{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
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  "results": [
    {
      "spl_product_data_elements": [
        "Proactiv Advanced Daily Oil Control SALICYLIC ACID NYLON-12 ALUMINUM STARCH OCTENYLSUCCINATE CYCLOMETHICONE 6 WATER BUTYLENE GLYCOL CYCLOMETHICONE 5 GLYCERYL MONOSTEARATE PEG-100 STEARATE DECYLENE GLYCOL CAPRYLYL GLYCOL HEXYLENE GLYCOL PENTYLENE GLYCOL 10-HYDROXYDECANOIC ACID SEBACIC ACID 1,10-DECANEDIOL SARCOSINE XANTHAN GUM SODIUM HYDROXIDE EDETATE DISODIUM PHENOXYETHANOL ALCOHOL SALICYLIC ACID SALICYLIC ACID"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "Distributed by Alchemee LLC Santa Monica, CA 90401 Made in the USA of Foreign and Domestic Components Questions? 1-800-950-4695 • proactiv.com Proactiv is a registered trademark of Taro Pharmaceuticals U.S.A., Inc."
      ],
      "active_ingredient": [
        "Active Ingredient Salicylic Acid 0.5%"
      ],
      "purpose": [
        "Purpose Acne treatment"
      ],
      "indications_and_usage": [
        "Use for the management of acne"
      ],
      "warnings": [
        "Warnings For external use only When using this product skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "when_using": [
        "When using this product skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water."
      ],
      "stop_use": [
        ""
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions Sensitivity Test for a New User. Apply product sparingly to one or two small affected areas during the first 3 days. If no discomfort occurs, follow the directions stated below. clean the skin thoroughly before applying this product. cover the entire affected area with a thin layer one to three times daily. because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor. if bothersome dryness or peeling occurs, reduce application to once a day or every other day."
      ],
      "inactive_ingredient": [
        "Inactive Ingredients water, alcohol denat., butylene glycol, cyclopentasiloxane, nylon-12, glyceryl stearate, PEG-100 stearate, PVM/MA decadiene crosspolymer, aluminum starch octenylsuccinate, cyclohexasiloxane, caprylyl glycol, decylene glycol, phenoxyethanol, sodium hydroxide, hexylene glycol, fragrance, disodium EDTA, pentylene glycol, sebacic acid, 10-hydroxydecanoic acid, 1,10-decanediol, sarcosine, xanthan gum Questions or comments ? 1-800-950-4695"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 75 mL Carton proactiv ® ADVANCED DAILY OIL CONTROL 2.5 FL. OZ. 75 mL salicylic acid acne medication unit carton image"
      ],
      "set_id": "945be4e4-1ca2-41df-b3c8-da7b8fe38bc4",
      "id": "47d28c49-56d8-75a1-e063-6294a90a03c5",
      "effective_time": "20260107",
      "version": "5",
      "openfda": {
        "application_number": [
          "M006"
        ],
        "brand_name": [
          "Proactiv Advanced Daily Oil Control"
        ],
        "generic_name": [
          "SALICYLIC ACID"
        ],
        "manufacturer_name": [
          "Alchemee, LLC"
        ],
        "product_ndc": [
          "11410-055"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "TOPICAL"
        ],
        "substance_name": [
          "SALICYLIC ACID"
        ],
        "spl_id": [
          "47d28c49-56d8-75a1-e063-6294a90a03c5"
        ],
        "spl_set_id": [
          "945be4e4-1ca2-41df-b3c8-da7b8fe38bc4"
        ],
        "package_ndc": [
          "11410-055-00",
          "11410-055-05"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "O414PZ4LPZ"
        ]
      }
    }
  ]
}