{ "meta": { "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.", "terms": "https://open.fda.gov/terms/", "license": "https://open.fda.gov/license/", "last_updated": "2026-09-09", "results": { "skip": 0, "limit": 1, "total": 1 } }, "results": [ { "codes": [ { "uuid": "8a3db08e-721d-4881-a941-2123de098d37", "code": "P27815", "type": "PRIMARY", "url": "http://www.uniprot.org/uniprot/P27815", "code_system": "UNIPROT", "references": [ "728f53ae-46df-c4c1-13d9-c356df52c7ac" ] }, { "uuid": "99a0d405-eaa8-42bb-84d6-4b3a3c95c8ba", "code": "0FY8X1RL72", "type": "PRIMARY", "code_system": "FDA UNII" } ], "relationships": [ { "uuid": "23a5c5a5-c49b-4b22-843d-c3417a928b4e", "amount": { "uuid": "f89b2906-42e8-4dd4-adde-c9e86b11de78" }, "type": "INHIBITOR->TARGET", "references": [ "07c67de5-a815-4ce0-8b1e-6009d3c56ce7", "37387f52-971a-4326-990c-f1aa275ce1cf" ], "related_substance": { "uuid": "6f2280d1-412a-4893-b26b-d1ffc54a665f", "refuuid": "d507f3ce-7182-46e0-a304-c77a03340314", "name": "ASP-9831", "unii": "TK9MSV53AD", "linking_id": "TK9MSV53AD", "ref_pname": "ASP-9831", "substance_class": "reference" } }, { "uuid": "c088e643-8779-460f-93c7-cdb9f73c339a", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "2b261a0b-271f-492e-9979-24a8fb29aa64", "refuuid": "b970e02b-f70e-491b-94ed-3dc355505bfe", "name": "APREMILAST", "unii": "UP7QBP99PN", "linking_id": "UP7QBP99PN", "ref_pname": "APREMILAST" } }, { "uuid": "204095e6-ff19-4bde-a00a-87d93d1aa958", "amount": { "uuid": "5eed8603-23b5-4fb1-8962-e7ccfba047a2", "average": 14000, "units": "NANOMOLAR" }, "comments": "Representative of PDE4", "type": "INHIBITOR->TARGET", "references": [ "0d719196-e4aa-4867-aaeb-6ded0ff6b135" ], "related_substance": { "uuid": "0e0c73fc-e066-4713-b2be-e6f8e65c09a4", "refuuid": "d516144e-6192-4394-af26-3da140462e02", "name": "RESVERATROL", "unii": "Q369O8926L", "linking_id": "Q369O8926L", "ref_pname": "RESVERATROL", "substance_class": "reference" } }, { "uuid": "01a2c5c8-f279-4150-8588-dd55fc7f14f7", "amount": { "uuid": "b2b27695-cfa4-48aa-a982-fb1c3f256aa4", "average": 42, "units": "NANOMOLAR" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "842ba71f-faa3-4acf-a7c3-4e365db9b3d5", "refuuid": "ec370f9e-b58d-45e6-ac17-1d728d244562", "name": "PICLAMILAST", "unii": "WM58D7C3ZT", "linking_id": "WM58D7C3ZT", "ref_pname": "PICLAMILAST", "substance_class": "reference" } }, { "uuid": "c04ca0e8-170b-4115-bf35-a8406bdcb00e", "amount": { "uuid": "a7e0bdec-8033-4bf9-a9ef-914026d398f4" }, "comments": "2-3 fold less active than ROFLUMILAST but much higher concentration in plasma.", "type": "INHIBITOR->TARGET", "references": [ "4b41e990-1fbf-4910-b668-33de949b7bda" ], "related_substance": { "uuid": "eb062d04-ca18-46fb-a8f6-7b2d8dd26749", "refuuid": "5f1afc4c-4558-445d-84d6-a5c27f83c0ea", "name": "Roflumilast N-oxide", "unii": "F08MQ6CZCS", "linking_id": "F08MQ6CZCS", "ref_pname": "Roflumilast N-oxide", "substance_class": "reference" } }, { "uuid": "2b9ef60f-3946-4c33-8c63-c8e26cf5eb57", "amount": { "uuid": "0b0fe66e-3729-4338-a136-8c28ba526a83", "average": 2.8, "high": 3.1, "low": 0.49, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "591e1e66-4d6d-4c69-89f4-df17b27b7752" ], "related_substance": { "uuid": "cbf36c0e-0683-432a-ace5-e7f84f492b76", "refuuid": "eeb646fc-dc6c-439f-af96-6d562e0bfd5e", "name": "LOTAMILAST", "unii": "TO043KKB9C", "linking_id": "TO043KKB9C", "ref_pname": "LOTAMILAST", "substance_class": "reference" } }, { "uuid": "eb4a73b0-232b-4ac5-b714-afc776b09de7", "amount": { "uuid": "cce3d3ac-e48b-4725-b2e8-dc61f07fc083", "average": 6.7, "units": "NANOMOLAR" }, "type": "INHIBITOR->TARGET", "references": [ "5731d09d-0207-4203-9610-4cbda04e795a", "7e6987f2-1355-45e2-aae6-45c34baff9e4" ], "related_substance": { "uuid": "75fba74e-5153-4a30-a819-6824104a153c", "refuuid": "4d4a3f7f-3656-4af1-b883-c981b9b01159", "name": "MK-0873", "unii": "K4KAC9XCCO", "linking_id": "K4KAC9XCCO", "ref_pname": "MK-0873", "substance_class": "reference" } }, { "uuid": "faa05859-cbbb-43a5-9111-9bb1612320c4", "amount": { "uuid": "27c81e9c-6978-45a6-a460-9b04fa3fb710", "average": 2.8, "units": "NANOMOLAR" }, "comments": "No specific PDE4 mentioned. Designed as a soft drug but lead to active metabolites.", "qualification": "IC50", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "afa2c44d-2ed4-4685-9159-2788b8a82e3b", "refuuid": "4eae9fbf-6efd-431d-bfa0-37804dbc3909", "name": "LEO-29102", "unii": "JKP2Z098S2", "linking_id": "JKP2Z098S2", "ref_pname": "LEO-29102", "substance_class": "reference" } }, { "uuid": "45f89388-0c5f-437b-9e01-21a0035485db", "amount": { "uuid": "7548c34f-e2e7-4a75-b626-e4d322758f4b", "average": 4.7, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "references": [ "83b82f94-bd7b-4f16-84f5-3c5f2f6a3508" ], "related_substance": { "uuid": "6dd513ec-202b-4dc5-ba3f-33bfe31710ee", "refuuid": "ebcc8fe5-0951-4301-aa44-c17f1138fb07", "name": "PF-06445974", "unii": "LDJ6344143", "linking_id": "LDJ6344143", "ref_pname": "PF-06445974", "substance_class": "reference" } }, { "uuid": "b1e6cf81-e934-4256-8a6f-f4094e203f44", "amount": { "uuid": "0af00acb-5379-4e1b-91c6-ba25d1e46fe1" }, "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "3d890cb7-5975-46b6-b7b6-7a720873d63e", "refuuid": "6b3a0a0d-39b3-45bd-809b-414e284e33c7", "name": "(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol", "unii": "6C7UKU3FVA", "linking_id": "6C7UKU3FVA", "ref_pname": "(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridin-2-ol", "substance_class": "reference" } }, { "uuid": "a618f53c-ac52-4970-b1b2-491c8161115e", "amount": { "uuid": "3f760891-b2b8-44dd-a491-b3ecaf3f8f28", "average": 0.036, "units": "NANOMOLAR" }, "qualification": "IC50", "type": "INHIBITOR->TARGET", "related_substance": { "uuid": "35218150-8461-4985-9fa8-ee75727d72cc", "refuuid": "00dbb8f7-c9fd-43b7-b090-ec1d54c9c845", "name": "ASP-3258", "unii": "BK39B3V2L3", "linking_id": "BK39B3V2L3", "ref_pname": "ASP-3258", "substance_class": "reference" } } ], "substance_class": "protein", "names": [ { "uuid": "2fa33763-3296-07e7-21aa-3554cc74ea11", "name": "CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE PDE4A1", "stdName": "CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE PDE4A1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "728f53ae-46df-c4c1-13d9-c356df52c7ac" ], "display_name": true }, { "uuid": "c920b194-39eb-194b-0606-7a1e4f43eacf", "name": "PDE-4A1", "stdName": "PDE-4A1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "728f53ae-46df-c4c1-13d9-c356df52c7ac" ], "display_name": false }, { "uuid": "d88dd95e-93e2-d577-bcc1-87369f82791c", "name": "PDE4A1", "stdName": "PDE4A1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "728f53ae-46df-c4c1-13d9-c356df52c7ac" ], "display_name": false }, { "uuid": "27de744f-32c5-102c-32d1-36b4f2bb82d0", "name": "RD1", "stdName": "RD1", "type": "cn", "languages": [ "en" ], "preferred": false, "references": [ "728f53ae-46df-c4c1-13d9-c356df52c7ac" ], "display_name": false } ], "references": [ { "uuid": "728f53ae-46df-c4c1-13d9-c356df52c7ac", "citation": "http://www.uniprot.org/uniprot/P27815", "doc_type": "SRS", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "7466b191-2792-4156-b733-9bf9e2537c87", "citation": "Aprile, Silvio, Marta Serafini, and Tracey Pirali. \"Soft drugs for dermatological applications: recent trends.\" Drug discovery today 24.12 (2019): 2234-2246.", "url": "https://www.sciencedirect.com/science/article/pii/S1359644619303356", "doc_type": "JA", "public_domain": true }, { "uuid": "4b41e990-1fbf-4910-b668-33de949b7bda", "citation": "Gross, Nicholas J., Mark A. 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Rennard. \"Treatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor.\" COPD: Journal of Chronic Obstructive Pulmonary Disease 7.2 (2010): 141-153.", "url": "https://www.tandfonline.com/doi/pdf/10.3109/15412551003758304", "doc_type": "JA", "public_domain": true }, { "uuid": "0d719196-e4aa-4867-aaeb-6ded0ff6b135", "citation": "Park, Sung-Jun, et al. \"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.\" Cell 148.3 (2012): 421-433.", "url": "https://www.sciencedirect.com/science/article/pii/S009286741200030X", "doc_type": "JA", "public_domain": true }, { "uuid": "5731d09d-0207-4203-9610-4cbda04e795a", "citation": "Park, Sung-Jun, et al. \"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.\" Cell 148.3 (2012): 421-433.", "url": "https://www.sciencedirect.com/science/article/pii/S009286741200030X", "doc_type": "JA", "public_domain": true }, { "uuid": "7e6987f2-1355-45e2-aae6-45c34baff9e4", "citation": "Li, Heng, Jianping Zuo, and Wei Tang. \"Phosphodiesterase-4 inhibitors for the treatment of inflammatory diseases.\" Frontiers in pharmacology 9 (2018): 1048.", "url": "https://www.frontiersin.org/articles/10.3389/fphar.2018.01048/full", "doc_type": "JA", "public_domain": true, "tags": [ "PUBLIC_DOMAIN_RELEASE" ] }, { "uuid": "07c67de5-a815-4ce0-8b1e-6009d3c56ce7", "citation": "ADIS-INSIGHT:ASP-9831", "url": "http://adisinsight.springer.com/drugs/800034973", "doc_type": "WEBSITE", "public_domain": true, "tags": [ "NOMEN" ] }, { "uuid": "37387f52-971a-4326-990c-f1aa275ce1cf", "citation": "Baillie, George S., Gonzalo S. 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