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Assay done on SH-SY5Y cells displacing [3H]DIPRENORPHINE.", "qualification": "Ki", "type": "INHIBITOR->TARGET", "references": [ "3934d153-fbde-4808-b2cd-9067b1e74e7d", "f70d2de5-d67b-45bd-91c2-d26e70fa5085" ], "related_substance": { "uuid": "cbb80803-ac4c-4679-9ed6-0f64b870d737", "refuuid": "735a0432-af86-4711-a046-4293b059c972", "name": "DIPRENORPHINE", "unii": "1F0L5N25ZZ", "linking_id": "1F0L5N25ZZ", "ref_pname": "DIPRENORPHINE", "substance_class": "reference" } }, { "uuid": "6d8bc72a-654e-4f41-99a5-42d57d50632a", "amount": { "uuid": "3a8dc7ae-2987-4aac-a019-59400d80b061", "average": 0.22, "high": 0.25, "low": 0.19, "units": "NANOMOLAR" }, "qualification": "Kd", "type": "RADIOLIGAND->TARGET", "references": [ "761b21c6-087a-46b7-91c9-0f2adf4dded1" ], "related_substance": { "uuid": "d63bc16b-f5ed-40e3-8ff4-205acc8555dd", "refuuid": "9a43cd59-f26c-445b-a45b-bedfdb9e0e85", "name": "Diprenorphine H-3", "unii": "H58945J6KL", "linking_id": "H58945J6KL", "ref_pname": "Diprenorphine H-3", "substance_class": "reference" } }, { "uuid": "fd45d6c5-e450-444c-b6fc-273514092f81", "amount": { "uuid": "70c122ec-40d1-4b20-86b8-654e7faace9a", "average": 16.6, "units": "NANOMOLAR/KG" }, "comments": "Mouse hot plate test. 2600 times more potent than morphine.", "qualification": "ED50", "type": "AGONIST->TARGET", "related_substance": { "uuid": "85dc88ee-f613-4d99-8df6-1902d43b164c", "refuuid": "539bd6a1-5e0f-44d0-9294-4191e88ac5cf", "name": "3-METHYLFENTANYL, (3R,4S)-", "unii": "P57PR7Y64W", "linking_id": "P57PR7Y64W", "ref_pname": "3-METHYLFENTANYL, (3R,4S)-", "substance_class": "reference" } }, { "uuid": "e2ff387a-628b-4efc-9314-b6225707a5ad", "amount": { "uuid": "d12dd3ad-5d64-456f-8fdc-d7f90f85e82e", "average": 107, "units": "NANOMOLAR/KG" }, "comments": "Mouse hot plate test. 1516 times more potent than morphine.", "qualification": "ED50", "type": "AGONIST->TARGET", "references": [ "229bcad2-796f-4b67-a872-942adc60d275" ], "related_substance": { "uuid": "21d65f61-75b7-4e98-bcc4-c6f43c949d06", "refuuid": "d0ca7a05-54e5-4920-8b9b-c5e58b6ae31c", "name": "3-METHYLFENTANYL, (3R,4R)-", "unii": "H488I3A7GJ", "linking_id": "H488I3A7GJ", "ref_pname": "3-METHYLFENTANYL, (3R,4R)-", "substance_class": "reference" } }, { "uuid": "bfa2f0a9-c020-48d5-9e5a-d2686c681312", "amount": { "uuid": "5ce81c89-b46d-4a69-9ab7-8210433de0b2", "average": 1.25, "units": "mg/kg" }, "comments": "Rat tail withdrawal test. Morphine ED50 3.15. 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"uuid": "02fb0582-03cf-4f87-b314-0ca8de6a51a0", "amount": { "uuid": "2430dd9c-6f4b-4067-9428-2f2ca105e4b4", "average": 10, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "04eab913-62cf-407c-bc67-4651ef8dcd27" ], "related_substance": { "uuid": "d04712e3-e628-4da0-af1c-86dd6b7d7e2b", "refuuid": "efefe2e6-47dc-40b8-bb15-9b8a0a0b49d2", "name": "Methylnitazene", "unii": "WR262T3N9P", "linking_id": "WR262T3N9P", "ref_pname": "Methylnitazene", "substance_class": "reference" } }, { "uuid": "537376d2-0650-4be3-961d-5a9b87aa4713", "amount": { "uuid": "ea9fdb03-0caf-40ca-9aab-ff03fb7714a4", "average": 30, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "9b144d16-5889-42b1-bf63-450dea197c56" ], "related_substance": { "uuid": "55b326a5-3569-480a-8b2f-823e88e8d84f", "refuuid": "ffe369c6-aca2-487c-9553-45217a1861e1", "name": "Ethylthionitazene", "unii": 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Emax=103% of Fentanyl. beta-Arrestin assay", "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "a79b371c-4749-489c-9590-741d67aaa0e4", "a076ca0a-29d9-4090-b109-0386a063893c" ], "related_substance": { "uuid": "59f1bb97-0a79-490d-9231-56e3fadb563f", "refuuid": "65e93042-119b-44d7-a00f-5b0339b7b5eb", "name": "BUTONITAZENE", "unii": "C4CE9FVR7N", "linking_id": "C4CE9FVR7N", "ref_pname": "BUTONITAZENE" } }, { "uuid": "e432e8e4-1624-4b6b-b818-8babf059dfc1", "amount": { "uuid": "ce66a6a1-5c65-4f35-9af4-676795596c0b" }, "type": "AGONIST->TARGET", "references": [ "0c60ba22-efdb-45bc-8c58-27f4c67bcc08" ], "related_substance": { "uuid": "1f0a936d-8ff8-46d8-b0f1-8f684ba20dfa", "refuuid": "a76d0153-386e-4a64-aaff-2d9b1beab7ea", "name": "AP-238", "unii": "N26WML8AR7", "linking_id": "N26WML8AR7", "ref_pname": "AP-238" } }, { "uuid": "41ace8cd-c81e-4361-983c-f8338e6c4e0a", "amount": { "uuid": "a7bff5d5-0dc3-40c3-ac9d-a9cba2f25c2a" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "84385328-0059-49b1-b2ef-77e5a71b5afd", "refuuid": "172ea944-5cb3-48c2-8593-710acaf14971", "name": "AXELOPRAN", "unii": "85U7ROB149", "linking_id": "85U7ROB149", "ref_pname": "AXELOPRAN", "substance_class": "reference" } }, { "uuid": "d52a1371-91c3-45f5-9ab8-6e461192e033", "amount": { "uuid": "c732ddb6-3b64-4300-b432-7bbd91e7259b" }, "type": "AGONIST->TARGET", "references": [ "8e24e60f-cacf-46ff-b9c2-27f508155ebc" ], "related_substance": { "uuid": "f5d79f02-1665-4a6f-a79d-ab40f4093033", "refuuid": "edeb6b01-8eb0-47ba-8703-cb38023d51c3", "name": "BISNORTILIDINE", "unii": "58NDD17NUF", "linking_id": "58NDD17NUF", "ref_pname": "BISNORTILIDINE", "substance_class": "reference" } }, { "uuid": "42c66312-e4fc-48ff-a644-128a600e23cd", "amount": { "uuid": "ec8381d0-536d-46d9-84c2-3b82866dd508" }, "type": "AGONIST->TARGET", "references": [ "617ece3e-06d7-484d-a485-8c112411ef8f" ], "related_substance": { "uuid": "159a711c-8744-4af8-922f-c45efb0ff1eb", "refuuid": "5c36b4a1-8fd7-4a18-9a4b-19d2c4c48d4a", "name": "BU-72", "unii": "KVN8RP2FQX", "linking_id": "KVN8RP2FQX", "ref_pname": "BU-72", "substance_class": "reference" } }, { "uuid": "05ed351e-e083-4ae3-b422-173d836bd457", "amount": { "uuid": "4ce33643-6f95-465f-91c3-db2154684ff4", "average": 10500, "high": 11600, "low": 9400, "units": "NANOMOLAR" }, "comments": "Inhibition of forskolin-induced cAMP accumulation", "qualification": "IC50", "type": "WEAK AGONIST->TARGET", "references": [ "46840bc2-7109-4543-b1b1-125d3196fea3" ], "related_substance": { "uuid": "c7ed87e5-c8b0-4415-973d-5c623bfbc208", "refuuid": "fd653e80-ad0d-4fbd-877a-c8d11bd846d0", "name": "TILIDINE", "unii": "GY33N31E9Y", "linking_id": "GY33N31E9Y", "ref_pname": "TILIDINE", "substance_class": "reference" } }, { "uuid": "1857b149-896a-4068-a02f-7e1e1119b020", "amount": { "uuid": "9d0c5d5c-7b6b-413f-b9d1-69186d4ce7f6" }, "type": "AGONIST->TARGET", "references": [ "f9ccb75f-6fdd-45e5-9fcc-4cf5565b11c5" ], "related_substance": { "uuid": "b50d91e3-bc92-4579-ac25-34011860bfc7", "refuuid": "3a6ff369-dfe1-43f2-a750-d668ea6461a6", "name": "PSICOFENTANIL", "unii": "2H7BA4EJ9L", "linking_id": "2H7BA4EJ9L", "ref_pname": "PSICOFENTANIL" } }, { "uuid": "b2023708-fd94-4b6b-b2f9-32272e309b49", "amount": { "uuid": "843b98dc-7a9e-426c-817d-22d74be9e2b5" }, "type": "AGONIST->TARGET", "references": [ "796a1825-36a3-47b7-9f2b-18b8e8695ef8" ], "related_substance": { "uuid": "faa6f4ab-414c-40c2-b21d-886c0c75dbd0", "refuuid": "80192b64-2eba-4dc0-a74b-35f2e04f6cbf", "name": "CYX-6", "unii": "6YTL4W7ABA", "linking_id": "6YTL4W7ABA", "ref_pname": "CYX-6", "substance_class": "reference" } }, { "uuid": "ce747166-373c-48f6-af5e-52bf20ce383f", "amount": { "uuid": "4ccf3e40-c74e-400b-9c70-fcdfa2a82ffe" }, "type": "AGONIST->TARGET", "related_substance": { "uuid": "f9ade4e9-779a-4a6f-91bf-843d627e7d38", "refuuid": "e5e96c0c-9624-4ac4-baa1-3b34f3400d53", "name": "PARA-METHYL ACRYLFENTANYL", "unii": "UMP6VQ9ZMQ", "linking_id": "UMP6VQ9ZMQ", "ref_pname": "PARA-METHYL ACRYLFENTANYL" } }, { "uuid": "2b689b08-f906-4db0-83d1-8d4bc156cb18", "amount": { "uuid": "9f0e3b5a-3b50-4264-888b-9a7f18bbad9a" }, "type": "AGONIST->TARGET", "references": [ "32db241f-a0d7-4867-a991-57f9919810cc" ], "related_substance": { "uuid": "b7398680-dcc3-46b6-a30b-184b46505854", "refuuid": "fcd21810-8a14-4d84-9635-09821c844bda", "name": "DIHYDROMORPHINE", "unii": "C3S5FRP6JW", "linking_id": "C3S5FRP6JW", "ref_pname": "DIHYDROMORPHINE" } }, { "uuid": "83e2a1c3-a22b-4a80-a6ce-dfe82329ed54", "amount": { "uuid": "efb71b62-049a-4bee-985c-c8f44e20fd80", "average": 42, "units": "NANOMOLAR" }, "comments": "The fluorinated MT‐45 derivatives have higher apparent potencies (2F‐MT‐45: 42 nM) than MT‐45 (1.3 μM) for inhibition of cAMP accumulation and β‐arrestin2 recruitment (2F‐MT‐45: 196 nM; MT‐45: 23.1 μM). ", "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "9efa05eb-3ac3-44b2-9f9c-ff1e03fba778" ], "related_substance": { "uuid": "12211877-818e-4c1f-bfc5-6ee4691591dc", "refuuid": "afb88a04-8bc9-422b-b3cf-11eb629bfd45", "name": "2F-MT-45", "unii": "B5PQ8A33Q9", "linking_id": "B5PQ8A33Q9", "ref_pname": "2F-MT-45" } }, { "uuid": "b4f3b62d-971c-4832-90cd-8b63d7b76cc5", "amount": { "uuid": "988ad4af-205e-4f32-9e3d-bece84f963f4", "average": 5.5, "high": 6.3, "low": 4.7, "units": "NANOMOLAR" }, "type": "AGONIST->TARGET", "references": [ "7a5350bd-f3e8-4cd4-9646-9f9c8afb4ac1" ], "related_substance": { "uuid": "4190a43b-0e72-4039-994f-57d7b63b2616", "refuuid": "feb6b87e-5f79-441b-96c2-80c81b7fb583", "name": "META-METHYLFENTANYL", "unii": "MC37HC9PZY", "linking_id": "MC37HC9PZY", "ref_pname": "META-METHYLFENTANYL" } }, { "uuid": "ac0f11a4-9e04-49b3-b8de-c7682b4b3d83", "amount": { "uuid": "651ad2d8-96dd-4115-b787-722b0545617f", "average": 377, "high": 481, "low": 295, "units": "NANOMOLAR" }, "comments": "In vitro data suggest that flunitazene is much less potent than fentanyl. Emax=118% of Fentanyl", "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "abf2bf52-8fd6-4894-b824-d1897825d35f" ], "related_substance": { "uuid": "147a9a1d-da9e-40f4-8adf-9b5273ee9afe", "refuuid": "8976f70a-c854-434f-9b00-1c322864a43b", "name": "FLUNITAZENE", "unii": "LQS4YF6P6L", "linking_id": "LQS4YF6P6L", "ref_pname": "FLUNITAZENE" } }, { "uuid": "fab71afa-eda0-4854-9b2a-c317418791fb", "amount": { "uuid": "43dc2c4b-2182-4a60-8164-73823bfb92ae", "average": 8.14, "high": 12.8, "low": 5.12, "units": "NANOMOLAR" }, "comments": "Emax=113% relative to Fentanyl", "qualification": "EC50", "type": "AGONIST->TARGET", "references": [ "a3ff63c4-6211-479a-8ede-c53454da093b" ], "related_substance": { "uuid": "eaf1282d-fa8e-411c-a36c-4725429ac3bb", "refuuid": "5122c975-2819-4d0b-96cd-3547f553a2f5", "name": "METONITAZENE", "unii": "A7FF4K4CWB", "linking_id": "A7FF4K4CWB", "ref_pname": "METONITAZENE", "substance_class": "reference" } }, { "uuid": 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}, { "uuid": "49723a4d-8e00-45ec-9651-0900b947100f", "amount": { "uuid": "43acf05a-5a04-450f-b7f8-ee56a94e8fd6", "average": 5, "units": "NANOMOLAR" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "related_substance": { "uuid": "0351753e-3f51-421e-a87d-f5c31f7189fe", "refuuid": "27eac5f7-70d5-4046-8c72-9f2d252c0eaa", "name": "BRONITAZENE", "unii": "PGR9Q9X5QW", "linking_id": "PGR9Q9X5QW", "ref_pname": "BRONITAZENE", "substance_class": "reference" } }, { "uuid": "0009c14a-2274-4975-90fa-03cc0062955a", "amount": { "uuid": "9dfb2602-8f08-4b40-813d-0367ac572ecc", "average": 1, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "60fc51dc-4a55-4607-92be-fc2d04e3e5f9" ], "related_substance": { "uuid": "4bb14c85-c338-4bb3-a240-eadc22db540a", "refuuid": "064bbe31-bf27-4d7e-a446-8e49261a16e5", "name": "ETODESNITAZENE PHENYLTHIOL ANALOGUE", "unii": "QVU7FQ2TVH", "linking_id": "QVU7FQ2TVH", "ref_pname": "ETODESNITAZENE PHENYLTHIOL ANALOGUE", "substance_class": "reference" } }, { "uuid": "94cce180-cf63-4250-9444-1faab5f72123", "amount": { "uuid": "6ecce747-ddfa-4515-9cf7-3df2e50be65b", "average": 383, "high": 554, "low": 263, "units": "NANOMOLAR" }, "qualification": "EC50", "type": "AGONIST->TARGET", "related_substance": { "uuid": "213a1b2e-1742-41d9-ac83-89333d6f4b44", "refuuid": "ceb6dd21-6b67-4471-b504-d96b8474d40d", "name": "5-AMINOISOTONITAZENE", "unii": "RK98SSC5RK", "linking_id": "RK98SSC5RK", "ref_pname": "5-AMINOISOTONITAZENE", "substance_class": "reference" } }, { "uuid": "996ed489-b501-4fd9-82ee-93f319a1e81f", "amount": { "uuid": "9dac7600-c9d0-4810-9492-4dbb91490e7d", "average": 20, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "3ddef150-59a9-4a0c-834f-c40d104b06fa" ], "related_substance": { "uuid": "6e8a5f71-54e7-4504-a15f-602dfd973991", "refuuid": "c7840ca9-c803-4c24-b397-9b531b145cff", "name": "ETHYLNITAZENE", "unii": "L8WSC53AU5", "linking_id": "L8WSC53AU5", "ref_pname": "ETHYLNITAZENE", "substance_class": "reference" } }, { "uuid": "bbca85ef-b9e9-4c90-bcfb-f1b16da95214", "amount": { "uuid": "3c3c9481-2640-4ce2-bd08-a8e80f5f349f", "average": 50, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "b70ecd42-201e-42f0-aa1a-980de865c270" ], "related_substance": { "uuid": "9fecc68a-cb4d-4f55-a464-4870a6fba1d2", "refuuid": "f7ab4b16-f3cb-481b-b210-e5b3b1809696", "name": "PROPYLNITAZENE", "unii": "TN458A7BPE", "linking_id": "TN458A7BPE", "ref_pname": "PROPYLNITAZENE", "substance_class": "reference" } }, { "uuid": "6f6808d2-4f27-401e-a91a-7c16e9b5a697", "amount": { "uuid": "a7a8955f-82eb-4e39-8ccc-a4b11641e533", "average": 1, "non_numeric_value": "RELATIVE TO MORPHINE" }, "qualification": "POTENCY", "type": "AGONIST->TARGET", "references": [ "42dfefcd-4fef-4bae-bb7a-718befb6f30d" ], "related_substance": { "uuid": "3072a101-ad73-49e7-9f09-2681f0a972b8", "refuuid": "12da2a12-2f1e-4fff-8cc9-4c704e2d0786", "name": "METODESNITAZENE", "unii": "TTR2RT8GBY", "linking_id": "TTR2RT8GBY", "ref_pname": "METODESNITAZENE" } }, { "uuid": "4653ea78-014f-49de-b884-ac006b8638ad", "amount": { "uuid": "689b0c9b-b39b-475f-afd6-2f816a81e192" }, "type": "AGONIST->TARGET", "references": [ "6ea7a536-86f9-4f2d-b880-1a17acaacaf3" ], "related_substance": { "uuid": "f81c4961-1825-41f7-ba06-0d089b335339", "refuuid": "e6a746ae-8ed3-4b4a-9421-19d0eec86548", "name": "N-(MDA)-FENTANYL", "unii": "9QS8BB23RH", "linking_id": "9QS8BB23RH", "ref_pname": "N-(MDA)-FENTANYL" } }, { "uuid": "4129dc94-cb45-4243-ae46-9828c103e4a7", "amount": { "uuid": "ea01edb9-db9e-4818-81e7-879907014137", "average": 0.4, "high": 0.6, "low": 0.2, "units": "NANOMOLAR" }, "comments": "Emax = 23% of DAMGO", "qualification": "EC50", "type": "PARTIAL AGONIST->TARGET", "references": [ "88747d1d-e6bc-4846-824d-6028c4b8c5cf" ], "related_substance": { "uuid": 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