{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "dd011b93-df56-42c8-91b6-dc5d2791c863", "code": "C03DA01", "comments": "ATC|CARDIOVASCULAR SYSTEM|DIURETICS|POTASSIUM-SPARING AGENTS|Aldosterone antagonists|spironolactone", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C03DA01&showdescription=yes", "code_system": "WHO-ATC", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "88af96a8-0abf-4c71-9665-d86f6663338b", "code": "N0000011310", "comments": "Cellular or Molecular Interactions [MoA]|Receptor Interactions [MoA]|Transcription Factor Activity [MoA]|Hormone Receptor Interactions [MoA]|Hormone Receptor Antagonists [MoA]|Steroid Receptor Antagonists [MoA]|Mineralocorticoid Receptor Antagonists [MoA]|Aldosterone Antagonists [MoA]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000011310", "code_system": "NDF-RT", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "dd1d75ee-fea4-4390-84df-1e63e9c5cc5f", "code": "N0000175557", "comments": "Established Pharmacologic Class [EPC]|Aldosterone Antagonist [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175557", "code_system": "NDF-RT", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "f30c2b78-8480-45a0-8e4e-d2c38f9abb5a", "code": "QC03DA01", "comments": "VATC|DIURETICS|POTASSIUM-SPARING AGENTS|Aldosterone antagonists|spironolactone", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC03DA01&showdescription=yes", "code_system": "WHO-VATC", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "27e15103-9c54-4c8b-bedd-8ed4e0e1abe2", "code": "52-01-7", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=52-01-7", "code_system": "CAS", "references": [ "ff02d3af-df03-4730-899c-773c154063ea", "824e0b2c-a671-4dfd-a979-95528817e8da" ] }, { "uuid": "51201813-d113-4308-bbd0-e70231583366", "code": "C840", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840", "code_system": "NCI_THESAURUS", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "965dc0ea-cbb0-4e69-b947-71ea7c67dd81", "code": "NBK547921", "comments": "LiverTox|Cardiac|Diuretic|Potassium sparing diuretic", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/NBK547921/", "code_system": "LIVERTOX", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "44b9a35a-6257-4d1d-a722-1e8c8109e7a7", "code": "16", "comments": "WHO ESSENTIAL MEDICINES LIST|Diuretics", "type": "PRIMARY", "url": "http://prais.paho.org/medicine/259/?section=109#type612", "code_system": "WHO-ESSENTIAL MEDICINES LIST", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "78fc2958-3f8e-4c35-a185-c4f0e3004bef", "code": "D013148", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68013148", "code_system": "MESH", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "2fb07d1c-4237-48b9-b5af-456f321e42cc", "code": "SPIRONOLACTONE", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Spironolactone", "code_system": "WIKIPEDIA", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "85f9edc8-d893-4cb2-b4d5-061229b3faae", "code": "SUB10631MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "6af2eee3-a4b8-4946-a6ab-310356b82c0b", "code": "987", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=987", "code_system": "INN", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "aea20282-6be2-412a-98b5-03881c00336b", "code": "2875", "type": "PRIMARY", "url": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2875", "code_system": "IUPHAR", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "83cd4a9b-731a-41e2-8046-9bbabddcd7b0", "code": "SPIRONOLACTONE", "comments": "Description: A light yellowish white to light yellowish brown powder; odourless or with a faint characteristic odour. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS. Category: Diuretic. Storage: Spironolactone should be kept in a well-closed container, protected from light. Additional information: Spironolactone may show preliminary melting at about 135?C, followed by resolidification. Definition: Spironolactone contains not less than 97.0% and not more than 101.5% of C24H32O4S, calculated with reference to the dried substance.", "type": "PRIMARY", "url": "http://apps.who.int/phint/pdf/b/Jb.6.1.396.pdf", "code_system": "WHO INTERNATIONAL PHARMACOPEIA", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "ff5a9767-ecf5-436c-adb7-e94a1b2fbb07", "code": "9997", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/9997/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "e9c58581-905f-44a0-b50b-cf26e77f8a17", "code": "m10157", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m10157?q=authorize", "code_system": "MERCK INDEX", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "2d560649-f412-43f5-a732-036722c1f7bb", "code": "DB00421", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00421", "code_system": "DRUG BANK", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "867d0b4a-518e-4320-bbac-10d49a49e2ae", "code": "CHEMBL1393", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1393", "code_system": "ChEMBL", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "52f1ee05-e34f-4f67-82d7-5c83e5577302", "code": "5833", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/5833", "code_system": "PUBCHEM", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "cef18c2e-5366-48a7-8011-60d84917dd82", "code": "200-133-6", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.000.122", "code_system": "ECHA (EC/EINECS)", "references": [ "ff02d3af-df03-4730-899c-773c154063ea" ] }, { "uuid": "e2302807-e24e-42ce-982c-494f6d86ec8a", "code": "CARDALIS (AUTHORISED)", "comments": "EMA VET. EPAR|DOGS|TREATMENT OF CONGESTION HEART FAILURE", "type": "PRIMARY", "url": "http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/medicines/002524/vet_med_000261.jsp&mid=WC0b01ac058001fa1c", "code_system": "EMA VETERINARY ASSESSMENT REPORTS", "references": [ "7a65f304-2c18-945f-ef98-79dda7752b1e" ] }, { "uuid": "54b3d922-3eca-476a-b158-76dac2f38a48", "code": "SPIRONOLACTONE CEVA [AUTHORIZED]", "comments": "EMA VET. EPAR|DOGS|TREATMENT OF CONGESTION HEART FAILURE", "type": "PRIMARY", "url": "http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/medicines/000105/vet_med_000166.jsp&mid=WC0b01ac058001fa1c", "code_system": "EMA VETERINARY ASSESSMENT REPORTS", "references": [ "e49410be-5c1e-47a2-ba50-3dc977da640f" ] }, { "uuid": "5b3313b5-62cc-acca-4ea0-dee13b84542a", "code": "3184", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3184", "code_system": "HSDB", "references": [ "c5dfa5ec-49e0-7716-cac8-e705b7cbda35" ] }, { "uuid": "24d92881-a0e5-4360-6414-0387401f2645", "code": "DTXSID6034186", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID6034186", "code_system": "EPA CompTox", "references": [ "8a8fb532-c73e-c0aa-a98a-7833297b8000" ] }, { "uuid": "8f86042b-890a-f4b7-3687-37987f3a9a20", "code": "Spironolactone", "comments": "IARC|GROUP 3 ( Not classifiable as to its carcinogenicity to humans)", "type": "PRIMARY", "code_system": "IARC", "references": [ "d9eb2570-a826-ded0-8e10-928670e56c3b" ] }, { "uuid": "a05f2557-03ed-7714-f6a7-d396d238a368", "code": "C49186", "comments": "Pharmacologic Substance[C1909]|Agent Affecting Blood or Body Fluid[C78275]|Diuretic[C448]|Potassium-Sparing Diuretic", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C49186", "code_system": "NCI_THESAURUS", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "8a7f421e-d3a3-63db-06ee-7d8e9e39c511", "code": "430614", "comments": "ORPHAN DRUG|Designated|Use in pediatric patients with primary hyperaldosteronism", "type": "PRIMARY", "url": "https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=430614", "code_system": "FDA ORPHAN DRUG" }, { "uuid": "5ce352f9-f051-4e7b-9e39-b3341ff8df60", "code": "SUB127260", "type": "ALTERNATIVE", "code_system": "EVMPD" }, { "uuid": "d3323a87-fa0e-4cf2-856a-a90e9c719135", "code": "27O7W4T232", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "344e972f-b6e3-7242-f20b-32788bd74667", "code": "Spironolactone", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/n/lactmed/LM246/", "code_system": "LACTMED", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "1adbeb47-44e1-db97-9106-8591a913278c", "code": "2475", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/2475", "code_system": "DRUG CENTRAL", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "8307c53e-a58d-347c-000f-050878732967", "code": "9241", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:9241", "code_system": "CHEBI", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "26ab9446-3517-97e5-016f-29b9c5191685", "code": "1619006", "type": "PRIMARY", "url": "https://store.usp.org/product/1619006", "code_system": "RS_ITEM_NUM", "references": [ "8ff85642-a47f-7385-870a-39fc5c3a1d9b" ] }, { "uuid": "c4b4a6d3-6e56-fc21-03d6-7da19b49a69d", "code": "150399", "type": "PRIMARY", "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=150399", "code_system": "NSC", "references": [ "184e5662-0a4e-7d15-4515-8966e6fb2f75" ] }, { "uuid": "1cd33925-cd0b-4aee-1e9b-37d9cf3e2129", "code": "27O7W4T232", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=27O7W4T232", "code_system": "DAILYMED", "references": [ "c2a9642e-5e74-c580-472c-cffcb6bc2711" ] }, { "uuid": "3569ffce-c5bf-3153-4fcc-10cd1373208a", "code": "100000092408", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "30e82ccd-ec5a-1693-f4cb-89ca8e99c2a7" ] } ], "substance_class": "chemical", "references": [ { "uuid": "d9046262-4b73-330a-e565-7549bf3af0a3", "citation": "Angus, Lachlan, et al. \"Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving estradiol therapy.\" Endocrine connections 1.aop (2019).", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488394/", "doc_type": "JA", "public_domain": true }, { "uuid": "394732de-a925-4b59-744b-d8cd7559107c", "citation": "Kolkhof, Peter, and Lars Bärfacker. \"30 years of the mineralocorticoid receptor: mineralocorticoid receptor antagonists: 60 years of research and development.\" Journal of Endocrinology 234.1 (2017): T125-T140.", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488394/", "doc_type": "JA", "public_domain": true }, { "uuid": "e68ac3a7-dcb8-3e26-8d28-34a7351164e4", "citation": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c23b6b9b-aec3-48a8-a518-76e4097f6479", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "6b4acaad-aec8-430f-835f-69baea26e302", "citation": "EUR J HEART FAIL. 2017 APR 12. DOI: 10.1002/EJHF.814", "url": "https://www.ncbi.nlm.nih.gov/pubmed/28401618", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "bc419390-d259-4be5-8fde-79afa2786a4c", "citation": "SRS import [27O7W4T232]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=27O7W4T232", "doc_type": "SRS", "public_domain": true, "document_date": 1493389691000, "tags": [ "NOMEN" ] }, { "uuid": "35200b4b-aa59-4840-9fea-d403644b38be", "citation": "SPIRONOLACTONE [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "5e5bda40-c473-4670-ae78-f4c97c21519e", "citation": "SPIRONOLACTONE [EP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "5f3af259-5525-4a78-be06-4a2819655ed8", "citation": "SPIRONOLACTONE [USP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "ca8e57f1-3500-4ffd-a002-097ed13aac4e", "citation": "SPIRONOLACTONE [ORANGE BOOK]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "006219ad-63df-4415-9f4b-88e66a727ff5", "citation": "SPIRONOLACTONE [MART.]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "44c0759b-10e5-4d78-be13-57852e5adbce", "citation": "SPIRONOLACTONE [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "e0de716a-c883-411f-9df7-8c9a6b3fc155", "citation": "SPIRONOLACTONE [INCI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b92a8763-ae5d-42fa-8c57-f10093566aa4", "citation": "SPIRONOLACTONE [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "3a88a5e1-ab5f-4ef4-8dd7-c7ac2827ba9b", "citation": "SPIRONOLACTONE [USP-RS]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "d2e1e332-db58-47ff-8560-412edffeb011", "citation": "SPIRONOLACTONE [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "b428ee7d-31ae-4d85-9173-b0c83587cd55", "citation": "SPIRONOLACTONE [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "6f483434-ae46-4a55-aa38-3768ab312a73", "citation": "SPIRONOLACTONE [WHO-IP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "90c064ec-08f9-41da-bb37-1930fde4eeb2", "citation": "USP Dictionary 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "1932cd4b-7a15-4fa2-8adf-a89fc95ee9e4", "citation": "USP DICTIONARY 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "49c38358-145d-4dbf-93ee-6b608f322cbc", "citation": "INN Proposed List 11", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL11.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "47875b1c-c2c2-43e8-8996-e5e27d2f4fb3", "citation": "EP 7.2", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "f7f15613-f2f1-4a50-b45a-8d63a53b03c8", "citation": "USP 33", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e30cec61-baac-486f-9b2b-b56363f218c1", "citation": "Drugs@FDA 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "81f78b31-fd8b-4a1d-bd93-942c22db7898", "citation": "Drugs@FDA 2012", "doc_type": "DRUGS@FDA", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "d829ddba-e3d0-4f10-b42a-d9fe892c7c97", "citation": "ORANGE BOOK 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ce7bdb8c-59ad-46d5-a225-898d022d14d0", "citation": "MARTINDALE 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "863991e1-355d-4200-b501-56a7dad58fd2", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "bca7c5c7-5663-4785-8f3d-8a4a65fc4549", "citation": "PCPC", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "6d012d2e-11e5-4b5a-85dd-6fb4ffb94dfb", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "2535925e-841a-4933-bb8d-ea7776c76ba6", "citation": "USP/NF", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1138609f-ae5e-41a8-89cf-221ec6b89137", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "0beb6f13-93f3-4aaa-b8fb-d66229e0b4a2", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "6f71081e-dcdb-458e-98f7-00d702559d84", "citation": "WHO-IP", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e72c5397-86db-4992-b3fb-9c1d4ca14257", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ff02d3af-df03-4730-899c-773c154063ea", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493389691000, "tags": [ "NOMEN" ] }, { "uuid": "6d4717bd-d9b5-44f8-90a3-517e4ddda6f6", "citation": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "url": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "0970f8ca-5140-4818-9bb0-d81d6d45cf3d", "citation": "THE JOURNAL OF CLINICAL PHARMACOLOGYVOLUME 29, ISSUE 4, ARTICLE FIRST PUBLISHED ONLINE: 8 MAR 2013", "url": "http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.1989.tb03339.x/pdf", "doc_type": "JOURNAL ARTICLE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7a65f304-2c18-945f-ef98-79dda7752b1e", "citation": "http://www.ema.europa.eu/ema/index.jsp?curl=pages%2Fmedicines%2Flanding%2Fvet_epar_search.jsp&mid=WC0b01ac058001fa1c&searchTab=&alreadyLoaded=true&isNewQuery=true&status=Authorised&status=Withdrawn&status=Suspended&status=Refused&startLetter=View+all&keyword=Enter+keywords&searchType=name&taxonomyPath=&treeNumber=", "doc_type": "EMA REVIEW", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE", "NOMEN" ] }, { "uuid": "b3dc8c77-a056-c2e3-c203-27d66d5fb8d9", "citation": "Pharmacol Rev 65:578–640, April 2013", "url": "http://dx.doi.org/10.1124/pr.111.005439", "doc_type": "JA", "public_domain": true }, { "uuid": "4bcf7b0e-bd14-9169-f9a6-711a4193d00d", "citation": "JAN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "e49410be-5c1e-47a2-ba50-3dc977da640f", "citation": "http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/medicines/000105/vet_med_000166.jsp&mid=WC0b01ac058001fa1c", "doc_type": "EMA REVIEW", "public_domain": true }, { "uuid": "c5dfa5ec-49e0-7716-cac8-e705b7cbda35", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+52-01-7", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "8a8fb532-c73e-c0aa-a98a-7833297b8000", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=52-01-7", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "77dcc3e1-2cd0-28bd-de55-978258e76bfb", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+lactmed:@term+@rel+@rn+52-01-7", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "30e82ccd-ec5a-1693-f4cb-89ca8e99c2a7", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "d9eb2570-a826-ded0-8e10-928670e56c3b", "citation": "IARC", "doc_type": "IARC", "public_domain": true }, { "uuid": "8ff85642-a47f-7385-870a-39fc5c3a1d9b", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "cc5d603b-6daa-4480-80a3-17eb08875e24", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "824e0b2c-a671-4dfd-a979-95528817e8da", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "52c20305-28d9-40cf-83fd-5ab3905fc95e", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9eb61a8b-9dd5-41c3-83d9-4b38db271800", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "6a5994f0-6302-4c29-9c67-aa1c3e1bf974", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "4d78f285-17d2-4942-9674-09541f068f6b", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "9f26a093-3459-466f-ad30-ebc48e1c74d4", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "a92b58fc-e685-44f7-aada-5f72d5e2823c", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "345f9f1d-e5a6-4559-955e-d05c7542b252", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "1120d183-47bd-4169-95da-982f7ffc605f", "citation": "European Pharmacopoeia Online 9.8, Spironolactone Monograph", "url": "http://online6.edqm.eu/ep908/", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "3de3ee50-fe47-c25c-0f4e-00716b3606af", "citation": "USP-RS", "doc_type": "USPNF", "public_domain": true }, { "uuid": "0bc61e44-8043-4218-9fef-37860f1e6c58", "citation": "Life Sci 1981;29(26):2727", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "849de760-9960-4958-9040-76b2112cf928", "citation": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "url": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c9a135e3-48f6-4101-b200-73ed3ac932d5", "citation": "Kolkhof, Peter, and Lars Bärfacker. \"30 years of the mineralocorticoid receptor: mineralocorticoid receptor antagonists: 60 years of research and development.\" Journal of Endocrinology 234.1 (2017): T125-T140.", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488394/", "doc_type": "JA", "public_domain": true }, { "uuid": "4cf90daa-4010-4ae2-8c70-c9101e02e283", "citation": "J Chromatogr 1985;341(2):279", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7a57c1f7-8ad7-41c2-93ae-859d832cf9d4", "citation": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "url": "http://www.accessdata.fda.gov/spl/data/563b3f57-28df-47cb-b929-86783f5414e1/563b3f57-28df-47cb-b929-86783f5414e1.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "41133d75-cbd9-485a-b2c4-781a550e1746", "citation": "J Chromatogr 1985;341(2):279", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "f4b257cd-95a1-5b89-6d72-72d52e160150", "citation": "USP 10/2020", "doc_type": "USPNF", "public_domain": true }, { "uuid": "4e7c7ddb-74ea-5470-4a2b-7d17af5dca98", "citation": "EP 10.5", "doc_type": "EP", "public_domain": true }, { "uuid": "184e5662-0a4e-7d15-4515-8966e6fb2f75", "citation": "NCI", "doc_type": "NCI DRUG DICTIONARY", "public_domain": true }, { "uuid": "c2a9642e-5e74-c580-472c-cffcb6bc2711", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "f1a58f9f-3da0-2783-0f09-6b4f52c6c037", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "7151e874-244d-4107-a9a1-e76e82e6c0ab", "citation": "EP 11.2", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "95d15d4e-2030-4962-9846-bd4a6d767de7", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "81b2c312-5035-4848-b50a-2767a2cfb277", "id": "81b2c312-5035-4848-b50a-2767a2cfb277", "molfile": "\n Marvin 01132106442D \n\n 29 33 0 0 1 0 999 V2000\n 0.8374 -5.2278 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 1.6239 -5.4747 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1176 -4.8079 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.6926 -4.1385 0.0000 C 0 0 2 0 0 0 0 0 0 1 0 0\n 2.5936 -3.8636 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5936 -3.0746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.8504 -2.8761 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5933 -2.2907 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.3541 -3.5047 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8374 -4.3981 0.0000 C 0 0 2 0 0 0 0 0 0 2 0 0\n 0.8374 -3.7491 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1197 -3.9782 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5904 -4.3981 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5904 -5.2278 0.0000 C 0 0 1 0 0 0 0 0 0 2 0 0\n 0.1197 -5.6402 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n 0.1197 -6.4648 0.0000 C 0 0 1 0 0 0 0 0 0 1 0 0\n -0.5904 -6.8848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.3260 -6.4648 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0361 -6.8848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7590 -6.4648 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -3.4843 -6.8848 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7590 -5.6402 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0361 -5.2278 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.3260 -5.6402 0.0000 C 0 0 2 0 0 0 0 0 0 1 0 0\n -1.3260 -4.8079 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8348 -6.8491 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5221 -6.4877 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1126 -6.7931 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5221 -5.8947 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 1 0 0 0\n 1 10 1 0 0 0 0\n 15 1 1 0 0 0 0\n 3 2 1 0 0 0 0\n 4 3 1 0 0 0 0\n 4 5 1 0 0 0 0\n 4 9 1 1 0 0 0\n 10 4 1 0 0 0 0\n 6 5 1 0 0 0 0\n 6 7 1 0 0 0 0\n 8 7 2 0 0 0 0\n 7 9 1 0 0 0 0\n 10 11 1 1 0 0 0\n 10 12 1 0 0 0 0\n 12 13 1 0 0 0 0\n 14 13 1 0 0 0 0\n 15 14 1 6 0 0 0\n 14 24 1 0 0 0 0\n 15 16 1 0 0 0 0\n 16 17 1 0 0 0 0\n 16 26 1 6 0 0 0\n 17 18 1 0 0 0 0\n 19 18 2 0 0 0 0\n 24 18 1 0 0 0 0\n 19 20 1 0 0 0 0\n 21 20 2 0 0 0 0\n 20 22 1 0 0 0 0\n 22 23 1 0 0 0 0\n 24 23 1 0 0 0 0\n 24 25 1 1 0 0 0\n 27 26 1 0 0 0 0\n 28 27 1 0 0 0 0\n 29 27 2 0 0 0 0\nM END", "smiles": "CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)[C@@H]31", "formula": "C24H32O4S", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ABSOLUTE", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "7d31879b-8b9b-440e-ae66-4232af486ba3" }, "defined_stereo": 6, "ez_centers": 0, "molecular_weight": "416.5755", "optical_activity": "UNSPECIFIED", "stereo_centers": 7 } ], "definition_level": "COMPLETE", "uuid": "61407b8f-da7a-4899-bbb6-94b1b6752859", "version": "60", "structure": { "id": "5b347e98-9248-4e9e-8fbd-0e200feaf24b", "molfile": "\n Marvin 01132104442D \n\n 32 36 0 0 1 0 999 V2000\n -1.3260 -5.6402 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n -1.3260 -6.4648 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8374 -4.3981 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n -0.5904 -5.2278 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 0.8374 -5.2278 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 1.6926 -4.1385 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 0.1197 -5.6402 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0\n 0.1197 -6.4648 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0\n 1.3541 -3.5047 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0361 -6.8848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5904 -6.8848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8348 -6.8491 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1197 -3.9782 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5904 -4.3981 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.8504 -2.8761 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.6239 -5.4747 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.0361 -5.2278 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5221 -6.4877 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1176 -4.8079 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7590 -6.4648 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5936 -3.8636 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5933 -2.2907 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.5221 -5.8947 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n -3.4843 -6.8848 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.5936 -3.0746 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7590 -5.6402 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.3260 -4.8079 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8374 -3.7491 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 2.1126 -6.7931 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.5752 -5.9252 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1171 -4.8104 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 0.8348 -6.0550 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0\n 2 1 1 0 0 0 0\n 3 13 1 0 0 0 0\n 4 1 1 0 0 0 0\n 5 7 1 0 0 0 0\n 6 3 1 0 0 0 0\n 7 4 1 0 0 0 0\n 8 7 1 0 0 0 0\n 6 9 1 1 0 0 0\n 10 2 2 0 0 0 0\n 11 2 1 0 0 0 0\n 8 12 1 6 0 0 0\n 13 14 1 0 0 0 0\n 14 4 1 0 0 0 0\n 15 9 1 0 0 0 0\n 16 5 1 0 0 0 0\n 17 1 1 0 0 0 0\n 18 12 1 0 0 0 0\n 19 16 1 0 0 0 0\n 20 26 1 0 0 0 0\n 6 21 1 6 0 0 0\n 22 15 2 0 0 0 0\n 23 18 2 0 0 0 0\n 24 20 2 0 0 0 0\n 25 21 1 0 0 0 0\n 26 17 1 0 0 0 0\n 1 27 1 1 0 0 0\n 3 28 1 1 0 0 0\n 29 18 1 0 0 0 0\n 4 30 1 6 0 0 0\n 7 31 1 1 0 0 0\n 5 32 1 6 0 0 0\n 11 8 1 0 0 0 0\n 10 20 1 0 0 0 0\n 5 3 1 0 0 0 0\n 19 6 1 0 0 0 0\n 25 15 1 0 0 0 0\nM END", "smiles": "CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]3([H])CC[C@@]4(C)[C@@]([H])(CC[C@]54CCC(=O)O5)[C@@]31[H]", "formula": "C24H32O4S", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ABSOLUTE", "defined_stereo": 7, "ez_centers": 0, "molecular_weight": "416.5755", "optical_activity": "UNSPECIFIED", "references": [ "bc419390-d259-4be5-8fde-79afa2786a4c", "90c064ec-08f9-41da-bb37-1930fde4eeb2", "49c38358-145d-4dbf-93ee-6b608f322cbc" ], "stereo_centers": 7 }, "unii": "27O7W4T232", "relationships": [ { "uuid": "43e5d903-3009-4a5d-b092-1fe34012830b", "amount": { "uuid": "46e000b4-f331-4baa-a1f5-a472e5cf28c5" }, "type": "ACTIVE MOIETY", "related_substance": { "uuid": "03603bc9-0939-462d-81eb-fc2d92251dfa", "refuuid": "61407b8f-da7a-4899-bbb6-94b1b6752859", "name": "SPIRONOLACTONE", "unii": "27O7W4T232", "linking_id": "27O7W4T232", "ref_pname": "SPIRONOLACTONE", "substance_class": "reference" } }, { "uuid": "81c4e4f3-f9c6-4905-9fc2-d83139a08083", "amount": { "uuid": "767cbb8e-51e4-48c2-b5db-89aedeb48fc8", "average": 391, "units": "ng/mL", "non_numeric_value": "Mean Peak Serum Concentration steady state at 100 mg" }, "qualification": "PLASMA", "type": "METABOLITE ACTIVE->PRODRUG", "interaction_type": "MAJOR", "references": [ "849de760-9960-4958-9040-76b2112cf928", "c9a135e3-48f6-4101-b200-73ed3ac932d5", "4cf90daa-4010-4ae2-8c70-c9101e02e283" ], "related_substance": { "uuid": "90f78dca-05db-46de-9a36-00c6d7b286b8", "refuuid": "961a0ac5-57e9-4e1e-b024-ab59a0171dc6", "name": "7.ALPHA.-THIOMETHYLSPIRONOLACTONE", "unii": "0YU66JY4WL", "linking_id": "0YU66JY4WL", "ref_pname": "7.ALPHA.-THIOMETHYLSPIRONOLACTONE", "substance_class": "reference" } }, { "uuid": "ceeed7c6-df81-48b3-99f9-ee3a02098e26", "comments": "Has in vitro activity", "type": "METABOLITE ACTIVE->PRODRUG", "references": [ "0970f8ca-5140-4818-9bb0-d81d6d45cf3d", "394732de-a925-4b59-744b-d8cd7559107c" ], "related_substance": { "uuid": "6eac6185-7537-4158-ad2c-aa1eede545cc", "refuuid": "961a0ac5-57e9-4e1e-b024-ab59a0171dc6", "name": "7.ALPHA.-THIOMETHYLSPIRONOLACTONE", "unii": "0YU66JY4WL", "linking_id": "0YU66JY4WL", "ref_pname": "7.ALPHA.-THIOMETHYLSPIRONOLACTONE", "substance_class": "reference" } }, { "uuid": "b0304a2f-fa53-477d-b5ba-cebaa286ab8c", "comments": "The pharmacological activity of spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to spironolactone, were 1.10, 1.28, and 0.32, respectively.", "type": "METABOLITE ACTIVE->PRODRUG", "references": [ "7a57c1f7-8ad7-41c2-93ae-859d832cf9d4", "41133d75-cbd9-485a-b2c4-781a550e1746" ], "related_substance": { "uuid": "a6fd4b8c-14b3-4e91-a2ee-8aa4576d376a", "refuuid": "65781840-aea3-44cd-9718-58070f0b0c38", "name": "6.BETA.-HYDROXY-7.ALPHA.-THIOMETHYLSPIROLACTONE", "unii": "4A93WO4Z3G", "linking_id": "4A93WO4Z3G", "ref_pname": "6.BETA.-HYDROXY-7.ALPHA.-THIOMETHYLSPIROLACTONE", "substance_class": "reference" } }, { "uuid": "8a5c3bbb-ef7f-44d7-b9f4-3aa21e31493c", "type": "METABOLITE->PARENT", "references": [ "0970f8ca-5140-4818-9bb0-d81d6d45cf3d" ], "related_substance": { "uuid": "ae3ab1cd-d1ba-4237-a180-c75189de06dd", "refuuid": "65781840-aea3-44cd-9718-58070f0b0c38", "name": "6.BETA.-HYDROXY-7.ALPHA.-THIOMETHYLSPIROLACTONE", "unii": "4A93WO4Z3G", "linking_id": "4A93WO4Z3G", "ref_pname": "6.BETA.-HYDROXY-7.ALPHA.-THIOMETHYLSPIROLACTONE", "substance_class": "reference" } }, { "uuid": "d5c608c7-58d2-4734-91d1-9683772d5945", "type": "METABOLITE ACTIVE->PARENT", "references": [ "0bc61e44-8043-4218-9fef-37860f1e6c58" ], "related_substance": { "uuid": "bc13fb8e-e656-475f-b376-2bd322f03de4", "refuuid": "8f68f3d0-f569-407e-bcf1-9358eb1a2eb2", "name": "DEACETYLSPIRONOLACTONE", "unii": "4LH70U7H4Z", "linking_id": "4LH70U7H4Z", "ref_pname": "DEACETYLSPIRONOLACTONE", "substance_class": "reference" } }, { "uuid": "fcd25248-638f-48be-804e-0e3588565e19", "type": "METABOLITE->PARENT", "references": [ "0970f8ca-5140-4818-9bb0-d81d6d45cf3d" ], "related_substance": { "uuid": "9a390535-96fd-4bcb-a344-a50b7d4acc2f", "refuuid": "8f68f3d0-f569-407e-bcf1-9358eb1a2eb2", "name": "DEACETYLSPIRONOLACTONE", "unii": "4LH70U7H4Z", "linking_id": "4LH70U7H4Z", "ref_pname": "DEACETYLSPIRONOLACTONE", "substance_class": "reference" } }, { "uuid": "14b8bfcb-b73e-4bef-99e7-f35cb8f2e6e9", "type": "METABOLITE ACTIVE->PRODRUG", "references": [ "b3dc8c77-a056-c2e3-c203-27d66d5fb8d9", "0970f8ca-5140-4818-9bb0-d81d6d45cf3d" ], "related_substance": { "uuid": "e708949b-acee-47bf-b986-f8180f330731", "refuuid": "2b8e07fe-405d-42bb-bf16-fb827f0c5086", "name": "CANRENONE", "unii": "78O20X9J0U", "linking_id": "78O20X9J0U", "ref_pname": "CANRENONE", "substance_class": "reference" } }, { "uuid": "c0b7e0ac-9e53-4e35-a88f-94e402909e69", "amount": { "uuid": "d2c86a2f-5ac6-4d3e-8b94-0973d5e1d0d9" }, "type": "TARGET->PARTIAL ANTAGONIST", "interaction_type": "BINDING", "references": [ "6b4acaad-aec8-430f-835f-69baea26e302", "d9046262-4b73-330a-e565-7549bf3af0a3" ], "related_substance": { "uuid": "2934a9e0-b1b0-4b6a-b330-1fcbb90ab5ea", "refuuid": "53389a82-61c4-4a11-84b6-1be471e934b3", "name": "ANDROGEN RECEPTOR", "unii": "EJC4C3UYXH", "linking_id": "EJC4C3UYXH", "ref_pname": "ANDROGEN RECEPTOR", "substance_class": "reference" } }, { "uuid": "24643e7d-b673-430f-b7ac-76ccdfefa499", "amount": { "uuid": "84b8dfae-0d28-4cdb-a29d-406256b69cdd", "average": 94, "units": "%" }, "type": "BINDER->LIGAND", "references": [ "b3dc8c77-a056-c2e3-c203-27d66d5fb8d9" ], "related_substance": { "uuid": "27186ddb-889e-44bf-9c7d-352ba3c2bdaa", "refuuid": "e95d330b-4c2d-44bb-a61b-860afeb4aa30", "name": "PLASMA PROTEIN FRACTION (HUMAN)", "unii": "6D53G0FD0Z", "linking_id": "6D53G0FD0Z", "ref_pname": "PLASMA PROTEIN FRACTION (HUMAN)", "substance_class": "reference" } }, { "uuid": "014bc2f7-65a6-4d5e-9007-90d8e0d08886", "amount": { "uuid": "074c0414-c4c9-4ae7-afd8-38e3e3bfe4b2", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.2 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "4d78f285-17d2-4942-9674-09541f068f6b" ], "related_substance": { "uuid": "543a3a2b-4671-45e6-bce5-827152a36f79", "refuuid": "efe7ca4a-7d6c-463d-9c19-e6ea70eafe78", "name": "(2'R)-7ALPHA-(ACETYLTHIO)-5'H-SPIRO(ANDROST-4-ENE-17,2'-FURAN)-3,5'-DIONE", "unii": "NE78JL28MG", "linking_id": "NE78JL28MG", "ref_pname": "(2'R)-7ALPHA-(ACETYLTHIO)-5'H-SPIRO(ANDROST-4-ENE-17,2'-FURAN)-3,5'-DIONE" } }, { "uuid": "9f24689b-bdf4-4acb-bef5-474c00e5dc0b", "amount": { "uuid": "59e6e241-5e7a-4813-b2d6-e98eb1f3c6e6", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.3 }, "comments": "correction factor: for the calculation of content, multiply the peak area of impurity F by 2.3", "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9f26a093-3459-466f-ad30-ebc48e1c74d4" ], "related_substance": { "uuid": "9842979e-24a2-45e1-b7c0-4b0d577f6c12", "refuuid": "2b8e07fe-405d-42bb-bf16-fb827f0c5086", "name": "CANRENONE", "unii": "78O20X9J0U", "linking_id": "78O20X9J0U", "ref_pname": "CANRENONE" } }, { "uuid": "4d52853c-d0b6-436d-9e53-4340840f3760", "amount": { "uuid": "76e47f50-902c-4ab9-b1eb-61c277e029d8", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.15 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "7151e874-244d-4107-a9a1-e76e82e6c0ab" ], "related_substance": { "uuid": "2300e62c-edb2-43d3-a4dc-10467e86690b", "refuuid": "55144281-338e-41f0-b490-537fa10822e0", "name": "Disulfanyl-spironolactone", "unii": "328EQ6WZ4M", "linking_id": "328EQ6WZ4M", "ref_pname": "Disulfanyl-spironolactone" } }, { "uuid": "36f6fb2f-51d5-4583-b90a-e17971c09660", "amount": { "uuid": "abeb81a0-77e1-42a0-80a8-1efecb6e1c1a", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "cc5d603b-6daa-4480-80a3-17eb08875e24" ], "related_substance": { "uuid": "95a83af5-aac7-42c1-87e5-2245fb530dc8", "refuuid": "b52d81ac-4fa5-4d98-8436-33a6657adc97", "name": "(2S)-SPIRO(ANDROST-4,6-DIENE-17,2-OXIRAN)-3-ONE", "unii": "6MS5KBN9CS", "linking_id": "6MS5KBN9CS", "ref_pname": "(2S)-SPIRO(ANDROST-4,6-DIENE-17,2-OXIRAN)-3-ONE" } }, { "uuid": "f7331ebb-7326-42c8-9b2d-5b6f323b494c", "amount": { "uuid": "3e11ccb3-a33c-41b8-8e29-eb20deffc71b" }, "comments": "Is a prodrug that Inhibits through active metabolites.", "type": "TARGET->INHIBITOR", "references": [ "d9046262-4b73-330a-e565-7549bf3af0a3" ], "related_substance": { "uuid": "30c8c22b-da91-412c-9273-333f153a8b87", "refuuid": "4b5c3b09-7ef3-4430-9f94-9e38f96a865f", "name": "MINERALOCORTICOID RECEPTOR", "unii": "33M0S99YTT", "linking_id": "33M0S99YTT", "ref_pname": "MINERALOCORTICOID RECEPTOR", "substance_class": "reference" } }, { "uuid": "29c7539c-bc44-4bb1-89c9-82e4962fa9ea", "amount": { "uuid": "c0d11865-84ca-407f-8197-6323275c0bd9", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "52c20305-28d9-40cf-83fd-5ab3905fc95e" ], "related_substance": { "uuid": "40e26ff0-22c1-433b-b082-61768080b1d5", "refuuid": "049cf6ec-7ca8-4832-84b4-067a5de56e15", "name": "6.BETA.-HYDROXY-SPIRONOLACTONE", "unii": "RH8L8AL2LR", "linking_id": "RH8L8AL2LR", "ref_pname": "6.BETA.-HYDROXY-SPIRONOLACTONE" } }, { "uuid": "97188e2c-e9d6-4183-bea6-d77f4aa22ac2", "amount": { "uuid": "fbf5801d-0132-4841-b001-2e677e9c91f2", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.5 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "9eb61a8b-9dd5-41c3-83d9-4b38db271800" ], "related_substance": { "uuid": "7af53976-d995-4aa9-85a2-9c75dd1b5b7e", "refuuid": "10fce3a7-3a3d-419e-848d-bc305f1927b8", "name": "S-(17.ALPHA.-(ETHOXYMETHYL)-17.BETA.-HYDROXY-3-OXOANDROST-4-EN-7.ALPHA.-YL) ETHANETHIOATE", "unii": "B5EG5XSV43", "linking_id": "B5EG5XSV43", "ref_pname": "S-(17.ALPHA.-(ETHOXYMETHYL)-17.BETA.-HYDROXY-3-OXOANDROST-4-EN-7.ALPHA.-YL) ETHANETHIOATE" } }, { "uuid": "553666d5-bd16-484b-9b03-b9212590ad04", "amount": { "uuid": "715a3adf-9bb3-4cfe-823f-a7b672e87c5d", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.3 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "a92b58fc-e685-44f7-aada-5f72d5e2823c" ], "related_substance": { "uuid": "3bbb610e-87cd-4449-9d1f-18b3a42e350f", "refuuid": "e385549e-f95e-44ae-9bd6-f9f540cfb550", "name": "17.ALPHA.-PREGN-4-ENE-21-CARBOXYLIC ACID, 17-HYDROXY-7.BETA.-MERCAPTO-3-OXO-, .GAMMA.-LACTONE, ACETATE", "unii": "8NK6P5VN96", "linking_id": "8NK6P5VN96", "ref_pname": "17.ALPHA.-PREGN-4-ENE-21-CARBOXYLIC ACID, 17-HYDROXY-7.BETA.-MERCAPTO-3-OXO-, .GAMMA.-LACTONE, ACETATE" } }, { "uuid": "32405748-35e5-4977-bc94-f87356591556", "amount": { "uuid": "dcfe380b-16d5-4bd1-9ee5-9ff544ec1f56", "type": "MOLE PERCENT", "units": "PERCENT PEAK AREA", "high_limit": 0.2 }, "qualification": "EP", "type": "IMPURITY->PARENT", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "6a5994f0-6302-4c29-9c67-aa1c3e1bf974" ], "related_substance": { "uuid": "912848d1-8320-4ca4-bde0-f6773ffbe4e0", "refuuid": "827bf669-6787-483a-b107-ca44e840f38c", "name": "(2R)-3,4-DIHYDRO-5H-SPIRO(ANDROST-4-ENE-17,2-FURAN)-3,5-DIONE", "unii": "3N8TCN29OP", "linking_id": "3N8TCN29OP", "ref_pname": "(2R)-3,4-DIHYDRO-5H-SPIRO(ANDROST-4-ENE-17,2-FURAN)-3,5-DIONE" } }, { "uuid": "03d74f60-392b-4287-83fa-892d10ff9bbd", "amount": { "uuid": "7ccbdeb0-03a4-4d54-bd9b-7713601e5e5a" }, "type": "LABELED->NON-LABELED", "references": [ "95d15d4e-2030-4962-9846-bd4a6d767de7" ], "related_substance": { "uuid": "31cce89e-b33f-43c1-a5a4-a52e31c26072", "refuuid": "59220337-b5d5-4f12-81e8-6110d1539175", "name": "Spironolactone H-3", "unii": "HP84A7VHS3", "linking_id": "HP84A7VHS3", "ref_pname": "Spironolactone H-3", "substance_class": "reference" } } ], "names": [ { "uuid": "24f99f90-4280-428c-ae7b-2d4494c930e5", "name": "17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid, γ-lactone acetate", "stdName": "17-HYDROXY-7.ALPHA.-MERCAPTO-3-OXO-17.ALPHA.-PREGN-4-ENE-21-CARBOXYLIC ACID, .GAMMA.-LACTONE ACETATE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1932cd4b-7a15-4fa2-8adf-a89fc95ee9e4" ], "display_name": false }, { "uuid": "e08237e2-ced0-440b-b279-37c72bdbf692", "name": "ALDACTAZIDE COMPONENT SPIRONOLACTONE", "stdName": "ALDACTAZIDE COMPONENT SPIRONOLACTONE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e30cec61-baac-486f-9b2b-b56363f218c1", "81f78b31-fd8b-4a1d-bd93-942c22db7898" ], "display_name": false }, { "uuid": "323df3ae-71c5-439c-9cea-71361c7bc79d", "name": "ALDACTONE", "stdName": "ALDACTONE", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "1932cd4b-7a15-4fa2-8adf-a89fc95ee9e4" ], "display_name": false }, { "uuid": "9a3827be-873c-4c98-b073-e75cd4b3f8fe", "name": "CARDALIS COMPONENT SPIRONOLACTONE", "stdName": "CARDALIS COMPONENT SPIRONOLACTONE", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "7a65f304-2c18-945f-ef98-79dda7752b1e" ], "display_name": false }, { "uuid": "8f892338-3dda-4623-8bf1-507eff700a37", "name": "NSC-150399", "stdName": "NSC-150399", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "e72c5397-86db-4992-b3fb-9c1d4ca14257" ], "display_name": false }, { "uuid": "de437eb7-87ba-4c91-814a-630752b6062c", "name": "PREGN-4-ENE-21-CARBOXYLIC ACID, 7-(ACETYLTHIO)-17-HYDROXY-3-OXO-,.GAMMA.-LACTONE, (7.ALPHA.,17.ALPHA.)-", "stdName": "PREGN-4-ENE-21-CARBOXYLIC ACID, 7-(ACETYLTHIO)-17-HYDROXY-3-OXO-,.GAMMA.-LACTONE, (7.ALPHA.,17.ALPHA.)-", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1932cd4b-7a15-4fa2-8adf-a89fc95ee9e4" ], "display_name": false }, { "uuid": "efb8f168-71b4-486b-b833-0374ae9015d5", "name": "SC-9420", "stdName": "SC-9420", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "e72c5397-86db-4992-b3fb-9c1d4ca14257" ], "display_name": false }, { "uuid": "3b809c07-60aa-47bb-a8ed-aab6aa820a22", "name": "SPIRONOLACTONE", "stdName": "SPIRONOLACTONE", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "3a88a5e1-ab5f-4ef4-8dd7-c7ac2827ba9b", "f7f15613-f2f1-4a50-b45a-8d63a53b03c8", "2535925e-841a-4933-bb8d-ea7776c76ba6", "5f3af259-5525-4a78-be06-4a2819655ed8", "1138609f-ae5e-41a8-89cf-221ec6b89137", "bca7c5c7-5663-4785-8f3d-8a4a65fc4549", "0beb6f13-93f3-4aaa-b8fb-d66229e0b4a2", "90c064ec-08f9-41da-bb37-1930fde4eeb2", "49c38358-145d-4dbf-93ee-6b608f322cbc", "5e5bda40-c473-4670-ae78-f4c97c21519e", "6d012d2e-11e5-4b5a-85dd-6fb4ffb94dfb", "d829ddba-e3d0-4f10-b42a-d9fe892c7c97", "e0de716a-c883-411f-9df7-8c9a6b3fc155", "6f71081e-dcdb-458e-98f7-00d702559d84", "47875b1c-c2c2-43e8-8996-e5e27d2f4fb3", "ce7bdb8c-59ad-46d5-a225-898d022d14d0", "35200b4b-aa59-4840-9fea-d403644b38be", "863991e1-355d-4200-b501-56a7dad58fd2", "b428ee7d-31ae-4d85-9173-b0c83587cd55", "44c0759b-10e5-4d78-be13-57852e5adbce", "b92a8763-ae5d-42fa-8c57-f10093566aa4", "006219ad-63df-4415-9f4b-88e66a727ff5", "6f483434-ae46-4a55-aa38-3768ab312a73", "d2e1e332-db58-47ff-8560-412edffeb011", "ca8e57f1-3500-4ffd-a002-097ed13aac4e" ], "display_name": true, "domains": [ "drug", "cosmetic" ], "name_orgs": [ { "uuid": "1d7075f4-9c0a-4b0e-8ef1-1f1daa4b7e85", "name_org": "INN" }, { "uuid": "ae142570-abc3-4e23-99a8-95474272e7d4", "name_org": "INCI" } ] }, { "uuid": "309f8133-d0a1-4e0b-aec5-b589755d60b4", "name": "SPIRONOLACTONE CEVA", "stdName": "SPIRONOLACTONE CEVA", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "e49410be-5c1e-47a2-ba50-3dc977da640f" ], "display_name": false }, { "uuid": "5154097c-21c9-0ffb-0181-63f603159e0c", "name": "SPIRONOLACTONE COMPONENT CARDALIS", "stdName": "SPIRONOLACTONE COMPONENT CARDALIS", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a65f304-2c18-945f-ef98-79dda7752b1e" ], "display_name": false }, { "uuid": "d11421ca-38fb-4561-987f-52c83d690e6c", "name": "SPIRONOLACTONE [EMA EPAR VETERINARY]", "stdName": "SPIRONOLACTONE [EMA EPAR VETERINARY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7a65f304-2c18-945f-ef98-79dda7752b1e" ], "display_name": false }, { "uuid": "fc57b127-85bd-cdfb-b1d5-89c0191e50da", "name": "SPIRONOLACTONE [EP MONOGRAPH]", "stdName": "SPIRONOLACTONE [EP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4e7c7ddb-74ea-5470-4a2b-7d17af5dca98" ], "display_name": false }, { "uuid": "ef0766cb-ebc8-4aa1-a0a8-a4cae1f10bd2", "name": "SPIRONOLACTONE [HSDB]", "stdName": "SPIRONOLACTONE [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6d012d2e-11e5-4b5a-85dd-6fb4ffb94dfb" ], "display_name": false }, { "uuid": "317740a9-d417-bbc7-a3dd-ff6af11843f1", "name": "SPIRONOLACTONE [IARC]", "stdName": "SPIRONOLACTONE [IARC]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "d9eb2570-a826-ded0-8e10-928670e56c3b" ], "display_name": false }, { "uuid": "4600f0fb-f912-402f-893e-7ee094178de6", "name": "SPIRONOLACTONE [JAN]", "stdName": "SPIRONOLACTONE [JAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4bcf7b0e-bd14-9169-f9a6-711a4193d00d" ], "display_name": false }, { "uuid": "00c036e1-eae9-4048-96ae-3a48745a8477", "name": "SPIRONOLACTONE [MART.]", "stdName": "SPIRONOLACTONE [MART.]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "ce7bdb8c-59ad-46d5-a225-898d022d14d0" ], "display_name": false }, { "uuid": "bdb42476-cde8-4263-aa95-2d855d54492b", "name": "SPIRONOLACTONE [MI]", "stdName": "SPIRONOLACTONE [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "863991e1-355d-4200-b501-56a7dad58fd2" ], "display_name": false }, { "uuid": "9d3cadb5-131d-478f-b95c-7092768cdd43", "name": "SPIRONOLACTONE [ORANGE BOOK]", "stdName": "SPIRONOLACTONE [ORANGE BOOK]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "d829ddba-e3d0-4f10-b42a-d9fe892c7c97" ], "display_name": false }, { "uuid": "850520a7-d0ff-9135-f0f9-3521ced082f4", "name": "SPIRONOLACTONE [USP MONOGRAPH]", "stdName": "SPIRONOLACTONE [USP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "f4b257cd-95a1-5b89-6d72-72d52e160150" ], "display_name": false }, { "uuid": "a4c59afc-f353-408f-aa18-358fc84b3eac", "name": "SPIRONOLACTONE [USP-RS]", "stdName": "SPIRONOLACTONE [USP-RS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "2535925e-841a-4933-bb8d-ea7776c76ba6" ], "display_name": false }, { "uuid": "db8e5650-02c0-437f-8716-08557bf2b01d", "name": "SPIRONOLACTONE [VANDF]", "stdName": "SPIRONOLACTONE [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "0beb6f13-93f3-4aaa-b8fb-d66229e0b4a2" ], "display_name": false }, { "uuid": "862dd8d5-e56e-46e9-9152-2dd22b1158a2", "name": "SPIRONOLACTONE [WHO-IP]", "stdName": "SPIRONOLACTONE [WHO-IP]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6f71081e-dcdb-458e-98f7-00d702559d84" ], "display_name": false }, { "uuid": "41140a8b-1cfd-43a0-91ed-28d3dce7e708", "name": "SPIRONOLACTONUM [WHO-IP LATIN]", "stdName": "SPIRONOLACTONUM [WHO-IP LATIN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "6f71081e-dcdb-458e-98f7-00d702559d84" ], "display_name": false }, { "uuid": "44f910a8-95d9-f3f7-c3a4-31300fc171c1", "name": "Spironolactone [WHO-DD]", "stdName": "SPIRONOLACTONE [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "f1a58f9f-3da0-2783-0f09-6b4f52c6c037" ], "display_name": false }, { "uuid": "08d83c53-3593-4b9b-adb6-2005e7ea2b91", "name": "VEROSPIRONE", "stdName": "VEROSPIRONE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e72c5397-86db-4992-b3fb-9c1d4ca14257" ], "display_name": false }, { "uuid": "a5410b7b-7454-40dd-9689-dc5458eaabec", "name": "spironolactone [INN]", "stdName": "SPIRONOLACTONE [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "49c38358-145d-4dbf-93ee-6b608f322cbc" ], "display_name": false } ], "properties": [ { "uuid": "d4bc6942-bce6-4956-82fe-3260b6fe4b01", "name": "Biological Half-life", "value": { "uuid": "175aa636-2047-46f5-b115-f09afba3db00", "average": 1.4, "units": "hours" }, "defining": false, "property_type": "PHARMACOKINETIC", "references": [ "e68ac3a7-dcb8-3e26-8d28-34a7351164e4" ] } ] } ] }