{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-30",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "Crest Pro Health Advanced Sensitive Relief Stannous fluoride POVIDONE, UNSPECIFIED TITANIUM DIOXIDE FD&C BLUE NO. 1 ZINC LACTATE GLYCERIN COCAMIDOPROPYL BETAINE SODIUM POLYMETAPHOSPHATE PROPYLENE GLYCOL POLYETHYLENE GLYCOL 300 SODIUM GLUCONATE WATER HYDRATED SILICA CARRAGEENAN XANTHAN GUM SODIUM LAURYL SULFATE SACCHARIN SODIUM SODIUM PHOSPHATE, TRIBASIC, ANHYDROUS STANNOUS FLUORIDE FLUORIDE ION"
      ],
      "active_ingredient": [
        "Drug Facts Active ingredient Stannous fluoride 0.454% (0.16% w/v fluoride ion)"
      ],
      "purpose": [
        "Purposes Anticavity, antigingivitis antisensitivity toothpaste"
      ],
      "indications_and_usage": [
        "Uses aids in the prevention of cavities helps prevent gingivitis helps interfere with the harmful effects of plaque associated with gingivitis helps control plaque bacteria that contribute to the development of gingivitis builds increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets, or contact"
      ],
      "warnings": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist. Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care. Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "when_using": [
        "When using this product do not use for sensitivity longer than four weeks unless recommended by a dentist."
      ],
      "stop_use": [
        "Stop use and ask a dentist if the sensitivity problem persists or worsens. Sensitive teeth may indicate a serious problem that may need prompt care."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 12 yrs. & older: apply at least a 1-inch strip of the product onto a soft bristle toothbrush. Brush teeth thoroughly for at least 1 minute twice a day (morning and evening) or as recommended by a dentist. Make sure to brush all sensitive areas of the teeth. do not swallow children under 12 yrs. of age: ask a dentist"
      ],
      "warnings_and_cautions": [
        "Other information products containing stannous fluoride may produce surface staining of the teeth adequate toothbrushing may prevent these stains which are not harmful or permanent and may be removed by your dentist this Crest is specially formulated to help prevent staining see your dentist regularly"
      ],
      "inactive_ingredient": [
        "Inactive ingredients glycerin, hydrated silica, sodium hexametaphosphate, propylene glycol, PEG-6, water, zinc lactate, flavor, sodium lauryl sulfate, sodium gluconate, sodium saccharin, trisodium phosphate, xanthan gum, PVP, carrageenan, cocamidopropyl betaine, titanium dioxide, blue 1"
      ],
      "questions": [
        "Questions? 1-800-594-4158"
      ],
      "spl_unclassified_section": [
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 144 g tube in carton Crest ® FLUORIDE TOOTHPASTE FOR ANTICAVITY, ANTIGINGIVITIS AND SENSITIVE TEETH CAVITIES GINGIVITIS ENAMEL SENSITIVITY PLAQUE TARTAR WHITENING FRESHENS BREATH NET WT 5.1 OZ (144 g) DENTIST DESIGNED CLINICALLY PROVEN* PRO HEALTH™ ADVANCED HELPS PREVENT PLAQUE GROWTH TO STOP ISSUES BEFORE THEY START.** SENSITIVE RELIEF Crest Pro Health Advanced Sensitive Relief"
      ],
      "set_id": "d7730674-7513-52cf-e053-2995a90ab32c",
      "id": "47e49826-a288-39ed-e063-6394a90a41d7",
      "effective_time": "20260108",
      "version": "8",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Pro Health Advanced Sensitive Relief"
        ],
        "generic_name": [
          "STANNOUS FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-868"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "STANNOUS FLUORIDE"
        ],
        "rxcui": [
          "416784"
        ],
        "spl_id": [
          "47e49826-a288-39ed-e063-6394a90a41d7"
        ],
        "spl_set_id": [
          "d7730674-7513-52cf-e053-2995a90ab32c"
        ],
        "package_ndc": [
          "69423-868-51",
          "69423-868-10",
          "69423-868-03"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "3FTR44B32Q"
        ]
      }
    }
  ]
}