{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
      "skip": 0,
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  "results": [
    {
      "spl_product_data_elements": [
        "Crest Fresh and White Sodium Fluoride WATER HYDRATED SILICA SODIUM LAURYL SULFATE SODIUM PHOSPHATE CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED FORM SACCHARIN SODIUM TITANIUM DIOXIDE SODIUM FLUORIDE FLUORIDE ION SORBITOL"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "DISTR. BY PROCTER & GAMBLE, CINCINNATI, OH 45202"
      ],
      "active_ingredient": [
        "Active ingredient Sodium fluoride 0.243% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toothpaste"
      ],
      "indications_and_usage": [
        "Use helps protect against cavities"
      ],
      "warnings": [
        "Warning Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in children under 6 supervise children's brushing until good habits are established children under 2 yrs.: ask a dentist"
      ],
      "inactive_ingredient": [
        "Inactive ingredients sorbitol, water, hydrated silica, sodium lauryl sulfate, flavor, trisodium phosphate, cellulose gum, sodium saccharin, sodium phosphate, carbomer, titanium dioxide"
      ],
      "questions": [
        "Questions? 1-800-492-7378"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 68 g Tube Carton CLEANS & WHITENS TEETH* Crest ® FLUORIDE ANTICAVITY TOOTHPASTE NET WT 2.4 OZ (68 g) FRESH AND WHITE Peppermint GLEEM ™ Paste 868"
      ],
      "set_id": "8693fa6d-e9c9-4cb7-bd3d-8ad87a7bb77e",
      "id": "4aa60484-78be-875c-e063-6294a90ab84f",
      "effective_time": "20260212",
      "version": "12",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Fresh and White"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "37000-868"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "4aa60484-78be-875c-e063-6294a90ab84f"
        ],
        "spl_set_id": [
          "8693fa6d-e9c9-4cb7-bd3d-8ad87a7bb77e"
        ],
        "package_ndc": [
          "37000-868-02",
          "37000-868-06",
          "37000-868-24",
          "37000-868-57"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}