{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
      "skip": 0,
      "limit": 1,
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    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "Crest Pro Health Clean Mint Stannous fluoride STANNOUS FLUORIDE FLUORIDE ION SODIUM GLUCONATE STANNOUS CHLORIDE SUCRALOSE TITANIUM DIOXIDE SORBITOL GLYCINE SODIUM CITRATE ZINC CITRATE CARRAGEENAN SODIUM HYDROXIDE FD&C BLUE NO. 1 WATER SACCHARIN SODIUM HYDRATED SILICA XANTHAN GUM SODIUM LAURYL SULFATE"
      ],
      "active_ingredient": [
        "Drug Facts Active ingredient Stannous fluoride 0.454% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purposes Anticavity, antigingivitis, antisensitivity toothpaste"
      ],
      "indications_and_usage": [
        "Uses aids in the prevention of cavities helps prevent gingivitis helps interfere with the harmful effects of plaque associated with gingivitis helps control plaque bacteria that contribute to the development of gingivitis builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact"
      ],
      "warnings": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist. Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care. Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "when_using": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist."
      ],
      "stop_use": [
        "Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 12 yrs. & older: apply at least a 1-inch strip of the product onto a soft bristle toothbrush. Brush teeth thoroughly for at least 1 minute twice a day (morning and evening) or as recommended by a dentist. Make sure to brush all sensitive areas of the teeth. do not swallow children under 12 yrs. of age: ask a dentist"
      ],
      "warnings_and_cautions": [
        "Other information products containing stannous fluoride may produce surface staining of the teeth adequate toothbrushing may prevent these stains which are not harmful or permanent and may be removed by your dentist this Crest is specially formulated to help prevent staining see your dentist regularly"
      ],
      "inactive_ingredient": [
        "Inactive ingredients water, sorbitol, hydrated silica, sodium lauryl sulfate, sodium gluconate, carrageenan, flavor, sodium citrate, xanthan gum, zinc citrate, glycine, sodium hydroxide, stannous chloride, sodium saccharin, sucralose, titanium dioxide, blue 1"
      ],
      "questions": [
        "Questions? 1-800-594-4158"
      ],
      "spl_unclassified_section": [
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 144 g tube in carton Crest ® PRO-HEALTH FLUORIDE TOOTHPASTE FOR ANTICAVITY, ANTIGINGIVITIS AND SENSITIVE TEETH CAVITIES GUM ENAMEL SENSITIVITY PLAQUE TARTAR WHITENS FRESHENS BREATH NET WT 5.9 OZ (167 g) FORMULATED WITH AMINO ACID GLYCINE CLEAN MINT PROTECTS 100% OF THE WHOLE MOUTH 69423-781"
      ],
      "set_id": "fb466fb4-0915-a41f-e053-6294a90a2dfb",
      "id": "47e36800-0672-cf64-e063-6294a90a85af",
      "effective_time": "20260108",
      "version": "12",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Pro Health Clean Mint"
        ],
        "generic_name": [
          "STANNOUS FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-781"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "STANNOUS FLUORIDE"
        ],
        "rxcui": [
          "416784"
        ],
        "spl_id": [
          "47e36800-0672-cf64-e063-6294a90a85af"
        ],
        "spl_set_id": [
          "fb466fb4-0915-a41f-e053-6294a90a2dfb"
        ],
        "package_ndc": [
          "69423-781-59",
          "69423-781-85",
          "69423-781-43",
          "69423-781-44",
          "69423-781-45",
          "69423-781-73",
          "69423-781-03",
          "69423-781-46",
          "69423-781-63",
          "69423-781-33",
          "69423-781-21",
          "69423-781-04"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "3FTR44B32Q"
        ]
      }
    }
  ]
}