{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-30",
    "results": {
      "skip": 0,
      "limit": 1,
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  "results": [
    {
      "spl_product_data_elements": [
        "Crest Pro-Health Advanced Gum Restore Deep Clean Stannous fluoride SUCRALOSE STANNOUS CHLORIDE WATER HYDRATED SILICA CARRAGEENAN SODIUM GLUCONATE COCAMIDOPROPYL BETAINE XANTHAN GUM ZINC CITRATE SODIUM LAURYL SULFATE SORBITOL GLYCINE SODIUM HYDROXIDE SACCHARIN SODIUM TITANIUM DIOXIDE STANNOUS FLUORIDE FLUORIDE ION SODIUM CITRATE"
      ],
      "active_ingredient": [
        "Drug Facts Active ingredient Stannous fluoride 0.454% (0.14% w/v fluoride ion)"
      ],
      "purpose": [
        "Purposes Anticavity, antigingivitis toothpaste"
      ],
      "indications_and_usage": [
        "Uses aids in the prevention of cavities helps prevent gingivitis helps interfere with the harmful effects of plaque associated with gingivitis helps control plaque bacteria that contribute to the development of gingivitis"
      ],
      "warnings": [
        "Warning Keep out of reach of children under 12 yrs. of age . If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 12 yrs. of age and older: Brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or physician. do not swallow children under 12 yrs. of age: ask a dentist"
      ],
      "keep_out_of_reach_of_children": [
        ""
      ],
      "warnings_and_cautions": [
        "Other information products containing stannous fluoride may produce surface staining of the teeth adequate toothbrushing may prevent these stains which are not harmful or permanent and may be removed by your dentist this Crest is specially formulated to help prevent staining see your dentist regularly"
      ],
      "inactive_ingredient": [
        "Inactive ingredients water, sorbitol, hydrated silica, glycine, sodium lauryl sulfate, sodium gluconate, carrageenan, flavor, sodium citrate, xanthan gum, zinc citrate, sodium hydroxide, stannous chloride, sodium saccharin, cocamidopropyl betaine, sucralose, titanium dioxide"
      ],
      "questions": [
        "Questions? 1-800-594-4158"
      ],
      "spl_unclassified_section": [
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 104 g tube in carton Crest ® PRO HEALTH™ FLUORIDE TOOTHPASTE FOR ANTICAVITY AND ANTIGINGIVITIS ADVANCED GUM RESTORE™ DEEP CLEAN Promotes Gum Healing Formulated with Amino Acid Glycine Clinically Proven Healthier Gums NET WT 3.7 OZ (104 g) 69423925"
      ],
      "set_id": "c5745cc4-213d-1dde-e053-2995a90af562",
      "id": "47e4c65f-d03c-daab-e063-6294a90a4a99",
      "effective_time": "20260108",
      "version": "10",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Pro-Health Advanced Gum Restore Deep Clean"
        ],
        "generic_name": [
          "STANNOUS FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-925"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "STANNOUS FLUORIDE"
        ],
        "rxcui": [
          "416784"
        ],
        "spl_id": [
          "47e4c65f-d03c-daab-e063-6294a90a4a99"
        ],
        "spl_set_id": [
          "c5745cc4-213d-1dde-e053-2995a90af562"
        ],
        "package_ndc": [
          "69423-925-37",
          "69423-925-85",
          "69423-925-52",
          "69423-925-27",
          "69423-925-63",
          "69423-925-48",
          "69423-925-03"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "3FTR44B32Q"
        ]
      }
    }
  ]
}