{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2025-09-19", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "66e190bf-a7ad-4716-98b6-5da491360ab2", "code": "N0000007641", "comments": "Chemical Ingredients [Chemical/Ingredient]|Heterocyclic Compounds [Chemical/Ingredient]|Heterocyclic Compounds, 1-Ring [Chemical/Ingredient]|Pyridines [Chemical/Ingredient]|Nicotinic Acids [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000007641", "code_system": "NDF-RT", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "a7ee47e9-b29d-44c5-a524-d9c05394047d", "code": "N0000007641", "comments": "Chemical Ingredients [Chemical/Ingredient]|Heterocyclic Compounds [Chemical/Ingredient]|Acids, Heterocyclic [Chemical/Ingredient]|Nicotinic Acids [Chemical/Ingredient]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000007641", "code_system": "NDF-RT", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "dafdc54f-40ae-4cc0-bedf-52565c069804", "code": "C10AD02", "comments": "ATC|CARDIOVASCULAR SYSTEM|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, PLAIN|Nicotinic acid and derivatives|nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C10AD02&showdescription=yes", "code_system": "WHO-ATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "c74da285-a13f-48cd-8bc4-94bf97cf3aa5", "code": "C04AC01", "comments": "ATC|CARDIOVASCULAR SYSTEM|PERIPHERAL VASODILATORS|PERIPHERAL VASODILATORS|Nicotinic acid and derivatives|nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C04AC01&showdescription=yes", "code_system": "WHO-ATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "2c24c656-a8d5-49bf-af9a-9b089e42dae7", "code": "N0000175594", "comments": "Established Pharmacologic Class [EPC]|Nicotinic Acid [EPC]", "type": "PRIMARY", "url": "https://nciterms.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=VA_NDFRT&code=N0000175594", "code_system": "NDF-RT", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "903d6b29-a4ca-4da9-85d8-aaeb1c44d3b2", "code": "QC10BA01", "comments": "VATC|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, COMBINATIONS|HMG CoA reductase inhibitors in combination with other lipid modifying agents|lovastatin and nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC10BA01&showdescription=yes", "code_system": "WHO-VATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "36291f9b-96ae-4a9f-9462-b902c10b418f", "code": "QC04AC01", "comments": "VATC|PERIPHERAL VASODILATORS|PERIPHERAL VASODILATORS|Nicotinic acid and derivatives|nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC04AC01&showdescription=yes", "code_system": "WHO-VATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "169773f8-484f-47c9-beae-6bf7ca38fded", "code": "QC10AD52", "comments": "VATC|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, PLAIN|Nicotinic acid and derivatives|nicotinic acid, combinations", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC10AD52&showdescription=yes", "code_system": "WHO-VATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "5949c849-f838-4ae0-82eb-08a1f03200ca", "code": "QC10AD02", "comments": "VATC|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, PLAIN|Nicotinic acid and derivatives|nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atcvet/atcvet_index/?code=QC10AD02&showdescription=yes", "code_system": "WHO-VATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "d26cecbc-e934-4716-a0f7-128d20e1aed4", "code": "59-67-6", "type": "PRIMARY", "url": "https://commonchemistry.cas.org/detail?cas_rn=59-67-6", "code_system": "CAS", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41", "bff51b43-0a6f-4fb6-8df6-80210d3bb948" ] }, { "uuid": "12bced83-170f-4d17-8514-5bb92bd5ff04", "code": "C689", "type": "PRIMARY", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C689", "code_system": "NCI_THESAURUS", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "17fe2424-01a0-4bb0-a5ac-3afff10a6e02", "code": "D009525", "type": "PRIMARY", "url": "http://www.ncbi.nlm.nih.gov/mesh/68009525", "code_system": "MESH", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "1928effa-de52-406c-919e-2d7d21d4a087", "code": "NBK548176", "comments": "LiverTox|Cardiac|lipid lowering agent|Vitamin B3, nicotinic acid", "type": "PRIMARY", "url": "https://www.ncbi.nlm.nih.gov/books/NBK548176/", "code_system": "LIVERTOX", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "2c8f4b8e-ed67-4e19-a6be-f9a932656e18", "code": "NIACIN", "type": "PRIMARY", "url": "https://en.wikipedia.org/wiki/Niacin", "code_system": "WIKIPEDIA", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "987149a9-4c94-46c1-9926-c5c0ef7c8aa4", "code": "21 CFR 102.23", "comments": "PART 102 -- COMMON OR USUAL NAME FOR NONSTANDARDIZED FOODS|Subpart B--Requirements for Specific Nonstandardized Foods|Sec. 102.23 Peanut spreads.", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=102.23", "code_system": "CFR", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "47bb1e71-ab5e-4187-8b56-337fadf2d07f", "code": "21 CFR 184.1530", "comments": "PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE|Subpart B--Listing of Specific Substances Affirmed as GRAS|Sec. 184.1530 Niacin", "type": "PRIMARY", "url": "http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.153", "code_system": "CFR", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "8284a48b-94b6-4097-9b64-956881e4d1bf", "code": "C10AD52", "comments": "ATC|CARDIOVASCULAR SYSTEM|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, PLAIN|Nicotinic acid and derivatives|nicotinic acid, combinations", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C10AD52&showdescription=yes", "code_system": "WHO-ATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "94ddd32d-b60a-4d04-99d9-c3b8057b2595", "code": "C10BA01", "comments": "ATC|CARDIOVASCULAR SYSTEM|LIPID MODIFYING AGENTS|LIPID MODIFYING AGENTS, COMBINATIONS|HMG CoA reductase inhibitors in combination with other lipid modifying agents|lovastatin and nicotinic acid", "type": "PRIMARY", "url": "http://www.whocc.no/atc_ddd_index/?code=C10BA01&showdescription=yes", "code_system": "WHO-ATC", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "213b9540-9a84-48a7-ac35-a060f6f610bb", "code": "SUB09247MIG", "type": "PRIMARY", "code_system": "EVMPD", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "55ed4ad3-dc60-4aec-8314-3c16aeb7b139", "code": "56701", "comments": "EPA PESTICIDE|CONVENTIONAL CHEMICAL", "type": "PRIMARY", "url": "http://iaspub.epa.gov/apex/pesticides/f?p=CHEMICALSEARCH:3:0::NO:21,3,31,7,12,25:P3_XCHEMICAL_ID:3041", "code_system": "EPA PESTICIDE CODE", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "a470ca8b-686f-4a95-9203-732946ec2f47", "code": "373", "type": "PRIMARY", "url": "https://extranet.who.int/soinn/mod/page/view.php?id=137&inn_n=373", "code_system": "INN", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "cdde1dad-fbdc-4014-98f0-fa873d84afb5", "code": "NIACIN", "comments": "Description: Colourless crystals or a white, crystalline powder; odourless or almost odourless. Solubility: Sparingly soluble in water; freely soluble in boiling water; soluble in 100 parts of ethanol (~750 g/l) TS; practicallyinsoluble in ether R. Category: Component of vitamin B complex; vasodilator. Storage: Nicotinic acid should be kept in a well-closed container, protected from light. Definition: Nicotinic acid contains not less than 99.0% and not more than 101.0% of C6H5NO2, calculated with reference to thedried substance.", "type": "PRIMARY", "url": "http://apps.who.int/phint/pdf/b/Jb.6.1.286.pdf", "code_system": "WHO INTERNATIONAL PHARMACOPEIA", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "bdceb87c-07e4-4293-9429-76bae1ac9415", "code": "7393", "comments": "RxNorm", "type": "PRIMARY", "url": "https://rxnav.nlm.nih.gov/REST/rxcui/7393/allProperties.xml?prop=all", "code_system": "RXCUI", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "2aab8264-8e6d-437b-bfe8-a97062a2eaf3", "code": "m7880", "comments": "Merck Index", "type": "PRIMARY", "url": "https://merckindex.rsc.org/monographs/m7880?q=authorize", "code_system": "MERCK INDEX", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "baa83051-458b-469d-a844-eae7f4c21515", "code": "DB00627", "type": "PRIMARY", "url": "http://www.drugbank.ca/drugs/DB00627", "code_system": "DRUG BANK", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "1eaffa54-0c1d-42d1-a755-236b5e869b62", "code": "CHEMBL573", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL573", "code_system": "ChEMBL", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "91ca23d7-d174-4f89-8198-ab9fb8b3c12b", "code": "200-441-0", "type": "PRIMARY", "url": "https://echa.europa.eu/substance-information/-/substanceinfo/100.000.401", "code_system": "ECHA (EC/EINECS)", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "53a80ae7-f762-407e-848f-2a6a0b206da7", "code": "938", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/938", "code_system": "PUBCHEM", "references": [ "387e633d-2517-4e0e-8daf-23ae507abf41" ] }, { "uuid": "aa5c5019-9a84-0d43-7360-f6e4481e18be", "code": "3134", "type": "PRIMARY", "url": "https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3134", "code_system": "HSDB", "references": [ "30063fc5-107e-5358-9487-a35bf9e517e7" ] }, { "uuid": "6ee0a89d-4459-51f9-541d-c380ee786541", "code": "DTXSID1020932", "type": "PRIMARY", "url": "https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020932", "code_system": "EPA CompTox", "references": [ "790e8dbe-bc7d-c39e-7b02-97f08779cabf" ] }, { "uuid": "936e4bda-399c-628a-d856-2429d2cf301e", "code": "C45812", "comments": "Food or Food Product[C1949]|Food Component[C1930]|Bioactive Food Component[C54060]|Vitamin[C944]|Water-Soluble Vitamin[C1551]|B Vitamin", "type": "CONCEPT", "url": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C45812", "code_system": "NCI_THESAURUS", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "4fc94f95-1cf4-5be2-af5a-dddd9bac4f42", "code": "10836-5", "comments": "LOINC|ACTIVE|CHEM|Bld|Niacin [Mass/volume] in Blood", "type": "PRIMARY", "url": "https://loinc.org/10836-5/", "code_system": "LOINC", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "c6703425-d02b-2ccb-bdf4-ce3733b1ed03", "code": "2656-7", "comments": "LOINC|ACTIVE|CHEM|Urine|Niacin [Mass/time] in 24 hour Urine", "type": "PRIMARY", "url": "https://loinc.org/2656-7/", "code_system": "LOINC", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "c04e0655-f542-1139-a37d-718c5e4224af", "code": "18244-4", "comments": "LOINC|ACTIVE|CHEM|Ser/Plas|Niacin [Mass/volume] in Serum or Plasma", "type": "PRIMARY", "url": "https://loinc.org/18244-4/", "code_system": "LOINC", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "eccca3de-41e5-02bf-5b18-049905f878b4", "code": "79402-4", "comments": "LOINC|ACTIVE|CHEM|Bld|Niacin [Moles/volume] in Blood", "type": "PRIMARY", "url": "https://loinc.org/79402-4/", "code_system": "LOINC", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "8d357de2-9efd-a332-524c-762b46d4f595", "code": "34342-6", "comments": "LOINC|ACTIVE|CHEM|Ser/Plas|Niacin [Moles/volume] in Serum or Plasma", "type": "PRIMARY", "url": "https://loinc.org/34342-6/", "code_system": "LOINC", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "5a244b42-781a-4876-b9ce-26ac847caed2", "code": "2679MF687A", "type": "PRIMARY", "code_system": "FDA UNII" }, { "uuid": "0cc09e24-1650-b5e9-88ab-4e8c33d84337", "code": "2835", "type": "PRIMARY", "url": "https://drugcentral.org/drugcard/2835", "code_system": "DRUG CENTRAL", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "d1988da9-2d64-c32c-20ba-4319da411834", "code": "204 (Number of products:661)", "comments": "Dietary Supplement Label Database|Vitamin|Niacin (Vitamin B3)", "type": "PRIMARY", "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=204&item=Niacin (Vitamin B3)", "code_system": "DSLD", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "928b2d81-e590-a342-0d50-85a690a93d73", "code": "1570 (Number of products:100)", "comments": "Dietary Supplement Label Database|Vitamin|Vitamin B3", "type": "PRIMARY", "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=1570&item=Vitamin B3", "code_system": "DSLD", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "5b1a2d91-e5eb-bd40-2e12-0332b4824e3d", "code": "2544 (Number of products:3520)", "comments": "Dietary Supplement Label Database|vitamin|Vitamin B3 (Niacin)", "type": "PRIMARY", "url": "https://dsld.od.nih.gov/dsld/rptIngredient.jsp?grpid=2544&item=Vitamin B3 (Niacin)", "code_system": "DSLD", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "3cb0e66f-50c6-d98d-2a6e-d36a594eb818", "code": "176839", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:176839", "code_system": "CHEBI", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "76c5250c-dd49-e2de-0b38-38bb5e152fc7", "code": "15940", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:15940", "code_system": "CHEBI", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "69b97e00-6cf6-f2c5-14a7-327ef699cb92", "code": "17154", "type": "PRIMARY", "url": "https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:17154", "code_system": "CHEBI", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "7df538a6-2f2e-0d88-3dfa-2bf6a19e2ff8", "code": "1461003", "type": "PRIMARY", "url": "https://store.usp.org/product/1461003", "code_system": "RS_ITEM_NUM", "references": [ "ddb976ca-f42a-7959-36f8-12372929d58d" ] }, { "uuid": "ff009b4e-a5f1-38a2-9127-be1be4cb23e8", "code": "2679MF687A", "type": "PRIMARY", "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?adv=1&query=2679MF687A", "code_system": "DAILYMED", "references": [ "8418aaf5-c6da-bcc4-a635-ae7663c94273" ] }, { "uuid": "7f76ffdb-1642-0d4d-a7c6-ba9be2a9b4d3", "code": "100000092214", "type": "PRIMARY", "code_system": "SMS_ID", "references": [ "7f55635f-e4f6-08c0-2285-f59b54d2aac5" ] }, { "uuid": "25ff1433-1f1c-4047-a1b6-a50fac7ea618", "code": "NBK548710", "comments": "LiverTox|HDS: Nutritional Sup|Vitamins|Vitamin B", "type": "CONCEPT", "url": "https://www.ncbi.nlm.nih.gov/books/NBK548710/", "code_system": "LIVERTOX" }, { "uuid": "9b5a6605-67fd-96fb-63ec-bf42b195c08a", "code": "169454", "type": "PRIMARY", "url": "https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=169454", "code_system": "NSC", "references": [ "897de3ec-0977-7c1e-6591-704ea6286962" ] } ], "substance_class": "chemical", "references": [ { "uuid": "1ec35d44-b2f3-0aae-0759-c66cedad3dc0", "citation": "European Pharmacopoeia Online 9.8, Methyl Nicotinate Monograph", "doc_type": "EP", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ac4f91d2-a559-458e-857b-7bec7fe7b9ef", "citation": "USP Dictionary 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE", "AUTO_SELECTED" ] }, { "uuid": "608f4ad4-6e35-4932-b0e0-46002309ae34", "citation": "NDF-RT", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "citation": "NDF-RT", "doc_type": "NDF-RT", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "c3e6d93c-bc5a-48b9-b409-3ee3f7351def", "citation": "MERCK", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7023f229-e1e6-4f6f-addf-8a66c17c6bb6", "citation": "USP DICTIONARY 2010", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "244fa1bc-c286-4a15-88f5-09b9000e3fba", "citation": "ORANGE BOOK", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "55d44eed-3af1-4b56-b3d6-b521032e1f29", "citation": "INN Proposed List 4", "url": "https://www.who.int/medicines/publications/druginformation/innlists/PL04.pdf", "doc_type": "INN_LIST", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "3bcc1701-1601-4c4d-a4a3-c7a9ae3350a6", "citation": "EP 7.2", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1596ffde-9ce4-4895-8375-9370f4be4449", "citation": "USP 33", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "e7be8da2-da96-4960-88f2-5d539e32f94c", "citation": "Drugs@FDA 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "5124d6a7-8a3e-47a2-8799-1578f0df7b8c", "citation": "Drugs@FDA 2012", "doc_type": "DRUGS@FDA", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1e7cdd66-945c-41c3-8937-51ebef773cb7", "citation": "ORANGE BOOK 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "4f4643e8-5883-41a9-9fc2-791c8e3b446f", "citation": "MARTINDALE 2011", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7a01f470-bcf2-489c-b035-1a8b6271b9c8", "citation": "MERCK INDEX", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1eeb1506-8084-4f4e-9acc-7efe1a32576c", "citation": "EMA", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "d783d4ad-bafe-4cb6-a081-bbc2db3bd62a", "citation": "PCPC", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "051fc9c0-324a-4397-8a6e-8b5f45df0a53", "citation": "FCC", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "60d04ecf-bd69-4182-8480-3e701c711481", "citation": "HSDB", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "7b7697aa-ceaa-4d88-a745-2783d9702cb4", "citation": "USP/NF", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "fd3fe916-bbf4-4766-aa00-851fc87fe760", "citation": "EMPIRICA", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "29a776a9-c556-43a3-9879-19ec14e81327", "citation": "WHO-DD", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "271ce6b8-1767-4dde-9634-578438b07ae6", "citation": "DSID", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "1b0e650a-30db-4cde-9435-cecf39e70986", "citation": "WHO-IP", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "ee4a9518-de98-45b3-bc5a-7303eb754729", "citation": "SCIFINDER", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "387e633d-2517-4e0e-8daf-23ae507abf41", "citation": "SRS CODE IMPORT", "doc_type": "SRS", "public_domain": true, "document_date": 1493390738000, "tags": [ "NOMEN" ] }, { "uuid": "03390f0a-feca-4046-a7fe-5646b836c105", "citation": "http://www.accessdata.fda.gov/spl/data/85d265f2-9b74-42d3-9b33-c34573be8c1e/85d265f2-9b74-42d3-9b33-c34573be8c1e.xml", "url": "http://www.accessdata.fda.gov/spl/data/85d265f2-9b74-42d3-9b33-c34573be8c1e/85d265f2-9b74-42d3-9b33-c34573be8c1e.xml", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "17c92309-18c7-4d9e-88d6-d55f18f238a5", "citation": "HTTP://WWW.ACCESSDATA.FDA.GOV/SPL/DATA/85D265F2-9B74-42D3-9B33-C34573BE8C1E/85D265F2-9B74-42D3-9B33-C34573BE8C1E.XML", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "18e20664-5b2a-45c3-8036-f972d8a7d6fd", "citation": "SRS import [2679MF687A]", "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=2679MF687A", "doc_type": "SRS", "public_domain": true, "document_date": 1493390738000, "tags": [ "NOMEN" ] }, { "uuid": "4f0c35b2-c6e6-4ece-80f7-b96c17187dc2", "citation": "NICOTINIC ACID [INN]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "7961989c-3d45-4ab1-a6c2-812107766ad4", "citation": "NICOTINIC ACID [EP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "7e92c2c3-8b79-40b7-a117-3fcc8147d39c", "citation": "NIACIN [USP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "e690bb63-76b5-43d1-b606-80e16e48ddc7", "citation": "NIACIN [ORANGE BOOK]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "cd40ef2a-10cf-45d9-86b9-f13894683651", "citation": "NICOTINIC ACID [MART.]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "4ba468c5-c9e2-413f-9824-d34cd155e5f6", "citation": "NICOTINIC ACID [MI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "2ae4bb68-5d13-49bb-9f32-951fad2b6171", "citation": "NICOTINIC ACID [EMA EPAR]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "219862ab-3771-4891-8714-0c4f92abda41", "citation": "NIACIN [INCI]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "541b335c-a98e-4ef5-bb61-c53fc968fc8c", "citation": "NIACIN [FCC]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "97f402b9-2f7f-4978-999c-b1c41c1e86ef", "citation": "NIACIN [HSDB]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "2d110296-771f-4615-9190-4938a17923c9", "citation": "NIACIN [USP-RS]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "f4cf82c5-560f-4381-81ba-def2c0ed3cf1", "citation": "NICOTINIC ACID [WHO-DD]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "49f2f823-4491-4181-8d3a-f809fd8dcf72", "citation": "VITAMIN B3 [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "8b7088cd-d933-4565-86d6-dbb8f8a4cd8f", "citation": "NIACIN [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "5a68bf14-9a2b-4178-8bbb-a63487eb7319", "citation": "NICOTINIC ACID [VANDF]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "febcb2c5-2b9a-4e58-9130-81181bf46139", "citation": "NICOTINIC ACID [WHO-IP]", "doc_type": "SRS_LOCATOR", "public_domain": true }, { "uuid": "73318f1b-3c32-54eb-d346-3584db56db05", "citation": "JAN", "doc_type": "SRS", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "30063fc5-107e-5358-9487-a35bf9e517e7", "citation": "WEBSITE", "url": "https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+@rel+59-67-6", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "790e8dbe-bc7d-c39e-7b02-97f08779cabf", "citation": "WEBSITE", "url": "https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=59-67-6", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN", "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7f55635f-e4f6-08c0-2285-f59b54d2aac5", "citation": "EU-SRS", "doc_type": "EMA LIST", "public_domain": true }, { "uuid": "63643895-b63f-94f7-8fe5-97605fb6430b", "citation": "Drug Information Handbook, 2016-2017 - 25th edition; Lexicomp Drug Reference Handbook; ISBN13: 9781591953531", "doc_type": "BOOK", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "ddb976ca-f42a-7959-36f8-12372929d58d", "doc_type": "SYSTEM", "public_domain": true }, { "uuid": "bff51b43-0a6f-4fb6-8df6-80210d3bb948", "citation": "STN", "doc_type": "STN (SCIFINDER)", "public_domain": true }, { "uuid": "862f2631-6f39-5cb1-5a39-9e933a22c623", "citation": "JAN", "doc_type": "JAN", "public_domain": true }, { "uuid": "0f913755-0e9b-2915-5c70-fe3616af0f41", "citation": "USP-RS", "doc_type": "USPNF", "public_domain": true }, { "uuid": "703ac695-e8dc-e5de-e5d3-007d3f5e5643", "citation": "EP 10.5", "doc_type": "EP", "public_domain": true }, { "uuid": "2328ca1e-9d8d-2257-3480-bd150b4c632d", "citation": "USP/NF", "doc_type": "USPNF", "public_domain": true }, { "uuid": "897de3ec-0977-7c1e-6591-704ea6286962", "citation": "NCI", "doc_type": "NCI DRUG DICTIONARY", "public_domain": true }, { "uuid": "8418aaf5-c6da-bcc4-a635-ae7663c94273", "citation": "DailyMed", "doc_type": "DAILYMED", "public_domain": true }, { "uuid": "33533331-532f-cf80-672a-5adcaab102e5", "citation": "WHO-DD", "doc_type": "WHO DRUG DICTIONARY", "public_domain": true }, { "uuid": "f58186a2-b991-4c64-9a1f-5acc3deb2c0f", "citation": "Ferrell, Marc, et al. \"A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.\" Nature Medicine (2024): 1-11.", "url": "https://www.nature.com/articles/s41591-023-02793-8", "doc_type": "JA", "public_domain": true }, { "uuid": "46d8b116-f667-45eb-813e-2cbe4c6c83da", "citation": "Makarov, Mikhail V., Samuel AJ Trammell, and Marie E. Migaud. \"The chemistry of the vitamin B3 metabolome.\" Biochemical Society Transactions 47.1 (2019): 131-147.", "url": "https://portlandpress.com/biochemsoctrans/article/47/1/131/119/The-chemistry-of-the-vitamin-B3-metabolome", "doc_type": "JA", "public_domain": true }, { "uuid": "b5d68bcb-e6fc-475f-8016-c939f8e27a07", "citation": "Lenglet, Aurélie, et al. \"N-methyl-2-pyridone-5-carboxamide (2PY)—major metabolite of nicotinamide: an update on an old uremic toxin.\" Toxins 8.11 (2016): 339.", "url": "https://www.mdpi.com/2072-6651/8/11/339", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "2d5e49a3-b3ec-4020-adf5-880b91e1b2f9", "citation": "Lenglet, Aurélie, et al. \"N-methyl-2-pyridone-5-carboxamide (2PY)—major metabolite of nicotinamide: an update on an old uremic toxin.\" Toxins 8.11 (2016): 339.", "url": "https://www.mdpi.com/2072-6651/8/11/339", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] } ], "definition_type": "PRIMARY", "moieties": [ { "uuid": "5a055aea-7447-4c79-890f-fd0f1a899fb5", "id": "5a055aea-7447-4c79-890f-fd0f1a899fb5", "molfile": "\n CDK 11152420562D\n\n 9 9 0 0 0 0 0 0 0 0999 V2000\n 26.6215 -7.6959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.2703 -8.4755 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.9190 -7.6959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.9190 -6.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.2703 -5.3572 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 26.6215 -6.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.5689 -8.4757 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.5691 -10.0348 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 21.2185 -7.6963 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 2 0 0 0 0\n 2 3 1 0 0 0 0\n 3 4 2 0 0 0 0\n 4 5 1 0 0 0 0\n 5 6 2 0 0 0 0\n 1 6 1 0 0 0 0\n 3 7 1 0 0 0 0\n 7 8 2 0 0 0 0\n 7 9 1 0 0 0 0\nM END", "smiles": "c1cc(cnc1)C(=O)O", "formula": "C6H5NO2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ACHIRAL", "count_amount": { "type": "MOL RATIO", "average": 1, "units": "MOL RATIO", "uuid": "e2e87f72-e11e-4e85-99b9-ce5446cac2dc" }, "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "123.1096", "optical_activity": "NONE", "stereo_centers": 0 } ], "definition_level": "COMPLETE", "uuid": "38ee7c5a-b1c4-4b84-9f56-f9a50c6c2cdd", "version": "64", "structure": { "id": "864f9026-101b-4335-ad8c-14be1903f5bb", "molfile": "\n JSDraw211152420562D\n\n 9 9 0 0 0 0 0 V2000\n 26.6215 -7.6959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.2703 -8.4755 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.9190 -7.6959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 23.9190 -6.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 25.2703 -5.3572 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 26.6215 -6.1368 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.5689 -8.4757 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 22.5691 -10.0348 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 21.2185 -7.6963 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 2 0 0 0 0\n 2 3 1 0 0 0 0\n 3 4 2 0 0 0 0\n 4 5 1 0 0 0 0\n 5 6 2 0 0 0 0\n 1 6 1 0 0 0 0\n 3 7 1 0 0 0 0\n 7 8 2 0 0 0 0\n 7 9 1 0 0 0 0\nM END", "smiles": "c1cc(cnc1)C(=O)O", "formula": "C6H5NO2", "atropisomerism": "No", "charge": 0, "count": 1, "stereochemistry": "ACHIRAL", "defined_stereo": 0, "ez_centers": 0, "molecular_weight": "123.1096", "optical_activity": "NONE", "references": [ "18e20664-5b2a-45c3-8036-f972d8a7d6fd", "ac4f91d2-a559-458e-857b-7bec7fe7b9ef", "55d44eed-3af1-4b56-b3d6-b521032e1f29" ], "stereo_centers": 0 }, "unii": "2679MF687A", "relationships": [ { "uuid": "30884c82-aa73-4b99-a8d3-8a2db7c67d6a", "amount": { "uuid": "4437c068-de33-4e1a-8d40-35b8dd166bd3" }, "type": "METABOLITE->PARENT", "references": [ "03390f0a-feca-4046-a7fe-5646b836c105" ], "related_substance": { "uuid": "bbb785c4-b125-4212-bd67-891c2a150f5f", "refuuid": "26e5a62b-e6d5-463f-a5f0-b087780c4280", "name": "NICOTINYL METHYLAMIDE", "unii": "X3I82S5L8I", "linking_id": "X3I82S5L8I", "ref_pname": "NICOTINYL METHYLAMIDE", "substance_class": "reference" } }, { "uuid": "5ab38782-2c4f-46ac-906b-8f614b112d9d", "amount": { "uuid": "ed0fcd33-f2ba-4539-adbf-115440ee6fc8" }, "type": "ACTIVE MOIETY", "related_substance": { "uuid": "cce07eca-b78b-49b1-91f5-2fe5f6c6155e", "refuuid": "38ee7c5a-b1c4-4b84-9f56-f9a50c6c2cdd", "name": "Niacin", "unii": "2679MF687A", "linking_id": "2679MF687A", "ref_pname": "Niacin", "substance_class": "reference" } }, { "uuid": "ee0d9db3-2fcc-4eae-bc03-8569c15daf99", "amount": { "uuid": "74b5daf4-59bf-44b2-97bf-a2f717f5833d" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "ac2f9a46-d91b-4c7e-92a0-638395e04be3", "refuuid": "a5ffd78c-e46f-413d-968c-b73c0e5e8681", "name": "PIMEPHYLLINE NICOTINATE", "unii": "8Y694512DA", "linking_id": "8Y694512DA", "ref_pname": "PIMEPHYLLINE NICOTINATE", "substance_class": "reference" } }, { "uuid": "92a96f21-77a4-4f9e-935f-dee4fbae667a", "amount": { "uuid": "ad008880-bc78-4547-ac02-99ef2dde3775" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "5e5b4334-0dca-47fc-9e39-50a0f7e7587d", "refuuid": "16703568-2d77-4899-a5da-3659ec0a9fbf", "name": "NIACIN ALUMINUM", "unii": "BDI80PUH9N", "linking_id": "BDI80PUH9N", "ref_pname": "NIACIN ALUMINUM", "substance_class": "reference" } }, { "uuid": "ac1b2b69-a4a8-4e2a-a9d4-05af45d614ba", "amount": { "uuid": "54650074-ef2a-46dd-b736-2ae7630fad57" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "483fb741-f47b-4064-be72-f89e14bb7eee", "refuuid": "60a90245-d6b0-4ffb-91e0-1b0ef93aea7f", "name": "NIACIN MEGLUMINE", "unii": "Q63V3NXS4D", "linking_id": "Q63V3NXS4D", "ref_pname": "NIACIN MEGLUMINE", "substance_class": "reference" } }, { "uuid": "0b856c7c-1b55-4c2c-9f92-cd820babe741", "amount": { "uuid": "9411976a-1586-42d4-908d-c73b77324abd" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "dda2f5b3-8e98-493e-952a-f2e0329d13e5", "refuuid": "4cfe169c-bfcc-4c78-855e-78feeccd71fa", "name": "NIACIN SODIUM", "unii": "3ZX78B4Q2L", "linking_id": "3ZX78B4Q2L", "ref_pname": "NIACIN SODIUM", "substance_class": "reference" } }, { "uuid": "f8125d1e-ce0f-4ee7-bbd8-051703f61cae", "amount": { "uuid": "58e0cb43-1b17-4c9a-a27e-8a8800a16a5e" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "f4329fa2-5106-41f8-8822-a945066d62f3", "refuuid": "d75497d9-5e5e-4ffb-9082-aa40891127d3", "name": "NICOTINATE ETHANOLAMINE", "unii": "71P617JXF6", "linking_id": "71P617JXF6", "ref_pname": "NICOTINATE ETHANOLAMINE", "substance_class": "reference" } }, { "uuid": "27f4a983-2877-4c67-a145-821e75fe2368", "amount": { "uuid": "9b9da40a-4ba5-423e-824e-e1ff35efd841" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "736270b1-ca68-42fb-8577-12253fde617d", "refuuid": "0b0dac8b-7f42-4bdd-927a-361c33f772ec", "name": "MAGNESIUM NICOTINATE", "unii": "OKD8A9SB2H", "linking_id": "OKD8A9SB2H", "ref_pname": "MAGNESIUM NICOTINATE", "substance_class": "reference" } }, { "uuid": "c93a1a30-afc2-43ae-afb9-529125e6c941", "amount": { "uuid": "75ebf861-1880-4f20-8e66-5afd0c8b0aa0" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "3ffd1e3e-8283-4763-bb63-90142245360c", "refuuid": "9f7c9881-2c6d-44f5-8f40-6807258cd078", "name": "CHROMIUM NICOTINATE", "unii": "A150AY412V", "linking_id": "A150AY412V", "ref_pname": "CHROMIUM NICOTINATE", "substance_class": "reference" } }, { "uuid": "482a34cc-e35d-4a22-b601-606557d159d6", "amount": { "uuid": "9cbaab33-11db-442d-beb3-bb76838b66ef", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 11.6, "units": "%" }, "comments": "administered niacin dose was recovered in urine as niacin metabolites, NUA, N-methylnicotinamide (MNA), and N-methyl-2-pyridone-5-carboxamide (2PY), respectively.", "qualification": "URINE", "type": "METABOLITE->PARENT", "interaction_type": "MAJOR", "references": [ "03390f0a-feca-4046-a7fe-5646b836c105", "46d8b116-f667-45eb-813e-2cbe4c6c83da" ], "related_substance": { "uuid": "a92eea1b-72e0-434e-90b9-e839301b3cf0", "refuuid": "a7e59825-e264-45c2-9e32-15a10176c492", "name": "NICOTINURIC ACID", "unii": "77V5315PIU", "linking_id": "77V5315PIU", "ref_pname": "NICOTINURIC ACID", "substance_class": "reference" } }, { "uuid": "999e1595-58db-4942-bd62-1846594e65dc", "amount": { "uuid": "0d4d7b48-f7a1-4b62-ac37-c0976ac318d3", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 37.9, "units": "%" }, "comments": "Oral administration of niacin (2 g of extended released form), the urine recovery of niacin and\nmetabolites accounted for 69.5% of the administered dose.", "qualification": "URINE", "type": "METABOLITE->PARENT", "interaction_type": "MAJOR", "references": [ "17c92309-18c7-4d9e-88d6-d55f18f238a5", "2d5e49a3-b3ec-4020-adf5-880b91e1b2f9" ], "related_substance": { "uuid": "686fd7eb-14d3-4e04-9bfb-a20a6f6f9466", "refuuid": "12855da3-c9aa-4ce4-88bc-7e3be361d021", "name": "NUDIFLORAMIDE", "unii": "68139USC7W", "linking_id": "68139USC7W", "ref_pname": "NUDIFLORAMIDE", "substance_class": "reference" } }, { "uuid": "f7656138-7824-4616-8e5b-11a56ac9ee99", "amount": { "uuid": "0934fbb5-af5d-4ee6-bd12-fc8bc37f808b" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "27764619-63d3-4431-830b-9548e86b86ab", "refuuid": "d78461ea-052b-432d-889b-15f7135f2083", "name": "FERROUS NICOTINATE", "unii": "2X09DF94BO", "linking_id": "2X09DF94BO", "ref_pname": "FERROUS NICOTINATE", "substance_class": "reference" } }, { "uuid": "14e659d5-cdc5-4d98-b6ba-6c9266b364dd", "amount": { "uuid": "54119e3d-9b25-4a08-9c43-ee119c801629" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "222280b8-f54d-4936-88d7-ec2372af658c", "refuuid": "65fa4998-b8e6-4528-94d7-0e5b85bd191a", "name": "CALCIUM NICOTINATE", "unii": "36RI01102M", "linking_id": "36RI01102M", "ref_pname": "CALCIUM NICOTINATE", "substance_class": "reference" } }, { "uuid": "f92031fd-20f4-436e-8d50-3ae6c4a07974", "amount": { "uuid": "8bb5027c-97f8-4a14-a0b3-384556e217ae", "units": "PERCENT PEAK AREA", "high_limit": 0.1 }, "qualification": "EP", "type": "PARENT->IMPURITY", "interaction_type": "CHROMATOGRAPHIC PURITY (HPLC/UV)", "references": [ "1ec35d44-b2f3-0aae-0759-c66cedad3dc0" ], "related_substance": { "uuid": "a6d10949-b2fc-4e87-8a41-4f59facc46e3", "refuuid": "351ace88-338e-4cf7-9323-cec42d8cea1b", "name": "METHYL NICOTINATE", "unii": "7B1AVU9DJN", "linking_id": "7B1AVU9DJN", "ref_pname": "METHYL NICOTINATE", "substance_class": "reference" } }, { "uuid": "a399df7c-be2e-4646-a269-b62fc0dfaaf6", "amount": { "uuid": "0d60137f-fccb-4ab7-9f95-f516730063c7" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "9f464a72-7c79-4142-9f7e-f74472d12470", "refuuid": "7e5cbc97-cf66-49ea-bcea-9e253828b4cd", "name": "ZINC NICOTINATE", "unii": "858T6FJ85V", "linking_id": "858T6FJ85V", "ref_pname": "ZINC NICOTINATE", "substance_class": "reference" } }, { "uuid": "32924c15-4f20-4dea-aef3-ef567ed8a7ce", "amount": { "uuid": "736f39ca-6d33-4028-9db4-89c546899f7f" }, "type": "SALT/SOLVATE->PARENT", "related_substance": { "uuid": "ec0d2fc3-12cd-40e0-9584-ddb09d34aa49", "refuuid": "c94da2ab-a7ef-46ce-ae08-4c7afe320001", "name": "Bepotastine nicotinate", "unii": "KEP4SBX4D8", "linking_id": "KEP4SBX4D8", "ref_pname": "Bepotastine nicotinate", "substance_class": "reference" } }, { "uuid": "958042c7-869f-4648-a2f1-326fc78e6a91", "amount": { "uuid": "983ca234-3a62-4582-97a6-2ea85598c2ad" }, "comments": "Promotes vascular inflammation and contributes to cardiovascular disease risk.", "type": "METABOLITE TOXIC->PARENT", "references": [ "f58186a2-b991-4c64-9a1f-5acc3deb2c0f" ], "related_substance": { "uuid": "654ed9b8-2f2b-45d7-84e8-1bc3fcbab11d", "refuuid": "b2ac34d8-a49c-4b99-8faf-19933b988e08", "name": "1,4-DIHYDRO-1-METHYL-4-OXO-3-PYRIDINECARBOXAMIDE", "unii": "VE4S15CI8D", "linking_id": "VE4S15CI8D", "ref_pname": "1,4-DIHYDRO-1-METHYL-4-OXO-3-PYRIDINECARBOXAMIDE", "substance_class": "reference" } }, { "uuid": "34e65ce1-d128-4082-8588-6fdd75d5cf0e", "amount": { "uuid": "c1c1fa3b-86ec-4dd3-8599-61bb89c7490d", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 3.2, "units": "%" }, "qualification": "URINE", "type": "EXCRETED UNCHANGED", "related_substance": { "uuid": "a7c01c5b-b352-46a5-8c33-d821b891aa49", "refuuid": "38ee7c5a-b1c4-4b84-9f56-f9a50c6c2cdd", "name": "Niacin", "unii": "2679MF687A", "linking_id": "2679MF687A", "ref_pname": "Niacin", "substance_class": "reference" } }, { "uuid": "685a4ee0-f020-45fe-936e-65b9c990902c", "amount": { "uuid": "568196e7-6b5c-4546-8384-3bb32942170a", "type": "MOLE PERCENT OF AMOUNT ADMINISTERED", "average": 16, "units": "%" }, "comments": "Oral administration of niacin (2 g of extended released form), the urine recovery of niacin and\nmetabolites accounted for 69.5% of the administered dose", "qualification": "URINE", "type": "METABOLITE->PARENT", "references": [ "b5d68bcb-e6fc-475f-8016-c939f8e27a07" ], "related_substance": { "uuid": "20e674ea-092c-49d2-a5b2-f17c5417a9f4", "refuuid": "ccdc151e-68dc-486b-af6b-d44d2d46cabc", "name": "TRIGONELLAMIDE", "unii": "UM47085BXC", "linking_id": "UM47085BXC", "ref_pname": "TRIGONELLAMIDE", "substance_class": "reference" } } ], "names": [ { "uuid": "121433cc-3b0b-4c4a-b3a8-f8495885d7bf", "name": "3-PYRIDINECARBOXYLIC ACID", "stdName": "3-PYRIDINECARBOXYLIC ACID", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "c3e6d93c-bc5a-48b9-b409-3ee3f7351def" ], "display_name": false }, { "uuid": "89167b6d-4744-4ac4-acd7-2855e48a4756", "name": "ACIDUM NICOTINICUM [WHO-IP LATIN]", "stdName": "ACIDUM NICOTINICUM [WHO-IP LATIN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "1b0e650a-30db-4cde-9435-cecf39e70986" ], "display_name": false }, { "uuid": "03b9aec5-9fa9-41cc-bb19-5cb904fffcaa", "name": "ADVICOR COMPONENT NIACIN", "stdName": "ADVICOR COMPONENT NIACIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e7be8da2-da96-4960-88f2-5d539e32f94c", "5124d6a7-8a3e-47a2-8799-1578f0df7b8c" ], "display_name": false }, { "uuid": "3ac9dcee-debe-5d00-a185-66c395fe8695", "name": "METHYL NICOTINATE IMPURITY A [EP IMPURITY]", "stdName": "METHYL NICOTINATE IMPURITY A [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1ec35d44-b2f3-0aae-0759-c66cedad3dc0" ], "display_name": false }, { "uuid": "f1dedc3e-0f51-478b-9fe3-df530c76c3f7", "name": "NIACIN EXTENDED RELEASE", "stdName": "NIACIN EXTENDED RELEASE", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "fd3fe916-bbf4-4766-aa00-851fc87fe760" ], "display_name": false }, { "uuid": "b2cf1744-0f54-41f2-a1f4-2165a5bebbf9", "name": "NIACIN [FCC]", "stdName": "NIACIN [FCC]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "051fc9c0-324a-4397-8a6e-8b5f45df0a53", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "a28b9dfc-352a-40ee-b9c0-43bebc8dacd8", "name": "NIACIN [HSDB]", "stdName": "NIACIN [HSDB]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "60d04ecf-bd69-4182-8480-3e701c711481" ], "display_name": false }, { "uuid": "7a938635-1903-4f77-a56b-1335138484c9", "name": "NIACIN [ORANGE BOOK]", "stdName": "NIACIN [ORANGE BOOK]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1e7cdd66-945c-41c3-8937-51ebef773cb7" ], "display_name": false }, { "uuid": "30a1af05-7d83-f4ca-d1a0-b4d74ef90856", "name": "NIACIN [USP MONOGRAPH]", "stdName": "NIACIN [USP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "2328ca1e-9d8d-2257-3480-bd150b4c632d" ], "display_name": false }, { "uuid": "bf7cb3ab-67e1-44d7-a13c-99df90659c69", "name": "NIACIN [USP-RS]", "stdName": "NIACIN [USP-RS]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "7b7697aa-ceaa-4d88-a745-2783d9702cb4", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "bb469596-8ce5-4ae6-b450-d898c39e5b11", "name": "NIACIN [VANDF]", "stdName": "NIACIN [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "608f4ad4-6e35-4932-b0e0-46002309ae34", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "e31a544a-3fba-42a9-9b6f-7ee3bff417c0", "name": "NIACOR", "stdName": "NIACOR", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "7023f229-e1e6-4f6f-addf-8a66c17c6bb6", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "cb1c692c-b833-4cea-b41e-1f105381ff76", "name": "NIASPAN", "stdName": "NIASPAN", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "7023f229-e1e6-4f6f-addf-8a66c17c6bb6", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "80b3015c-db91-4dca-8505-0eb527d59d8f", "name": "NICOLAR", "stdName": "NICOLAR", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "244fa1bc-c286-4a15-88f5-09b9000e3fba", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "3e017008-ed1a-4dd4-8015-470620db63dc", "name": "NICOTINIC ACID [EMA EPAR]", "stdName": "NICOTINIC ACID [EMA EPAR]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "1eeb1506-8084-4f4e-9acc-7efe1a32576c", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "cb74677d-41ed-e8cf-8e4a-e35fa4bb3480", "name": "NICOTINIC ACID [EP IMPURITY]", "stdName": "NICOTINIC ACID [EP IMPURITY]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "3bcc1701-1601-4c4d-a4a3-c7a9ae3350a6" ], "display_name": false }, { "uuid": "6d00aaa4-9049-649c-208a-ac9a91bae93f", "name": "NICOTINIC ACID [EP MONOGRAPH]", "stdName": "NICOTINIC ACID [EP MONOGRAPH]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "703ac695-e8dc-e5de-e5d3-007d3f5e5643" ], "display_name": false }, { "uuid": "b7a55f60-c4e4-8409-bdaf-08c819bde8a8", "name": "NICOTINIC ACID [JAN]", "stdName": "NICOTINIC ACID [JAN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "862f2631-6f39-5cb1-5a39-9e933a22c623" ], "display_name": false }, { "uuid": "6e407354-fef1-4491-b458-83cf303a6345", "name": "NICOTINIC ACID [MART.]", "stdName": "NICOTINIC ACID [MART.]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "4f4643e8-5883-41a9-9fc2-791c8e3b446f" ], "display_name": false }, { "uuid": "25662a30-6090-43e0-9dc0-b41d28c62c45", "name": "NICOTINIC ACID [MI]", "stdName": "NICOTINIC ACID [MI]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "7a01f470-bcf2-489c-b035-1a8b6271b9c8" ], "display_name": false }, { "uuid": "d60c49bc-a2d6-4c33-86cf-af94a6125687", "name": "NICOTINIC ACID [VANDF]", "stdName": "NICOTINIC ACID [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "608f4ad4-6e35-4932-b0e0-46002309ae34", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "a1f8dd1d-adff-4455-a6ab-dd795bdaaf8f", "name": "NICOTINIC ACID [WHO-IP]", "stdName": "NICOTINIC ACID [WHO-IP]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "1b0e650a-30db-4cde-9435-cecf39e70986" ], "display_name": false }, { "uuid": "405dd029-b0f1-4acc-9b2e-7e5d4070883e", "name": "NSC-169454", "stdName": "NSC-169454", "type": "cd", "languages": [ "en" ], "preferred": false, "references": [ "ee4a9518-de98-45b3-bc5a-7303eb754729", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "fa5703c1-796a-4a5a-b92e-b1207374f91e", "name": "Niacin", "stdName": "NIACIN", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "051fc9c0-324a-4397-8a6e-8b5f45df0a53", "97f402b9-2f7f-4978-999c-b1c41c1e86ef", "d783d4ad-bafe-4cb6-a081-bbc2db3bd62a", "7b7697aa-ceaa-4d88-a745-2783d9702cb4", "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "1e7cdd66-945c-41c3-8937-51ebef773cb7", "60d04ecf-bd69-4182-8480-3e701c711481", "541b335c-a98e-4ef5-bb61-c53fc968fc8c", "219862ab-3771-4891-8714-0c4f92abda41", "ac4f91d2-a559-458e-857b-7bec7fe7b9ef", "608f4ad4-6e35-4932-b0e0-46002309ae34", "e690bb63-76b5-43d1-b606-80e16e48ddc7", "8b7088cd-d933-4565-86d6-dbb8f8a4cd8f", "2d110296-771f-4615-9190-4938a17923c9", "7e92c2c3-8b79-40b7-a117-3fcc8147d39c", "1596ffde-9ce4-4895-8375-9370f4be4449" ], "display_name": true, "domains": [ "cosmetic" ], "name_orgs": [ { "uuid": "c24ddbef-4bf7-4365-917e-c88cfeb780fd", "name_org": "INCI" } ] }, { "uuid": "279770ba-f80a-4410-b9eb-38db4c850803", "name": "Nicotinic acid", "stdName": "NICOTINIC ACID", "type": "of", "languages": [ "en" ], "preferred": false, "references": [ "1eeb1506-8084-4f4e-9acc-7efe1a32576c", "4ba468c5-c9e2-413f-9824-d34cd155e5f6", "febcb2c5-2b9a-4e58-9130-81181bf46139", "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "7a01f470-bcf2-489c-b035-1a8b6271b9c8", "55d44eed-3af1-4b56-b3d6-b521032e1f29", "f4cf82c5-560f-4381-81ba-def2c0ed3cf1", "4f4643e8-5883-41a9-9fc2-791c8e3b446f", "608f4ad4-6e35-4932-b0e0-46002309ae34", "7961989c-3d45-4ab1-a6c2-812107766ad4", "cd40ef2a-10cf-45d9-86b9-f13894683651", "5a68bf14-9a2b-4178-8bbb-a63487eb7319", "2ae4bb68-5d13-49bb-9f32-951fad2b6171", "29a776a9-c556-43a3-9879-19ec14e81327", "3bcc1701-1601-4c4d-a4a3-c7a9ae3350a6", "4f0c35b2-c6e6-4ece-80f7-b96c17187dc2", "1b0e650a-30db-4cde-9435-cecf39e70986" ], "display_name": false, "domains": [ "drug" ], "name_orgs": [ { "uuid": "2b812b2f-7a1a-486c-84ae-4d239c37ecf2", "name_org": "INN" } ] }, { "uuid": "c10d3122-92f1-783d-7255-f9dc8923cc4f", "name": "Nicotinic acid [WHO-DD]", "stdName": "NICOTINIC ACID [WHO-DD]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "33533331-532f-cf80-672a-5adcaab102e5" ], "display_name": false }, { "uuid": "28cbbd25-1971-4aae-9976-a24b99ee9676", "name": "SIMCOR COMPONENT NIACIN", "stdName": "SIMCOR COMPONENT NIACIN", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "e7be8da2-da96-4960-88f2-5d539e32f94c", "5124d6a7-8a3e-47a2-8799-1578f0df7b8c" ], "display_name": false }, { "uuid": "f31e0a0a-ee12-42ce-a977-a451c770dbdc", "name": "VITAMIN B-3", "stdName": "VITAMIN B-3", "type": "sys", "languages": [ "en" ], "preferred": false, "references": [ "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "271ce6b8-1767-4dde-9634-578438b07ae6" ], "display_name": false }, { "uuid": "c6bbb9d8-cd8a-4191-a0b6-886f430ded1c", "name": "VITAMIN B3", "stdName": "VITAMIN B3", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "608f4ad4-6e35-4932-b0e0-46002309ae34", "49f2f823-4491-4181-8d3a-f809fd8dcf72", "b7188c87-3326-4a47-ac56-6c9ebd1516f7", "c3e6d93c-bc5a-48b9-b409-3ee3f7351def" ], "display_name": false }, { "uuid": "119a0033-a00e-4fba-8192-7181fcd8da9c", "name": "VITAMIN B3 [VANDF]", "stdName": "VITAMIN B3 [VANDF]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "608f4ad4-6e35-4932-b0e0-46002309ae34", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "107de2a9-4e78-482c-ac82-f6d57e467942", "name": "WAMPOCAP", "stdName": "WAMPOCAP", "type": "bn", "languages": [ "en" ], "preferred": false, "references": [ "244fa1bc-c286-4a15-88f5-09b9000e3fba", "b7188c87-3326-4a47-ac56-6c9ebd1516f7" ], "display_name": false }, { "uuid": "58bd1c08-e6c8-4d75-b6a1-9ae21e8d74ca", "name": "nicotinic acid [INN]", "stdName": "NICOTINIC ACID [INN]", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "55d44eed-3af1-4b56-b3d6-b521032e1f29" ], "display_name": false } ], "properties": [ { "uuid": "d53d2a36-b75d-47a4-a8ad-c64acbfd4940", "name": "Biological Half-life", "value": { "uuid": "a8d956f5-68b0-4ef4-b53e-f2fbd35b619f" }, "defining": false, "parameters": [ { "uuid": "3d87468a-466f-414d-99d3-9a88462646d7", "name": "Elimination", "type": "PHARMACOKINETIC", "value": { "uuid": "15d68f3b-dbbd-464a-8c36-4e70108d314c", "average": 34, "high": 48, "low": 20, "units": "minutes", "references": [] }, "references": [] } ], "property_type": "PHARMACOKINETIC", "references": [ "63643895-b63f-94f7-8fe5-97605fb6430b" ] } ] } ] }