{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
      "skip": 0,
      "limit": 1,
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    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "Crest Densify Daily Protection Stannous fluoride SODIUM HYDROXIDE SACCHARIN SODIUM XANTHAN GUM GLYCERIN SODIUM LAURYL SULFATE SORBITOL TITANIUM DIOXIDE COCAMIDOPROPYL BETAINE STANNOUS FLUORIDE FLUORIDE ION SUCRALOSE STANNOUS CHLORIDE SODIUM CITRATE WATER HYDRATED SILICA CARRAGEENAN SODIUM GLUCONATE"
      ],
      "active_ingredient": [
        "Drug Facts Active ingredient Stannous fluoride 0.454% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purposes Anticavity, antisensitivity toothpaste"
      ],
      "indications_and_usage": [
        "Uses aids in the prevention of cavities builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact"
      ],
      "warnings": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist. Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care. Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "when_using": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist."
      ],
      "stop_use": [
        "Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 12 yrs. & older: apply at least a 1-inch strip of the product onto a soft bristle toothbrush. Brush teeth thoroughly for at least 1 minute twice a day (morning and evening) or as recommended by a dentist. Make sure to brush all sensitive areas of the teeth do not swallow children under 12 yrs. of age: ask a dentist"
      ],
      "warnings_and_cautions": [
        "Other information products containing stannous fluoride may produce surface staining of the teeth adequate toothbrushing may prevent these stains which are not harmful or permanent and may be removed by your dentist this Crest is specially formulated to help prevent staining see your dentist regularly"
      ],
      "inactive_ingredient": [
        "Inactive ingredients glycerin, sorbitol, water, hydrated silica, sodium lauryl sulfate, sodium citrate, flavor, sodium gluconate, carrageenan, xanthan gum, sodium saccharin, cocamidopropyl betaine, sodium hydroxide, stannous chloride, sucralose, titanium dioxide"
      ],
      "questions": [
        "Questions? 1-800-594-4158"
      ],
      "spl_unclassified_section": [
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 116 g tube in carton Crest ® PRO HEALTH™ FLUORIDE TOOTHPASTE FOR ANTICAVITY AND SENSITIVE TEETH DENSIFY™ ACTIVELY REBUILDS TOOTH DENSITY TO EXTEND THE LIFE OF TEETH 2X ENAMEL PROTECTION SYSTEM DAILY PROTECTION NET WT 4.1 OZ (116 g) Crest Densify Daily Protection"
      ],
      "set_id": "d810d4e5-ba66-efe1-e053-2995a90abfc0",
      "id": "47e497ef-68fb-4404-e063-6394a90a0dac",
      "effective_time": "20260108",
      "version": "7",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Densify Daily Protection"
        ],
        "generic_name": [
          "STANNOUS FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-873"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "STANNOUS FLUORIDE"
        ],
        "rxcui": [
          "416784"
        ],
        "spl_id": [
          "47e497ef-68fb-4404-e063-6394a90a0dac"
        ],
        "spl_set_id": [
          "d810d4e5-ba66-efe1-e053-2995a90abfc0"
        ],
        "package_ndc": [
          "69423-873-41",
          "69423-873-85",
          "69423-873-12",
          "69423-873-53"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "3FTR44B32Q"
        ]
      }
    }
  ]
}