{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-30",
    "results": {
      "skip": 0,
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  "results": [
    {
      "spl_product_data_elements": [
        "Crest Cavity Protection Regular Sodium Fluoride SORBITOL WATER HYDRATED SILICA SODIUM LAURYL SULFATE SODIUM PHOSPHATE CARBOXYMETHYLCELLULOSE SODIUM SACCHARIN SODIUM TITANIUM DIOXIDE FD&C BLUE NO. 1 SODIUM FLUORIDE FLUORIDE ION"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "Dist. by Procter & Gamble, Cincinnati, OH 45202"
      ],
      "active_ingredient": [
        "Active Ingredient Sodium fluoride 0.243% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toothpaste"
      ],
      "indications_and_usage": [
        "Use helps protect teeth and roots against cavities"
      ],
      "warnings": [
        "Warnings Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away. Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in childrenunder 6 supervise children’s brushing until good habits are established children under 2 yrs.: ask a dentist"
      ],
      "inactive_ingredient": [
        "Inactive ingredients sorbitol, water, hydrated silica, sodium lauryl sulfate, trisodium phosphate, flavor, sodium phosphate, cellulose gum, carbomer, sodium saccharin, titanium dioxide, blue 1"
      ],
      "questions": [
        "Questions? 1-800-492-7378"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 161 g Tube Carton HELPS STOP CAVITIES BEFORE THEY START Crest ® CAVITY PROTECTION ADA Accepted American Dental Association® FLUORIDE ANTICAVITY TOOTHPASTE NET WT 5.7 OZ (161 g) Regular Paste Cavity protection"
      ],
      "set_id": "852889b4-59ba-4592-b4fc-c0127a1ad075",
      "id": "508a90bf-922a-2e4c-e063-6394a90a239a",
      "effective_time": "20260428",
      "version": "15",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Cavity Protection Regular"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "Procter & Gamble Manufactura, S. de R.L. de C.V."
        ],
        "product_ndc": [
          "58933-005"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "508a90bf-922a-2e4c-e063-6394a90a239a"
        ],
        "spl_set_id": [
          "852889b4-59ba-4592-b4fc-c0127a1ad075"
        ],
        "package_ndc": [
          "58933-005-04",
          "58933-005-11",
          "58933-005-57",
          "58933-005-82",
          "58933-005-24",
          "58933-005-85",
          "58933-005-03"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
      }
    }
  ]
}