{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-30",
    "results": {
      "skip": 0,
      "limit": 1,
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  "results": [
    {
      "spl_product_data_elements": [
        "PERIOE Whitening Essentials Fresh Aloe Green Mint Sodium Fluoride HEXASODIUM HEXAMETAPHOSPHATE CARRAGEENAN GLYCERIN WATER POLYETHYLENE GLYCOL 300 SODIUM PHOSPHATE, TRIBASIC, ANHYDROUS SODIUM LAURYL SULFATE COCAMIDOPROPYL BETAINE SACCHARIN SODIUM SACCHARIN SUCRALOSE TITANIUM DIOXIDE CITRUS LIMON FRUIT OIL SODIUM CHLORIDE HYDRATED SILICA XANTHAN GUM MICA ACTIVATED CHARCOAL SILICON DIOXIDE ALOE SODIUM FLUORIDE FLUORIDE ION Fresh Aloe"
      ],
      "spl_unclassified_section": [
        "Drug Facts Drug Facts"
      ],
      "active_ingredient": [
        "Active Ingredient Sodium fluoride 0.243% (0.16% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity"
      ],
      "indications_and_usage": [
        "Use helps protect against cavities"
      ],
      "warnings": [
        "Warnings Warnings Keep out of reach of children. Keep out of reach of children under 6 years of age. Do not swallow. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. Keep out of reach of children under 6 years of age. Do not swallow. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions Adults and children 6 years and older Brush teeth thoroughly after each means or at least twice a day, or as directed by a dentist and physician. Do not swallow. Children between 6 and 12 years To minimize swallowing, use a pea-sized amount and supervise children's brushing and rinsing until good habits are established. Children under 6 years Ask a dentist or physician."
      ],
      "dosage_and_administration_table": [
        "<table border=\"0\" width=\"100%\"><tbody><tr><td>Adults and children 6 years and older</td><td>Brush teeth thoroughly after each means or at least twice a day, or as directed by a dentist and physician. Do not swallow.</td></tr><tr><td>Children between 6 and 12 years</td><td>To minimize swallowing, use a pea-sized amount and supervise children&apos;s brushing and rinsing until good habits are established.</td></tr><tr><td>Children under 6 years</td><td>Ask a dentist or physician.</td></tr></tbody></table>"
      ],
      "inactive_ingredient": [
        "Inactive Ingredients glycerin, hydrated silica, sodium hexametaphosphate, water, PEG-6, flavor, trisodium phosphate, sodium lauryl sulfate, carrageenan, cocamidopropyl betaine, sodium saccharin, sucralose, xanthan gum, titanium dioxide, mica, charcoal powder, citru limon(lemon) fruit extract, sodium chloride, aloe extract"
      ],
      "questions": [
        "1-800-FOR-AVON www.avon.com"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel - 156 g Tube Carton PERIOE Whitening Essentials. ALOE FLUORIDE TOOTHPASTE CAVITY PROTECTION HELPS WHITEN TEETH - REMOVES SURFACE STAINS FRESH ALOE GREEN MINT NET WT 5.5 oz (156 g) PERIOE Whitening Essentials Fresh Aloe Green Mint 156g"
      ],
      "set_id": "a3b21ceb-5aa5-29b4-e053-2a95a90a9545",
      "id": "2aac2197-aad4-e890-e063-6394a90a61db",
      "effective_time": "20250101",
      "version": "2",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "PERIOE Whitening Essentials Fresh Aloe Green Mint"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "Tai Guk Pharm. Co., Ltd."
        ],
        "product_ndc": [
          "43136-802"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "2aac2197-aad4-e890-e063-6394a90a61db"
        ],
        "spl_set_id": [
          "a3b21ceb-5aa5-29b4-e053-2a95a90a9545"
        ],
        "package_ndc": [
          "43136-802-01"
        ],
        "is_original_packager": [
          true
        ],
        "upc": [
          "0803954402049"
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}