{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-10-30",
    "results": {
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  "results": [
    {
      "spl_product_data_elements": [
        "Crest Cavity Protection Cool Mint Gel Sodium Fluoride SACCHARIN SODIUM SORBITOL WATER HYDRATED SILICA SODIUM LAURYL SULFATE SODIUM PHOSPHATE FD&C BLUE NO. 1 CARBOXYMETHYLCELLULOSE SODIUM SODIUM FLUORIDE FLUORIDE ION SODIUM PHOSPHATE, TRIBASIC"
      ],
      "spl_unclassified_section": [
        "Drug Facts",
        "Dist. by Procter & Gamble, Cincinnati OH 45202 www.crest.com"
      ],
      "active_ingredient": [
        "Active ingredient Sodium fluoride 0.243% (0.15% w/v fluoride ion)"
      ],
      "purpose": [
        "Purpose Anticavity toothpaste"
      ],
      "indications_and_usage": [
        "Use helps protect teeth and roots against cavities"
      ],
      "warnings": [
        "Warnings Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."
      ],
      "dosage_and_administration": [
        "Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in children under 6 supervise children's brushing until good habits are established children under 2 yrs.: ask a dentist"
      ],
      "inactive_ingredient": [
        "Inactive ingredients sorbitol, water, hydrated silica, sodium lauryl sulfate, trisodium phosphate, cellulose gum, flavor, sodium phosphate, sodium saccharin, carbomer, blue 1"
      ],
      "questions": [
        "Questions? 1-800-492-7378"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 161 g Carton Crest Plus FLUORIDE ANTICAVITY TOOTHPASTE CAVITY PROTECTION WITH ACTIVE FLUORIDE Regular Paste Net Wt .85 OZ (24 g) Label"
      ],
      "set_id": "102e4d9c-0fae-d48a-e063-6294a90aac94",
      "id": "49ef9a5d-2bd1-2d93-e063-6394a90a3fe3",
      "effective_time": "20260203",
      "version": "10",
      "openfda": {
        "application_number": [
          "M021"
        ],
        "brand_name": [
          "Crest Cavity Protection Cool Mint Gel"
        ],
        "generic_name": [
          "SODIUM FLUORIDE"
        ],
        "manufacturer_name": [
          "The Procter & Gamble Manufacturing Company"
        ],
        "product_ndc": [
          "69423-815"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "DENTAL"
        ],
        "substance_name": [
          "SODIUM FLUORIDE"
        ],
        "rxcui": [
          "891775"
        ],
        "spl_id": [
          "49ef9a5d-2bd1-2d93-e063-6394a90a3fe3"
        ],
        "spl_set_id": [
          "102e4d9c-0fae-d48a-e063-6294a90aac94"
        ],
        "package_ndc": [
          "69423-815-57",
          "69423-815-82",
          "69423-815-85",
          "69423-815-11",
          "69423-815-24",
          "69423-815-42",
          "69423-815-35"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "8ZYQ1474W7"
        ]
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    }
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}