{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-09",
    "results": {
      "skip": 0,
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  "results": [
    {
      "product_ndc": "0280-8272",
      "generic_name": "ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, and PHENYLEPHRINE HYDROCHLORIDE",
      "labeler_name": "Bayer HealthCare LLC.",
      "brand_name": "ALKA SELTZER COLD Cold and Flu plus Congestion Severe Fast Hot Liquid Night",
      "active_ingredients": [
        {
          "name": "ACETAMINOPHEN",
          "strength": "650 mg/1"
        },
        {
          "name": "DEXTROMETHORPHAN HYDROBROMIDE",
          "strength": "20 mg/1"
        },
        {
          "name": "DOXYLAMINE SUCCINATE",
          "strength": "12.5 mg/1"
        },
        {
          "name": "PHENYLEPHRINE HYDROCHLORIDE",
          "strength": "10 mg/1"
        }
      ],
      "finished": true,
      "packaging": [
        {
          "package_ndc": "0280-8272-06",
          "description": "6 PACKET in 1 CARTON (0280-8272-06)  / 1 POWDER, FOR SOLUTION in 1 PACKET",
          "marketing_start_date": "20260601",
          "sample": false
        }
      ],
      "listing_expiration_date": "20271231",
      "openfda": {
        "manufacturer_name": [
          "Bayer HealthCare LLC."
        ],
        "rxcui": [
          "1534835"
        ],
        "spl_set_id": [
          "5349dbde-730c-610f-e063-6394a90a952a"
        ],
        "is_original_packager": [
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        ],
        "upc": [
          "0016500559399"
        ],
        "unii": [
          "362O9ITL9D",
          "9D2RTI9KYH",
          "V9BI9B5YI2",
          "04JA59TNSJ"
        ]
      },
      "marketing_category": "OTC MONOGRAPH DRUG",
      "dosage_form": "POWDER, FOR SOLUTION",
      "spl_id": "5349dbde-730d-610f-e063-6394a90a952a",
      "product_type": "HUMAN OTC DRUG",
      "route": [
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      ],
      "marketing_start_date": "20260601",
      "product_id": "0280-8272_5349dbde-730d-610f-e063-6394a90a952a",
      "application_number": "M012",
      "brand_name_base": "ALKA SELTZER COLD Cold and Flu plus Congestion Severe Fast Hot Liquid Night",
      "pharm_class": [
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        "Antihistamine [EPC]",
        "Histamine Receptor Antagonists [MoA]",
        "Sigma-1 Agonist [EPC]",
        "Sigma-1 Receptor Agonists [MoA]",
        "Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]",
        "Uncompetitive NMDA Receptor Antagonists [MoA]",
        "alpha-1 Adrenergic Agonist [EPC]"
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    }
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}