{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-29",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "PERIOE Microbiome Total Care Strong Mint Sodium Fluoride HYDRATED SILICA PROPOLIS WAX GLYCERIN WATER SODIUM PYROPHOSPHATE .ALPHA.-TOCOPHEROL ACETATE, DL- SODIUM LAURYL SULFATE XYLITOL SACCHARIN SODIUM SACCHARIN CARBOXYMETHYLCELLULOSE SODIUM TITANIUM DIOXIDE CITRUS LIMON FRUIT OIL SODIUM CHLORIDE SORBITAN MONOOLEATE XANTHAN GUM MICA ACTIVATED CHARCOAL CANNABIS SATIVA SEED OIL SODIUM FLUORIDE FLUORIDE ION Strong"
      ],
      "spl_unclassified_section": [
        "Drug Facts Drug Facts"
      ],
      "active_ingredient": [
        "Active Ingredient Sodium fluoride 0.243% (0.14% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toopaste"
      ],
      "indications_and_usage": [
        "Use helps protect against cavities"
      ],
      "warnings": [
        "Warnings Warnings Keep out of reach of children. Keep out of reach of children under 6 years of age. Do not swallow. If you accidentally swallow more than used for brushing, seek professional assistance or contact a poison control center right away. If an allergic reaction develops, discontinue use immediately."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. Keep out of reach of children under 6 years of age. Do not swallow. If you accidentally swallow more than used for brushing, seek professional assistance or contact a poison control center right away. If an allergic reaction develops, discontinue use immediately."
      ],
      "dosage_and_administration": [
        "Directions Adults and children 2 years of age and and older: Brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist. Do not swallow. To minimize swallowing use a pea-sized amount in children under 6. Supervise children's brushing until good habits are established. Children under 2 years: ask a dentist."
      ],
      "inactive_ingredient": [
        "Inactive Ingredients WATER, SORBITOL, HYDRATED SILICA, SODIUM LAURYL SULFATE, GLYCERIN, FLAVOR, CELLULOSE GUM, TETRASODIUM PYROPHOSPHATE, XANTHAN GUM, TITANIUM DIOXIDE, SORBITAN OLEATE, SODIUM SACCHARIN, CHARCOAL POWDER, BIFIDA FERMENT EXTRACT FILTRATE, SODIUM CHLORIDE, CANNABIS SATINA SEED OIL, PROPOLIS EXTRACT, TOCOPHERYL ACETATE, XYLITOL"
      ],
      "questions": [
        "Questions? 1-800-FOR-AVON"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 153 g Tube Carton PERIOE MICROBIOME TOOTHPASTE THE POWER OF PREBIOTICS helps support good bacteria to maintain healthy balance TOTAL CARE - CAVITIES - WHITENING - PLAQUE - TARTAR - ORAL HYGIENE - FRESH BREATH STRONG MINT 153 g net wt. 5.4 oz LABEL_CASE_PERIOE MICROBIOME TOTAL CARE TOOTHPASTE 153g LABEL_CASE_PERIOE MICROBIOME TOTAL CARE TOOTHPASTE 153g"
      ],
      "set_id": "de996aeb-9ac0-836f-e053-2a95a90aeda6",
      "id": "2aabf040-16c1-b772-e063-6294a90afd70",
      "effective_time": "20250101",
      "version": "3",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "PERIOE Microbiome Total Care Strong Mint"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "Tai Guk Pharm. Co., Ltd."
        ],
        "product_ndc": [
          "43136-820"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "2aabf040-16c1-b772-e063-6294a90afd70"
        ],
        "spl_set_id": [
          "de996aeb-9ac0-836f-e053-2a95a90aeda6"
        ],
        "package_ndc": [
          "43136-820-01"
        ],
        "is_original_packager": [
          true
        ],
        "upc": [
          "0803954304954"
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}