{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-28",
    "results": {
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  "results": [
    {
      "spl_product_data_elements": [
        "Diphenhydramine HCl and Zinc Acetate Extra Strength Itch Relief GLYCERIN WATER ALCOHOL TROMETHAMINE ALOE VERA LEAF DIPHENHYDRAMINE HYDROCHLORIDE DIPHENHYDRAMINE ZINC ACETATE ZINC CATION"
      ],
      "active_ingredient": [
        "Active ingredients Diphenhydramine HCl 2.0% Zinc Acetate 0.1%"
      ],
      "purpose": [
        "Purpose External Analgesic Skin protectant"
      ],
      "indications_and_usage": [
        "Uses for temporary relief of pain and itching associated with: minor burns sunburns minor cuts scrapes insect bites minor skin irritations rashes due to poison ivy, poison oak and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac"
      ],
      "warnings": [
        "Warnings For external use only. Flammable: Keep away from fire or flame. Do not puncture or incinerate. Contents under pressure. Do not store at temperature above 120ºF. Intentional misuse by deliberately concentrating and inhaling contents cans be harmful or fatal. Do not use on large areas of the body with any other products containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles Stop use and ask doctor if condition worsens symptoms last more than 7 days or clear up and occur again within a few days When using this product avoid contact with eyes use only as directed Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "safe_handling_warning": [
        "Flammable: Keep away from fire or flame. Do not puncture or incinerate. Contents under pressure. Do not store at temperature above 120ºF. Intentional misuse by deliberately concentrating and inhaling contents cans be harmful or fatal."
      ],
      "do_not_use": [
        "Do not use on large areas of the body with any other products containing diphenhydramine, even one taken by mouth"
      ],
      "ask_doctor": [
        "Ask a doctor before use on chicken pox on measles"
      ],
      "stop_use": [
        "Stop use and ask doctor if condition worsens symptoms last more than 7 days or clear up and occur again within a few days"
      ],
      "when_using": [
        "When using this product avoid contact with eyes use only as directed"
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor"
      ],
      "other_safety_information": [
        "Other information store between 20° to 25°C (68° to 77°F)"
      ],
      "inactive_ingredient": [
        "Inactive ingredients aloe barbadensis leaf juice, glycerin, purified water, SD alcohol 40-B, tromethamine"
      ],
      "questions": [
        "Questions? call 1-866-964-0939"
      ],
      "package_label_principal_display_panel": [
        "Principal Display Panel HEB Itch Relief Extra Strength | Continuous Spray Histamine Blocking Topical Analgesic Skin Protectant Relieves Itching and pain from insect bites, rashes, poison ivy, sumac and oak. NET WT 2.7 OZ (76 g) H-E-B_Itch Relief Spray_50-082HE.jpg"
      ],
      "set_id": "2aedbf1d-c8b7-4d5d-83ee-e38872c37d4f",
      "id": "42653e08-8894-9563-e063-6394a90a5e77",
      "effective_time": "20251030",
      "version": "7",
      "openfda": {
        "application_number": [
          "M017"
        ],
        "brand_name": [
          "Diphenhydramine HCl and Zinc Acetate"
        ],
        "generic_name": [
          "EXTRA STRENGTH ITCH RELIEF"
        ],
        "manufacturer_name": [
          "HEB"
        ],
        "product_ndc": [
          "37808-526"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "TOPICAL"
        ],
        "substance_name": [
          "DIPHENHYDRAMINE HYDROCHLORIDE",
          "ZINC ACETATE"
        ],
        "rxcui": [
          "1053138"
        ],
        "spl_id": [
          "42653e08-8894-9563-e063-6394a90a5e77"
        ],
        "spl_set_id": [
          "2aedbf1d-c8b7-4d5d-83ee-e38872c37d4f"
        ],
        "package_ndc": [
          "37808-526-27"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "TC2D6JAD40",
          "FM5526K07A"
        ]
      }
    }
  ]
}