3-57dcafade65b",
          "code": "TETRANDRINE",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/Tetrandrine",
          "code_system": "WIKIPEDIA",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb"
          ]
        },
        {
          "uuid": "6b05f8ee-c532-41d4-b336-23802344a5e2",
          "code": "m10649",
          "comments": "Merck Index",
          "type": "PRIMARY",
          "url": "https://merckindex.rsc.org/monographs/m10649?q=authorize",
          "code_system": "MERCK INDEX",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb"
          ]
        },
        {
          "uuid": "e1211e5b-eed6-4f10-9a9d-75337f686cf2",
          "code": "5990-67-0",
          "type": "SUPERSEDED",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=5990-67-0",
          "code_system": "CAS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
            "9cdc0749-0c6e-48f8-87e7-7fa7716c3ea1"
          ]
        },
        {
          "uuid": "ed9d8a40-f6c9-4d8b-bfca-1392e2fc24dc",
          "code": "6490-80-8",
          "type": "SUPERSEDED",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=6490-80-8",
          "code_system": "CAS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
            "95bdc69e-d669-4839-ab2a-9277add9b5ac"
          ]
        },
        {
          "uuid": "845aa55d-0556-4c69-8138-a3d4c7441c0f",
          "code": "607379-81-7",
          "type": "SUPERSEDED",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=607379-81-7",
          "code_system": "CAS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
            "7261d9e3-68b9-4d1f-85a3-80cf5d7849bc"
          ]
        },
        {
          "uuid": "592f61a5-15da-4044-a8f7-4231ef4835fe",
          "code": "916770-74-6",
          "type": "SUPERSEDED",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=916770-74-6",
          "code_system": "CAS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
            "56895676-1bd3-46c7-b990-530cd0d9925b"
          ]
        },
        {
          "uuid": "8f62c770-7002-4ff7-a9e5-3532dc7901a3",
          "code": "73078",
          "type": "PRIMARY",
          "url": "https://pubchem.ncbi.nlm.nih.gov/compound/73078",
          "code_system": "PUBCHEM",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb"
          ]
        },
        {
          "uuid": "b3ae1572-add2-47f4-bfec-caca06229379",
          "code": "518-34-3",
          "type": "PRIMARY",
          "url": "https://commonchemistry.cas.org/detail?cas_rn=518-34-3",
          "code_system": "CAS",
          "references": [
            "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
            "ac0985bc-a6da-4ddd-97da-ed62d478abc7"
          ]
        },
        {
          "uuid": "95daaec9-389f-6aa9-f072-11871ca3f524",
          "code": "518916",
          "comments": "ORPHAN DRUG|Designated|Treatment of chronic myeloid leukemia.",
          "type": "PRIMARY",
          "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=518916",
          "code_system": "FDA ORPHAN DRUG"
        },
        {
          "uuid": "e207437c-117f-d600-b1aa-b1ae4051e85b",
          "code": "545716",
          "comments": "ORPHAN DRUG|Designated|Treatment of acute myeloid leukemia.",
          "type": "PRIMARY",
          "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=545716",
          "code_system": "FDA ORPHAN DRUG"
        },
        {
          "uuid": "de610306-0b2d-0aea-b159-73845d944ceb",
          "code": "C574",
          "comments": "Pharmacologic Substance[C1909]|Immunotherapeutic Agent[C308]|Immunosuppressant",
          "type": "CONCEPT",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C574",
          "code_system": "NCI_THESAURUS",
          "references": [
            "cc835511-da14-2bac-d95f-04d14dceaa09"
          ]
        },
        {
          "uuid": "7b7947ae-87f4-c234-908b-13eff77990ef",
          "code": "C333",
          "comments": "Pharmacologic Substance[C1909]|Cation Channel Blocker[C93038]|Calcium Channel Blocker",
          "type": "CONCEPT",
          "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C333",
          "code_system": "NCI_THESAURUS",
          "references": [
            "cc835511-da14-2bac-d95f-04d14dceaa09"
          ]
        },
        {
          "uuid": "359cc359-1bf5-a5b0-8f64-db4c9e7f599a",
          "code": "DB14066",
          "type": "PRIMARY",
          "url": "https://go.drugbank.com/drugs/DB14066",
          "code_system": "DRUG BANK",
          "references": [
            "cc835511-da14-2bac-d95f-04d14dceaa09"
          ]
        },
        {
          "uuid": "50281af9-6383-4514-97a9-71d16aab5978",
          "code": "29EX23D5AJ",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        },
        {
          "uuid": "5a1a85df-06f0-a03b-642a-3a33e2825530",
          "code": "77037",
          "type": "PRIMARY",
          "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=77037",
          "code_system": "NSC",
          "references": [
            "475fb2d3-8006-fe4a-1daf-108cc81b992c"
          ]
        },
        {
          "uuid": "39d14f3a-e469-196d-6491-71d951f3c393",
          "code": "100000174928",
          "type": "PRIMARY",
          "code_system": "SMS_ID",
          "references": [
            "59d1718c-ab08-91bc-618a-5147381b6a25"
          ]
        },
        {
          "uuid": "5b1a220b-8847-278b-0dc0-11771ee011e4",
          "code": "DTXSID10178062",
          "type": "PRIMARY",
          "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID10178062",
          "code_system": "EPA CompTox",
          "references": [
            "cc835511-da14-2bac-d95f-04d14dceaa09"
          ]
        }
      ],
      "relationships": [
        {
          "uuid": "d680088e-3292-4b26-9195-652558ee9386",
          "amount": {
            "uuid": "a94c0532-9560-4990-95d8-adab16165b21"
          },
          "comments": "multi-drug resistance (MDR) modulator, antineoplastic",
          "type": "ACTIVE MOIETY",
          "references": [
            "f9a1cd40-eb13-4884-966e-3e3baef26771"
          ],
          "related_substance": {
            "uuid": "86006947-ff2a-485d-bcca-dfab0ac4ccc2",
            "refuuid": "57c2d6ee-c851-4883-b45b-90855c60da95",
            "name": "Tetrandrine",
            "unii": "29EX23D5AJ",
            "linking_id": "29EX23D5AJ",
            "ref_pname": "Tetrandrine",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "9ffe8872-ad7a-4b01-ae27-3ff8ff16b286",
          "amount": {
            "uuid": "aa526ce1-2844-438a-a7c9-379bc91b27f0"
          },
          "type": "RACEMATE->ENANTIOMER",
          "related_substance": {
            "uuid": "9a5a18ff-1aff-4bab-b70f-55db3540c277",
            "refuuid": "53b9b4aa-add2-4808-9306-c913f32ebb14",
            "name": "TETRANDRINE, (±)-",
            "unii": "VS4W77H3SD",
            "linking_id": "VS4W77H3SD",
            "ref_pname": "TETRANDRINE, (±)-",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "d6336f7a-2b03-4f64-884c-452b26d4971b",
          "amount": {
            "uuid": "18625a4e-57ac-4b71-bc2c-9906a3aa3bc9"
          },
          "type": "TARGET->INHIBITOR",
          "references": [
            "dc7673f2-4f7c-9cd6-7d64-e4dafd347c9d"
          ],
          "related_substance": {
            "uuid": "eb86780e-c79c-492c-ad41-5d3299f191e3",
            "refuuid": "96ca1558-9857-49ae-8dcc-721fc6a72592",
            "name": "VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D",
            "unii": "OIC6NC9Q3P",
            "linking_id": "OIC6NC9Q3P",
            "ref_pname": "VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "04839f16-c8f9-4c9e-8e59-6d125f71c3b1",
          "amount": {
            "uuid": "0843e7bc-bde4-4118-8188-77db12698785"
          },
          "type": "ENANTIOMER->ENANTIOMER",
          "related_substance": {
            "uuid": "7571c88f-bdf6-4101-aedf-754e03424e1f",
            "refuuid": "7ec74b72-2762-417e-b198-8db017461a05",
            "name": "TETRANDRINE, (-)-",
            "unii": "DDW9ZLW86P",
            "linking_id": "DDW9ZLW86P",
            "ref_pname": "TETRANDRINE, (-)-"
          }
        },
        {
          "uuid": "6bbd9a3e-1305-4c2d-96f5-9b58f6621e8e",
          "amount": {
            "uuid": "23bcef9f-6dbb-4a0f-9322-8823719dd2aa"
          },
          "type": "TRANSPORTER->INHIBITOR",
          "references": [
            "d02647fc-8d1f-4a86-822b-e909cc9d88d7"
          ],
          "related_substance": {
            "uuid": "11c0c504-f866-44ee-9108-912fd272f189",
            "refuuid": "3921aa0b-fd6d-40ec-9c07-d83e5c6f124a",
            "name": "MULTIDRUG RESISTANCE PROTEIN 1",
            "unii": "22ES734693",
            "linking_id": "22ES734693",
            "ref_pname": "MULTIDRUG RESISTANCE PROTEIN 1",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "72148d53-531a-4b8c-bd07-fdc7335d0db3",
          "amount": {
            "uuid": "56372f22-e5b3-498a-82a6-cc8950b31a48"
          },
          "type": "DIASTEREOISOMER->DIASTEREOISOMER",
          "related_substance": {
            "uuid": "36a6e43f-a491-4b09-b009-9e449765c47d",
            "refuuid": "6419e35d-0363-410e-a532-37a468784481",
            "name": "ISOTETRANDRINE, (-)-",
            "unii": "99JX36W62B",
            "linking_id": "99JX36W62B",
            "ref_pname": "ISOTETRANDRINE, (-)-"
          }
        },
        {
          "uuid": "6013ef80-9005-4c4b-a8e5-74381afb6cea",
          "amount": {
            "uuid": "aa645277-3f3c-4063-a0f1-626dc63f06ae"
          },
          "type": "DIASTEREOISOMER->DIASTEREOISOMER",
          "related_substance": {
            "uuid": "8c12ef51-ef79-48c3-8c98-fb4cede569cd",
            "refuuid": "1b020f50-007a-463d-a3d0-29a18cd33492",
            "name": "ISOTETRANDRINE, (+)-",
            "unii": "84T861CP2N",
            "linking_id": "84T861CP2N",
            "ref_pname": "ISOTETRANDRINE, (+)-"
          }
        }
      ],
      "substance_class": "chemical",
      "names": [
        {
          "uuid": "aa63cef4-d4b0-490c-8c0a-e9ae8fb19c2e",
          "name": "(+)-TETRANDRINE",
          "stdName": "(+)-TETRANDRINE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "4bc4e493-9b2c-43e4-9e01-d70f1599a10a",
          "name": "(1.BETA.)-6,6',7,12-TETRAMETHOXY-2,2'-DIMETHYLBERBAMAN",
          "stdName": "(1.BETA.)-6,6',7,12-TETRAMETHOXY-2,2'-DIMETHYLBERBAMAN",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "568f3962-9800-4889-a456-05f331496037",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "26548a7e-64bc-445f-bbe1-4c7609e51ef2",
          "name": "(S,S)-TETRANDRINE",
          "stdName": "(S,S)-TETRANDRINE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "6f3e560c-6e4d-47af-9f94-0fa774f1348b",
          "name": "D-TETRANDRINE",
          "stdName": "D-TETRANDRINE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "3665ee25-8818-4ba2-b676-5298d413e926",
          "name": "NSC-77037",
          "stdName": "NSC-77037",
          "type": "cd",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "0cf5a8ee-9594-49f3-93c7-c5391d0ebb6f",
          "name": "SINOMENINE A",
          "stdName": "SINOMENINE A",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "6a8492b0-b6a2-4f89-8911-ca55f67d297e",
          "name": "TETRANDRIN",
          "stdName": "TETRANDRIN",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "1609a201-4262-4ad6-8392-9d081f58429f",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "7180917d-68e8-45ea-ae06-6e8f7b2fa035",
          "name": "TETRANDRINE",
          "stdName": "TETRANDRINE",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": true,
          "references": [
            "0aa4b631-5666-412a-9912-5ac3d717f3c1",
            "e8ca13af-6df3-458a-b156-7ec223dc8f2e",
            "568f3962-9800-4889-a456-05f331496037",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb",
            "d46c853f-5665-45b8-b40d-9a217231b6dc",
            "f5f8d2e9-8b33-4954-9067-a4a766dde22c",
            "2d9ace5f-7a9e-41dc-9df8-91d6961f282b",
            "74cec928-d214-47f7-9612-abff194c60a9",
            "e00bf31d-9bc4-48ff-ab11-60b4600b110e"
          ],
          "display_name": false,
          "domains": [
            "cosmetic"
          ],
          "name_orgs": [
            {
              "uuid": "f9451e2a-ee38-4604-a068-a5d4736dae83",
              "name_org": "INCI"
            }
          ]
        },
        {
          "uuid": "c9889228-561f-4f5c-9b14-7b8605b8dd9c",
          "name": "TETRANDRINE [MI]",
          "stdName": "TETRANDRINE [MI]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "0aa4b631-5666-412a-9912-5ac3d717f3c1",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "196ab400-8753-4717-a8c0-8b5772d647fb",
          "name": "TETRANDRINE, (+)-",
          "stdName": "TETRANDRINE, (+)-",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb",
            "cbd80f1f-359b-40d7-a1e0-63c1e2c452cf"
          ],
          "display_name": false
        },
        {
          "uuid": "71d12d4b-32c2-425b-9a78-749f7f0b2384",
          "name": "TETRANDRINE, D-",
          "stdName": "TETRANDRINE, D-",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "568f3962-9800-4889-a456-05f331496037",
            "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb"
          ],
          "display_name": false
        },
        {
          "uuid": "07aa0b03-bc5c-4c48-8421-0864b55a0222",
          "name": "Tetrandrine",
          "stdName": "TETRANDRINE",
          "type": "of",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "5f39b256-d4f5-4416-8195-ca4fa7bb79da",
            "f9a1cd40-eb13-4884-966e-3e3baef26771"
          ],
          "display_name": true,
          "domains": [
            "drug"
          ],
          "name_orgs": [
            {
              "uuid": "69e62ece-bb30-44d6-a77a-01bc6a035fea",
              "name_org": "INN"
            }
          ]
        },
        {
          "uuid": "198f4247-2385-11b5-d0e8-a95105ebd918",
          "name": "Tetrandrine [WHO-DD]",
          "stdName": "TETRANDRINE [WHO-DD]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f38804f4-f890-4baa-a8ef-b95fe89e0ca4"
          ],
          "display_name": false
        },
        {
          "uuid": "35885aba-a5ac-4513-8675-2a3801befbdc",
          "name": "tetrandrine [INN]",
          "stdName": "TETRANDRINE [INN]",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "f9a1cd40-eb13-4884-966e-3e3baef26771"
          ],
          "display_name": false
        }
      ],
      "references": [
        {
          "uuid": "568f3962-9800-4889-a456-05f331496037",
          "citation": "MERCK",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "f0b1858a-14c0-4a55-87bc-6dc6077fbdfb",
          "citation": "MERCK INDEX",
          "doc_type": "MERCK INDEX",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "1609a201-4262-4ad6-8392-9d081f58429f",
          "citation": "CHEMID",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "0aa4b631-5666-412a-9912-5ac3d717f3c1",
          "citation": "MERCK INDEX",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "f5f8d2e9-8b33-4954-9067-a4a766dde22c",
          "citation": "PCPC",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "e00bf31d-9bc4-48ff-ab11-60b4600b110e",
          "citation": "WHO-DD",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "cbd80f1f-359b-40d7-a1e0-63c1e2c452cf",
          "citation": "FDA_SRS",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "5d0bc626-8c79-4027-ada1-07a0881f3dbb",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493393611000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "49e63253-fa36-419c-bba7-619642e8ad78",
          "citation": "SRS import [29EX23D5AJ]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=29EX23D5AJ",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493393611000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "74cec928-d214-47f7-9612-abff194c60a9",
          "citation": "TETRANDRINE [MI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "2d9ace5f-7a9e-41dc-9df8-91d6961f282b",
          "citation": "TETRANDRINE [INCI]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "d46c853f-5665-45b8-b40d-9a217231b6dc",
          "citation": "TETRANDRINE [WHO-DD]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "e8ca13af-6df3-458a-b156-7ec223dc8f2e",
          "citation": "TETRANDRINE [DASH]",
          "doc_type": "SRS_LOCATOR",
          "public_domain": true
        },
        {
          "uuid": "59d1718c-ab08-91bc-618a-5147381b6a25",
          "citation": "EU-SRS",
          "doc_type": "EMA LIST",
          "public_domain": true
        },
        {
          "uuid": "cc835511-da14-2bac-d95f-04d14dceaa09",
          "doc_type": "SYSTEM",
          "public_domain": true
        },
        {
          "uuid": "ac0985bc-a6da-4ddd-97da-ed62d478abc7",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "56895676-1bd3-46c7-b990-530cd0d9925b",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "7261d9e3-68b9-4d1f-85a3-80cf5d7849bc",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "95bdc69e-d669-4839-ab2a-9277add9b5ac",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "9cdc0749-0c6e-48f8-87e7-7fa7716c3ea1",
          "citation": "STN",
          "doc_type": "STN (SCIFINDER)",
          "public_domain": true
        },
        {
          "uuid": "dc7673f2-4f7c-9cd6-7d64-e4dafd347c9d",
          "citation": "Bhagya, N. C. K. R., and K. R. Chandrashekar. \"Tetrandrine and cancer–An overview on the molecular approach.\" Biomedicine & Pharmacotherapy 97 (2018): 624-632.",
          "url": "https://www.sciencedirect.com/science/article/pii/S0753332217326628",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "d02647fc-8d1f-4a86-822b-e909cc9d88d7",
          "citation": "Engle, Kritika, and Gautam Kumar. \"Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.\" European Journal of Medicinal Chemistry (2022): 114542.",
          "url": "https://reader.elsevier.com/reader/sd/pii/S0223523422004445?token=B3EF98BA0FAAF433D381FC1940C0A0821598B2CD02A38085CDCBCDC6820386D96F5F5C32DDBD9012577502F3F6A9B6C9&originRegion=us-east-1&originCreation=20220716171256",
          "doc_type": "JA",
          "public_domain": true
        },
        {
          "uuid": "475fb2d3-8006-fe4a-1daf-108cc81b992c",
          "citation": "NCI",
          "doc_type": "NCI DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "5169191c-52fb-3285-31b2-db04ab313465",
          "citation": "DailyMed",
          "doc_type": "DAILYMED",
          "public_domain": true
        },
        {
          "uuid": "f38804f4-f890-4baa-a8ef-b95fe89e0ca4",
          "citation": "WHO-DD",
          "doc_type": "WHO DRUG DICTIONARY",
          "public_domain": true
        },
        {
          "uuid": "5f39b256-d4f5-4416-8195-ca4fa7bb79da",
          "citation": "Mednet",
          "doc_type": "INN",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "f9a1cd40-eb13-4884-966e-3e3baef26771",
          "citation": "Proposed INN: List 132",
          "doc_type": "INN_LIST",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        }
      ],
      "definition_type": "PRIMARY",
      "moieties": [
        {
          "uuid": "eb645b14-1cbf-430a-ade6-8386523476d4",
          "id": "eb645b14-1cbf-430a-ade6-8386523476d4",
          "molfile": "\n  Marvin  01132112112D          \n\n 46 52  0  0  1  0            999 V2000\n   10.6847   -6.4377    0.0000 C   0  0  1  0  0  0  0  0  0  2  0  0\n    9.5320   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3938   -6.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3938   -5.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.6654   -5.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9323   -5.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1991   -5.4393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1991   -4.1611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9275   -3.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9275   -2.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -2.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -2.0775    0.0000 C   0  0  2  0  0  0  0  0  0  2  0  0\n    6.8117   -1.6722    0.0000 N   0  0  1  0  0  0  0  0  0  0  0  0\n    6.0978   -2.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.8117   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.2442   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9628   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.6863   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.4147   -0.4954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   11.0416   -0.8234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.6863   -1.6722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.3906   -2.0678    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   11.0610   -1.6626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9532   -2.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9532   -3.7608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    9.9902   -4.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.9902   -5.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6847   -5.5984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.3985   -5.2029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   12.1076   -5.6322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   12.1076   -6.4521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.4131   -6.8477    0.0000 N   0  0  2  0  0  0  0  0  0  0  0  0\n   11.4131   -7.7497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.3985   -4.3734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6896   -3.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6896   -3.2205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   10.0723   -2.8636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.2442   -1.6722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.2328   -2.5260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.4948   -2.9215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.4948   -3.7222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8534   -4.1225    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    4.2167   -3.7801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9323   -6.6403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.6653   -7.0599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n  1  2  1  0  0  0  0\n  1 29  1  0  0  0  0\n  1 33  1  1  0  0  0\n  3  2  1  0  0  0  0\n  4  3  1  0  0  0  0\n 46  3  2  0  0  0  0\n  5  4  2  0  0  0  0\n  5  6  1  0  0  0  0\n  6  7  1  0  0  0  0\n 45  6  2  0  0  0  0\n  7  8  1  0  0  0  0\n  8  9  1  0  0  0  0\n 42  8  2  0  0  0  0\n  9 10  2  0  0  0  0\n 10 11  1  0  0  0  0\n 40 10  1  0  0  0  0\n 12 11  1  0  0  0  0\n 12 13  1  6  0  0  0\n 12 39  1  0  0  0  0\n 14 13  1  0  0  0  0\n 15 13  1  0  0  0  0\n 15 16  1  0  0  0  0\n 16 17  1  0  0  0  0\n 18 17  1  0  0  0  0\n 17 39  2  0  0  0  0\n 18 19  2  0  0  0  0\n 20 19  1  0  0  0  0\n 19 22  1  0  0  0  0\n 21 20  1  0  0  0  0\n 23 22  1  0  0  0  0\n 22 25  2  0  0  0  0\n 24 23  1  0  0  0  0\n 26 25  1  0  0  0  0\n 39 25  1  0  0  0  0\n 27 26  1  0  0  0  0\n 28 27  1  0  0  0  0\n 36 27  2  0  0  0  0\n 29 28  2  0  0  0  0\n 30 29  1  0  0  0  0\n 31 30  1  0  0  0  0\n 30 35  2  0  0  0  0\n 32 31  1  0  0  0  0\n 32 33  1  0  0  0  0\n 34 33  1  0  0  0  0\n 35 36  1  0  0  0  0\n 37 36  1  0  0  0  0\n 38 37  1  0  0  0  0\n 41 40  2  0  0  0  0\n 42 41  1  0  0  0  0\n 43 42  1  0  0  0  0\n 44 43  1  0  0  0  0\n 45 46  1  0  0  0  0\nM  END",
          "smiles": "CN1CCc2cc(c3cc2[C@@H]1Cc4ccc(cc4)Oc5cc(ccc5OC)C[C@H]6c7c(CCN6C)cc(c(c7O3)OC)OC)OC",
          "formula": "C38H42N2O6",
          "atropisomerism": "No",
          "charge": 0,
          "count": 1,
          "stereochemistry": "ABSOLUTE",
          "count_amount": {
            "type": "MOL RATIO",
            "average": 1,
            "units": "MOL RATIO",
            "uuid": "157c4a4d-6013-4360-be0d-e34133c83eba"
          },
          "defined_stereo": 2,
          "ez_centers": 0,
          "molecular_weight": "622.7513",
          "optical_activity": "UNSPECIFIED",
          "stereo_centers": 2
        }
      ],
      "definition_level": "COMPLETE",
      "uuid": "57c2d6ee-c851-4883-b45b-90855c60da95",
      "version": "30",
      "structure": {
        "id": "c6078be0-2582-41f9-90db-ca96fac5a5b8",
        "molfile": "\n  Marvin  01132110142D          \n\n 48 54  0  0  1  0            999 V2000\n    8.9532   -2.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.2442   -1.6722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -2.0775    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n    6.8117   -1.6722    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n    6.0978   -2.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.8117   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.2442   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9628   -0.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.6863   -0.8523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.6863   -1.6722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.3906   -2.0678    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   11.0610   -1.6626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.4147   -0.4954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   11.0416   -0.8234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.5256   -2.6273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9275   -2.9360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9275   -3.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1991   -4.1611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.1991   -5.4393    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9323   -5.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    7.6654   -5.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3938   -5.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.3938   -6.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.5320   -7.2190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6847   -6.4377    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0\n   10.6847   -5.5984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.9902   -5.1836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.9902   -4.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.9532   -3.7608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6896   -3.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.3985   -4.3734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.3985   -5.2029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   12.1076   -5.6322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   12.1076   -6.4521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   11.4131   -6.8477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0\n   11.4131   -7.7497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n   10.6896   -3.2205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n   10.0723   -2.8636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    9.9636   -5.9337    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n    7.6653   -7.0599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.9323   -6.6403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.4948   -3.7222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    5.4948   -2.9215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    6.2328   -2.5260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    4.8534   -4.1225    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0\n    4.2167   -3.7801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0\n    8.1044   -2.5840    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0\n  2  1  2  0  0  0  0\n  3  2  1  0  0  0  0\n  4  3  1  0  0  0  0\n  5  4  1  0  0  0  0\n  6  4  1  0  0  0  0\n  6  7  1  0  0  0  0\n  7  8  1  0  0  0  0\n  8  2  1  0  0  0  0\n  9  8  2  0  0  0  0\n  9 10  1  0  0  0  0\n 10 11  2  0  0  0  0\n 11  1  1  0  0  0  0\n 12 11  1  0  0  0  0\n 13 12  1  0  0  0  0\n 14 10  1  0  0  0  0\n 15 14  1  0  0  0  0\n 16  3  1  0  0  0  0\n 17 16  1  0  0  0  0\n 18 17  1  0  0  0  0\n 19 18  2  0  0  0  0\n 20 19  1  0  0  0  0\n 21 20  1  0  0  0  0\n 22 21  2  0  0  0  0\n 22 23  1  0  0  0  0\n 23 24  2  0  0  0  0\n 24 25  1  0  0  0  0\n 25 26  1  0  0  0  0\n 26 27  1  0  0  0  0\n 27 28  1  0  0  0  0\n 28 29  2  0  0  0  0\n 29 30  1  0  0  0  0\n 30  1  1  0  0  0  0\n 31 29  1  0  0  0  0\n 32 31  2  0  0  0  0\n 33 32  1  0  0  0  0\n 34 33  1  0  0  0  0\n 35 34  1  0  0  0  0\n 35 36  1  0  0  0  0\n 36 26  1  0  0  0  0\n 37 36  1  0  0  0  0\n 33 27  2  0  0  0  0\n 38 31  1  0  0  0  0\n 39 38  1  0  0  0  0\n 26 40  1  6  0  0  0\n 41 24  1  0  0  0  0\n 42 41  2  0  0  0  0\n 42 21  1  0  0  0  0\n 43 19  1  0  0  0  0\n 43 44  2  0  0  0  0\n 44 45  1  0  0  0  0\n 45 17  2  0  0  0  0\n 46 43  1  0  0  0  0\n 47 46  1  0  0  0  0\n  3 48  1  1  0  0  0\nM  END",
        "smiles": "CN1CCc2cc(c3cc2[C@]1([H])Cc4ccc(cc4)Oc5cc(ccc5OC)C[C@@]6([H])c7c(CCN6C)cc(c(c7O3)OC)OC)OC",
        "formula": "C38H42N2O6",
        "atropisomerism": "No",
        "charge": 0,
        "count": 1,
        "stereochemistry": "ABSOLUTE",
        "defined_stereo": 2,
        "ez_centers": 0,
        "molecular_weight": "622.7513",
        "optical_activity": "( + )",
        "references": [
          "568f3962-9800-4889-a456-05f331496037",
          "49e63253-fa36-419c-bba7-619642e8ad78",
          "f9a1cd40-eb13-4884-966e-3e3baef26771",
          "5f39b256-d4f5-4416-8195-ca4fa7bb79da"
        ],
        "stereo_centers": 2
      },
      "unii": "29EX23D5AJ"
    }
  ]
}