{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-29",
    "results": {
      "skip": 0,
      "limit": 1,
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  "results": [
    {
      "spl_product_data_elements": [
        "Colgate Total Advanced Pro-Shield Peppermint Blast CETYLPYRIDINIUM CHLORIDE CETYLPYRIDINIUM CHLORIDE CETYLPYRIDINIUM WATER GLYCERIN PROPYLENE GLYCOL SORBITOL POLOXAMER 407 POTASSIUM SORBATE SACCHARIN SODIUM ANHYDROUS CITRIC ACID FD&C BLUE NO. 1"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "Dist. by: COLGATE-PALMOLIVE CO. New York, NY 10022 U.S.A."
      ],
      "active_ingredient": [
        "Active ingredient Cetylpyridinium chloride 0.075%"
      ],
      "purpose": [
        "Purpose Antigingivitis/Antiplaque"
      ],
      "indications_and_usage": [
        "Uses helps prevent and reduce plaque and gingivitis helps control plaque bacteria that contribute to the development of gingivitis, an early form of gum disease, and bleeding gums"
      ],
      "warnings": [
        "Warnings Stop use and ask a dentist if gingivitis, bleeding, or redness persists for more than 2 weeks you have painful or swollen gums, pus from the gum line, loose teeth, or increasing spacing between the teeth. These may be signs or symptoms of periodontitis, a serious form of gum disease. Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "stop_use": [
        "Stop use and ask a dentist if gingivitis, bleeding, or redness persists for more than 2 weeks you have painful or swollen gums, pus from the gum line, loose teeth, or increasing spacing between the teeth. These may be signs or symptoms of periodontitis, a serious form of gum disease."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 12 years of age and older vigorously swish 20 mL of rinse between your teeth twice a day for 30 seconds and then spit out. Do not swallow the rinse. children 6 years to under 12 years of age supervise use children under 6 years of age do not use"
      ],
      "dosage_and_administration_table": [
        "<table width=\"60%\" styleCode=\"Noautorules\"><col width=\"30%\" align=\"left\" valign=\"top\"/><col width=\"70%\" align=\"left\" valign=\"top\"/><tbody><tr styleCode=\"Botrule\"><td styleCode=\"Rrule\">adults and children 12 years of age and older</td><td>vigorously swish 20 mL of rinse between your teeth twice a day for 30 seconds and then spit out. Do not swallow the rinse.</td></tr><tr styleCode=\"Botrule\"><td styleCode=\"Rrule\">children 6 years to under 12 years of age</td><td>supervise use</td></tr><tr><td styleCode=\"Rrule\">children under 6 years of age</td><td>do not use</td></tr></tbody></table>"
      ],
      "storage_and_handling": [
        "Other information this rinse is not intended to replace brushing or flossing store at 59°F to 77°F keep from freezing"
      ],
      "inactive_ingredient": [
        "Inactive ingredients water, glycerin, propylene glycol, sorbitol, poloxamer 407, flavor, potassium sorbate, citric acid, sodium saccharin, FD&C blue no. 1"
      ],
      "questions": [
        "Questions? 1-800-468-6502"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 500 mL Bottle Label Colgate ® Antigingivitis Antiplaque Mouthwash Total 12 HR PROTECTION* EVEN AFTER EATING AND DRINKING ANTIBACTERIAL Kills 99% of Germs on Contact Significantly Reduces Plaque Helps Prevent Gingivitis 10X LONGER LASTING COOL** PEPPERMINT 16.9 FL OZ (1.05 PT) 500 mL PS0040932 PRINCIPAL DISPLAY PANEL - 500 mL Bottle Label"
      ],
      "set_id": "cb15af39-c146-4aab-9771-d42832a2c4b2",
      "id": "ace362ca-06fe-45e1-a7ec-1362bca05247",
      "effective_time": "20241001",
      "version": "14",
      "openfda": {
        "application_number": [
          "505G(a)(3)"
        ],
        "brand_name": [
          "Colgate Total Advanced Pro-Shield Peppermint Blast"
        ],
        "generic_name": [
          "CETYLPYRIDINIUM CHLORIDE"
        ],
        "manufacturer_name": [
          "Colgate-Palmolive Company"
        ],
        "product_ndc": [
          "35000-720"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "CETYLPYRIDINIUM CHLORIDE"
        ],
        "rxcui": [
          "1599135",
          "1599137"
        ],
        "spl_id": [
          "ace362ca-06fe-45e1-a7ec-1362bca05247"
        ],
        "spl_set_id": [
          "cb15af39-c146-4aab-9771-d42832a2c4b2"
        ],
        "package_ndc": [
          "35000-720-02",
          "35000-720-84",
          "35000-720-16",
          "35000-720-33",
          "35000-720-50"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "D9OM4SK49P"
        ]
      }
    }
  ]
}