{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "Crest 3D White Brilliance Pro Enamel Protect Sodium Fluoride GLYCERIN TITANIUM DIOXIDE CARRAGEENAN SODIUM POLYMETAPHOSPHATE SODIUM PHOSPHATE, TRIBASIC, ANHYDROUS POLYETHYLENE GLYCOL 300 WATER HYDRATED SILICA COCAMIDOPROPYL BETAINE SACCHARIN SODIUM SODIUM LAURYL SULFATE XANTHAN GUM SUCRALOSE MICA SODIUM FLUORIDE FLUORIDE ION w/teal gel stripe"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "Dist. by Procter & Gamble, Cincinnati, OH 45202"
      ],
      "active_ingredient": [
        "Active ingredient Sodium fluoride 0.243% (0.16% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toothpaste"
      ],
      "indications_and_usage": [
        "Use helps protect against cavities"
      ],
      "warnings": [
        "Warning Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in children under 6 supervise children's brushing until good habits are established children under 2 yrs.: ask a dentist"
      ],
      "inactive_ingredient": [
        "Inactive ingredients glycerin, hydrated silica, sodium hexametaphosphate, water, PEG-6, flavor, sodium lauryl sulfate, carrageenan, cocamidopropyl betaine, trisodium phosphate, sodium saccharin, xanthan gum, sucralose, mica, titanium dioxide"
      ],
      "questions": [
        "Questions? 1-800-492-7378"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 110 g Tube Carton LARGE SIZE CREST 3D WHITE fluoride anticavity toothpaste enamel safe BRILLIANCE 100% MORE STAIN REMOVAL* ENAMEL PROTECT NT WT 3.9 OZ (110 g) Artwork"
      ],
      "set_id": "f32d5708-8cb1-6499-e053-2995a90ac632",
      "id": "47e28064-055d-b334-e063-6394a90a3252",
      "effective_time": "20260108",
      "version": "8",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest 3D White Brilliance Pro Enamel Protect"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-750"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "47e28064-055d-b334-e063-6394a90a3252"
        ],
        "spl_set_id": [
          "f32d5708-8cb1-6499-e053-2995a90ac632"
        ],
        "package_ndc": [
          "69423-750-03",
          "69423-750-20",
          "69423-750-39"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}