{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-09-09",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "codes": [
        {
          "uuid": "bddcb1e2-4e1a-47ec-ae68-ac96b2422d93",
          "code": "P29320",
          "type": "PRIMARY",
          "url": "http://www.uniprot.org/uniprot/P29320?sort=score",
          "code_system": "UNIPROT",
          "references": [
            "06152fdf-704e-4afc-a670-b826f01534e7"
          ]
        },
        {
          "uuid": "72879c81-ca0f-4129-bf0a-4cd901bcc6e2",
          "code": "P29320",
          "type": "PRIMARY",
          "url": "https://pharos.nih.gov/idg/search?q=P29320",
          "code_system": "PHAROS",
          "references": [
            "06152fdf-704e-4afc-a670-b826f01534e7"
          ]
        },
        {
          "uuid": "a98ad27d-a238-4190-a56c-fd8ee560001a",
          "code": "EPH RECEPTOR A3",
          "type": "PRIMARY",
          "url": "https://en.wikipedia.org/wiki/EPH_receptor_A3",
          "code_system": "WIKIPEDIA",
          "references": [
            "06152fdf-704e-4afc-a670-b826f01534e7"
          ]
        },
        {
          "uuid": "9d0b28aa-451a-445c-8996-42efd0ab78e8",
          "code": "EC 2.7.10.1",
          "type": "PRIMARY",
          "url": "http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.1&UniProtAcc=P29320&OrganismID=2681",
          "code_system": "EC (ENZYME CLASS)",
          "references": [
            "06152fdf-704e-4afc-a670-b826f01534e7"
          ]
        },
        {
          "uuid": "02df3eff-c46f-4e1c-bbd8-65ba7c468f6a",
          "code": "13U1W2G8EZ",
          "type": "PRIMARY",
          "code_system": "FDA UNII"
        }
      ],
      "substance_class": "protein",
      "references": [
        {
          "uuid": "84e09ae7-380e-40e8-b121-e8de5dfa6825",
          "citation": "http://www.uniprot.org/uniprot/P29320",
          "url": "http://www.uniprot.org/uniprot/P29320",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN",
            "PUBLIC_DOMAIN_RELEASE",
            "AUTO_SELECTED"
          ]
        },
        {
          "uuid": "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
          "citation": "UNIPROT",
          "doc_type": "UNIPROT",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "6a51e6be-335e-49ff-b8b0-7d1955a10d45",
          "citation": "http://www.uniprot.org/uniprot/P29320?sort=score",
          "url": "http://www.uniprot.org/uniprot/P29320?sort=score",
          "doc_type": "SRS",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "06152fdf-704e-4afc-a670-b826f01534e7",
          "citation": "SRS CODE IMPORT",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493393424000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee",
          "citation": "http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1823",
          "url": "http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1823",
          "doc_type": "WEBSITE",
          "public_domain": true,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "4968c384-5611-45d7-a89c-c7b089919792",
          "citation": "SRS import [13U1W2G8EZ]",
          "url": "http://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=13U1W2G8EZ",
          "doc_type": "SRS",
          "public_domain": true,
          "document_date": 1493393424000,
          "tags": [
            "NOMEN"
          ]
        },
        {
          "uuid": "d3ee8f20-9c84-49b1-b4b2-42cb944d15c4",
          "citation": "https://www.creativebiolabs.net/Ifabotuzumab-67682.htm",
          "doc_type": "WEB PAGE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        },
        {
          "uuid": "bfa01d34-773f-4f19-9718-6699e2bcb3da",
          "citation": "https://www.creativebiolabs.net/Ifabotuzumab-67682.htm",
          "doc_type": "WEB PAGE",
          "public_domain": true,
          "tags": [
            "PUBLIC_DOMAIN_RELEASE"
          ]
        }
      ],
      "definition_type": "PRIMARY",
      "definition_level": "COMPLETE",
      "uuid": "94293cbe-9d33-40b7-9744-b94700bb0dd2",
      "version": "6",
      "unii": "13U1W2G8EZ",
      "relationships": [
        {
          "uuid": "2200181c-14fd-4641-87e3-25ddb27e9590",
          "amount": {
            "uuid": "99ccf28e-b3fb-4aee-a3cf-3a175a07da72"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "65824d23-aff2-4311-bebe-944221fb5e2a",
            "refuuid": "743bff12-2476-42d3-8c45-09d47a5f1127",
            "name": "1H-Imidazo[2,1-f]purine-2,4(3H,8H)-dione, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-",
            "unii": "8S7CMB69GB",
            "linking_id": "8S7CMB69GB",
            "ref_pname": "1H-Imidazo[2,1-f]purine-2,4(3H,8H)-dione, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "a0ef4be5-f260-4e13-ac9b-197131e6d8ea",
          "amount": {
            "uuid": "bfe439f5-2446-4414-8a8e-45221be27952"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "8faac779-f1bf-4ca2-8356-9ba2946cf951",
            "refuuid": "a3e8e5c7-7421-463c-9ab9-243a31dfb001",
            "name": "DASATINIB",
            "unii": "RBZ1571X5H",
            "linking_id": "RBZ1571X5H",
            "ref_pname": "DASATINIB",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "76f846ec-c60f-4214-9bc5-d62637d68389",
          "amount": {
            "uuid": "e16c9a31-6966-4c50-9d39-d87851d49a41"
          },
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "9b5fc296-912e-4b57-9563-3c9869725c65",
            "refuuid": "efa1bc44-0aee-4e07-a243-88dd6ebb9ad4",
            "name": "STAUROSPORINE",
            "unii": "H88EPA0A3N",
            "linking_id": "H88EPA0A3N",
            "ref_pname": "STAUROSPORINE",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "e658515c-5562-4054-962e-bf6d308d322c",
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "807b776a-3291-4dd4-b686-5cad2b07e50f",
            "refuuid": "39d4eb04-ec84-44c6-a6df-40fd4ebf7111",
            "name": "BOSUTINIB",
            "unii": "5018V4AEZ0",
            "linking_id": "5018V4AEZ0",
            "ref_pname": "BOSUTINIB",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "8e7f6363-8aed-43c8-ba4c-a75a5264b067",
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "bd83934e-8220-4cb6-ac4b-a91c2250b0c1",
            "refuuid": "c11bdd22-f48f-4310-8114-30ce899b8c41",
            "name": "Nilotinib",
            "unii": "F41401512X",
            "linking_id": "F41401512X",
            "ref_pname": "Nilotinib",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "71c22835-2e87-4fc4-bfe2-582567d89978",
          "type": "WEAK INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "bce54346-9b44-4c3b-979c-37fbf6e3eb3f",
            "refuuid": "84043338-fe1b-44c8-b623-63547ae3e369",
            "name": "TOZASERTIB",
            "unii": "234335M86K",
            "linking_id": "234335M86K",
            "ref_pname": "TOZASERTIB",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "cfb02698-c347-4b7d-a581-df944252b0e2",
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "38d0bc0b-d340-4756-9eb9-d7edf2ab8f17",
            "refuuid": "5d71bbcd-8ae0-433e-82ca-120c15023e72",
            "name": "DORSOMORPHIN",
            "unii": "10K52CIC1Z",
            "linking_id": "10K52CIC1Z",
            "ref_pname": "DORSOMORPHIN",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "7a83c155-46ac-4327-99bf-0ccd7add8d42",
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "a4df91d8-a8ef-469b-bd19-05efebb99e58",
            "refuuid": "9555b8e2-a3fb-4d7a-afe5-9b1a0fd83ecf",
            "name": "VANDETANIB",
            "unii": "YO460OQ37K",
            "linking_id": "YO460OQ37K",
            "ref_pname": "VANDETANIB",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "19f4d16c-60d8-4405-9ced-a9610dd6438e",
          "type": "INHIBITOR->TARGET",
          "references": [
            "77f4d69d-a2f8-4492-a8c2-ccdfc93bccee"
          ],
          "related_substance": {
            "uuid": "1299f503-f0a1-4a61-ac6c-94dca5c0b03e",
            "refuuid": "c0f4782e-c45a-4651-9845-89bae64c6ea5",
            "name": "INDIRUBIN E804",
            "unii": "BYW31FWC1X",
            "linking_id": "BYW31FWC1X",
            "ref_pname": "INDIRUBIN E804",
            "substance_class": "reference"
          }
        },
        {
          "uuid": "95167548-8ba6-4028-8170-fbdca69b6187",
          "amount": {
            "uuid": "20fe81ae-2c17-4b1d-ae7e-565807321859"
          },
          "comments": "EphA3 is an oncofetal antigen with restricted tissue expression, the development of a targeted agent holds promise. Four mechanisms of cell killing have been described: direct induction of apoptosis, activation of antibody-dependent cell-mediated cytotoxicity (ADCC), disruption of tumor vasculature and inhibition of survival signaling from the marrow microenvironment.",
          "type": "LIGAND->TARGET",
          "references": [
            "d3ee8f20-9c84-49b1-b4b2-42cb944d15c4"
          ],
          "related_substance": {
            "uuid": "fe278069-8de3-4185-a1d2-fc6f00500f48",
            "refuuid": "498cce8f-ca5a-4166-9abe-cf931c7103a1",
            "name": "IFABOTUZUMAB",
            "unii": "2BN89552WP",
            "linking_id": "2BN89552WP",
            "ref_pname": "IFABOTUZUMAB"
          }
        }
      ],
      "names": [
        {
          "uuid": "75208686-e893-4542-8d54-5605df9e4914",
          "name": "EPH-LIKE KINASE 4",
          "stdName": "EPH-LIKE KINASE 4",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "fe262aee-dd48-4d70-9705-bf3446388e18",
          "name": "EPH-LIKE TYROSINE KINASE 1",
          "stdName": "EPH-LIKE TYROSINE KINASE 1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "84e09ae7-380e-40e8-b121-e8de5dfa6825",
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af"
          ],
          "display_name": false
        },
        {
          "uuid": "5041c758-161e-4868-8714-3064f01a5bd0",
          "name": "EPHRIN TYPE-A RECEPTOR 3",
          "stdName": "EPHRIN TYPE-A RECEPTOR 3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "84e09ae7-380e-40e8-b121-e8de5dfa6825",
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af"
          ],
          "display_name": true
        },
        {
          "uuid": "4cdedb32-85c2-4ea3-a713-496b6fbea261",
          "name": "ETK1",
          "stdName": "ETK1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "d9a08994-05fd-42cd-b836-6277b7be5749",
          "name": "EphA3",
          "stdName": "EPHA3",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "314a68e7-964f-4d2f-9d2c-f7ed9f4cde38",
          "name": "EphA3 Kinase",
          "stdName": "EPHA3 KINASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "06152fdf-704e-4afc-a670-b826f01534e7"
          ],
          "display_name": false
        },
        {
          "uuid": "5458eef6-a8b9-4f90-ac4b-f239bcef8456",
          "name": "HEK",
          "stdName": "HEK",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "6000581f-e211-4a20-a8e4-e0ee8e35e6a7",
          "name": "HEK4",
          "stdName": "HEK4",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "84e09ae7-380e-40e8-b121-e8de5dfa6825",
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af"
          ],
          "display_name": false
        },
        {
          "uuid": "248ca7b8-8958-406c-84f1-c335b19115ed",
          "name": "HUMAN EMBRYO KINASE",
          "stdName": "HUMAN EMBRYO KINASE",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "3d39a11f-5793-493e-acad-e0f44b69625b",
          "name": "TYRO4",
          "stdName": "TYRO4",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af",
            "6a51e6be-335e-49ff-b8b0-7d1955a10d45"
          ],
          "display_name": false
        },
        {
          "uuid": "cf2a1b1f-59aa-433f-834d-66b4a735a8d2",
          "name": "TYROSINE-PROTEIN KINASE RECEPTOR ETK1",
          "stdName": "TYROSINE-PROTEIN KINASE RECEPTOR ETK1",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "84e09ae7-380e-40e8-b121-e8de5dfa6825",
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af"
          ],
          "display_name": false
        },
        {
          "uuid": "8cc11163-5c26-4c25-9615-0d65d156ae39",
          "name": "TYROSINE-PROTEIN KINASE TYRO4",
          "stdName": "TYROSINE-PROTEIN KINASE TYRO4",
          "type": "cn",
          "languages": [
            "en"
          ],
          "preferred": false,
          "references": [
            "84e09ae7-380e-40e8-b121-e8de5dfa6825",
            "4f0f5a9d-aa15-40fe-9939-5acebb23c7af"
          ],
          "display_name": false
        }
      ],
      "protein": {
        "uuid": "84e0e309-3be4-43d3-a348-bd404fbb335c",
        "glycosylation": {
          "uuid": "ba21cc08-8040-4d9f-a43a-0670ffe601b9",
          "glycosylation_type": "HUMAN",
          "n_glycosylation_sites": [
            {
              "residue_index": 212,
              "subunit_index": 1
            },
            {
              "residue_index": 317,
              "subunit_index": 1
            },
            {
              "residue_index": 371,
              "subunit_index": 1
            },
            {
              "residue_index": 384,
              "subunit_index": 1
            },
            {
              "residue_index": 473,
              "subunit_index": 1
            }
          ]
        },
        "subunits": [
          {
            "uuid": "68d8af8c-f788-4dbe-8bbe-36a8e08d2089",
            "sequence": "ELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV",
            "subunit_index": 1
          }
        ],
        "references": [
          "4968c384-5611-45d7-a89c-c7b089919792",
          "84e09ae7-380e-40e8-b121-e8de5dfa6825"
        ],
        "protein_sub_type": "",
        "sequence_type": "COMPLETE"
      },
      "properties": [
        {
          "uuid": "86a49ce0-78e7-48ab-b529-bf878f4764bd",
          "name": "MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)",
          "type": "amount",
          "value": {
            "uuid": "a7c6a5b9-cf8c-4ef9-954c-a5d778d49a0f",
            "type": "NUMBER AVERAGE",
            "average": 107991,
            "units": "DA",
            "non_numeric_value": "UNMODIFIED MW"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        },
        {
          "uuid": "4b6dec52-b1e7-47e4-afaf-647315059282",
          "name": "Molecular Formula",
          "value": {
            "uuid": "c0482905-a719-40c0-8f2f-b32d8a0c8f66",
            "type": "ESTIMATED",
            "non_numeric_value": "C4788H7475N1300O1466P5S49"
          },
          "defining": false,
          "property_type": "CHEMICAL"
        }
      ],
      "modifications": {
        "uuid": "5e739997-41f1-4776-8dbb-980643d09a95",
        "structural_modifications": [
          {
            "uuid": "be046e05-3562-4e14-9f98-eb1f63f9d112",
            "extent": "COMPLETE",
            "sites": [
              {
                "residue_index": 917,
                "subunit_index": 1
              }
            ],
            "molecular_fragment": {
              "uuid": "7a58e4a3-761f-4537-b29f-51a449dbda74",
              "refuuid": "6534bbf5-6eb4-4a29-aba8-46e6ed9c50bd",
              "name": "TYROSINE O-PHOSPHATE",
              "unii": "2R86C98KDX",
              "linking_id": "2R86C98KDX",
              "ref_pname": "TYROSINE O-PHOSPHATE",
              "substance_class": "reference"
            },
            "residue_modified": "TYROSINE",
            "structural_modification_type": "AMINO ACID SUBSTITUTION"
          },
          {
            "uuid": "dac290d1-f00b-4a42-998d-a95bb93529f9",
            "extent": "COMPLETE",
            "sites": [
              {
                "residue_index": 576,
                "subunit_index": 1
              },
              {
                "residue_index": 582,
                "subunit_index": 1
              },
              {
                "residue_index": 681,
                "subunit_index": 1
              },
              {
                "residue_index": 759,
                "subunit_index": 1
              }
            ],
            "molecular_fragment": {
              "uuid": "2008984f-a8ba-4ba4-99e8-1b722e0efe6d",
              "refuuid": "6534bbf5-6eb4-4a29-aba8-46e6ed9c50bd",
              "name": "TYROSINE O-PHOSPHATE",
              "unii": "2R86C98KDX",
              "linking_id": "2R86C98KDX",
              "ref_pname": "TYROSINE O-PHOSPHATE",
              "substance_class": "reference"
            },
            "residue_modified": "TYROSINE",
            "structural_modification_type": "AMINO ACID SUBSTITUTION"
          }
        ]
      }
    }
  ]
}