{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 1
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "Crest Premium Plus Deep Clean Active Foam Sodium Fluoride XANTHAN GUM TITANIUM DIOXIDE FD&C BLUE NO. 1 WATER SORBITOL HYDRATED SILICA SODIUM ACID PYROPHOSPHATE SODIUM LAURYL SULFATE CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED FORM SODIUM HYDROXIDE SACCHARIN SODIUM SODIUM FLUORIDE FLUORIDE ION CARBOXYPOLYMETHYLENE"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "active_ingredient": [
        "Active ingredient Sodium fluoride 0.243% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toothpaste"
      ],
      "indications_and_usage": [
        "Use helps protect against cavities"
      ],
      "warnings": [
        "Warning Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in children under 6 supervise children's brushing until good habits are established children under 2 yrs.: ask a dentist"
      ],
      "inactive_ingredient": [
        "Inactive ingredients sorbitol, water, hydrated silica, disodium pyrophosphate, sodium lauryl sulfate, flavor, sodium hydroxide, xanthan gum. sodium saccharin, cellulose gum, carbomer, titanium dioxide, blue 1"
      ],
      "questions": [
        "Questions? 1-800-492-7378"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 204 g Tube Carton Crest ® plus PREMIUM ANTICAVITY FLUORIDE TOOTHPASTE NET WT 7.2 OZ (204 g) ACTIVE FOAM + WHITENING DEEP CLEAN WHITENS & PREVENTS TARTAR BUILDUP foaming mint 994"
      ],
      "set_id": "b851fe5c-d904-12da-e053-2a95a90a86f9",
      "id": "47e347f8-eb74-9c1c-e063-6294a90ab479",
      "effective_time": "20260108",
      "version": "8",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Premium Plus Deep Clean Active Foam"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "37000-994"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "47e347f8-eb74-9c1c-e063-6294a90ab479"
        ],
        "spl_set_id": [
          "b851fe5c-d904-12da-e053-2a95a90a86f9"
        ],
        "package_ndc": [
          "37000-994-72",
          "37000-994-52",
          "37000-994-15"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}